| Medawar, P. B | An Unsolved Problem of Biology | — | 1952 | — |
| Harman, D | Aging: a theory based on free radical and radiation chemistry | Journal of Gerontology | 1956 | — |
| Williams, G. C | Pleiotropy, natural selection, and the evolution of senescence | Evolution | 1957 | — |
| Katz, S., et al | Studies of illness in the aged | The index of ADL: a standardized measure of biological and psychosocial function | 1963 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ |
| Hamilton, W. D | The moulding of senescence by natural selection | Journal of Theoretical Biology | 1966 | — |
| Lawton, M. P., & Brody, E. M | Assessment of older people: Self-maintaining and instrumental activities of daily living | Gerontologist, 9(3), 179–186 | 1969 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ |
| Kirkwood, T. B. L | Evolution of ageing | Nature | 1977 | — |
| Kirkwood, T. B. L., Holliday, R | The evolution of ageing and longevity | Proceedings of the Royal Society of London B | 1979 | — |
| Fries, J. F | Aging, natural death, and the compression of morbidity | Milbank Quarterly, 58(2), 397-419 | 1980 | https://varifo.ch/wp-content/uploads/2021/06/830427fries.pdf |
| Fries, J. F | The compression of morbidity | The Lancet | 1983 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7482385/ |
| Baker, G. T., & Sprott, R. L | Biomarkers of aging | Experimental Gerontology, 23(4-5), 223-239 | 1988 | https://pubmed.ncbi.nlm.nih.gov/3058488/ |
| Rose, M. R | Evolutionary Biology of Aging | — | 1991 | — |
| Guralnik, J. M., et al | A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission | Journal of Gerontology, 49(2), M85–M94 | 1994 | https://onlinelibrary.wiley.com/doi/10.1155/2023/9409918 |
| Verbrugge, L. M., & Jette, A. M | The disablement process | Social Science & Medicine, 38(1), 1-14 | 1994 | https://pubmed.ncbi.nlm.nih.gov/8146699/ |
| Murray, C. J. L., & Lopez, A. D | The Global Burden of Disease | Harvard School of Public Health | 1996 | — |
| Fried, L. P., & Guralnik, J. M | Disability in older adults: evidence regarding significance, etiology, and risk | — | 1997 | https://pubmed.ncbi.nlm.nih.gov/8994496/ |
| Martin, P | Wound healing--aiming for perfect skin regeneration | Science | 1997 | https://www.science.org/doi/10.1126/science.276.5309.75 |
| Rantanen, T., Guralnik, J. M., Foley, D., et al | Midlife hand grip strength as a predictor of old age disability | JAMA, 281(6), 558-560 | 1999 | https://doi.org/10.1001/jama.281.6.558 |
| Schmelzle, T., & Hall, M. N | TOR, a central controller of cell growth | Cell | 2000 | https://pubmed.ncbi.nlm.nih.gov/11057898/ |
| Kirkwood, T. B. L., Austad, S. N | Why do we age? | Nature | 2000 | — |
| Mitnitski, A. B., Mogilner, A. J., & Rockwood, K | Accumulation of deficits as a proxy measure of aging | — | 2001 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6084020/ |
| Fried, L. P., Tangen, C. M., Walston, J., et al | Frailty in older adults: evidence for a phenotype | The Journals of Gerontology: Series A, 56(3), M146-M157 | 2001 | https://pubmed.ncbi.nlm.nih.gov/11253156/ |
| Marteau, T. M., & Lerman, C | Genetic risk and behavioural change | BMJ, 322, 1056-1059 | 2001 | https://www.bmj.com/content/322/7293/1056 |
| Guralnik, J. M | Chronological and functional ageing | In Encyclopedia of Aging (2nd ed.) | 2002 | https://onlinelibrary.wiley.com/doi/abs/10.1002/0470846410.ch13 |
| Hubert, H. B., et al | Lifestyle and the compression of morbidity | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/12023263/ |
| Stern, Y | What is cognitive reserve? Theory and research application of the reserve concept | — | 2002 | https://doi.org/10.1017/S1355617702813248 |
| Thesleff, I | Developmental biology and building a tooth | Current Opinion in Genetics & Development | 2003 | https://www.sciencedirect.com/science/article/pii/S0959437X03000039 |
| Rantanen, T., Volpato, S., Ferrucci, L., et al | Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism | Journal of the American Geriatrics Society, 51(5), 636-641 | 2003 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| Trifunovic, A. et al | Premature ageing in mice expressing defective mitochondrial DNA polymerase | Nature | 2004 | https://www.nature.com/articles/nature02517 |
| Freedman, V. A., et al | Resolving inconsistencies in trends in old-age disability | — | 2004 | https://pubmed.ncbi.nlm.nih.gov/15461008/ |
| Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G | Untangling the concepts of disability, frailty, and comorbidity | — | 2004 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3028599/ |
| Gill, T. M., et al | Hospitalization, restricted activity, and the development of disability among older persons | JAMA, 292(17), 2115-2124 | 2004 | https://pubmed.ncbi.nlm.nih.gov/15523072/ |
| Conboy, I. M. et al | Rejuvenation of aged progenitor cells by exposure to a young systemic environment | Nature | 2005 | https://www.nature.com/articles/nature03260 |
| Kirkwood, T. B. L | Systems biology of ageing and longevity | Philosophical Transactions of the Royal Society B | 2005 | — |
| Blagosklonny, M. V | Aging is quasi-programmed: from growth to hyperfunction to death | Aging | 2006 | — |
| Sanchez Alvarado, A., Tsonis, P. A | Bridging the regenerative gap: genetic insights from diverse animal models | Nature Reviews Genetics | 2006 | https://www.nature.com/articles/nrg1879 |
| Takahashi, K., & Yamanaka, S | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors | Cell | 2006 | https://pubmed.ncbi.nlm.nih.gov/16904174/ |
| Rando, T. A | Stem cells, ageing and the quest for immortality | Nature | 2006 | https://www.nature.com/articles/nature04958 |
| Scadden, D. T | The stem cell niche | Nature | 2006 | https://pubmed.ncbi.nlm.nih.gov/16799783/ |
| Yu, J. et al | Induced pluripotent stem cell lines derived from human somatic cells | Science | 2007 | https://doi.org/10.1126/science.1151526 |
| Takahashi, K. et al | Induction of pluripotent stem cells from adult human fibroblasts by defined factors | Cell | 2007 | https://pubmed.ncbi.nlm.nih.gov/18035408/ |
| Commission on Social Determinants of Health | Closing the gap in a generation | World Health Organization | 2008 | https://www.who.int/publications/i/item/9789241563703 |
| Brockes, J. P., Kumar, A | Comparative aspects of animal regeneration | Annual Review of Cell and Developmental Biology | 2008 | https://www.annualreviews.org/doi/10.1146/annurev.cellbio.24.110707.175336 |
| Oldenhuis, C. N. A. M., Oosting, S. F., Gietema, J. A., & de Vries, E. G. E | Prognostic versus predictive value of biomarkers in oncology | European Journal of Cancer, 44(7), 946-953 | 2008 | https://www.sciencedirect.com/science/article/abs/pii/S0959804908002335 |
| Morrison, S. J., Spradling, A. C | Stem cell niches: mechanisms that promote stem cell maintenance throughout life | Cell | 2008 | https://www.sciencedirect.com/science/article/pii/S0092867408002776 |
| Gurtner, G. C. et al | Wound repair and regeneration | Nature | 2008 | https://www.nature.com/articles/nature07039 |
| Cesari, M., Kritchevsky, S. B., Newman, A. B., et al | Added value of physical performance measures in predicting adverse health-related events: results from the Health ABC Study | Journal of the American Geriatrics Society, 57(2), 251-259 | 2009 | https://pubmed.ncbi.nlm.nih.gov/19170785/ |
| Huang, Y., & Pepe, M. S | Biomarker evaluation and comparison using the controls as a reference population | Biostatistics, 10(2), 228-244 | 2009 | https://academic.oup.com/biostatistics/article/10/2/228/259645 |
| Abellan van Kan, G., Rolland, Y., Andrieu, S., et al | Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people | Journal of Nutrition Health and Aging, 13(10), 881-889 | 2009 | https://pubmed.ncbi.nlm.nih.gov/19812893/ |
| Cesari, M., Kritchevsky, S. B., Penninx, B. W., et al | Prognostic value of usual gait speed in well-functioning older people—results from the Health, Aging and Body Composition Study | Journal of the American Geriatrics Society, 53(10), 1675-1680 | 2005 | https://pubmed.ncbi.nlm.nih.gov/16181165/ |
| Harrison, D. E. et al | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice | Nature | 2009 | https://www.nature.com/articles/nature08221 |
| Poss, K. D | Advances in understanding tissue regenerative capacity and mechanisms in animals | Nature Reviews Genetics | 2010 | https://www.nature.com/articles/nrg2879 |
| Galliot, B., Ghila, L | Cellular and molecular mechanisms of regeneration in Hydra | Developmental Biology | 2010 | https://www.sciencedirect.com/science/article/pii/S0012160610003082 |
| Bossuyt, P. M | Clinical validity: defining biomarker performance | Scandinavian Journal of Clinical and Laboratory Investigation Supplement, 70(242), 46-52 | 2010 | https://pubmed.ncbi.nlm.nih.gov/20515277/ |
| Li, L., Clevers, H | Coexistence of quiescent and active adult stem cells in mammals | Science | 2010 | https://www.science.org/doi/10.1126/science.1192275 |
| Bely, A. E., Nyberg, K. G | Evolution of animal regeneration: re-emergence of a field | Trends in Ecology & Evolution | 2010 | https://www.sciencedirect.com/science/article/pii/S0169534709002912 |
| Makary, M. A., Segev, D. L., Pronovost, P. J., et al | Frailty as a predictor of surgical outcomes in older patients | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20510798/ |
| Cooper, R., Kuh, D., & Hardy, R | Objectively measured physical capability levels and mortality: systematic review and meta-analysis | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2938886/ |
| Ricklefs, R. E | Insights from comparative analyses of aging in birds and mammals | Aging Cell | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2858791/ |
| Crimmins, E. M., & Beltrán-Sánchez, H | Mortality and morbidity trends: is there compression of morbidity? | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5486403/ |
| Alibardi, L | Review: Tail regeneration in lizards | Journal of Experimental Zoology Part B | 2010 | https://onlinelibrary.wiley.com/doi/10.1002/jez.b.21367 |
| Cruz-Jentoft, A. J., et al | Sarcopenia: European consensus on definition and diagnosis (EWGSOP) | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2886201/ |
| Gill, T. M | Assessment of function and disability in longitudinal studies | Journal of the American Geriatrics Society, 58 Suppl 2, S308-S312 | 2010 | https://pubmed.ncbi.nlm.nih.gov/21029063/ |
| Gill, T. M., et al | Change in disability after hospitalization or restricted activity in older persons | JAMA, 304(17), 1919-1928 | 2010 | https://pubmed.ncbi.nlm.nih.gov/21045098/ |
| Frantz, C., Stewart, K. M., Weaver, V. M | The extracellular matrix at a glance | Journal of Cell Science | 2010 | https://journals.biologists.com/jcs/article/123/24/4195/32071/The-extracellular-matrix-at-a-glance |
| Roberts, H. C., Denison, H. J., Martin, H. J., et al | A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardized approach | Age and Ageing, 40(4), 423-429 | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| Crimmins, E. M | Biomarkers related to aging in human populations | Current Gerontology and Geriatrics Research, 2011, 471738 | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5938178/ |
| Studenski, S., Perera, S., Patel, K., et al | Gait speed and survival in older adults | JAMA, 305(1), 50-58 | 2011 | https://pubmed.ncbi.nlm.nih.gov/21205966/ |
| Hanahan, D., Weinberg, R. A | Hallmarks of cancer: the next generation | Cell | 2011 | https://www.sciencedirect.com/science/article/pii/S0092867411001279 |
| Youle, R. J., & Narendra, D. P | Mechanisms of mitophagy | Nature Reviews Molecular Cell Biology | 2011 | https://doi.org/10.1038/nrm3028 |
| Bohannon, R. W., & Williams Andrews, A | Normal walking speed: a descriptive meta-analysis | Physiotherapy, 97(3), 182-189 | 2011 | https://pubmed.ncbi.nlm.nih.gov/21722974/ |
| Salthouse, T. A | Influence of age on practice effects in longitudinal neurocognitive change | Neuropsychology | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2933088/ |
| Kirkwood, T. B. L., Melov, S | On the programmed/non-programmed nature of ageing within the life history | Current Biology | 2011 | — |
| Tanaka, E. M., Reddien, P. W | The cellular basis for animal regeneration | Developmental Cell | 2011 | https://www.sciencedirect.com/science/article/pii/S1534580711002983 |
| Traphagan, J. W | Tragedy and delight: the ethics of decelerated ageing | Journal of Medical Ethics, 37(9), 556-559 | 2011 | https://jme.bmj.com/content/37/9/556 |
| Dykiert, D. et al | Age Differences in Intra-Individual Variability in Simple and Choice Reaction Time | Psychology and Aging | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3469552/ |
| Conboy, I. M., Rando, T. A | Aging, stem cells and tissue regeneration: lessons from muscle | Cell Stem Cell | 2012 | https://www.sciencedirect.com/science/article/pii/S1934590912004184 |
| Koolhaas, W., et al | Associations between chronological age, functional age and work outcomes | European Journal of Public Health, 22(3), 424–429 | 2012 | https://academic.oup.com/eurpub/article/22/3/424/506558 |
| Barnett, K., et al | Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study | The Lancet, 380(9836), 37-43 | 2012 | https://pubmed.ncbi.nlm.nih.gov/22579043/ |
| Laplante, M., & Sabatini, D. M | mTOR signaling in growth control and disease | Cell | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3331679/ |
| — | The Nobel Prize in Physiology or Medicine 2012. NobelPrize.org | — | 2012 | https://www.nobelprize.org/prizes/medicine/2012/summary/ |
| Jernvall, J., Thesleff, I | Tooth shape formation and tooth renewal: evolving with the same signals | Development | 2012 | https://journals.biologists.com/dev/article/139/19/3487/45562/Tooth-shape-formation-and-tooth-renewal |
| Cheung, C.-L., Nguyen, U.-S. D. T., Au, E., Tan, K. C., & Kung, A. W. C | Association of handgrip strength with chronic diseases and multimorbidity | Age (Dordr), 35(3), 929-941 | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| Horvath, S | DNA methylation age of human tissues and cell types | Genome Biology, 14(10), R115 | 2013 | https://onlinelibrary.wiley.com/doi/10.1111/acel.13229 |
| Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K | Frailty in elderly people | Lancet, 381(9868), 752-762 | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4098658/ |
| Peel, N. M., Kuys, S. S., & Klein, K | Gait speed as a measure in geriatric assessment in clinical settings: a systematic review | Journal of Gerontology: Biological Sciences, 68(1), 39-46 | 2013 | https://pubmed.ncbi.nlm.nih.gov/22989186/ |
| Hannum, G., et al | Genome-wide methylation profiles reveal quantitative views of human aging rates | Genome Research, 23(12), 2124-2132 | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12539533/ |
| Giorgio, M. et al | Reactive oxygen species and the free radical theory of aging | Free Radical Biology and Medicine | 2013 | https://doi.org/10.1016/j.freeradbiomed.2013.02.011 |
| Rodriguez-Manas, L., Feart, C., Mann, G., et al | Searching for an operational definition of frailty: a Delphi method based consensus statement | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3598366/ |
| Palmer, D. B | The Effect of Age on Thymic Function | Frontiers in Immunology | 2013 | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2013.00316/full |
| Lopez-Otin, C. et al | The Hallmarks of Aging | Cell | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ |
| Clevers, H | The intestinal crypt, a prototype stem cell compartment | Cell | 2013 | https://www.sciencedirect.com/science/article/pii/S0092867413004055 |
| Gemberling, M. et al | The zebrafish as a model for complex tissue regeneration | Nature Reviews Genetics | 2013 | https://www.nature.com/articles/nrg3561 |
| Martin-Ruiz, C., et al | Biomarkers of healthy ageing: expectations and validation | Proceedings of the Nutrition Society | 2014 | https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/biomarkers-of-healthy-ageing-expectations-and-validation/5710EA381976F548980F7A3EA54FC09C |
| Salthouse, T. A | Why are there different age relations in cross-sectional and longitudinal comparisons of cognitive functioning? | Current Directions in Psychological Science | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4219741/ |
| Jones, O. R. et al | Diversity of ageing across the tree of life | Nature | 2014 | — |
| Afilalo, J., Alexander, K. P., Mack, M. J., et al | Frailty assessment in the cardiovascular care of older adults | — | 2014 | https://www.aafp.org/pubs/afp/issues/2021/0215/p219.html |
| Kennedy, B. K., Berger, S. L., Brunet, A., et al | Geroscience: linking aging to chronic disease | Cell, 159(4), 709-713 | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4852871/ |
| Alley, D. E., Shardell, M. D., Peters, K. W., et al | Grip strength cutpoints for the identification of clinically relevant weakness | Journal of Gerontology: Biological Sciences, 69(5), 559-566 | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| Mannick, J. B. et al | mTOR inhibition improves immune function in the elderly | Science Translational Medicine | 2014 | https://pubmed.ncbi.nlm.nih.gov/25540326/ |
| Zhang, Y. et al | Rapamycin extends life and health in C57BL/6 mice | Journals of Gerontology: Series A | 2014 | https://pubmed.ncbi.nlm.nih.gov/23682161/ |
| Eming, S. A., Martin, P., Tomic-Canic, M | Wound repair and regeneration: mechanisms, signaling, and translation | Science Translational Medicine | 2014 | https://www.science.org/doi/10.1126/scitranslmed.3009337 |
| Marengoni, A., et al | Aging with multimorbidity: A systematic review of the literature | Ageing Research Reviews, 10(4), 430-439 | 2011 | https://pubmed.ncbi.nlm.nih.gov/21402176/ |
| Sayer, A. A., & Kirkwood, T. B. L | Grip strength and mortality: a biomarker of ageing? The Lancet, 386(9990), 226-227 | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| Crimmins, E. M | Lifespan and healthspan: past, present, and promise | Gerontologist, 55(6), 901-911 | 2015 | — |
| Pinto, M., & Moraes, C. T | Mechanisms linking mtDNA damage and aging | Free Radical Biology and Medicine | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4508218/ |
| Middleton, A., Fritz, S. L., & Lusardi, M | Walking speed: the functional vital sign | Journal of Aging and Physical Activity, 23(2), 314-322 | 2015 | https://pubmed.ncbi.nlm.nih.gov/24812254/ |
| Weuve, J., et al | Guidelines for reporting methodological challenges and evaluating potential bias in dementia research | Alzheimer's & Dementia | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4655106/ |
| Sharpe, P. T | Dental stem cells | Development | 2016 | https://journals.biologists.com/dev/article/143/13/2273/47703/Dental-stem-cells |
| Chen, B. H., et al | DNA methylation-based measures of biological age: meta-analysis predicting mortality | Aging Cell, 15(4), 686-698 | 2016 | https://onlinelibrary.wiley.com/doi/10.1111/acel.13229 |
| Seals, D. R., et al | DOI: 10.1113/JP270805 | — | 2016 | — |
| Sen, P. et al | Epigenetic mechanisms of longevity and aging | Cell | 2016 | https://www.sciencedirect.com/science/article/pii/S0092867416303074 |
| Dent, E., Kowal, P., & Hoogendijk, E. O | Frailty measurement in research and clinical practice: a review | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27039014/ |
| Ocampo, A. et al | In vivo amelioration of age-associated hallmarks by partial reprogramming | Cell | 2016 | https://doi.org/10.1016/j.cell.2016.11.052 |
| Wynn, T. A., Vannella, K. M | Macrophages in tissue repair, regeneration, and fibrosis | Immunity | 2016 | https://www.sciencedirect.com/science/article/pii/S1074761316303840 |
| Pavasini, R., et al | Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis | BMC Medicine, 14, 215 | 2016 | https://onlinelibrary.wiley.com/doi/10.1155/2023/9409918 |
| Sun, N., Youle, R. J., & Finkel, T | The mitochondrial basis of aging | Molecular Cell | 2016 | https://doi.org/10.1016/j.molcel.2016.01.028 |
| Tanaka, E. M | The molecular and cellular choreography of appendage regeneration | Cell | 2016 | https://www.cell.com/cell/fulltext/S0092-8674(16 |
| Lin, S. F. et al | From Noise to Signal: The Age and Social Patterning of Intra-individual Variability in Health Trajectories | J Gerontol B | 2017 | https://academic.oup.com/psychsocgerontology/article/72/1/168/2632037 |
| Pilling, L. C. et al. | Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants | Aging | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4833145/ |
| Korolchuk, V. I. et al | Mitochondria in cell senescence: Is mitophagy the weakest link? | EBioMedicine | 2017 | https://doi.org/10.1016/j.ebiom.2017.03.020 |
| Saxton, R. A., & Sabatini, D. M | mTOR signaling in growth, metabolism, and disease | Cell | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5394987/ |
| Whitty, C. J. M., et al | New horizons in the management of multimorbidity | Age and Ageing, 46(6), 882-888 | 2017 | https://academic.oup.com/ageing/article/46/6/882/4103436 |
| Lemaitre, J. F., Gaillard, J. M | Reproductive senescence: new perspectives in the wild | Biological Reviews | 2017 | https://discovery.ucl.ac.uk/id/eprint/10172184/3/Cunningham_Manuscript%2030-03-2022_submitted.pdf |
| Bohannon, R. W | Test-retest reliability of hand-held dynamometry for grip strength: a systematic review | Isokinetics and Exercise Science, 25(1), 1-9 | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| Sarkar, T. J. et al | Transient transcription factor expression is key to reprogramming and rejuvenation | EMBO Molecular Medicine | 2017 | https://doi.org/10.15252/emmm.201707650 |
| Cohen, A. A | Aging across the tree of life: The importance of a comparative perspective for the use of animal models in aging | Biochim Biophys Acta Mol Basis Dis | 2018 | https://www.sciencedirect.com/science/article/pii/S0925443917302193 |
| Levine, M. E., et al | An epigenetic biomarker of aging for lifespan and healthspan | Aging (Albany NY), 10(4), 573-591 | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12539533/ ; https://pmc.ncbi.nlm.nih.gov/articles/PMC8176216/ |
| Veronese, N., Stubbs, B., Volpato, S., et al | Association between gait speed with mortality, cardiovascular disease and cancer: a systematic review and meta-analysis | Journal of the American Medical Directors Association, 19(11), 981-988.e7 | 2018 | https://pubmed.ncbi.nlm.nih.gov/30122444/ |
| Fong, J. H., & Feng, J | Comparing the loss of functional independence of older adults in the U.S | and China | 2018 | https://www.sciencedirect.com/science/article/pii/S0167494317303126 |
| Devi, J | The scales of functional assessment of activities of daily living in geriatrics | Age and Ageing, 47(4), 500-502 | 2018 | https://pubmed.ncbi.nlm.nih.gov/29608661/ |
| Sechidis, K., Papangelou, K., Metcalfe, P. D., Svensson, D., Weatherall, J., & Brown, G | Distinguishing prognostic and predictive biomarkers: an information theoretic approach | Bioinformatics, 34(19), 3365-3376 | 2018 | https://academic.oup.com/bioinformatics/article/34/19/3365/4991984 |
| Horvath, S., & Raj, K | DNA methylation-based biomarkers and the epigenetic clock theory of ageing | Nature Reviews Genetics, 19(6), 371-384 | 2018 | https://onlinelibrary.wiley.com/doi/full/10.1002/ajhb.23488 ; https://onlinelibrary.wiley.com/doi/10.1002/mef2.50 ; https://onlinelibrary.wiley.com/doi/abs/10.1002/mef2.50 |
| Franceschi, C. et al | Inflammaging and immunosenescence: from theory to practice | Nature Reviews Endocrinology | 2018 | https://www.nature.com/articles/s41574-018-0059-4 |
| Ferrucci, L., & Fabbri, E | Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty | Nature Reviews Cardiology, 15(9), 505-522 | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6146930/ |
| Rabanal-Ruiz, Y., Otten, E. G., & Korolchuk, V. I. | mTORC1 as the main gateway to autophagy | Essays in Biochemistry | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5869864/ |
| Reddien, P. W | The cellular and molecular basis for planarian regeneration | Cell | 2018 | https://www.cell.com/cell/fulltext/S0092-8674(18 |
| Menardi, A., et al | The role of cognitive reserve in Alzheimer's disease and healthy ageing | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8972845/ |
| Nuffield Council on Bioethics | The search for a treatment for ageing | — | 2018 | https://www.nuffieldbioethics.org/publications/the-search-for-a-treatment-for-ageing |
| Berkovitz, B. K. B., Shellis, R. P | Tooth replacement in reptiles and fish | Journal of Anatomy | 2018 | https://onlinelibrary.wiley.com/doi/10.1111/joa.12822 |
| Mannick, J. B. et al | TORC1 inhibition enhances immune function and reduces infections in the elderly | Science Translational Medicine | 2018 | https://pubmed.ncbi.nlm.nih.gov/29997249/ |
| Sharma, A. et al | Causal roles of mitochondrial dynamics in longevity and healthy aging | EMBO Reports | 2019 | https://doi.org/10.15252/embr.201948395 |
| Yanai, H., et al | Compression of morbidity by interventions that steepen the survival curve | — | 2019 | https://weizmann.elsevierpure.com/en/publications/compression-of-morbidity-by-interventions-that-steepen-the-surviv-2 |
| Fong, J. H | Disability incidence and functional decline among older adults with major chronic diseases | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6873710/ |
| Lu, A. T., et al | DNA methylation GrimAge strongly predicts lifespan and healthspan | Aging (Albany NY), 11(4), 1183-1199 | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11404624/ |
| Bohannon, R. W | Grip strength: an indispensable biomarker for older adults | Journal of Strength and Conditioning Research | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| Olova, N. et al | Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity | Aging Cell | 2019 | https://doi.org/10.1111/acel.12877 |
| — | The Hallmarks of Aging (Biochemia Medica, 2019) | — | 2019 | — |
| Zhang, Y., et al | Epigenetic clocks: theory and applications in human biology | American Journal of Human Biology, 33(1), e23488 | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10411856/ |
| Thomas, R., Wang, W., & Su, D.-M. | Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging. | Immunity & Ageing | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6971920/ |
| Nguyen, H., et al | Multimorbidity patterns and healthy ageing in the English Longitudinal Study of Ageing | Geriatrics & Gerontology International, 20(12), 1173-1180 | 2020 | https://onlinelibrary.wiley.com/doi/10.1111/ggi.14051 |
| Lu, Y. et al | Reprogramming to recover youthful epigenetic information and restore vision | Nature | 2020 | https://doi.org/10.1038/s41586-020-2975-4 |
| Fraser, G. J. et al | Tooth replacement in vertebrates: development, maintenance, and regeneration | Biological Reviews | 2020 | https://onlinelibrary.wiley.com/doi/10.1111/brv.12547 |
| Launay, C., et al | Chronological age or biological age: What drives the choice? Frontiers in Aging | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8640726/ |
| Galvin, A. E., et al | Focus on disability-free life expectancy: implications for health-related quality of life | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/33733432/ |
| Garmany, A., et al | npj Aging | — | 2021 | https://www.nature.com/articles/s41536-021-00169-5 |
| Hartmann, A., Hartmann, C., Secci, R., et al | Ranking biomarkers of aging by citation profiling and effort scoring | Frontiers in Genetics, 12, 686320 | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8176216/ |
| Higgins-Chen, A. T., et al | A computational solution for bias and noise in epigenetic clocks | Clinical Epigenetics, 14(1), 117 | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12539533/ |
| Liang, J. et al | Age-related thymic involution: mechanisms and functional impact | Frontiers in Immunology | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9381902/ |
| Guo, J., Huang, H. et al | Aging and aging-related diseases: from molecular mechanisms to interventions | Signal Transduction and Targeted Therapy | 2022 | https://www.nature.com/articles/s41392-022-01251-0 |
| Kivimaki, M., et al | Association of multimorbidity with dementia: A longitudinal study | BMJ, 376, e068005 | 2022 | https://www.bmj.com/content/376/bmj-2021-068005 |
| Fraser, H. C. et al | Biological mechanisms of aging predict age-related disease onset | Communications Biology | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9009120/ |
| Orchard, S. G., et al | Combination of gait speed and grip strength to predict cognitive decline or dementia | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9494608/ |
| Geyer, S., et al | Compression, expansion, or dynamic equilibrium of morbidity? Evidence from European populations | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9906028/ |
| Belsky, D. W., et al | DunedinPACE, a DNA methylation biomarker of the pace of aging | Nature Medicine, 28(10), 2086-2095 | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11404624/ |
| Lehallier, B., et al | Hallmarks of aging in human cells | Nature Aging, 2(5), 441-453 | 2022 | https://www.nature.com/articles/s43587-022-00220-0 |
| Patel, A. et al | Inter- and intra-individual variation in brain structural trajectories | NeuroImage | 2022 | https://www.sciencedirect.com/science/article/pii/S1053811922003494 |
| Jagger, C., et al | The impact of long-term conditions on disability-free life expectancy | PLoS Global Public Health | 2022 | https://journals.plos.org/globalpublichealth/article?id=10.1371%2Fjournal.pgph.0000745 |
| "Aging hallmarks and progression and age-related diseases: A landscape view of research advancement." | ACS Chemical Neuroscience | — | 2023 | https://pubs.acs.org/doi/10.1021/acschemneuro.3c00531 |
| Tian, X., et al | Biological age is superior to chronological age in predicting ICU mortality | Critical Care | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10543822/ |
| Aging Biomarker Consortium, Bao, H., Cao, J., Chen, M., et al | Biomarkers of aging | Science China Life Sciences, 66(5), 893-1066 | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10115486/ |
| Biomarkers of Aging Consortium, Moqri, M., Herzog, C., Poganik, J. R., et al | Biomarkers of aging for the identification and evaluation of longevity interventions | Cell, 186(18), 3758-3775 | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11088934/ |
| Salih, A., Ghosh, R., & Becerra, S. P | Conceptual overview of biological age estimation | Aging and Disease, 14(3), 583-588 | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10187689/ |
| Tyshkovskiy, A. et al | Distinct longevity mechanisms across and within species and their association with aging | Cell | 2023 | https://pubmed.ncbi.nlm.nih.gov/37269831/ |
| Frangos, E., Graf, C., & Samaras, N | Functional aging: Integrating functionality to a multidimensional assessment of healthy aging | Current Gerontology and Geriatrics Research, 2023, 9409918 | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ |
| Wu, Z., et al | Grip strength, gait speed, and trajectories of cognitive function | — | 2023 | https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12388 |
| Lopez-Otin, C. et al | Hallmarks of aging: An expanding universe | Cell | 2023 | https://pubmed.ncbi.nlm.nih.gov/36599349/ ; https://doi.org/10.1016/j.cell.2022.11.001 |
| Stojic, M | Hallmarks of Aging: Causes and Consequences | Aging Biology | 2023 | https://agingbiologyjournal.org/Archive/Volume3/hallmarks_of_aging_causes_and_consequences/agingbio.20230011.pdf |
| Nuffield Council on Bioethics | The future of ageing: ethical considerations for research and innovation | — | 2023 | https://www.nuffieldbioethics.org/publications/the-future-of-ageing |
| Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G | The hallmarks of aging as a conceptual framework for biomarkers | Biogerontology, 24(1), 1-27 | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10824251/ |
| Dombrowsky, T. D | Trajectories of functional decline in older adults: a latent class growth curve analysis | — | 2023 | https://journals.sagepub.com/doi/10.1177/01939459231180365 |
| Valenzuela-Sanchez, A. et al | Variable rate of ageing within species | — | 2023 | https://discovery.ucl.ac.uk/id/eprint/10172184/3/Cunningham_Manuscript%2030-03-2022_submitted.pdf |
| Belsky, D. W., Kritchevsky, S. B., Cuervo, A. M., Niedernhofer, L. J., Gladyshev, V. N., et al | An expert consensus statement on biomarkers of aging for use in human intervention studies | Journal of Gerontology: Biological Sciences, 80(5), glae297 | 2024 | https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 |
| Chen, L. et al | Associations between biological ageing and the risk of, and reduced life expectancy in, rheumatoid arthritis | The Lancet Healthy Longevity | 2024 | https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23 |
| Tao, X., Wang, X., Huang, Y., et al | Biomarkers of Aging and Relevant Evaluation Techniques | Biomedicines, 12(5), 1046 | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11081160/ |
| McGlinchey, E., et al | Biomarkers of neurodegeneration across the Global South | The Lancet Healthy Longevity, 5(9), e611-e627 | 2024 | https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24 |
| Herzog, C., et al | Challenges and recommendations for the translation of biomarkers of aging | Nature Aging | 2024 | https://www.nature.com/articles/s43587-024-00683-3 |
| Johnson, A. A., & Shokhirev, M. N | Contextualizing aging clocks and properly describing biological age | Aging Cell, 23(12), e14377 | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11634725/ |
| Kim, D. H., & Rockwood, K | Frailty in older adults | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11634188/ |
| Poganik, J. R., Perri, G., Belsky, D. W., et al | Framework to standardize biomarkers of aging and accelerate clinical translation | — | 2024 | https://www.ucl.ac.uk/population-health-sciences/news/2024/feb/study-proposes-framework-standardize-biomarkers-aging-and-accelerate-clinical-use |
| WHO ICD-11 ageing-related coding discussed in: He, Q. et al | Frontiers in Public Health | — | 2024 | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1451737/full |
| Moqri, M., et al | Generalizability and cohort effects in biomarker models of aging | GeroScience | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12262637/ |
| Hu, P., Kohler, S., & Goldman, N | Harmonization of four biomarkers across nine nationally representative studies of people 50 years of age and over | American Journal of Human Biology, 36(4), e24030 | 2024 | https://onlinelibrary.wiley.com/doi/full/10.1002/ajhb.24030 |
| Balachandran, A., et al | Pace of Aging in older adults matters for healthspan and lifespan | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11071564/ |
| Liu, J., et al | Quantification of epigenetic aging in population studies | Clinical Epigenetics, 16(1), 175 | 2024 | https://pubmed.ncbi.nlm.nih.gov/36206857/ |
| He, Q. et al | The association between accelerated biological aging and osteoarthritis | Frontiers in Public Health | 2024 | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1451737/full |
| Garcia-Prat, L. et al | The hallmarks of aging as a conceptual framework for geroscience | Frontiers in Aging | 2024 | https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2024.1334261/full |
| "Hallmarks of aging: A user's guide for comparative biologists." | Trends in Endocrinology & Metabolism | — | 2024 | https://www.sciencedirect.com/science/article/pii/S1568163724004343 |
| Brognara, L., et al | Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review | International Journal of Molecular Sciences | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10855721/ |
| Tangestani Fard, M., et al | Peripheral inflammation marker relationships to cognition in healthy older adults - A systematic review | Psychoneuroendocrinology | 2022 | https://pubmed.ncbi.nlm.nih.gov/35908534/ |
| Xu, Y., et al | Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies | Aging Clinical and Experimental Research | 2022 | https://pubmed.ncbi.nlm.nih.gov/34981430/ |
| Singh, T., & Newman, A. B | Inflammatory markers in population studies of aging | Ageing Research Reviews | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3098911/ |
| Giovannini, S., et al | Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals | Journal of the American Geriatrics Society | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4321727/ |
| Soysal, P., et al | Inflammation and frailty in the elderly: A systematic review and meta-analysis | Ageing Research Reviews | 2016 | https://pubmed.ncbi.nlm.nih.gov/27592340/ |
| Moqri, M., et al | Validation of biomarkers of aging | Nature Medicine, 30, 360-372 | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11090477/ |
| Perri, G., Poganik, J. R., Levine, M. E., et al | An expert consensus statement on biomarkers of aging for use in intervention studies | Journal of Gerontology: Biological Sciences, 80(5), glae297 | 2025 | https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 |
| Expert consensus statement | Biomarkers of ageing for use in intervention studies | The Journals of Gerontology: Series A | 2025 | https://repository.monashhealth.org/monashhealthjspui/handle/1/53106 |
| Furrer, R., & Handschin, C | Biomarkers of aging: functional aspects still trump molecular parameters | npj Aging, 11, 15 | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11876623/ |
| Perri, R., et al | Expert consensus statement on biomarkers of aging for use in clinical trials | The Journals of Gerontology: Biological Sciences | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11979094/ |
| "Targeting the hallmarks of aging: mechanisms and therapeutic opportunities." | Frontiers in Cardiovascular Medicine | — | 2025 | https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1631578/full |
| Handgrip strength as a potential indicator of aging: insights from its association with aging-related laboratory biomarkers | Frontiers in Medicine | Frontiers in Medicine, 10, 1491584 | 2025 | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1491584/full |
| Expert consensus statement on biomarkers of ageing for use in intervention studies | Journal of Gerontology: Biological Sciences | — | 2025 | https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 |
| Harel, I. | Scaling life as an interspecies hallmark of aging. | Genes & Development | 2025 | https://pubmed.ncbi.nlm.nih.gov/40664504/ |
| Li, G. et al | Predicting healthspan and disease risks through biological ageing measures | — | 2025 | https://www.sciencedirect.com/science/article/pii/S1471491425002576 |
| — | Aging: Overview (NCBI Bookshelf) | — | — | — |
| — | APA Dictionary of Psychology. Functional age. American Psychological Association | — | — | https://dictionary.apa.org/functional-age |
| — | Biomarkers of Aging and Biological Age Clocks (Frontiers in Medicine) | — | — | — |
| McHugh, D., & Gil, J. | Senescence and aging: Causes, consequences, and therapeutic avenues | Journal of Cell Biology | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5748990/ |
| — | Disposable Soma Theory (Programmed-Aging) | — | — | — |
| — | Evolution of Ageing (Wikipedia) | — | — | — |
| Rose, M. R | Evolutionary Biology of Aging | — | — | — |
| — | Evolutionary Theories of Aging (Demographic Research) | — | — | — |
| — | Fries, J. F. Compression of morbidity (foundational framing for DFLE) | — | — | https://www.nber.org/system/files/working_papers/w22306/w22306.pdf |
| — | Geroscience: Aging Biology and Chronic Disease (NIA) | — | — | — |
| — | H70 study: Health, Aging and Body Composition trends in morbidity | — | — | https://www.sciencedirect.com/science/article/abs/pii/S0167494303000487 |
| Barzilai, D. A. | Mikhail 'Misha' Blagosklonny's enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin | Aging | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11810056/ |
| — | Immunosenescence and Inflammaging (Nature) | — | — | — |
| — | PMC article on disability-free life expectancy measurement limitations and multimorbidity | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11966715/ |
| UK Biobank | Prospective studies of ageing and age-related diseases | — | — | https://www.ukbiobank.ac.uk/projects/prospective-studies-of-ageing-and-age-related-diseases/ |
| — | Proteostasis and Aging (BioEssays) | — | — | — |
| Afanas'ev, I. | Signaling and damaging functions of free radicals in aging—free radical theory, hormesis, and TOR | Aging and Disease | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3295029/ |
| — | Senescence (Wikipedia) | — | — | — |
| Ljubuncic, P., & Reznick, A. Z. | The evolutionary theories of aging revisited—a mini-review | Gerontology | 2009 | https://pubmed.ncbi.nlm.nih.gov/19202326/ |
| Fekete, M. et al. | Geroscience and pathology: a new frontier in understanding age-related diseases | Pathology & Oncology Research | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10922957/ |
| Gems, D. | The hyperfunction theory: An emerging paradigm for the biology of aging | Ageing Research Reviews | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7612201/ |
| — | World Health Organization. Healthy Life Expectancy (HALE) methodology | — | — | https://cdn.who.int/media/docs/default-source/gho-documents/metadata/hale-metadata.pdf |
| World Health Organization | Multimorbidity: Technical Series on Safer Primary Care | World Health Organization | 2016 | https://www.who.int/publications/i/item/9789241511650 |
| Yaggi, H. K., et al | Obstructive sleep apnea as a risk factor for stroke and death | NEJM | 2005 | https://www.nejm.org/doi/full/10.1056/NEJMoa043104 |
| Kodama, S., et al | Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events | JAMA | 2009 | https://jamanetwork.com/journals/jama/fullarticle/183510 |
| Hamer, M., O'Donovan, G | Cardiorespiratory fitness and mortality in men and women: a meta-analysis | Scandinavian Journal of Medicine and Science in Sports | 2010 | https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0838.2009.01071.x |
| Cappuccio, F. P., et al | Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies | Sleep | 2010 | https://academic.oup.com/sleep/article/33/5/585/2454444 |
| Lee, I.-M., et al | Effect of physical inactivity on major non-communicable diseases worldwide | The Lancet | 2012 | https://www.sciencedirect.com/science/article/pii/S0140673612610319 |
| Leong, D. P., et al | Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study | The Lancet | 2015 | https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)62000-6/abstract?code=lancet-site&ncid=txtlnkusaolp00000618 |
| Arem, H., et al | Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship | JAMA Internal Medicine | 2015 | https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2212267 |
| Ross, R., et al | Importance of assessing cardiorespiratory fitness in clinical practice | Circulation | 2016 | https://www.ahajournals.org/doi/10.1161/CIR.0000000000000461 |
| Itani, O., et al | Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression | Sleep Medicine | 2017 | https://doi.org/10.1016/j.sleep.2016.08.006 |
| Lear, S. A., et al | The effect of physical activity on mortality and cardiovascular disease in 130,000 people from 17 high-income, middle-income, and low-income countries: the PURE study | The Lancet | 2017 | https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31634-3/abstract?rs_oid_rd=259360191118728 |
| Medic, G., Wille, M., Hemels, M. E. H | Short- and long-term health consequences of sleep disruption | Nature and Science of Sleep | 2017 | https://www.tandfonline.com/doi/full/10.2147/NSS.S134864 |
| Mandsager, K., et al | Association of cardiorespiratory fitness with long-term mortality among adults undergoing exercise treadmill testing | JAMA Network Open | 2018 | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2707428 |
| Ekelund, U., et al | Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality | BMJ | 2019 | https://www.bmj.com/content/366/bmj.l4570 |
| Myers, J., et al | Exercise capacity and mortality among men referred for exercise testing | NEJM | 2002 | https://www.nejm.org/doi/full/10.1056/NEJMoa011858 |
| Dodds, R. M., et al | Grip strength across the life course: normative data from twelve British studies | PLoS ONE | 2014 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113637 |
| Di Micco, R. et al. "Cellular senescence in ageing: from mechanisms to therapeutic opportunities." Nature Reviews Molecular Cell Biology | Cellular senescence in ageing: from mechanisms to therapeutic opportunities. | Nature Reviews Molecular Cell Biology | 2021 | https://pubmed.ncbi.nlm.nih.gov/33328614/ |
| Serrano, M. et al. "Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a." Cell | Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. | Cell | 1997 | https://pubmed.ncbi.nlm.nih.gov/9054499/ |
| Campisi, J., d'Adda di Fagagna, F. "Cellular senescence: when bad things happen to good cells." Nature Reviews Molecular Cell Biology | Cellular senescence: when bad things happen to good cells. | Nature Reviews Molecular Cell Biology | 2007 | https://pubmed.ncbi.nlm.nih.gov/17667954/ |
| Gorgoulis, V. et al. "Cellular Senescence: Defining a Path Forward." Cell | Cellular Senescence: Defining a Path Forward. | Cell | 2019 | https://doi.org/10.1016/j.cell.2019.10.005 |
| Galluzzi, L. et al. "Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018." Cell Death & Differentiation | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. | Cell Death & Differentiation | 2018 | https://pubmed.ncbi.nlm.nih.gov/29362479/ |
| Youle, R. J., Strasser, A. "The BCL-2 protein family: opposing activities that mediate cell death." Nature Reviews Molecular Cell Biology | The BCL-2 protein family: opposing activities that mediate cell death. | Nature Reviews Molecular Cell Biology | 2008 | https://pubmed.ncbi.nlm.nih.gov/18097445/ |
| Czabotar, P. E. et al. "Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy." Nature Reviews Molecular Cell Biology | Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. | Nature Reviews Molecular Cell Biology | 2014 | https://pubmed.ncbi.nlm.nih.gov/24355989/ |
| d'Adda di Fagagna, F. et al. "A DNA damage checkpoint response in telomere-initiated senescence." Nature | A DNA damage checkpoint response in telomere-initiated senescence. | Nature | 2003 | https://pubmed.ncbi.nlm.nih.gov/14608368/ |
| Childs, B. G. et al. "Cellular senescence in aging and age-related disease: from mechanisms to therapy." Nature Medicine | Cellular senescence in aging and age-related disease: from mechanisms to therapy. | Nature Medicine | 2015 | https://pubmed.ncbi.nlm.nih.gov/26646499/ |
| — | Aging: Overview (NCBI Bookshelf) | — | — | https://www.ncbi.nlm.nih.gov/books/NBK10041/ |
| — | The Hallmarks of Aging (Biochemia Medica, 2019) | — | — | https://www.biochemia-medica.com/en/journal/29/3/10.11613/BM.2019.030501/fullArticle |
| — | Immunosenescence and Inflammaging (Nature) | — | — | https://www.nature.com/articles/s12276-025-01527-9 |
| — | Geroscience: Aging Biology and Chronic Disease (NIA) | — | — | https://www.nia.nih.gov/research/dab/geroscience-intersection-basic-aging-biology-chronic-disease-and-health |
| — | Biomarkers of Aging and Biological Age Clocks (Frontiers in Medicine) | — | — | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00061/full |
| — | Senescence (Wikipedia) | — | — | https://en.wikipedia.org/wiki/Senescence |
| Coppe, J. P. et al. "The senescence-associated secretory phenotype: the dark side of tumor suppression." Annual Review of Pathology | The senescence-associated secretory phenotype: the dark side of tumor suppression. | Annual Review of Pathology | 2010 | https://pubmed.ncbi.nlm.nih.gov/20078217/ |
| Basisty, N. et al. "A proteomic atlas of senescence-associated secretomes for aging biomarker development." PLoS Biology | A proteomic atlas of senescence-associated secretomes for aging biomarker development. | PLoS Biology | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6964821/ |
| Wiley, C. D. et al. "Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis." JCI Insight | Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. | JCI Insight | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6975274/ |
| Demaria, M. et al. "An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA." Developmental Cell | An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. | Developmental Cell | 2014 | https://pubmed.ncbi.nlm.nih.gov/25499914/ |
| Munoz-Espin, D., Serrano, M. "Cellular senescence: from physiology to pathology." Nature Reviews Molecular Cell Biology | Cellular senescence: from physiology to pathology. | Nature Reviews Molecular Cell Biology | 2014 | https://pubmed.ncbi.nlm.nih.gov/24954210/ |
| Ruhland, M. K. et al. "Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis." Nature Communications | Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. | Nature Communications | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4899869/ |
| Herranz, N., Gil, J. "Mechanisms and functions of cellular senescence." Journal of Clinical Investigation | Mechanisms and functions of cellular senescence. | Journal of Clinical Investigation | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5873888/ |
| Ovadya, Y., Krizhanovsky, V. "Strategies targeting cellular senescence." Journal of Clinical Investigation | Strategies targeting cellular senescence. | Journal of Clinical Investigation | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5873866/ |
| Ovadya, Y. et al. "Impaired immune surveillance accelerates accumulation of senescent cells and aging." Nature Medicine | Impaired immune surveillance accelerates accumulation of senescent cells and aging. | Nature Medicine | 2018 | https://pubmed.ncbi.nlm.nih.gov/30575733/ |
| Krizhanovsky, V. et al. "Senescence of activated stellate cells limits liver fibrosis." Cell | Senescence of activated stellate cells limits liver fibrosis. | Cell | 2008 | https://pubmed.ncbi.nlm.nih.gov/18724938/ |
| Sagiv, A. et al. "Granule exocytosis mediates immune surveillance of senescent cells." Oncogene | Granule exocytosis mediates immune surveillance of senescent cells. | Oncogene | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3630483/ |
| Xue, W. et al. "Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas." Nature | Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. | Nature | 2007 | https://pubmed.ncbi.nlm.nih.gov/17251933/ |
| Kang, T.-W. et al. "Senescence surveillance of pre-malignant hepatocytes limits liver cancer development." Nature | Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. | Nature | 2011 | https://pubmed.ncbi.nlm.nih.gov/22080947/ |
| Prata, L. G. P. L. et al. | Senescent cell clearance by the immune system: Emerging therapeutic opportunities. | Seminars in Immunology | 2019 | https://pubmed.ncbi.nlm.nih.gov/31088710/ |
| Hayflick, L., Moorhead, P. S. "The serial cultivation of human diploid cell strains." Experimental Cell Research | The serial cultivation of human diploid cell strains. | Experimental Cell Research | 1961 | https://doi.org/10.1016/0014-4827(61)90192-6 |
| — | Evolutionary Theories of Aging (Demographic Research) | — | — | https://www.demographic-research.org/volumes/vol4/1/4-1.pdf |
| — | Evolution of Ageing (Wikipedia) | — | — | https://en.wikipedia.org/wiki/Evolution_of_ageing |
| — | Disposable Soma Theory (Programmed-Aging) | — | — | http://www.programmed-aging.org/theories/disposable_soma.html |
| — | Proteostasis and Aging (BioEssays) | — | — | https://onlinelibrary.wiley.com/doi/10.1002/bies.201200014 |
| Lee, S., Schmitt, C. A. "The dynamic nature of senescence in cancer." Nature Cell Biology | The dynamic nature of senescence in cancer. | Nature Cell Biology | 2019 | https://pubmed.ncbi.nlm.nih.gov/30602768/ |
| Collado, M., Serrano, M. "Senescence in tumours: evidence from mice and humans." Nature Reviews Cancer | Senescence in tumours: evidence from mice and humans. | Nature Reviews Cancer | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3672965/ |
| Calcinotto, A. et al. "Cellular Senescence: Aging, Cancer, and Injury." Physiological Reviews | Cellular Senescence: Aging, Cancer, and Injury. | Physiological Reviews | 2019 | https://pubmed.ncbi.nlm.nih.gov/30648461/ |
| Faget, D. V., Ren, Q., Stewart, S. A. "Unmasking senescence: context-dependent effects of SASP in cancer." Nature Reviews Cancer | Unmasking senescence: context-dependent effects of SASP in cancer. | Nature Reviews Cancer | 2019 | https://pubmed.ncbi.nlm.nih.gov/31235879/ |
| Baars, J | Aging and Time | — | 2013 | http://www.janbaars.nl/wp-content/uploads/Aging-and-Time-Chapter-01-Jan-Baars.pdf |
| Witzel, D. D., et al | age three ways | Age and inflammation: Insights on "age three ways" from population cohorts | 2025 | https://www.sciencedirect.com/science/article/abs/pii/S0889159125001035 |
| — | University of Georgia, College of Public Health | — | — | https://publichealth.uga.edu/research/research-institutes/institute-of-gerontology/about/what-is-gerontology/ |
| — | Rasmussen University | — | — | https://www.rasmussen.edu/degrees/nursing/blog/what-is-gerontology/ |
| — | ScienceDirect Topics | — | — | https://www.sciencedirect.com/topics/neuroscience/gerontology |
| — | National Center for Biotechnology Information | — | — | https://www.ncbi.nlm.nih.gov/books/NBK218728/ |
| Baker, D. J., et al | Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders | — | 2011 | https://www.nature.com/articles/nature10600 |
| Zhu, Y., et al | The Achilles’ heel of senescent cells: From transcriptome to senolytic drugs | — | 2015 | https://onlinelibrary.wiley.com/doi/10.1111/acel.12344 |
| Kirkland, J. L., & Tchkonia, T | Senolytic drugs: From discovery to translation | — | 2020 | https://onlinelibrary.wiley.com/doi/10.1111/joim.13056 |
| Short, S., Fielder, E., Miwa, S., & von Zglinicki, T | Senolytics and senostatics as adjuvant tumour therapy | — | 2019 | https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30024-8/fulltext |
| Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M | Strategies for targeting senescent cells in human disease | — | 2021 | https://www.nature.com/articles/s41591-021-01521-0 |
| Kaeberlein, M., et al | Cold Spring Harbor Perspectives in Medicine | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4817738/ |
| Lemoine, M., et al | Cells | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10202082/ |
| — | Baylor OpenBooks | — | — | https://openbooks.library.baylor.edu/lifespanhumandevelopment/chapter/22-1-lifespan-life-expectancy-healthy-aging/ |
| — | ScienceDirect Topics | — | — | https://www.sciencedirect.com/topics/medicine-and-dentistry/lifespan |
| Austad, S. N., & Fischer, K. E | Journal of Nutrition in Gerontology and Geriatrics | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3257745/ |
| Bird, A | DNA methylation patterns and epigenetic memory | — | 2002 | https://doi.org/10.1101/gad.947102 |
| Jones, P. A., et al | The epigenomics of cancer | — | 2008 | https://doi.org/10.1016/j.cell.2008.08.012 |
| Marioni, R. E., et al | DNA methylation age at birth is associated with child health outcomes | — | 2021 | https://doi.org/10.1038/s41467-021-21218-x |
| — | Blaum, C | — | — | https://www.americangeriatrics.org/sites/default/files/inline-files/caroline_blaum.pdf |
| — | University of Glasgow | — | — | https://www.gla.ac.uk/schools/healthwellbeing/research/generalpractice/internationalmultimorbidity/blog/headline_1224242_en.html |
| Berger, S. L., et al | An operational definition of epigenetics | — | 2009 | https://doi.org/10.1101/gad.1787609 |
| Allis, C. D., & Jenuwein, T | The molecular hallmarks of epigenetic control | — | 2016 | https://doi.org/10.1038/nrg.2016.59 |
| Kouzarides, T | Chromatin modifications and their function | — | 2007 | https://doi.org/10.1016/j.cell.2007.02.005 |
| Portela, A., & Esteller, M | Epigenetic modifications and human disease | — | 2010 | https://doi.org/10.1038/nbt.1684 |
| Benayoun, B. A., et al | Epigenetic regulation of ageing: linking environmental inputs to genomic stability | — | 2016 | https://doi.org/10.1038/nrm.2015.16 |
| Rowe, J. W., & Kahn, R. L | Science | — | 1987 | https://healthjournalism.org/glossary-terms/healthspan/ |
| — | FoodMed Center | — | — | https://foodmedcenter.org/lifespan-vs-healthspan-the-critical-gap-in-modern-aging/ |
| — | ResearchBunny | — | — | https://www.researchbunny.com/papers/how-healthy-is-the-healthspan-concept-l4nw |
| Blackburn, E. H., Greider, C. W., & Szostak, J. W | Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and ageing | — | 2006 | https://doi.org/10.1038/nm1006-1133 |
| de Lange, T | How Shelterin Solves the Telomere End-Protection Problem | — | 2010 | https://doi.org/10.1101/sqb.2010.75.017 |
| Olovnikov, A. M | Principle of marginotomy in template synthesis of polynucleotides | — | 1971 | https://pubmed.ncbi.nlm.nih.gov/5167114/ |
| Watson, J. D | Origin of concatemeric T7 DNA | — | 1972 | https://pubmed.ncbi.nlm.nih.gov/4570499/ |
| Sanders, J. L., & Newman, A. B | Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? | — | 2013 | https://doi.org/10.1093/epirev/mxs008 |
| Epel, E. S., et al | Accelerated telomere shortening in response to life stress | — | 2004 | https://doi.org/10.1073/pnas.0407162101 |
| Bernardes de Jesus, B., & Blasco, M. A | Telomerase at the intersection of cancer and aging | — | 2013 | https://doi.org/10.1016/j.tig.2013.05.003 |
| Jylhava, J., et al | Biological Age Predictors | — | 2017 | https://doi.org/10.1016/j.ebiom.2017.03.046 |
| Eisenberg, D. T. A | Telomere length measurement validity: the cohabitation problem and what to do about it | — | 2019 | https://doi.org/10.1002/ajhb.23280 |
| Bernardes de Jesus, B., et al | Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer | — | 2012 | https://doi.org/10.1002/emmm.201200245 |
| Wallace, D. C | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer | — | 2005 | https://doi.org/10.1146/annurev.genet.39.110304.095751 |
| Larsson, N. G | Somatic mitochondrial DNA mutations in mammalian aging | — | 2010 | https://doi.org/10.1146/annurev-biochem-060408-093701 |
| Stewart, J. B., & Chinnery, P. F | The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease | — | 2015 | https://doi.org/10.1038/nrg3966 |
| Scarpulla, R. C | Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network | — | 2011 | https://doi.org/10.1016/j.bbabio.2010.09.019 |
| Twig, G., & Shirihai, O. S | The interplay between mitochondrial dynamics and mitophagy | — | 2011 | https://doi.org/10.1089/ars.2010.3779 |
| West, A. P., et al | Mitochondrial DNA in innate immune responses and inflammatory diseases | — | 2015 | https://doi.org/10.1038/nri3864 |
| Ristow, M | Unraveling the truth about antioxidants: mitohormesis explains the beneficial effects of ROS | — | 2014 | https://doi.org/10.1016/j.redox.2014.03.004 |
| Sies, H., & Jones, D. P | Reactive oxygen species (ROS) as pleiotropic physiological signalling agents | — | 2020 | https://doi.org/10.1038/s41580-020-0230-3 |
| Willey, C. A., & Walsh, K | Exercise and mitochondrial health | — | 2023 | https://doi.org/10.1002/cphy.c220045 |
| Hamczyk, M. R., et al | Biological versus chronological aging: A review | — | 2020 | https://www.lidsen.com/journals/geriatrics/geriatrics-03-02-051 |
| Gómez-Virgilio, L. et al. | Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators | Cells | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9329718/ |
| Hansen, M., et al | Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, and Implications for Ageing | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38725847/ |
| Mizushima, N., et al | Autophagy: An Essential Degradation Program for Cellular Homeostasis | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6315530/ |
| Levine, B., et al | Autophagy: Cellular and Molecular Mechanisms | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2990190/ |
| Minciullo, P. L., et al | An update on inflamm-aging: Mechanisms, prevention, and treatment | — | 2016 | https://onlinelibrary.wiley.com/doi/10.1155/2016/8426874 |
| Xia, X., et al | Inflammaging: Triggers, molecular mechanisms, and consequences | — | 2025 | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1704203/full |
| Verdi, S., et al | Global research trends in inflammaging and neurodegeneration | — | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12018403/ |
| Guyatt GH, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ | — | — | 2008 | https://www.bmj.com/content/336/7650/924 |
| Page MJ, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ | — | — | 2021 | https://www.bmj.com/content/372/bmj.n71 |
| Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMJ | — | — | 2010 | https://www.bmj.com/content/340/bmj.c332 |
| von Elm E, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. PLoS Medicine | — | — | 2007 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2020496/ |
| Sterne JA, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ | — | — | 2016 | https://www.bmj.com/content/355/bmj.i4919 |
| — | Cochrane Handbook for Systematic Reviews of Interventions (Version 6+) | — | — | https://www.ncbi.nlm.nih.gov/books/NBK326791/ |
| — | BEST (Biomarkers, EndpointS, and other Tools) Resource | — | — | https://www.ncbi.nlm.nih.gov/books/NBK338448/ |
| Ioannidis JPA. Why Most Published Research Findings Are False. PLoS Medicine | — | — | 2005 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1182327/ |
| Justice JN, et al. Frameworks for proof-of-concept clinical trials of interventions that target fundamental aging processes. Journals of Gerontology A | — | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6523054/ |
| — | PubMed User Guide / Help (NLM) | — | — | https://pubmed.ncbi.nlm.nih.gov/help/ |
| Hopewell S, et al. CONSORT for reporting randomised trials in journal and conference abstracts. Lancet | — | — | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6398298/ |
| Lee JW, et al. Fit-for-purpose method development and validation for successful biomarker measurement. Pharmaceutical Research | — | — | 2006 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4975285/ |
| Collins GS, et al. Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD). BMJ | — | — | 2015 | https://www.bmj.com/content/350/bmj.g7594 |
| Wolff RF, et al. PROBAST: A Tool to Assess Risk of Bias and Applicability of Prediction Model Studies. BMJ | — | — | 2019 | https://www.bmj.com/content/366/bmj.l4898 |
| — | National Cancer Institute Dictionary: relative risk | — | — | https://www.cancer.gov/publications/dictionaries/cancer-terms/def/relative-risk |
| — | National Cancer Institute Dictionary: absolute risk | — | — | https://www.cancer.gov/publications/dictionaries/cancer-terms/def/absolute-risk |
| Deeks JJ. Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes. BMJ | — | — | 2002 | https://doi.org/10.1002/sim.1188 |
| Bland JM, Altman DG. Statistics Notes: The odds ratio. BMJ | — | — | 1998 | https://www.bmj.com/content/316/7136/989 |
| — | CEBM Oxford: Number Needed to Treat (NNT) and absolute effects (EBM tools) | — | — | https://www.cebm.ox.ac.uk/resources/ebm-tools/number-needed-to-treat-nnt |
| — | PubMed (NLM/NCBI) | — | — | https://pubmed.ncbi.nlm.nih.gov/ |
| — | PubMed Central (PMC) (NLM/NCBI) | — | — | https://pmc.ncbi.nlm.nih.gov/ |
| — | ClinicalTrials | — | — | https://clinicaltrials.gov/ |
| Zarin DA, Tse T, et al. The ClinicalTrials.gov results database. New England Journal of Medicine | — | — | 2011 | https://www.ovid.com/journals/nejm/abstract/00006024-201106020-00038~the-clinicaltrialsgov-results-database |
| — | About bioRxiv | — | — | https://www.biorxiv.org/about-biorxiv |
| — | About medRxiv | — | — | https://www.medrxiv.org/content/about-medrxiv |
| — | PubMed Central (PMC): Preprints in PMC | — | — | https://www.nlm.nih.gov/oet/ed/pmc/index.html |
| — | ASAPbio: Preprint FAQ | — | — | https://asapbio.org/preprint-info/preprint-faq |
| Fraser N, et al. Preprinting a pandemic: the role of preprints in the COVID-19 pandemic. bioRxiv/PLoS Biology context paper | — | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7081173/ |
| Weinstein, M. C., Torrance, G., & McGuire, A | Value in Health | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19250132/ |
| EuroQol Group | Health Policy | — | 1990 | https://pubmed.ncbi.nlm.nih.gov/10109801/ |
| Whitehead, S. J., & Ali, S | British Medical Bulletin | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/21037243/ |
| Dawoud, D., et al | Quality of Life Research | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35247152/ |
| Bulamu, N. B., Kaambwa, B., & Ratcliffe, J | Health and Quality of Life Outcomes | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26553129/ |
| Makai, P., et al | Social Science & Medicine | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24565145/ |
| Huter, K., et al | BMC Health Services Research | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5016726/ |
| Asaria, M., Griffin, S., & Cookson, R | Medical Decision Making | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4853814/ |
| Rosenberg, I. H. "Sarcopenia: Origins and clinical relevance." Journal of Nutrition | Sarcopenia: Origins and clinical relevance. | Journal of Nutrition | 1997 | https://pubmed.ncbi.nlm.nih.gov/9164280/ |
| Chen, L.-K. et al. "Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment." Journal of the American Medical Directors Association | Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. | Journal of the American Medical Directors Association | 2020 | https://pubmed.ncbi.nlm.nih.gov/32033882/ |
| Bhasin, S. et al. "Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium." Journal of the American Geriatrics Society | Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium. | Journal of the American Geriatrics Society | 2020 | https://pubmed.ncbi.nlm.nih.gov/31990347/ |
| Cawthon, P. M. et al. "Cut-points for low appendicular lean mass that identify older adults with clinically significant weakness." Journals of Gerontology Series A | Cut-points for low appendicular lean mass that identify older adults with clinically significant weakness. | Journals of Gerontology Series A | 2020 | https://pubmed.ncbi.nlm.nih.gov/32108288/ |
| McLean, R. R. et al. "Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project." Journals of Gerontology Series A | Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project. | Journals of Gerontology Series A | 2014 | https://pubmed.ncbi.nlm.nih.gov/24737560/ |
| Larsson, L. et al. "Sarcopenia: Aging-Related Loss of Muscle Mass and Function." Physiological Reviews | Sarcopenia: Aging-Related Loss of Muscle Mass and Function. | Physiological Reviews | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6442923/ |
| Beaudart, C. et al. "Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis." PLoS ONE | Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis. | PLoS ONE | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5240970/ |
| Yeung, S. S. Y. et al. "Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis." Journal of Cachexia, Sarcopenia and Muscle | Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. | Journal of Cachexia, Sarcopenia and Muscle | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6596401/ |
| Pal, S., & Tyler, J. K. "Epigenetics and aging." Science Advances | Epigenetics and aging. | Science Advances | 2016 | https://www.science.org/doi/10.1126/sciadv.1600584 |
| Oberdoerffer, P., & Sinclair, D. A. "The role of nuclear architecture in genomic instability and ageing." Nature Reviews Molecular Cell Biology | The role of nuclear architecture in genomic instability and ageing. | Nature Reviews Molecular Cell Biology | 2007 | https://www.nature.com/articles/nrm2238 |
| Feser, J., & Tyler, J. "Chromatin structure as a mediator of aging." FEBS Letters | Chromatin structure as a mediator of aging. | FEBS Letters | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3988783/ |
| Hu, Z. et al. "Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging." Genes & Development | Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. | Genes & Development | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3937517/ |
| Stegeman, R., & Weake, V. M. "Transcriptional Signatures of Aging." Journal of Molecular Biology | Transcriptional Signatures of Aging. | Journal of Molecular Biology | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5662117/ |
| Sun, L., Yu, R., & Dang, W. "Chromatin Architectural Changes during Cellular Senescence and Aging." Genes | Chromatin Architectural Changes during Cellular Senescence and Aging. | Genes | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5924553/ |
| Moskalev, A. A. et al. "The role of DNA damage and repair in aging through the prism of Koch-like criteria." Ageing Research Reviews | The role of DNA damage and repair in aging through the prism of Koch-like criteria. | Ageing Research Reviews | 2013 | https://pubmed.ncbi.nlm.nih.gov/22353384/ |
| Geiger, H., de Haan, G., Florian, M. C. "The ageing haematopoietic stem cell compartment." Nature Reviews Immunology | The ageing haematopoietic stem cell compartment. | Nature Reviews Immunology | 2013 | https://www.nature.com/articles/nri3433 |
| Flach, J. et al. "Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells." Nature | Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. | Nature | 2014 | https://www.nature.com/articles/nature13619 |
| Choi, J., Augenlicht, L. H. "Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges." Experimental & Molecular Medicine | Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges. | Experimental & Molecular Medicine | 2024 | https://www.nature.com/articles/s12276-024-01179-1 |
| Novak, J. S. et al. "Human muscle stem cells are refractory to aging." Aging Cell | Human muscle stem cells are refractory to aging. | Aging Cell | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8282247/ |
| Villeda, S. A. et al. "The ageing systemic milieu negatively regulates neurogenesis and cognitive function." Nature | The ageing systemic milieu negatively regulates neurogenesis and cognitive function. | Nature | 2011 | https://pubmed.ncbi.nlm.nih.gov/21886162/ |
| Robbins, P. D., Morelli, A. E. "Extracellular vesicles and aging." Aging Medicine | Extracellular vesicles and aging. | Aging Medicine | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5762993/ |
| Eitan, E. et al. "Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes." Scientific Reports | Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes. | Scientific Reports | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5430958/ |
| Alibhai, F. J. et al. "Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function." Aging Cell | Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function. | Aging Cell | 2020 | https://pubmed.ncbi.nlm.nih.gov/31960578/ |
| Borghesan, M. et al. "Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3." Cell Reports | Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. | Cell Reports | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6613042/ |
| Rakyan, V. K. et al. "Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains." Genome Research | Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. | Genome Research | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2847746/ |
| Teschendorff, A. E. et al. "Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer." Genome Research | Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. | Genome Research | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2847747/ |
| Yang, Z. et al. "Correlation of an epigenetic mitotic clock with cancer risk." Genome Biology | Correlation of an epigenetic mitotic clock with cancer risk. | Genome Biology | 2016 | https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1064-3 |
| Zhang, Z. et al. "Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell-type deconvolution applied to human blood epigenetic clocks." Aging Cell | Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell-type deconvolution applied to human blood epigenetic clocks. | Aging Cell | 2024 | https://pubmed.ncbi.nlm.nih.gov/38146185/ |
| Labbadia, J., & Morimoto, R. I. "The Biology of Proteostasis in Aging and Disease." Annu Rev Biochem | The Biology of Proteostasis in Aging and Disease. | Annu Rev Biochem | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4539002/ |
| Hipp, M. S., Kasturi, P., & Hartl, F. U. "The proteostasis network and its decline in ageing." Nat Rev Mol Cell Biol | The proteostasis network and its decline in ageing. | Nat Rev Mol Cell Biol | 2019 | https://www.nature.com/articles/s41580-019-0101-y |
| Morimoto, R. I., & Cuervo, A. M. "Proteostasis and the Aging Proteome in Health and Disease." J Gerontol A Biol Sci Med Sci | Proteostasis and the Aging Proteome in Health and Disease. | J Gerontol A Biol Sci Med Sci | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4022129/ |
| Hetz, C., & Papa, F. R. "The Unfolded Protein Response and Cell Fate Control." Mol Cell | The Unfolded Protein Response and Cell Fate Control. | Mol Cell | 2018 | https://pubmed.ncbi.nlm.nih.gov/29107536/ |
| Martinez, G., Duran-Aniotz, C., Cabral-Miranda, F., Vivar, J. P., & Hetz, C. "Endoplasmic reticulum proteostasis impairment in aging." Aging Cell | Endoplasmic reticulum proteostasis impairment in aging. | Aging Cell | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5506418/ |
| Jensen, M. B., & Jasper, H. "Mitochondrial proteostasis in the control of aging and longevity." Cell Metab | Mitochondrial proteostasis in the control of aging and longevity. | Cell Metab | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4274350/ |
| Kaushik, S. et al. "Autophagy and the Hallmarks of Aging." Ageing Res Rev | Autophagy and the Hallmarks of Aging. | Ageing Res Rev | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8616816/ |
| Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. "Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging." Proc Natl Acad Sci U S A | Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. | Caenorhabditis elegans | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2736453/ |
| Pinti, M., Appay, V., Campisi, J., Frasca, D., Fulop, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. | Aging of the immune system: Focus on inflammation and vaccination | European Journal of Immunology | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5141180/ |
| Allen, J. C., Toapanta, F. R., Chen, W., & Tennant, S. M. | Understanding immunosenescence and its impact on vaccination of older adults | Vaccine | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7719610/ |
| Tu, W., & Rao, S. | Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection | Frontiers in Microbiology | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4671221/ |
| Weyand, C. M., & Goronzy, J. J. | Aging of the Immune System. Mechanisms and Therapeutic Targets | Annals of the American Thoracic Society | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4707747/ |
| Frasca, D., Blomberg, B. B., Paganelli, R., et al. | B Cell Immunosenescence | International Journal of Molecular Sciences | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7144305/ |
| Bandaranayake, T., & Shaw, A. C. | Host Resistance and Immune Aging | Clinical Geriatric Medicine | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6986475/ |
| Lakatta, E. G | Heart Failure Reviews | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/11790921/ |
| Vakka, A., Warren, J. S., & Drosatos, K | Journal of Cardiovascular Aging | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10238104/ |
| Ghebre, Y. T., Yakubov, E., Wong, W. T., et al | Translational Medicine | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5602592/ |
| Donato, A. J., Machin, D. R., & Lesniewski, L. A | Circulation Research | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6207260/ |
| Singam, N. S. V., Fine, C., & Fleg, J. L | Clinical Cardiology | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7021646/ |
| Cheng, S., Fernandes, V. R. S., Bluemke, D. A., et al | Circulation | — | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2744970/ |
| Cruz-Jentoft, A. J., Bahat, G., Bauer, J., et al | Age and Ageing | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6322506/ |
| Compston, J. E., McClung, M. R., & Leslie, W. D | Lancet | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30696576/ |
| Harada, C. N., Natelson Love, M. C., & Triebel, K. L | Normal cognitive aging | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4015335/ |
| Raz, N., & Rodrigue, K. M | Differential aging of the brain: patterns, cognitive correlates and modifiers | — | 2006 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2776933/ |
| Albert, M. S., DeKosky, S. T., Dickson, D., et al | The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3312027/ |
| McKhann, G. M., Knopman, D. S., Chertkow, H., et al | The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3312024/ |
| Studart Neto, A., & Nitrini, R | Subjective cognitive decline: The first clinical manifestation of Alzheimer’s disease? | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5642412/ |
| Boyle, P. A., Yu, L., Wilson, R. S., et al | Combined neuropathological pathways account for age-related risk of dementia | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6119518/ |
| Robinson, J. L., Corrada, M. M., Kovacs, G. G., et al | Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4540246/ |
| Maass, A., Lockhart, S. N., Harrison, T. M., et al | Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5777108/ |
| Petersen, R. C., Roberts, R. O., Knopman, D. S., et al | Criteria for Mild Cognitive Impairment Due to Alzheimer’s Disease in the Community | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3804562/ |
| Perneczky, R., Pohl, C., Sorg, C., et al | Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/16880382/ |
| Hedden, T., Oh, H., Younger, A. P., & Patel, T. A | Meta-analysis of amyloid-cognition relations in cognitively normal older adults | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3656457/ |
| Attems, J., Jellinger, K. A., & Robinson, J. L | Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9616381/ |
| Soldan, A., Pettigrew, C., Cai, Q., et al | Cognitive reserve and long-term change in cognition in aging and preclinical Alzheimer’s disease | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5679465/ |
| Seals, D. R., Justice, J. N., & LaRocca, T. J. "Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity." The Journal of Physiology | Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. | The Journal of Physiology | 2016 | https://doi.org/10.1113/JP270805 |
| Cooper, R., Kuh, D., Hardy, R., & Mortality Review Group | BMJ | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2938884/ |
| Porrello, E. R. et al. "Transient regenerative potential of the neonatal mouse heart." Science | Transient regenerative potential of the neonatal mouse heart. | Science | 2011 | https://www.science.org/doi/10.1126/science.1200708 |
| Silver, J., Miller, J. H. "Regeneration beyond the glial scar." Nature Reviews Neuroscience | Regeneration beyond the glial scar. | Nature Reviews Neuroscience | 2004 | https://www.nature.com/articles/nrn1326 |
| Sophia Fox, A. J., Bedi, A., Rodeo, S. A. "The basic science of articular cartilage: structure, composition, and function." Sports Health | The basic science of articular cartilage: structure, composition, and function. | Sports Health | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3535123/ |
| Mitsiadis, T. A., Feki, A., Papaccio, G., Caton, J. "Dental pulp stem cells, niches, and notch signaling in tooth injury." Advances in Dental Research | Dental pulp stem cells, niches, and notch signaling in tooth injury. | Advances in Dental Research | 2011 | https://journals.sagepub.com/doi/full/10.1177/0022034511405386 |
| Banach, M. et al. "The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis." European Journal of Preventive Cardiology | The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis. | European Journal of Preventive Cardiology | 2023 | https://pubmed.ncbi.nlm.nih.gov/37555441/ |
| Paluch, A. E. et al. "Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts." The Lancet Public Health | Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts. | The Lancet Public Health | 2022 | https://pubmed.ncbi.nlm.nih.gov/35247352/ |
| Kelly, P. et al. "Systematic review and meta-analysis of reduction in all-cause mortality from walking and cycling and shape of dose response relationship." International Journal of Behavioral Nutrition and Physical Activity | Systematic review and meta-analysis of reduction in all-cause mortality from walking and cycling and shape of dose response relationship. | International Journal of Behavioral Nutrition and Physical Activity | 2014 | https://pubmed.ncbi.nlm.nih.gov/25344355/ |
| Stamatakis, E. et al. "Walking Pace Is Associated with Lower Risk of All-Cause and Cause-Specific Mortality." Medicine & Science in Sports & Exercise | Walking Pace Is Associated with Lower Risk of All-Cause and Cause-Specific Mortality. | Medicine & Science in Sports & Exercise | 2018 | https://pubmed.ncbi.nlm.nih.gov/30303933/ |
| Timmins, I. R. et al. "Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival." Communications Biology | Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival. | Communications Biology | 2020 | https://pubmed.ncbi.nlm.nih.gov/33128006/ |
| Saint-Maurice, P. F. et al. "Association of Daily Step Count and Step Intensity With Mortality Among US Adults." JAMA | Association of Daily Step Count and Step Intensity With Mortality Among US Adults. | JAMA | 2020 | https://pubmed.ncbi.nlm.nih.gov/32207799/ |
| Wu, S. H. et al. "Metabolic syndrome and all-cause mortality: a meta-analysis of prospective cohort studies." European Journal of Epidemiology | Metabolic syndrome and all-cause mortality: a meta-analysis of prospective cohort studies. | European Journal of Epidemiology | 2010 | https://pubmed.ncbi.nlm.nih.gov/20425137/ |
| Mottillo, S. et al. "The metabolic syndrome and cardiovascular risk: a systematic review and meta-analysis." Journal of the American College of Cardiology | The metabolic syndrome and cardiovascular risk: a systematic review and meta-analysis. | Journal of the American College of Cardiology | 2010 | https://pubmed.ncbi.nlm.nih.gov/20863953/ |
| Gunter, M. J. et al. "Insulin Resistance and Cancer-Specific and All-Cause Mortality in Postmenopausal Women: The Women's Health Initiative." JNCI: Journal of the National Cancer Institute | Insulin Resistance and Cancer-Specific and All-Cause Mortality in Postmenopausal Women: The Women's Health Initiative. | JNCI: Journal of the National Cancer Institute | 2019 | https://pubmed.ncbi.nlm.nih.gov/31184362/ |
| Gonzalez-Montalvo, J. I. et al. "Dual effects of insulin resistance on mortality and function in non-diabetic older adults: findings from the Toledo Study of Healthy Aging." Aging | Dual effects of insulin resistance on mortality and function in non-diabetic older adults: findings from the Toledo Study of Healthy Aging. | Aging | 2021 | https://pubmed.ncbi.nlm.nih.gov/34075557/ |
| Silva, F. M. et al. "The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis." Scientific Reports | The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis. | Scientific Reports | 2024 | https://pubmed.ncbi.nlm.nih.gov/38253590/ |
| Amirato, G. R. et al. "Effects of exercise training on inflammatory and cardiometabolic health markers in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials." The Journal of Sports Medicine and Physical Fitness | Effects of exercise training on inflammatory and cardiometabolic health markers in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials. | The Journal of Sports Medicine and Physical Fitness | 2022 | https://pubmed.ncbi.nlm.nih.gov/35816146/ |
| Loprinzi, P. D. et al. "Replacing Sedentary Time with Physical Activity in Relation to Mortality." Medicine & Science in Sports & Exercise | Replacing Sedentary Time with Physical Activity in Relation to Mortality. | Medicine & Science in Sports & Exercise | 2016 | https://pubmed.ncbi.nlm.nih.gov/26918559/ |
| Ekblom-Bak, E. et al. "Replacing sedentary time with physical activity: a 15-year follow-up of mortality in a national cohort." Clinical Epidemiology | Replacing sedentary time with physical activity: a 15-year follow-up of mortality in a national cohort. | Clinical Epidemiology | 2018 | https://pubmed.ncbi.nlm.nih.gov/29416378/ |
| Matthews, C. E. et al. "Association of sedentary time with mortality independent of moderate to vigorous physical activity." Medicine & Science in Sports & Exercise | Association of sedentary time with mortality independent of moderate to vigorous physical activity. | Medicine & Science in Sports & Exercise | 2012 | https://pubmed.ncbi.nlm.nih.gov/22719846/ |
| Chau, J. Y. et al. "Daily sitting time and all-cause mortality: a meta-analysis." PLoS ONE | Daily sitting time and all-cause mortality: a meta-analysis. | PLoS ONE | 2013 | https://pubmed.ncbi.nlm.nih.gov/24236168/ |
| Dempsey, P. C. et al. "Sitting Time, Physical Activity and Mortality: A Cohort Study In Low-Income Older Americans." American Journal of Preventive Medicine | Sitting Time, Physical Activity and Mortality: A Cohort Study In Low-Income Older Americans. | American Journal of Preventive Medicine | 2024 | https://pubmed.ncbi.nlm.nih.gov/39089431/ |
| Del Pozo-Cruz, J. et al. "Replacing Sedentary Time: Meta-analysis of Objective-Assessment Studies." American Journal of Preventive Medicine | Replacing Sedentary Time: Meta-analysis of Objective-Assessment Studies. | American Journal of Preventive Medicine | 2018 | https://pubmed.ncbi.nlm.nih.gov/30122216/ |
| Momma, H. et al. "Resistance Training and Mortality Risk: A Systematic Review and Meta-Analysis." American Journal of Preventive Medicine | Resistance Training and Mortality Risk: A Systematic Review and Meta-Analysis. | American Journal of Preventive Medicine | 2022 | https://pubmed.ncbi.nlm.nih.gov/35599175/ |
| Saeidifard, F. et al. "The association of resistance training with mortality: A systematic review and meta-analysis." European Journal of Preventive Cardiology | The association of resistance training with mortality: A systematic review and meta-analysis. | European Journal of Preventive Cardiology | 2019 | https://pubmed.ncbi.nlm.nih.gov/31104484/ |
| Lopez, P. et al. "Benefits of Resistance Training in Early and Late Stages of Frailty and Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies." Journal of Clinical Medicine | Benefits of Resistance Training in Early and Late Stages of Frailty and Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies. | Journal of Clinical Medicine | 2021 | https://pubmed.ncbi.nlm.nih.gov/33921356/ |
| Khodadad Kashi, S. et al. "A Systematic Review and Meta-Analysis of Resistance Training on Quality of Life, Depression, Muscle Strength, and Functional Exercise Capacity in Older Adults Aged 60 Years or More." Biological Research for Nursing | A Systematic Review and Meta-Analysis of Resistance Training on Quality of Life, Depression, Muscle Strength, and Functional Exercise Capacity in Older Adults Aged 60 Years or More. | Biological Research for Nursing | 2023 | https://pubmed.ncbi.nlm.nih.gov/35968662/ |
| Marques, E. A. et al. "Chronic effect of resistance training on blood pressure in older adults with prehypertension and hypertension: A systematic review and meta-analysis." Experimental Gerontology | Chronic effect of resistance training on blood pressure in older adults with prehypertension and hypertension: A systematic review and meta-analysis. | Experimental Gerontology | 2023 | https://pubmed.ncbi.nlm.nih.gov/37121334/ |
| Hart, P. D., Buck, D. J. "The role of resistance training in influencing insulin resistance among adults living with obesity/overweight without diabetes: A systematic review and meta-analysis." Sports Medicine - Open | The role of resistance training in influencing insulin resistance among adults living with obesity/overweight without diabetes: A systematic review and meta-analysis. | Sports Medicine - Open | 2023 | https://pubmed.ncbi.nlm.nih.gov/37331899/ |
| Huang, R. et al. "Effects of resistance training on cardiovascular risk factors in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials." Acta Diabetologica | Effects of resistance training on cardiovascular risk factors in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. | Acta Diabetologica | 2024 | https://pubmed.ncbi.nlm.nih.gov/39692776/ |
| Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. "NAD+ homeostasis in health and disease." Nature Metabolism | NAD+ homeostasis in health and disease. | Nature Metabolism | 2020 | https://www.nature.com/articles/s42255-019-0161-5 |
| Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. "NAD+ metabolism and its roles in cellular processes during ageing." Nature Reviews Molecular Cell Biology | NAD+ metabolism and its roles in cellular processes during ageing. | Nature Reviews Molecular Cell Biology | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/ |
| Ramsey, K. M. et al. "Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis." Science | Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis. | Science | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2738420/ |
| Gomes, A. P. et al. "Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging." Cell | Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. | Cell | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4076149/ |
| Camacho-Pereira, J. et al. "CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism." Cell Metabolism | CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. | Cell Metabolism | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4911708/ |
| Massudi, H. et al. "Age-associated changes in oxidative stress and NAD+ metabolism in human tissue." PLoS ONE | Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. | PLoS ONE | 2012 | https://pubmed.ncbi.nlm.nih.gov/22848760/ |
| Clement, J. et al. "The Plasma NAD+ Metabolome Is Dysregulated in 'Normal' Aging." Rejuvenation Research | The Plasma NAD+ Metabolome Is Dysregulated in 'Normal' Aging. | Rejuvenation Research | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6482912/ |
| Høyland, L. E. et al. "Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+." Nature Metabolism | Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+. | Nature Metabolism | 2024 | https://pubmed.ncbi.nlm.nih.gov/39702414/ |
| Vinten, K. T. et al. "NAD+ precursor supplementation in human ageing: clinical evidence and challenges." Nature Metabolism | NAD+ precursor supplementation in human ageing: clinical evidence and challenges. | Nature Metabolism | 2025 | https://www.nature.com/articles/s42255-025-01387-7 |
| Haigis, M. C., & Sinclair, D. A. "Mammalian sirtuins: biological insights and disease relevance." Annual Review of Pathology | Mammalian sirtuins: biological insights and disease relevance. | Annual Review of Pathology | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2866163/ |
| Imai, S., & Guarente, L. "It takes two to tango: NAD+ and sirtuins in aging/longevity control." npj Aging and Mechanisms of Disease | It takes two to tango: NAD+ and sirtuins in aging/longevity control. | npj Aging and Mechanisms of Disease | 2016 | https://www.nature.com/articles/npjamd201617 |
| Burnett, C. et al. "Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila." Nature | Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. | Nature | 2011 | https://www.nature.com/articles/nature10296 |
| Herranz, D. et al. "Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer." Nature Communications | Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. | Nature Communications | 2010 | https://www.nature.com/articles/ncomms1001 |
| Satoh, A. et al. "Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH." Cell Metabolism | Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. | Cell Metabolism | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3794712/ |
| Mostoslavsky, R. et al. "Genomic instability and aging-like phenotype in the absence of mammalian SIRT6." Cell | Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. | Cell | 2006 | https://www.sciencedirect.com/science/article/pii/S0092867406000493 |
| Kanfi, Y. et al. "The sirtuin SIRT6 regulates lifespan in male mice." Nature | The sirtuin SIRT6 regulates lifespan in male mice. | Nature | 2012 | https://www.nature.com/articles/nature10815 |
| Roichman, A. et al. "Restoration of energy homeostasis by SIRT6 extends healthy lifespan." Nature Communications | Restoration of energy homeostasis by SIRT6 extends healthy lifespan. | Nature Communications | 2021 | https://www.nature.com/articles/s41467-021-23545-7 |
| Fontana, L., Partridge, L., & Longo, V. D. "Extending healthy life span from yeast to humans." Science | Extending healthy life span from yeast to humans. | Science | 2010 | https://doi.org/10.1126/science.1172539 |
| Kenyon, C. et al. "A C. elegans mutant that lives twice as long as wild type." Nature | A C. elegans mutant that lives twice as long as wild type. | Nature | 1993 | https://doi.org/10.1038/366461a0 |
| Tatar, M., Bartke, A., & Antebi, A. "The endocrine regulation of aging by insulin-like signals." Science | The endocrine regulation of aging by insulin-like signals. | Science | 2003 | https://doi.org/10.1126/science.1081447 |
| Holzenberger, M. et al. "IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice." Nature | IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. | Nature | 2003 | https://doi.org/10.1038/nature01498 |
| Burkewitz, K., Zhang, Y., & Mair, W. B. "AMPK at the nexus of energetics and aging." Cell Metabolism | AMPK at the nexus of energetics and aging. | Cell Metabolism | 2014 | https://doi.org/10.1016/j.cmet.2014.03.002 |
| Greer, E. L. et al. "An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans." Current Biology | An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. | Current Biology | 2007 | https://doi.org/10.1016/j.cub.2007.08.047 |
| Gkogkolou, P., & Bohm, M | Advanced glycation end products: Key players in skin aging? | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3583887/ |
| Singh, R., Barden, A., Mori, T., & Beilin, L | Advanced glycation end-products: a review. | — | 2001 | https://link.springer.com/article/10.1007/s001250051591 |
| Kuzan, A | Toxicity of advanced glycation end products (Review). | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7995243/ |
| Uribarri, J., Woodruff, S., Goodman, S., et al | Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet. | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3704564/ |
| Semba, R. D., Nicklett, E. J., & Ferrucci, L | Does accumulation of advanced glycation end products contribute to the aging phenotype? | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2920582/ |
| Verzijl, N., DeGroot, J., Thorpe, S. R., et al | Effect of collagen turnover on the accumulation of advanced glycation end products. | — | 2000 | https://pubmed.ncbi.nlm.nih.gov/10976109/ |
| Verzijl, N. et al | Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage. | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/11822407/ |
| Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., & Schmidt, A. M | Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. | — | 2005 | https://pubmed.ncbi.nlm.nih.gov/15764591/ |
| Ott, C., Jacobs, K., Haucke, E., Navarrete Santos, A., Grune, T., & Simm, A | Role of advanced glycation end products in cellular signaling. | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3949097/ |
| Schumacher, B., Pothof, J., Vijg, J., & Hoeijmakers, J. H. J. "The central role of DNA damage in the ageing process." Nature | The central role of DNA damage in the ageing process. | Nature | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9844150/ |
| Sarikaya, S., Cakir, H., Gozuacik, D., & Akkoc, Y. "Crosstalk between autophagy and DNA repair systems." Turkish Journal of Biology | Crosstalk between autophagy and DNA repair systems. | Turkish Journal of Biology | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8313936/ |
| Gumeni, S., Evangelakou, Z., Gorgoulis, V. G., & Trougakos, I. P. "Proteome Stability as a Key Factor of Genome Integrity." Int J Mol Sci | Proteome Stability as a Key Factor of Genome Integrity. | Int J Mol Sci | 2017 | https://www.mdpi.com/1422-0067/18/10/2036 |
| Moskalev, A. A. et al. | The role of DNA damage and repair in aging through the prism of Koch-like criteria. | Ageing Research Reviews | 2013 | https://pubmed.ncbi.nlm.nih.gov/22353384/ |
| Percie du Sert, N., Hurst, V., Ahluwalia, A., et al | PLOS Biology | — | 2020 | https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000410 |
| — | Cochrane | — | — | https://www.ncbi.nlm.nih.gov/books/NBK557996/ |
| Dwan, K., Gamble, C., Williamson, P. R., and Kirkham, J. J | PLOS ONE | — | 2013 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066844 |
| Turner, E. H., Matthews, A. M., Linardatos, E., Tell, R. A., and Rosenthal, R | New England Journal of Medicine | — | 2008 | https://www.nejm.org/doi/full/10.1056/NEJMsa065779 |
| Chan, A.-W., Hrobjartsson, A., Haahr, M. T., Gøtzsche, P. C., and Altman, D. G | JAMA | — | 2004 | https://doi.org/10.1001/jama.291.20.2457 |
| Sumner, P., Vivian-Griffiths, S., Boivin, J., et al | BMJ | — | 2014 | https://www.bmj.com/content/349/bmj.g7015 |
| Sterne, J. A. C., Sutton, A. J., Ioannidis, J. P. A., et al | BMJ | — | 2011 | https://www.bmj.com/content/343/bmj.d4002 |
| Higgins, J. P. T., et al., editors | Cochrane Handbook for Systematic Reviews of Interventions | — | 2024 | https://training.cochrane.org/handbook/current |
| Shea, B. J., et al | BMJ | — | 2017 | https://www.bmj.com/content/358/bmj.j4008 |
| Baethge, C., et al | Research Integrity and Peer Review | — | 2019 | https://researchintegrityjournal.biomedcentral.com/articles/10.1186/s41073-019-0064-8 |
| Ferrari, R | Medical Writing | — | 2015 | https://www.tandfonline.com/doi/full/10.1179/2047480615Z.000000000329 |
| Faggion, C. M., Jr., et al | BMC Medical Research Methodology | — | 2017 | https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-017-0453-y |
| Rethlefsen, M. L., et al | Journal of Clinical Epidemiology | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38052277/ |
| Justice, J. N., et al | Journals of Gerontology Series A | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5055651/ |
| Cummings, S. R., & Kritchevsky, S. B | GeroScience | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9768060/ |
| Fleming, T. R., & Powers, J. H | Statistics in Medicine | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3551627/ |
| Hernan, M. A., & Robins, J. M | Journal of Epidemiology and Community Health | — | 2006 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2652882/ |
| Horvat, C. M | Pediatric Critical Care Medicine | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8882362/ |
| Wakeford, R | Journal of the Royal Society of Medicine | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4291331/ |
| Mansournia, M. A., et al | BMJ | — | 2017 | https://www.bmj.com/content/359/bmj.j4587 |
| Shrank, W. H., Patrick, A. R., & Brookhart, M. A | Journal of General Internal Medicine | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3077477/ |
| Hernan, M. A., et al | American Journal of Epidemiology | — | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3731075/ |
| Loudon, K., et al | BMJ | — | 2015 | https://www.bmj.com/content/350/bmj.h2147 |
| Guyatt, G. H., et al | BMJ | — | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2335261/ |
| Hinz, B. et al. "The Role of Myofibroblasts in Physiological and Pathological Tissue Repair." Cold Spring Harbor Perspectives in Biology | The Role of Myofibroblasts in Physiological and Pathological Tissue Repair. | Cold Spring Harbor Perspectives in Biology | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9808581/ |
| Wang, K. et al. "Extracellular matrix stiffness-The central cue for skin fibrosis." Frontiers in Molecular Biosciences | Extracellular matrix stiffness-The central cue for skin fibrosis. | Frontiers in Molecular Biosciences | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10031116/ |
| Moyer, A. L., Wagner, K. R. "Regeneration versus fibrosis in skeletal muscle." Current Opinion in Rheumatology | Regeneration versus fibrosis in skeletal muscle. | Current Opinion in Rheumatology | 2011 | https://pubmed.ncbi.nlm.nih.gov/21934499/ |
| Mahdy, M. A. A. "Skeletal muscle fibrosis: an overview." Cell and Tissue Research | Skeletal muscle fibrosis: an overview. | Cell and Tissue Research | 2019 | https://pubmed.ncbi.nlm.nih.gov/30421315/ |
| Oliveira Dias, D., Göritz, C. "Fibrotic scarring following lesions to the central nervous system." Matrix Biology | Fibrotic scarring following lesions to the central nervous system. | Matrix Biology | 2018 | https://pubmed.ncbi.nlm.nih.gov/29428230/ |
| Tanaka, M., Miyajima, A. "Liver regeneration and fibrosis after inflammation." Inflammation and Regeneration | Liver regeneration and fibrosis after inflammation. | Inflammation and Regeneration | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5725806/ |
| Chen, W. et al. "Cardiac Fibroblasts and Myocardial Regeneration." Frontiers in Bioengineering and Biotechnology | Cardiac Fibroblasts and Myocardial Regeneration. | Frontiers in Bioengineering and Biotechnology | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8026894/ |
| Larson, B. J., Longaker, M. T., Lorenz, H. P. "Scarless Fetal Wound Healing: A Basic Science Review." Plastic and Reconstructive Surgery | Scarless Fetal Wound Healing: A Basic Science Review. | Plastic and Reconstructive Surgery | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4229131/ |
| Ferguson, M. W. J., O'Kane, S | Philosophical Transactions of the Royal Society B | — | 2004 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1693414/ |
| Seifert, A. W., Kiama, S. G., Seifert, M. G., Goheen, J. R., Palmer, T. M., Maden, M | Nature | — | 2012 | https://www.nature.com/articles/nature11499 |
| Hinz, B., Lagares, D | Nature Reviews Molecular Cell Biology | — | 2020 | https://www.nature.com/articles/s41580-020-0263-4 |
| Godwin, J. W., Pinto, A. R., Rosenthal, N. A | Proceedings of the National Academy of Sciences | — | 2013 | https://www.pnas.org/doi/10.1073/pnas.1300290110 |
| Porrello, E. R., Mahmoud, A. I., Simpson, E., et al | Science | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21350179/ |
| Ozarda, Y., Sikaris, K., Streichert, T., & Macri, J | Critical Reviews in Clinical Laboratory Sciences | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/30047297/ |
| Miller, W. G., Horowitz, G. L., Ceriotti, F., Fleming, J. K., Greenberg, N., Katayev, A., et al | Clinical Chemistry | — | 2016 | https://academic.oup.com/clinchem/article/62/7/916/5611870 |
| Apsley, A. T., Etzel, L., Ye, Q., & Shalev, I | Epigenomics | — | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12714307/ |
| Roubenoff, R | Journal of Gerontology Series A | — | 2003 | https://pubmed.ncbi.nlm.nih.gov/14630883/ |
| Donini, L. M., et al | Obesity Facts | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9210010/ |
| Melo, T. A., et al | Frontiers in Nutrition | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9263164/ |
| Andreoli, A., et al | Contrast Media & Molecular Imaging | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31275083/ |
| Batsis, J. A., et al | International Journal of Obesity | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/26620887/ |
| Woo, J., Leung, J., & Kwok, T | Obesity | — | 2007 | https://pubmed.ncbi.nlm.nih.gov/17636108/ |
| McCoy, C. E | Understanding the Use of Composite Endpoints in Clinical Trials | Western Journal of Emergency Medicine | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6040910/ |
| Freemantle, N., et al | Composite outcomes in randomized trials: greater precision but with greater uncertainty? | JAMA | 2003 | https://pubmed.ncbi.nlm.nih.gov/12759327/ |
| Cordoba, G., et al | Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review | BMJ | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2923692/ |
| Barzilai, N., et al | Metformin as a Tool to Target Aging | Cell Metabolism | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5943638/ |
| Vart, P | Hierarchical composite endpoints in clinical trials for multimorbid older adults | EClinicalMedicine | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12441725/ |
| Hara, H., et al | Statistical methods for composite endpoints | EuroIntervention | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9724993/ |
| Goodman, S. N., Fanelli, D., & Ioannidis, J. P. A | Science Translational Medicine | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27252173/ |
| National Academies of Sciences, Engineering, and Medicine | Reproducibility and Replicability in Science | — | 2019 | https://nap.nationalacademies.org/catalog/25303/reproducibility-and-replicability-in-science |
| Munafo, M. R., et al | Nature Human Behaviour | — | 2017 | https://www.nature.com/articles/s41562-016-0021 |
| Lucanic, M., et al | Nature Communications | — | 2017 | https://www.nature.com/articles/ncomms14256 |
| Bell, C. G., et al | Genome Biology | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6876109/ |
| Cohen, J | Psychological Bulletin | — | 1992 | https://pubmed.ncbi.nlm.nih.gov/19565683/ |
| Button, K. S., et al | Nature Reviews Neuroscience | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23571845/ |
| Altman, D. G., & Bland, J. M | BMJ | — | 1995 | https://www.bmj.com/content/311/7003/485 |
| Lochner, H. V., et al | Journal of Bone and Joint Surgery | — | 2001 | https://pubmed.ncbi.nlm.nih.gov/11701786/ |
| Gelman, A., & Carlin, J | Perspectives on Psychological Science | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/26186114/ |
| Wasserstein, R. L., & Lazar, N. A | The American Statistician | — | 2016 | https://doi.org/10.1080/00031305.2016.1154108 |
| Egger, M., et al | BMJ | — | 1997 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2127453/ |
| Panagiotou, O. A., et al | International Journal of Epidemiology | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6942244/ |
| Lee, D. H., et al | European Journal of Epidemiology | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8035269/ |
| Pai, H., & Gulliford, M. C | BMJ Open | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9341213/ |
| Shea, M. K., et al | American Journal of Clinical Nutrition | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3155925/ |
| Supiano, M. A., Pajewski, N. M., & Williamson, J. D | Journal of the American Geriatrics Society | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5777872/ |
| Davey Smith, G., & Hemani, G | Human Molecular Genetics | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4170722/ |
| Penninkilampi, R., & Eslick, G. D | CNS Drugs | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29926372/ |
| Khan, M. S., et al | JAMA Network Open | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6503494/ |
| Oxman, M., et al | F1000Research | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8756300/ |
| Cofield, S. S., Corona, R. V., and Allison, D. B | Public Health Nutrition | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3280017/ |
| van der Worp, H. B., et al | PLOS Medicine | — | 2010 | https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000245 |
| Gardner, M. J., & Altman, D. G | British Medical Journal | — | 1986 | https://www.bmj.com/content/292/6522/746 |
| Amrhein, V., Greenland, S., & McShane, B | Nature | — | 2019 | https://www.nature.com/articles/d41586-019-00857-9 |
| Jaeschke, R., Singer, J., & Guyatt, G. H | Controlled Clinical Trials | — | 1989 | https://pubmed.ncbi.nlm.nih.gov/2646486/ |
| Sullivan, G. M., & Feinn, R | Journal of Graduate Medical Education | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3444174/ |
| Sterne, J. A. C., & Smith, G. D | BMJ | — | 2001 | https://www.bmj.com/content/322/7280/226 |
| Ho, J., Tumkaya, T., Aryal, S., Choi, H., & Claridge-Chang, A | Nature Methods | — | 2019 | https://www.nature.com/articles/s41592-019-0470-3 |
| Nichols, E., and Hayes-Larson, E | BMJ | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12406907/ |
| Hernan, M. A., Hernandez-Diaz, S., and Robins, J. M | Epidemiology | — | 2004 | https://journals.lww.com/epidem/abstract/2004/09000/a_structural_approach_to_selection_bias.8.aspx |
| Hollestein, L., Baser, O., Stricker, B. H. C., and Nijsten, T | Archives of Public Health | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4582295/ |
| Chewning, B | BMJ | — | 2006 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1488753/ |
| Tabula Muris Consortium | A single-cell transcriptomic atlas characterizes ageing tissues in the mouse | Nature | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8240505/ |
| Uyar, B. et al. | Single-cell analyses of aging, inflammation and senescence | Ageing Research Reviews | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7493798/ |
| Luecken, M. D. and Theis, F. J. | Current best practices in single-cell RNA-seq analysis: a tutorial | Molecular Systems Biology | 2019 | https://link.springer.com/article/10.15252/msb.20188746 |
| Lu, T.-C. et al. | Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution | Science | 2023 | https://pubmed.ncbi.nlm.nih.gov/37319212/ |
| Bartz, J. et al. | Human Cell Aging Transcriptome Atlas (HCATA): a single-cell atlas of age-associated transcriptomic alterations across human tissues | Communications Biology | 2025 | https://www.nature.com/articles/s42003-025-08845-8 |
| Jin, K. et al. | Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice | Nature | 2025 | https://www.nature.com/articles/s41586-024-08350-8 |
| Jeffries, A. M. et al. | Single-cell transcriptomic and genomic changes in the ageing human brain | Nature | 2025 | https://www.nature.com/articles/s41586-025-09435-8 |
| Wang, B. et al. | The senescence-associated secretory phenotype and its physiological and pathological implications | Nature Reviews Molecular Cell Biology | 2024 | https://www.nature.com/articles/s41580-024-00727-x |
| Wechter, N. et al. | Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations | Aging | 2023 | https://www.aging-us.com/article/204666/text |
| Jaiswal, S. et al. | Age-related clonal hematopoiesis associated with adverse outcomes | New England Journal of Medicine | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4306669/ |
| Gao, X. et al. | The aging hematopoietic stem cell niche: a mini review | Frontiers in Hematology | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12237420/ |
| Kharchenko, P. V. | The triumphs and limitations of computational methods for scRNA-seq | Nature Methods | 2021 | https://www.nature.com/articles/s41592-021-01171-x |
| Denisenko, E. et al. | Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows | Genome Biology | 2020 | https://pubmed.ncbi.nlm.nih.gov/32487174/ |
| Phillip, J. M., et al. | The Mechanobiology of Aging | Annual Review of Biomedical Engineering | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4886230/ |
| De Luca, M. | The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature | Mechanisms of Ageing and Development | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6170735/ |
| Paluch, E. K., et al. | Mechanotransduction: use the force(s) | BMC Biology | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4491211/ |
| Ge, H., et al. | Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism | Frontiers in Oncology | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7943852/ |
| Vatner, S. F. et al. | Vascular Stiffness in Aging and Disease | Frontiers in Physiology | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8688960/ |
| Pavan, P., et al. | Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles | International Journal of Molecular Sciences | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7312402/ |
| Kaur, A., et al. | Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility | Cancer Discovery | 2019 | https://pubmed.ncbi.nlm.nih.gov/30279173/ |
| Mebratu, Y. A., et al. | The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype | American Journal of Physiology-Cell Physiology | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10511170/ |
| Engler, A. J., et al. | Matrix elasticity directs stem cell lineage specification | Cell | 2006 | https://doi.org/10.1016/j.cell.2006.06.044 |
| Bajpai, A., et al. | The cellular mechanobiology of aging: from biology to mechanics | Annals of the New York Academy of Sciences | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8102302/ |
| Cawthon, R. M | Telomere measurement by quantitative PCR | Nucleic Acids Research | 2002 | https://academic.oup.com/nar/article/30/10/e47/1031599 |
| Aubert, G., & Lansdorp, P. M | Telomeres and aging | Physiological Reviews | 2008 | https://pubmed.ncbi.nlm.nih.gov/18391173/ |
| Mather, K. A., Jorm, A. F., Parslow, R. A., & Christensen, H | Is telomere length a biomarker of aging? A review | The Journals of Gerontology: Series A | 2011 | https://pubmed.ncbi.nlm.nih.gov/21030466/ |
| Sanders, J. L., & Newman, A. B | Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? | Epidemiologic Reviews | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4707879/ |
| Haycock, P. C., et al | Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis | BMJ | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4086028/ |
| Gutierrez-Rodrigues, F., et al | Direct Comparison of Flow-FISH and qPCR as Diagnostic Tests for Telomere Length Measurement in Humans | PLoS ONE | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4237503/ |
| Wang, Q., et al | Telomere Length and All-Cause Mortality: A Meta-analysis | Ageing Research Reviews | 2018 | https://pubmed.ncbi.nlm.nih.gov/30254001/ |
| Vaiserman, A., & Krasnienkov, D | Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives | Frontiers in Genetics | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7859450/ |
| Codd, V., et al | Polygenic basis and biomedical consequences of telomere length variation | Nature Genetics | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8492471/ |
| Imai, K., Sato, H., Hori, M., et al | Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure | Journal of the American College of Cardiology, 24(6), 1529-1535 | 1994 | https://pubmed.ncbi.nlm.nih.gov/7930286/ |
| Seals, D. R., Taylor, J. A., Ng, A. V., & Esler, M. D | Exercise and aging: autonomic control of the circulation | Medicine and Science in Sports and Exercise, 26(5), 568-576 | 1994 | https://pubmed.ncbi.nlm.nih.gov/8007804/ |
| Cole, C. R., Blackstone, E. H., Pashkow, F. J., Snader, C. E., & Lauer, M. S | Heart-rate recovery immediately after exercise as a predictor of mortality | New England Journal of Medicine, 341(18), 1351-1357 | 1999 | https://pubmed.ncbi.nlm.nih.gov/10536127/ |
| Cole, C. R., Foody, J. M., Blackstone, E. H., & Lauer, M. S | Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort | Annals of Internal Medicine, 132(7), 552-555 | 2000 | https://pubmed.ncbi.nlm.nih.gov/10744592/ |
| Morshedi-Meibodi, A., Larson, M. G., Levy, D., O'Donnell, C. J., & Vasan, R. S | Heart rate recovery after treadmill exercise testing and risk of cardiovascular disease events (The Framingham Heart Study) | American Journal of Cardiology, 90(8), 848-852 | 2002 | https://pubmed.ncbi.nlm.nih.gov/12372572/ |
| Yawn, B. P., Ammar, K. A., Thomas, R., & Wollan, P. C | Test-retest reproducibility of heart rate recovery after treadmill exercise | Annals of Family Medicine, 1(4), 236-241 | 2003 | https://pubmed.ncbi.nlm.nih.gov/15055414/ |
| Tulumen, E., Khalilayeva, I., Aytemir, K., et al | The reproducibility of heart rate recovery after treadmill exercise test | Annals of Noninvasive Electrocardiology, 16(4), 365-372 | 2011 | https://pubmed.ncbi.nlm.nih.gov/22008492/ |
| Pecanha, T., Silva-Junior, N. D., & Forjaz, C. L. M | Heart rate recovery: autonomic determinants, methods of assessment and association with mortality and cardiovascular diseases | Clinical Physiology and Functional Imaging, 34(5), 327-339 | 2014 | https://pubmed.ncbi.nlm.nih.gov/24237859/ |
| Pecanha, T., Bartels, R., Brito, L. C., Paula-Ribeiro, M., Oliveira, R. S., & Goldberger, J. J | Methods of assessment of the post-exercise cardiac autonomic recovery: a methodological review | International Journal of Cardiology, 227, 795-802 | 2017 | https://pubmed.ncbi.nlm.nih.gov/27836300/ |
| Qiu, S., Cai, X., Sun, Z., Li, L., Zuegel, M., Steinacker, J. M., & Schumann, U | Heart rate recovery and risk of cardiovascular events and all-cause mortality: a meta-analysis of prospective cohort studies | Journal of the American Heart Association, 6(5), e005505 | 2017 | https://pubmed.ncbi.nlm.nih.gov/28487388/ |
| Sydo, N., Sydo, T., Gonzalez Carta, K. A., et al | Prognostic performance of heart rate recovery on an exercise test in a primary prevention population | Journal of the American Heart Association, 7(7), e008143 | 2018 | https://pubmed.ncbi.nlm.nih.gov/29581219/ |
| Taanman, J. W. "The mitochondrial genome: structure, transcription, translation and replication." Biochimica et Biophysica Acta | The mitochondrial genome: structure, transcription, translation and replication. | Biochimica et Biophysica Acta | 1999 | https://doi.org/10.1016/S0005-2728(98)00161-3 |
| Taylor, R. W., & Turnbull, D. M. "Mitochondrial DNA mutations in human disease." Nature Reviews Genetics | Mitochondrial DNA mutations in human disease. | Nature Reviews Genetics | 2005 | https://doi.org/10.1038/nrg1606 |
| Greaves, L. C., & Turnbull, D. M. "Mitochondrial DNA mutations and ageing." Biochimica et Biophysica Acta | Mitochondrial DNA mutations and ageing. | Biochimica et Biophysica Acta | 2009 | https://doi.org/10.1016/j.bbagen.2009.04.018 |
| Kujoth, G. C. et al. "Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging." Science | Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. | Science | 2005 | https://doi.org/10.1126/science.1112125 |
| Vermulst, M. et al. "DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice." Nature Genetics | DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. | Nature Genetics | 2008 | https://doi.org/10.1038/ng.95 |
| Cao, Z. et al. "Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers." Nucleic Acids Research | Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers. | Nucleic Acids Research | 2001 | https://pmc.ncbi.nlm.nih.gov/articles/PMC60181/ |
| Bender, A. et al. "High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease." Nature Genetics | High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. | Nature Genetics | 2006 | https://doi.org/10.1038/ng1769 |
| Kraytsberg, Y. et al. "Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons." Nature Genetics | Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. | Nature Genetics | 2006 | https://doi.org/10.1038/ng1778 |
| Taylor, R. W. et al. "Mitochondrial DNA mutations in human colonic crypt stem cells." Journal of Clinical Investigation | Mitochondrial DNA mutations in human colonic crypt stem cells. | Journal of Clinical Investigation | 2003 | https://pmc.ncbi.nlm.nih.gov/articles/PMC228466/ |
| Nooteboom, M. et al. "Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts." Aging Cell | Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts. | Aging Cell | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2816353/ |
| Yousefzadeh, M. J., Robbins, P. D., & Huffman, D. M | Aging | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9037264/ |
| Katsimpardi, L., et al | Science | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4123747/ |
| Mehdipour, M., et al | Aging | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7288913/ |
| Rodriguez, K. A. et al | Molecular mechanisms of proteasome plasticity in aging | Mechanisms of Ageing and Development | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2849732/ |
| Barbosa, M. C. et al | Hallmarks of Aging: An Autophagic Perspective | Frontiers in Endocrinology | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6333684/ |
| Chen, G., Kroemer, G., & Kepp, O. | Mitophagy: An Emerging Role in Aging and Age-Associated Diseases | Frontiers in Cell and Developmental Biology | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7113588/ |
| Nixon, R. A | The aging lysosome: an essential catalyst for late-onset neurodegenerative diseases | Biochimica et Biophysica Acta - Proteins and Proteomics | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7388076/ |
| Guerrero-Navarro, L., Jansen-Dürr, P., & Cavinato, M. | Age-Related Lysosomal Dysfunctions | Cells | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9221958/ |
| Ilie, O.-D. et al | Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality | Medicina | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7699382/ |
| McEwen, B. S., & Stellar, E | Stress and the individual. Mechanisms leading to disease | Archives of Internal Medicine | 1993 | https://pubmed.ncbi.nlm.nih.gov/8379800/ |
| McEwen, B. S., & Seeman, T | Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load | Annals of the New York Academy of Sciences | 1999 | https://pubmed.ncbi.nlm.nih.gov/10681886/ |
| Seeman, T. E., McEwen, B. S., Rowe, J. W., & Singer, B. H | Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging | Proceedings of the National Academy of Sciences | 2001 | https://pmc.ncbi.nlm.nih.gov/articles/PMC31909/ |
| Karlamangla, A. S., Singer, B. H., McEwen, B. S., Rowe, J. W., & Seeman, T. E | Allostatic load as a predictor of functional decline. MacArthur studies of successful aging | Journal of Clinical Epidemiology | 2002 | https://pubmed.ncbi.nlm.nih.gov/12160918/ |
| Juster, R.-P., McEwen, B. S., & Lupien, S. J | Allostatic load biomarkers of chronic stress and impact on health and cognition | Neuroscience & Biobehavioral Reviews | 2010 | https://doi.org/10.1016/j.neubiorev.2009.10.002 |
| Guidi, J., Lucente, M., Sonino, N., & Fava, G. A | Allostatic Load and Its Impact on Health: A Systematic Review | Psychotherapy and Psychosomatics | 2021 | https://pubmed.ncbi.nlm.nih.gov/32799204/ |
| D'Amico, D., Amestoy, M. E., & Fiocco, A. J | The association between allostatic load and cognitive function: A systematic and meta-analytic review | Psychoneuroendocrinology | 2020 | https://pubmed.ncbi.nlm.nih.gov/32892066/ |
| Polick, C. S., Harris-Gersten, M. L., Dennis, P. A., et al | Allostatic Load, Morbidity, and Mortality Among Older Adults: A Multi-Wave Analysis From the National Health and Aging Trends Study | Journal of Aging and Health | 2024 | https://pubmed.ncbi.nlm.nih.gov/38299792/ |
| Arkesteijn, M., Bennett, R., Davies, J. L., & Sumner, R. C | Does Allostatic Load in 50-89-Year-Olds Predict the Development of Frailty? Evidence From a National Longitudinal Study Over 12 Years | Stress and Health | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11878747/ |
| Doan, S. N | Allostatic load: Developmental and conceptual considerations in a multi-system physiological indicator of chronic stress exposure | Developmental Psychobiology | 2021 | https://pubmed.ncbi.nlm.nih.gov/33650132/ |
| Ming, G. L., & Song, H | Adult neurogenesis in the mammalian brain: significant answers and significant questions | Neuron | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3106107/ |
| Bond, A. M., Ming, G. L., & Song, H | Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later | Cell Stem Cell | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4683085/ |
| Kempermann, G. et al | Human Adult Neurogenesis: Evidence and Remaining Questions | Cell Stem Cell | 2018 | https://pubmed.ncbi.nlm.nih.gov/29681514/ |
| Kuhn, H. G., Dickinson-Anson, H., & Gage, F. H | Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation | Journal of Neuroscience | 1996 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6578509/ |
| Encinas, J. M. et al | Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus | Cell Stem Cell | 2011 | https://www.sciencedirect.com/science/article/pii/S1934590911001202 |
| Eriksson, P. S. et al | Neurogenesis in the adult human hippocampus | Nature Medicine | 1998 | https://www.nature.com/articles/nm1198_1313 |
| Spalding, K. L. et al | Dynamics of hippocampal neurogenesis in adult humans | Cell | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4394608/ |
| Boldrini, M. et al | Human Hippocampal Neurogenesis Persists throughout Aging | Cell Stem Cell | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5957089/ |
| Sorrells, S. F. et al | Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults | Nature | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6179355/ |
| Moreno-Jimenez, E. P. et al | Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease | Nature Medicine | 2019 | https://www.nature.com/articles/s41591-019-0375-9 |
| Ruby, J. G. et al. | Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating | Genetics | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6218226/ |
| National Institute for Health and Care Excellence | Hypertension in adults: diagnosis and management (NG136) | NICE guideline | — | https://www.nice.org.uk/guidance/ng136/chapter/recommendations |
| National Institute for Health and Care Excellence | Type 2 diabetes in adults: management—initial medicines (NG28) | NICE guideline | 2026 | https://www.nice.org.uk/guidance/NG28/chapter/initial-medicines |
| British Geriatrics Society | Fit for Frailty: Recognition and management of frailty in individuals in community and outpatient settings | Clinical guidance | — | https://www.bgs.org.uk/sites/default/files/content/resources/files/2018-05-14/fff2_short.pdf |
| Barker, N. et al. "Identification of stem cells in small intestine and colon by marker gene Lgr5." Nature | Identification of stem cells in small intestine and colon by marker gene Lgr5. | Nature | 2007 | https://www.nature.com/articles/nature06196 |
| Sato, T. et al. "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche." Nature | Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. | Nature | 2009 | https://www.nature.com/articles/nature07935 |
| Santos, A. J. M. et al. "The Intestinal Stem Cell Niche: Homeostasis and Adaptations." Trends in Cell Biology | The Intestinal Stem Cell Niche: Homeostasis and Adaptations. | Trends in Cell Biology | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6338454/ |
| Ayyaz, A. et al. "Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell." Nature | Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. | Nature | 2019 | https://www.nature.com/articles/s41586-019-1154-y |
| van Es, J. H. et al. "Dll1+ secretory progenitor cells revert to stem cells upon crypt damage." Nature Cell Biology | Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. | Nature Cell Biology | 2012 | https://www.nature.com/articles/ncb2581 |
| Nalapareddy, K. et al. "Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells." Cell Reports | Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. | Cell Reports | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5987258/ |
| Moorefield, E. C. et al. "Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells." Aging | Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells. | Aging | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5611984/ |
| Pentinmikko, N. et al. "Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium." Nature | Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. | Nature | 2019 | https://www.nature.com/articles/s41586-019-1383-0 |
| Blokzijl, F. et al. "Tissue-specific mutation accumulation in human adult stem cells during life." Nature | Tissue-specific mutation accumulation in human adult stem cells during life. | Nature | 2016 | https://www.nature.com/articles/nature19768 |
| Lee-Six, H. et al. "The landscape of somatic mutation in normal colorectal epithelial cells." Nature | The landscape of somatic mutation in normal colorectal epithelial cells. | Nature | 2019 | https://www.nature.com/articles/s41586-019-1672-7 |
| Wilms, E. et al. "Intestinal barrier function is maintained with aging – a comprehensive study in healthy subjects and irritable bowel syndrome patients." Scientific Reports | Intestinal barrier function is maintained with aging – a comprehensive study in healthy subjects and irritable bowel syndrome patients. | Scientific Reports | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6965102/ |
| Nalapareddy, K., Zheng, Y., Geiger, H. "Aging of intestinal stem cells." Stem Cell Reports | Aging of intestinal stem cells. | Stem Cell Reports | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9023768/ |
| Hickey, J. W. et al. "Organization of the human intestine at single-cell resolution." Nature | Organization of the human intestine at single-cell resolution. | Nature | 2023 | https://www.nature.com/articles/s41586-023-05915-x |
| Hageb, A. et al. "Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift." Life Science Alliance | Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift. | Life Science Alliance | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9057243/ |
| Jui, J., & Goldman, D | Annual Review of Genetics | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38876121/ |
| Ramachandran, R., Fausett, B. V., & Goldman, D | Journal of Neuroscience | — | 2008 | https://pubmed.ncbi.nlm.nih.gov/18234889/ |
| Jorstad, N. L., Wilken, M. S., Grimes, W. N., et al | Nature | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28746305/ |
| Pearson, R. A., Barber, A. C., Rizzi, M., et al | Nature | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22522934/ |
| da Cruz, L., Fynes, K., Georgiadis, O., et al | Nature Biotechnology | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29553577/ |
| Mehat, M. S., Sundaram, V., Ripamonti, C., et al | Ophthalmology | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29884405/ |
| Hirami, Y., Mandai, M., Sugita, S., et al | Cell Stem Cell | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/38065067/ |
| Ozaki, A., Kawai, A., Akiba, R., et al | Molecular Therapy | — | 2026 | https://pubmed.ncbi.nlm.nih.gov/42365435/ |
| Russell, S., Bennett, J., Wellman, J. A., et al | The Lancet | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28712537/ |
| Sahel, J.-A., Boulanger-Scemama, E., Pagot, C., et al | Nature Medicine | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34031601/ |
| Martins, R. R., Zamzam, M., Tracey-White, D., et al | Aging Cell | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35315590/ |
| Potente, M., Gerhardt, H., & Carmeliet, P | Cell | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21925313/ |
| Johnson, K. E., & Wilgus, T. A | Advances in Wound Care | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4183920/ |
| Bao, P., Kodra, A., Tomic-Canic, M., Golinko, M. S., Ehrlich, H. P., & Brem, H | Journal of Surgical Research | — | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2728016/ |
| DiPietro, L. A | Journal of Leukocyte Biology | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6608066/ |
| Gurevich, D. B., Severn, C. E., Twomey, C., et al | The EMBO Journal | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6028026/ |
| Rafii, S., Butler, J. M., & Ding, B.-S | Nature | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4878406/ |
| Ding, B.-S., Nolan, D. J., Butler, J. M., et al | Nature | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3058628/ |
| Galiano, R. D., Tepper, O. M., Pelo, C. R., et al | American Journal of Pathology | — | 2004 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1615774/ |
| Liu, L., Marti, G. P., Wei, X., et al | Journal of Cellular Physiology | — | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2716010/ |
| Matsuo, R., Kishibe, M., Horiuchi, K., et al | JID Innovations | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9573932/ |
| Jang, H. et al. "Aging of hair follicle stem cells and their niches." BMB Reports | Aging of hair follicle stem cells and their niches. | BMB Reports | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9887102/ |
| Oh, J. W. et al. "A Guide to Studying Human Hair Follicle Cycling In Vivo." Journal of Investigative Dermatology | A Guide to Studying Human Hair Follicle Cycling In Vivo. | Journal of Investigative Dermatology | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4785090/ |
| Matsumura, H. et al. "Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis." Science | Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. | Science | 2016 | https://pubmed.ncbi.nlm.nih.gov/26912707/ |
| Koester, J. et al. "Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility." Nature Cell Biology | Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. | Nature Cell Biology | 2021 | https://www.nature.com/articles/s41556-021-00705-x |
| Nishimura, E. K., Granter, S. R., Fisher, D. E. "Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche." Science | Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. | Science | 2005 | https://pubmed.ncbi.nlm.nih.gov/15618488/ |
| Ito, M. et al. "Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding." Nature | Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. | Nature | 2007 | https://www.nature.com/articles/nature05766 |
| Doles, J. et al. "Age-associated inflammation inhibits epidermal stem cell function." Genes & Development | Age-associated inflammation inhibits epidermal stem cell function. | Genes & Development | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3465736/ |
| Oak, A. S. W., Cotsarelis, G. "Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration." Cold Spring Harbor Perspectives in Biology | Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration. | Cold Spring Harbor Perspectives in Biology | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9899649/ |
| McLaughlin, K. A., & Levin, M | Developmental Biology | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29291972/ |
| Adams, D. S., Masi, A., & Levin, M | Xenopus | Development | 2007 | https://pubmed.ncbi.nlm.nih.gov/17329365/ |
| Beane, W. S., Morokuma, J., Adams, D. S., & Levin, M | Chemistry & Biology | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3278711/ |
| Beane, W. S., Morokuma, J., Lemire, J. M., & Levin, M | Development | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3597208/ |
| Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., & Levin, M | Biophysical Journal | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28538159/ |
| Zhao, M., Song, B., Pu, J., et al | Nature | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/16871217/ |
| Franklin, B. M., Voss, S. R., & Osborn, J. L | Mechanisms of Development | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6386162/ |
| Yi, C., Spitters, T. W. G. M., Al-Far, E. A.-D. A., et al | eLife | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8110307/ |
| Chang-Panesso, M., Kadyrov, F. F., Lalli, M., et al | Journal of Clinical Investigation | — | 2019 | https://www.jci.org/articles/view/125519 |
| Lee, S., Huen, S., Nishio, H., et al | Journal of the American Society of Nephrology | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3029904/ |
| Aggarwal, S., Grange, J., Mugisho, O. O., et al | Science | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38386758/ |
| Kwon, O., Hong, S.-M., Sutton, T. A., & Temm, C. J | American Journal of Physiology - Renal Physiology | — | 2008 | https://pubmed.ncbi.nlm.nih.gov/18562634/ |
| Klocke, J., Kim, S. J., Skopnik, C. M., et al | Kidney International | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/36049643/ |
| Marquez-Exposito, L., Tejedor-Santamaria, L., Valentijn, F. A., et al | Frontiers in Pharmacology | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34239439/ |
| Lu, P., Takai, K., Weaver, V. M., & Werb, Z | Cold Spring Harbor Perspectives in Biology | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3225943/ |
| Gattazzo, F., Urciuolo, A., & Bonaldo, P | Biochimica et Biophysica Acta | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4081568/ |
| Matsubayashi, Y | Fly | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9302511/ |
| Garcia-Puig, A., Mosquera, J. L., Jimenez-Delgado, S., et al | Molecular & Cellular Proteomics | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6731076/ |
| Atala, A., Irvine, D. J., Moses, M., & Shaunak, S | MRS Bulletin | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3826556/ |
| Allen, J. B., Ludtka, C., James, B. D. "Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine." Annual Review of Biomedical Engineering | Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine. | Annual Review of Biomedical Engineering | 2023 | https://pubmed.ncbi.nlm.nih.gov/37104652/ |
| Klein, S. L., Flanagan, K. L. "Sex differences in immune responses." Nature Reviews Immunology | Sex differences in immune responses. | Nature Reviews Immunology | 2016 | https://pubmed.ncbi.nlm.nih.gov/27546235/ |
| McHale, M. J. et al. "Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones. | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | 2012 | https://pubmed.ncbi.nlm.nih.gov/22116509/ |
| You, J. S., Barai, P., Chen, J. "Sex differences in skeletal muscle size, function, and myosin heavy chain isoform expression during post-injury regeneration in mice." Physiological Reports | Sex differences in skeletal muscle size, function, and myosin heavy chain isoform expression during post-injury regeneration in mice. | Physiological Reports | 2023 | https://pubmed.ncbi.nlm.nih.gov/37620103/ |
| Seko, D. et al. "Estrogen Receptor beta Controls Muscle Growth and Regeneration in Young Female Mice." Stem Cell Reports | Estrogen Receptor beta Controls Muscle Growth and Regeneration in Young Female Mice. | Stem Cell Reports | 2020 | https://pubmed.ncbi.nlm.nih.gov/32822588/ |
| Batmunkh, B. et al. "Estrogen Accelerates Cell Proliferation through Estrogen Receptor alpha during Rat Liver Regeneration after Partial Hepatectomy." Acta Histochemica et Cytochemica | Estrogen Accelerates Cell Proliferation through Estrogen Receptor alpha during Rat Liver Regeneration after Partial Hepatectomy. | Acta Histochemica et Cytochemica | 2017 | https://pubmed.ncbi.nlm.nih.gov/28386149/ |
| Vogt, A. et al. "The Effects of Gender on Mesenchymal Stromal Cell (MSC) Proliferation and Differentiation In Vitro: A Systematic Review." International Journal of Molecular Sciences | The Effects of Gender on Mesenchymal Stromal Cell (MSC) Proliferation and Differentiation In Vitro: A Systematic Review. | International Journal of Molecular Sciences | 2024 | https://pubmed.ncbi.nlm.nih.gov/39769346/ |
| Spence, J. R., Mayhew, C. N., Rankin, S. A., et al | Nature | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21151107/ |
| Huch, M., Gehart, H., van Boxtel, R., et al | Cell | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25533785/ |
| Gjorevski, N., Sachs, N., Manfrin, A., et al | Nature | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27851739/ |
| Takebe, T., Sekine, K., Enomura, M., et al | Nature | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23823721/ |
| Jopling, C. et al. "Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation." Nature | Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. | Nature | 2010 | https://www.nature.com/articles/nature08899 |
| Kikuchi, K. et al. "Primary contribution to zebrafish heart regeneration by gata4-positive cardiomyocytes." Nature | Primary contribution to zebrafish heart regeneration by gata4-positive cardiomyocytes. | Nature | 2010 | https://www.nature.com/articles/nature08804 |
| Knopf, F. et al. "Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin." Developmental Cell | Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. | Developmental Cell | 2011 | https://pubmed.ncbi.nlm.nih.gov/21571227/ |
| Kragl, M. et al. "Cells keep a memory of their tissue origin during axolotl limb regeneration." Nature | Cells keep a memory of their tissue origin during axolotl limb regeneration. | Nature | 2009 | https://www.nature.com/articles/nature08152 |
| Tata, P. R. et al. "Dedifferentiation of committed epithelial cells into stem cells in vivo." Nature | Dedifferentiation of committed epithelial cells into stem cells in vivo. | Nature | 2013 | https://www.nature.com/articles/nature12777 |
| Donati, G. et al. "Wounding induces dedifferentiation of epidermal Gata6-positive cells and acquisition of stem cell properties." Nature Cell Biology | Wounding induces dedifferentiation of epidermal Gata6-positive cells and acquisition of stem cell properties. | Nature Cell Biology | 2017 | https://www.nature.com/articles/ncb3532 |
| Sehring, I. M. et al. "Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses." eLife | Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. | eLife | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9259016/ |
| Senyo, S. E. et al. "Mammalian heart renewal by pre-existing cardiomyocytes." Nature | Mammalian heart renewal by pre-existing cardiomyocytes. | Nature | 2013 | https://www.nature.com/articles/nature11682 |
| Yu, F.-X., Zhao, B., & Guan, K.-L | Cell | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4638384/ |
| Wehner, D., Cizelsky, W., Vasudevaro, M. D., et al | Cell Reports | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24485658/ |
| Carlson, M. E., Suetta, C., Conboy, M. J., et al | EMBO Molecular Medicine | — | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2875071/ |
| Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y., & Wrana, J. L | Nature | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26503053/ |
| Yimlamai, D., Christodoulou, C., Galli, G. G., et al | Cell | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4136468/ |
| Xue, J. et al. "Transcriptome-based network analysis reveals a spectrum model of human macrophage activation." Immunity | Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. | Immunity | 2014 | https://pubmed.ncbi.nlm.nih.gov/25035950/ |
| Arnold, L. et al. "Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis." Journal of Experimental Medicine | Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. | Journal of Experimental Medicine | 2007 | https://pubmed.ncbi.nlm.nih.gov/17485518/ |
| Shang, M. et al. "Macrophage-derived glutamine boosts satellite cells and muscle regeneration." Nature | Macrophage-derived glutamine boosts satellite cells and muscle regeneration. | Nature | 2020 | https://pubmed.ncbi.nlm.nih.gov/33116312/ |
| Gurevich, D. B. et al. "Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression." EMBO Journal | Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. | EMBO Journal | 2018 | https://pubmed.ncbi.nlm.nih.gov/29866703/ |
| Godwin, J. W. et al. "Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape." npj Regenerative Medicine | Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape. | npj Regenerative Medicine | 2017 | https://pubmed.ncbi.nlm.nih.gov/29201433/ |
| Epelman, S., Lavine, K. J., Randolph, G. J. "Origin and functions of tissue macrophages." Immunity | Origin and functions of tissue macrophages. | Immunity | 2014 | https://pubmed.ncbi.nlm.nih.gov/24439267/ |
| Doran, A. C., Yurdagul, A. Jr., Tabas, I. "Efferocytosis in health and disease." Nature Reviews Immunology | Efferocytosis in health and disease. | Nature Reviews Immunology | 2020 | https://pubmed.ncbi.nlm.nih.gov/31822793/ |
| Reidy, P. T. et al. "Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse." American Journal of Physiology-Endocrinology and Metabolism | Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse. | American Journal of Physiology-Endocrinology and Metabolism | 2019 | https://pubmed.ncbi.nlm.nih.gov/30964703/ |
| McCusker, C., Bryant, S. V., Gardiner, D. M. "The axolotl limb blastema: cellular and molecular mechanisms driving blastema formation and limb regeneration in tetrapods." Regeneration | The axolotl limb blastema: cellular and molecular mechanisms driving blastema formation and limb regeneration in tetrapods. | Regeneration | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4895312/ |
| Currie, J. D. et al. "Live imaging of axolotl digit regeneration reveals spatiotemporal choreography of diverse connective tissue progenitor pools." Developmental Cell | Live imaging of axolotl digit regeneration reveals spatiotemporal choreography of diverse connective tissue progenitor pools. | Developmental Cell | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5127896/ |
| Gerber, T. et al. "Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration." Science | Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. | Science | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6669047/ |
| Ferris, D. R. et al. "Ex vivo generation of a functional and regenerative wound epithelium from axolotl (Ambystoma mexicanum) skin." Development, Growth & Differentiation | Ex vivo generation of a functional and regenerative wound epithelium from axolotl (Ambystoma mexicanum) skin. | Development, Growth & Differentiation | 2010 | https://pubmed.ncbi.nlm.nih.gov/20874715/ |
| Kumar, A. et al. "Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate." Science | Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate. | Science | 2007 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2696928/ |
| Monaghan, J. R. et al. "Gene expression patterns specific to the regenerating limb of the Mexican axolotl." Biology Open | Gene expression patterns specific to the regenerating limb of the Mexican axolotl. | Biology Open | 2012 | https://pubmed.ncbi.nlm.nih.gov/23213371/ |
| Nacu, E. et al. "FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration." Nature | FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration. | Nature | 2016 | https://www.nature.com/articles/nature17972 |
| Haas, B. J., Whited, J. L. "Advances in decoding axolotl limb regeneration." Trends in Genetics | Advances in decoding axolotl limb regeneration. | Trends in Genetics | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5534018/ |
| Otsuki, L. et al. "Molecular basis of positional memory in limb regeneration." Nature | Molecular basis of positional memory in limb regeneration. | Nature | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12176643/ |
| Coste, B., Mathur, J., Schmidt, M., et al | Science | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20813920/ |
| Dupont, S., Morsut, L., Aragona, M., et al | Nature | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21654799/ |
| Hirano, K., Tsuchiya, M., Shiomi, A., et al | Life Science Alliance | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/36446523/ |
| Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., et al | Science | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2929271/ |
| Silver, J. S., Günay, K. A., Cutler, A. A., et al | Science Advances | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7954458/ |
| Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., et al | Cell | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/29107331/ |
| Fullerton, J. N., Gilroy, D. W. "Resolution of inflammation: a new therapeutic frontier." Nature Reviews Drug Discovery | Resolution of inflammation: a new therapeutic frontier. | Nature Reviews Drug Discovery | 2016 | https://pubmed.ncbi.nlm.nih.gov/27020098/ |
| Murray, P. J., Wynn, T. A. "Protective and pathogenic functions of macrophage subsets." Nature Reviews Immunology | Protective and pathogenic functions of macrophage subsets. | Nature Reviews Immunology | 2011 | https://pubmed.ncbi.nlm.nih.gov/21350564/ |
| Schilperoort, M. et al. "The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation." Immunological Reviews | The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation. | Immunological Reviews | 2023 | https://pubmed.ncbi.nlm.nih.gov/37158427/ |
| Tsarouchas, T. M. et al. "Neutrophil immune profile guides spinal cord regeneration in zebrafish." Brain, Behavior, and Immunity | Neutrophil immune profile guides spinal cord regeneration in zebrafish. | Brain, Behavior, and Immunity | 2024 | https://pubmed.ncbi.nlm.nih.gov/38925414/ |
| Yurdagul, A. Jr. et al. "Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury." Cell Metabolism | Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury. | Cell Metabolism | 2020 | https://pubmed.ncbi.nlm.nih.gov/32004476/ |
| Oishi, Y. et al. "Macrophage SREBP1 regulates skeletal muscle regeneration." Frontiers in Immunology | Macrophage SREBP1 regulates skeletal muscle regeneration. | Frontiers in Immunology | 2024 | https://pubmed.ncbi.nlm.nih.gov/38259495/ |
| Ojeh, N. et al. "Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications." International Journal of Molecular Sciences | Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications. | International Journal of Molecular Sciences | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4632811/ |
| Solé-Boldo, L. et al. "Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming." Communications Biology | Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming. | Communications Biology | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7181753/ |
| Raja, E., Clarin, M. T. R. D. C., Yanagisawa, H. "Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin." International Journal of Molecular Sciences | Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin. | International Journal of Molecular Sciences | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10531864/ |
| Bentov, I., Reed, M. J. "The Effect of Aging on the Cutaneous Microvasculature." Microvascular Research | The Effect of Aging on the Cutaneous Microvasculature. | Microvascular Research | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4461519/ |
| Dube, C. T. et al. "Age-Related Alterations in Macrophage Distribution and Function Are Associated With Delayed Cutaneous Wound Healing." Frontiers in Immunology | Age-Related Alterations in Macrophage Distribution and Function Are Associated With Delayed Cutaneous Wound Healing. | Frontiers in Immunology | 2022 | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.943159/full |
| Low, E. et al. "How good is the evidence that cellular senescence causes skin ageing?" Ageing Research Reviews | How good is the evidence that cellular senescence causes skin ageing? | Ageing Research Reviews | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8524668/ |
| Wells, J. M., Watt, F. M | Nature | — | 2018 | https://www.nature.com/articles/s41586-018-0073-7 |
| Romagnani, P., Rinkevich, Y., Dekel, B | Nature Reviews Nephrology | — | 2015 | https://www.nature.com/articles/nrneph.2015.67 |
| Trachtenberg, J. E., Vo, T. N., Mikos, A. G | Annals of Biomedical Engineering | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4380647/ |
| Bois, A., et al | npj Regenerative Medicine | — | 2025 | https://www.nature.com/articles/s41536-025-00394-2 |
| Huang, W., Percie du Sert, N., Vollert, J., Rice, A. S. C | Handbook of Experimental Pharmacology | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7610693/ |
| Basso, D. M., et al | Journal of Neurotrauma | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/16689667/ |
| Wagner, D. E., Klein, A. M | Nature Reviews Genetics | — | 2020 | https://www.nature.com/articles/s41576-020-0223-2 |
| Mauro, A | Journal of Biophysical and Biochemical Cytology | — | 1961 | https://pubmed.ncbi.nlm.nih.gov/13768451/ |
| Yin, H., Price, F., Rudnicki, M. A | Physiological Reviews | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23303905/ |
| Kuang, S., Kuroda, K., Le Grand, F., Rudnicki, M. A | Cell | — | 2007 | https://pubmed.ncbi.nlm.nih.gov/17540178/ |
| Bjornson, C. R. R., Cheung, T. H., Liu, L., et al | Stem Cells | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22045613/ |
| Yamamoto, M., Legendre, N. P., Biswas, A. A., et al | Stem Cell Reports | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29478898/ |
| Jackson, J. R., Mula, J., Kirby, T. J., et al | American Journal of Physiology - Cell Physiology | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22895262/ |
| Tidball, J. G | Nature Reviews Immunology | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28163303/ |
| Gurevich, D. B., Nguyen, P. D., Siegel, A. L., et al | Science | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27198673/ |
| Miyaoka, Y., Ebato, K., Kato, H., et al | Current Biology | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22658593/ |
| Aoki, T., Imamura, H., Matsuyama, Y., et al | Journal of Gastrointestinal Surgery | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21710329/ |
| Olthoff, K. M., Emond, J. C., Shearon, T. H., et al | Liver Transplantation | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4276514/ |
| Raven, A., Lu, W.-Y., Man, T. Y., et al | Nature | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5522613/ |
| Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., et al | Science | — | 1996 | https://pubmed.ncbi.nlm.nih.gov/8910279/ |
| Yamanaka, N., Okamoto, E., Kawamura, E., et al | Hepatology | — | 1993 | https://pubmed.ncbi.nlm.nih.gov/8392029/ |
| Aierken, Y., Kong, L.-X., Li, B., et al | Medicine | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32481371/ |
| Enkhbold, C., Morine, Y., Utsunomiya, T., et al | Journal of Gastroenterology and Hepatology | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25682855/ |
| Mori, S., Kim, H., Park, M.-S., et al | Hepato-Gastroenterology | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23574637/ |
| Kaelin, W. G., Jr., & Ratcliffe, P. J | Molecular Cell | — | 2008 | https://pubmed.ncbi.nlm.nih.gov/18498744/ |
| Ivan, M., Kondo, K., Yang, H., et al | Science | — | 2001 | https://pubmed.ncbi.nlm.nih.gov/11292862/ |
| Semenza, G. L | Cell | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3437543/ |
| Duscher, D., Maan, Z. N., Whittam, A. J., et al | Plastic and Reconstructive Surgery | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26505703/ |
| Majmundar, A. J., Skuli, N., Mesquita, R. C., et al | Molecular and Cellular Biology | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22006022/ |
| Yang, X., Yang, S., Wang, C., & Kuang, S | Journal of Biological Chemistry | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28232488/ |
| Puente, B. N., Kimura, W., Muralidhar, S. A., et al | Cell | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24766806/ |
| Nakada, Y., Canseco, D. C., Thet, S., et al | Nature | — | 2017 | https://www.nature.com/articles/nature20173 |
| Rivera, K. R., et al | Cellular and Molecular Gastroenterology and Hepatology | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37562653/ |
| Yin, A., Fu, W., Elengickal, A., et al | Journal of Cachexia, Sarcopenia and Muscle | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38333911/ |
| Tsissios, G., Leleu, M., Hu, K., et al | Science | — | 2026 | https://pubmed.ncbi.nlm.nih.gov/41955383/ |
| Noble, A., Qubrosi, R., Cariba, S., Favaro, K., & Payne, S. L | Developmental Dynamics | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/37638700/ |
| Stocum, D. L | European Journal of Neuroscience | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21929624/ |
| Simões, M. G., Bensimon-Brito, A., Fonseca, M., et al | BMC Developmental Biology | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/25551555/ |
| Wells, K. M., Kelley, K., Baumel, M., Vieira, W. A., & McCusker, C. D | eLife | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34779399/ |
| Lu, Y.-Z., Nayer, B., Singh, S. K., et al | Nature | — | 2024 | https://www.nature.com/articles/s41586-024-07237-y |
| Smith, P. G., & Liu, M | Cell and Tissue Research | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/11904764/ |
| Jessen, K. R., & Mirsky, R | The Journal of Physiology | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/26864683/ |
| Farkas, J. E., & Monaghan, J. R | Neurogenesis | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28459075/ |
| Raven, A. et al. "Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration." Nature | Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration. | Nature | 2017 | https://www.nature.com/articles/nature23015 |
| Bergmann, O., Bhardwaj, R. D., Bernard, S., et al | Science | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19342590/ |
| Bergmann, O., Zdunek, S., Felker, A., et al | Cell | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26073943/ |
| van Berlo, J. H., Kanisicak, O., Maillet, M., et al | Nature | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24805242/ |
| Vagnozzi, R. J., Maillet, M., Sargent, M. A., et al | Nature | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/31775156/ |
| Chong, J. J. H., Yang, X., Don, C. W., et al | Nature | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24776797/ |
| Jebran, A.-F., Seidler, T., Tiburcy, M., et al | Nature | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/39880949/ |
| Khalid, K. A. et al. "Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks." Life | Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks. | Life | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9784880/ |
| Thanapaul, R. J. R. S. et al. "An Insight into Aging, Senescence, and Their Impacts on Wound Healing." Advances in Geriatric Medicine and Research | An Insight into Aging, Senescence, and Their Impacts on Wound Healing. | Advances in Geriatric Medicine and Research | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8373038/ |
| Wang, Y., Wehling-Henricks, M., Welc, S. S., et al | FASEB Journal | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30130434/ |
| Ahmadi, M., Karlsen, A., Mehling, J., et al | Experimental Gerontology | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/36228835/ |
| Jun, J.-I., Lau, L. F. "The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing." Nature Cell Biology | The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. | Nature Cell Biology | 2010 | https://pubmed.ncbi.nlm.nih.gov/20526329/ |
| Ritschka, B. et al. "The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration." Genes & Development | The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. | Genes & Development | 2017 | https://pubmed.ncbi.nlm.nih.gov/28143833/ |
| Sousa-Victor, P. et al. "Geriatric muscle stem cells switch reversible quiescence into senescence." Nature | Geriatric muscle stem cells switch reversible quiescence into senescence. | Nature | 2014 | https://pubmed.ncbi.nlm.nih.gov/24522534/ |
| Young, L. V. et al. "Muscle injury induces a transient senescence-like state that is required for myofiber growth during muscle regeneration." The FASEB Journal | Muscle injury induces a transient senescence-like state that is required for myofiber growth during muscle regeneration. | The FASEB Journal | 2022 | https://pubmed.ncbi.nlm.nih.gov/36190443/ |
| Wijayasiri, P. et al. "Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression." Cells | Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression. | Cells | 2022 | https://pubmed.ncbi.nlm.nih.gov/35883664/ |
| Burzyn, D. et al. "A special population of regulatory T cells potentiates muscle repair." Cell | A special population of regulatory T cells potentiates muscle repair. | Cell | 2013 | https://pubmed.ncbi.nlm.nih.gov/24315098/ |
| Arpaia, N. et al. "A Distinct Function of Regulatory T Cells in Tissue Protection." Cell | A Distinct Function of Regulatory T Cells in Tissue Protection. | Cell | 2015 | https://pubmed.ncbi.nlm.nih.gov/26317471/ |
| Naik, S. et al. "Inflammatory memory sensitizes skin epithelial stem cells to tissue damage." Nature | Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. | Nature | 2017 | https://pubmed.ncbi.nlm.nih.gov/29045388/ |
| Wang, H. et al. "Altered macrophage phenotype transition impairs skeletal muscle regeneration." The American Journal of Pathology | Altered macrophage phenotype transition impairs skeletal muscle regeneration. | The American Journal of Pathology | 2014 | https://pubmed.ncbi.nlm.nih.gov/24525152/ |
| Rinn, J. L. et al. "A dermal HOX transcriptional program regulates site-specific epidermal fate." Genes & Development | A dermal HOX transcriptional program regulates site-specific epidermal fate. | Genes & Development | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2216690/ |
| Rodgers, J. T., King, K. Y., Brett, J. O., et al | Nature | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4065227/ |
| Schell, J. C., Wisidagama, D. R., Bensard, C., et al | Nature Cell Biology | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28812582/ |
| Wang, X., Menezes, C. J., Jia, Y., et al | Science | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38870309/ |
| Chaves-Perez, A., Millman, S. E., Janaki-Raman, S., et al | Nature | — | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12240837/ |
| Ciuffoli, V., Feng, X., Jiang, K., et al | Genes & Development | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38453480/ |
| Kang, J. et al. "Modulation of tissue repair by regeneration enhancer elements." Nature | Modulation of tissue repair by regeneration enhancer elements. | Nature | 2016 | https://www.nature.com/articles/nature17644 |
| Hirose, K., Shimoda, N., Kikuchi, Y. "Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin." Epigenetics | Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin. | Epigenetics | 2013 | https://pubmed.ncbi.nlm.nih.gov/23880758/ |
| Schwörer, S. et al. "Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals." Nature | Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. | Nature | 2016 | https://pubmed.ncbi.nlm.nih.gov/27919074/ |
| Kawaguchi, A. et al. "A chromatin code for limb segment identity in axolotl limb regeneration." Developmental Cell | A chromatin code for limb segment identity in axolotl limb regeneration. | Developmental Cell | 2024 | https://pubmed.ncbi.nlm.nih.gov/38788714/ |
| Cordero, J. et al. "Leveraging chromatin state transitions for the identification of regulatory networks orchestrating heart regeneration." Nucleic Acids Research | Leveraging chromatin state transitions for the identification of regulatory networks orchestrating heart regeneration. | Nucleic Acids Research | 2024 | https://pubmed.ncbi.nlm.nih.gov/38364861/ |
| Hunziker, E. B | Osteoarthritis and Cartilage | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/12056848/ |
| Lotz, M., Loeser, R. F | Bone | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22487298/ |
| Loeser, R. F., Gandhi, U., Long, D. L., et al | Arthritis & Rheumatology | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24664641/ |
| Jeuken, R. M., et al | Orthopaedic Journal of Sports Medicine | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34676269/ |
| van der Kraan, P. M., Blaney Davidson, E. N., van den Berg, W. B | Arthritis Research & Therapy | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20156325/ |
| Singla, M., et al | Science | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/41308124/ |
| Nabhan, A. N., Brownfield, D. G., Harbury, P. B., Krasnow, M. A., & Desai, T. J | Science | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29420258/ |
| Zacharias, W. J., Frank, D. B., Zepp, J. A., et al | Nature | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29489752/ |
| Rowbotham, S. P., Pessina, P., Garcia-de-Alba, C., et al | Developmental Cell | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37977149/ |
| Hirsch, M. S., Hildebrand, C. B., Geltinger, F., et al | American Journal of Respiratory Cell and Molecular Biology | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/39088755/ |
| Godoy, R. S., Cober, N. D., Cook, D. P., et al | eLife | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37078698/ |
| Einhorn, T. A., & Gerstenfeld, L. C | Nature Reviews Rheumatology | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4464690/ |
| Lu, C., et al | Journal of Orthopaedic Research | — | 2005 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2844440/ |
| Ambrosi, T. H., et al | Nature | — | 2021 | https://www.nature.com/articles/s41586-021-03795-7 |
| Zou, N.-Y., et al | Bone Research | — | 2024 | https://www.nature.com/articles/s41413-023-00309-1 |
| Taormina, D. P., et al | Geriatric Orthopaedic Surgery & Rehabilitation | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4212425/ |
| Saunders, G. H., & Echt, K. V | Trends in Amplification | — | 2007 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4111537/ |
| Raina, P., Wong, M., & Massfeller, H | BMC Geriatrics | — | 2004 | https://pmc.ncbi.nlm.nih.gov/articles/PMC425581/ |
| Mueller-Schotte, S., et al | The Journals of Gerontology: Series A | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/29982391/ |
| Kong, H. H., Shin, K., & Won, C. W | International Journal of Environmental Research and Public Health | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9964928/ |
| Assi, S., et al | Journal of Aging and Health | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/37505080/ |
| Mick, P., et al | Canadian Family Physician | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5962968/ |
| Hwang, P. H., et al | Alzheimer's & Dementia: Translational Research & Clinical Interventions | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7340796/ |
| Wood, I., et al | Alzheimer Disease & Associated Disorders | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/36706321/ |
| Ang, B. H., Oxley, J., Chen, W. S., & Lee, S. W. H | Journal of Safety Research | — | 2019 | https://doi.org/10.1016/j.jsr.2019.03.007 |
| Molnar, L. J., et al | Accident Analysis & Prevention | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23659865/ |
| Huisingh, C., Levitan, E. B., Sawyer, P., Kennedy, R., Brown, C. J., & McGwin, G | Journal of Applied Gerontology | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/26912737/ |
| Webber, S. C., Porter, M. M., & Menec, V. H | The Gerontologist | — | 2010 | https://doi.org/10.1093/geront/gnq013 |
| Pellichero, A., Lafont, S., Paire-Ficout, L., Fabrigoule, C., & Chavoix, C | Annals of Physical and Rehabilitation Medicine | — | 2021 | https://doi.org/10.1016/j.rehab.2020.03.003 |
| Dickerson, A. E., et al | Innovation in Aging | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11212369/ |
| Mander, B. A., Winer, J. R., & Walker, M. P | Neuron | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5810920/ |
| Landry, G. J., Best, J. R., & Liu-Ambrose, T | Frontiers in Aging Neuroscience | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4561455/ |
| Li, J., Vitiello, M. V., & Gooneratne, N. S | Sleep Medicine Clinics | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5841578/ |
| Blackwell, T., Yaffe, K., Laffan, A., et al | Sleep | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4044750/ |
| Lee, Y.-H., Kong, D., Lee, Y.-T. H., et al | European Geriatric Medicine | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35191012/ |
| Kim, M., Yoshida, H., Sasai, H., Kojima, N., & Kim, H | Geriatrics & Gerontology International | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25312049/ |
| Köhler, S., Soons, L. M., Tange, H., Deckers, K., & van Boxtel, M. P. J | Journal of Alzheimer's Disease | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10741338/ |
| Yogev-Seligmann, G., Hausdorff, J. M., & Giladi, N | Movement Disorders | — | 2008 | https://pubmed.ncbi.nlm.nih.gov/18058946/ |
| Al-Yahya, E., Dawes, H., Smith, L., Dennis, A., Howells, K., & Cockburn, J | Neuroscience & Biobehavioral Reviews | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/20833198/ |
| Smith, E., Cusack, T., Cunningham, C., & Blake, C | Journal of Aging and Physical Activity | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28253049/ |
| Gonçalves, J., Ansai, J. H., Masse, F. A. A., et al | Brazilian Journal of Physical Therapy | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29636306/ |
| Gutiérrez-Valencia, M., et al | British Journal of Clinical Pharmacology | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29575094/ |
| Toh, J. J. Y., et al | Ageing Research Reviews | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/36455791/ |
| Rodrigues, M. C. S., & de Oliveira, C | Revista Latino-Americana de Enfermagem | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27598380/ |
| Al Rihani, S. B., et al | Drugs & Aging | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34751922/ |
| Yu, X., et al | Geriatric Nursing | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/39111065/ |
| Wastesson, J. W., et al | Expert Opinion on Drug Safety | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/30540223/ |
| Diamond, A | Annual Review of Psychology | — | 2013 | https://doi.org/10.1146/annurev-psych-113011-143750 |
| Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D | frontal lobe | Cognitive Psychology | 2000 | https://doi.org/10.1006/cogp.1999.0734 |
| Carlson, M. C., Fried, L. P., Xue, Q. L., Bandeen-Roche, K., Zeger, S. L., & Brandt, J | The Journals of Gerontology: Series B | — | 1999 | https://pubmed.ncbi.nlm.nih.gov/10542828/ |
| Cahn-Weiner, D. A., Boyle, P. A., & Malloy, P. F | Applied Neuropsychology | — | 2002 | https://doi.org/10.1207/S15324826AN0903_8 |
| Tomaszewski Farias, S., Cahn-Weiner, D. A., Harvey, D. J., et al | The Clinical Neuropsychologist | — | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2881703/ |
| Overdorp, E. J., Kessels, R. P. C., Claassen, J. A., & Oosterman, J. M | Neuropsychology Review | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4762929/ |
| McAlister, C., & Schmitter-Edgecombe, M | Aging, Neuropsychology, and Cognition | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3708986/ |
| Raimo, S., Maggi, G., Ilardi, C. R., et al | Neurological Sciences | — | 2024 | https://doi.org/10.1007/s10072-024-07366-2 |
| Demontiero, O., Vidal, C., & Duque, G | Therapeutic Advances in Musculoskeletal Disease | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3383520/ |
| Edwards, M. H., et al | Bone | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23159464/ |
| Larsson, B. A., et al | Osteoporosis International | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/33089354/ |
| Haentjens, P., et al | Annals of Internal Medicine | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20231569/ |
| Pollock, A. S., Durward, B. R., Rowe, P. J., & Paul, J. P | Clinical Rehabilitation | — | 2000 | https://pubmed.ncbi.nlm.nih.gov/10945424/ |
| Salzman, B | American Family Physician | — | 2010 | https://www.aafp.org/pubs/afp/issues/2010/0701/p61.html |
| Jahn, K., Zwergal, A., & Schniepp, R | Deutsches Arzteblatt International | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2872829/ |
| Ambrose, A. F., Paul, G., & Hausdorff, J. M | Maturitas | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23523272/ |
| Hausdorff, J. M., Rios, D. A., & Edelberg, H. K | Archives of Physical Medicine and Rehabilitation | — | 2001 | https://pubmed.ncbi.nlm.nih.gov/11494184/ |
| Rantanen, T., et al | BMC Public Health | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3534010/ |
| The Consensus Committee of the American Autonomic Society and the American Academy of Neurology | Neurology | — | 1996 | https://www.neurology.org/doi/10.1212/WNL.46.5.1470 |
| Wieling, W., et al | The Lancet Neurology | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35841911/ |
| Mol, A., et al | Journal of the American Medical Directors Association | — | 2019 | https://doi.org/10.1016/j.jamda.2018.11.003 |
| O'Connell, M. D. L., et al | Archives of Gerontology and Geriatrics | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25687529/ |
| Olofsson, J. K., Ekstrom, I., Larsson, M., & Nordin, S | i-Perception | — | 2021 | https://journals.sagepub.com/doi/10.1177/20416695211020331 |
| Doty, R. L., & Kamath, V | Frontiers in Psychology | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3916729/ |
| Bauer, S., Blanar, V., Pospichal, J., & Eglseer, D | Nutrition Reviews | — | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12793606/ |
| Alves, L. S. M., Munduri, J. M. S., Mattos, M. C. O., Stefani, C. M., & Dame-Teixeira, N | Frontiers in Oral Health | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/39703868/ |
| Ponzo, V., Bo, M., Favaro, E., et al | Aging Clinical and Experimental Research | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10984891/ |
| Laudisio, A., Navarini, L., Margiotta, D. P. E., et al | Mediators of Inflammation | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6402210/ |
| Yeo, B. S. Y., Chan, J. H., Tan, B. K. J., et al | JAMA Otolaryngology-Head & Neck Surgery | — | 2024 | https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2821102 |
| Clark, D., Kotronia, E., Ramsay, S. E., et al | Periodontology 2000 | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8771712/ |
| Villalobos, V., et al | Frontiers in Immunology | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9630574/ |
| Darveau, R. P | Nature Reviews Microbiology | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20514045/ |
| Aquino-Martinez, R., Khosla, S., Farr, J. N., & Monroe, D. G | International Journal of Molecular Sciences | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/33050175/ |
| Chen, S., Zhou, D., Liu, O., Chen, H., Wang, Y., & Zhou, Y | Biology | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9598109/ |
| Hakeem, F. F., Bernabe, E., & Sabbah, W | Gerodontology | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31025772/ |
| Li, L., Zhang, Q., Yang, D., et al | Frontiers in Neurology | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10150074/ |
| Rozas, N. S., Stephens, N., Lu, K. Y. F., & Jeter, C. B | Archives of Oral Biology | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/40349643/ |
| Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A | Nature Reviews Endocrinology | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/30046148/ |
| Lokman, N., Mohd Nayan, N. A., & Choong, E. K. M | International Dental Journal | — | 2026 | https://pubmed.ncbi.nlm.nih.gov/41380483/ |
| Tinetti, M. E., Richman, D., & Powell, L | Journal of Gerontology | — | 1990 | https://pubmed.ncbi.nlm.nih.gov/2229948/ |
| Delbaere, K., Close, J. C. T., Brodaty, H., Sachdev, P., & Lord, S. R | BMJ | — | 2010 | https://www.bmj.com/content/341/bmj.c4165 |
| Makino, K., Makizako, H., Doi, T., et al | International Journal of Geriatric Psychiatry | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29231272/ |
| Lim, J. H., Joo, M. J., Ko, J., Kim, D. B., Park, E. C., & Ha, M. J | The Journal of Nutrition, Health & Aging | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/40435859/ |
| Sánchez-Sánchez, J. L., Lu, W.-H., Gallardo-Gómez, D., et al | The Lancet Healthy Longevity | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38945130/ |
| Chew, J., Lee, J., Hernandez, H. H. C., et al | The Journal of Frailty & Aging | — | 2025 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12399253/ |
| Giacomino, K., Hilfiker, R., Beckwée, D., Taeymans, J., & Sattelmayer, K. M | PeerJ | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10590575/ |
| Sager, M. A., Franke, T., Inouye, S. K., et al | Archives of Internal Medicine | — | 1996 | https://pubmed.ncbi.nlm.nih.gov/8629876/ |
| Katz, S., Ford, A. B., Moskowitz, R. W., Jackson, B. A., & Jaffe, M. W | JAMA | — | 1963 | https://pubmed.ncbi.nlm.nih.gov/14044222/ |
| Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R., & Evans, W. J | JAMA | — | 2007 | https://pubmed.ncbi.nlm.nih.gov/17456818/ |
| Dirks, M. L., Wall, B. T., van de Valk, B., et al | Diabetes | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27358494/ |
| Hajj-Boutros, G., Sonjak, V., Faust, A., et al | Gerontology | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37717560/ |
| Greenleaf, J. E., Wade, C. E., & Leftheriotis, G | Aviation, Space, and Environmental Medicine | — | 1989 | https://pubmed.ncbi.nlm.nih.gov/2751583/ |
| van der Wiel, H. E., Lips, P., Nauta, J., Netelenbos, J. C., & Hazenberg, G. J | Bone and Mineral | — | 1991 | https://pubmed.ncbi.nlm.nih.gov/2059676/ |
| LeBlanc, A. D., Schneider, V. S., Evans, H. J., Engelbretson, D. A., & Krebs, J. M | Journal of Bone and Mineral Research | — | 1990 | https://pubmed.ncbi.nlm.nih.gov/2239368/ |
| Scott, J. M., Downs, M., Buxton, R., et al | Critical Care Explorations | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7688251/ |
| ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories | American Journal of Respiratory and Critical Care Medicine | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/12091180/ |
| Holland, A. E., Spruit, M. A., Troosters, T., et al | European Respiratory Journal | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/25359355/ |
| Steffen, T. M., Hacker, T. A., & Mollinger, L | Physical Therapy | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/11856064/ |
| Ng, S. S., Yu, P. C., To, F. P., Chung, J. S., & Cheung, T. H | Physiotherapy | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23219645/ |
| Cederholm, T., Jensen, G. L., Correia, M. I. T. D., et al | Clinical Nutrition | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30181091/ |
| Fávaro-Moreira, N. C., Krausch-Hofmann, S., Matthys, C., et al | Advances in Nutrition | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4863272/ |
| Kramer, C. S., et al | Current Developments in Nutrition | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8989279/ |
| Almohaisen, N., Gittins, M., Todd, C., et al | Nutrients | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9032775/ |
| Thomson, K. H., Rice, S., Arisa, O., et al | Health Technology Assessment | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9791461/ |
| Kim, D. J., Massa, M. S., Potter, C. M., & Clarke, R. "Systematic review of the utility of the frailty index and frailty phenotype to predict all-cause mortality in older people." Systematic Reviews | Systematic review of the utility of the frailty index and frailty phenotype to predict all-cause mortality in older people. | Systematic Reviews | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9438224/ |
| Miller, D. S., Robert, P., Ereshefsky, L., et al | Alzheimer's & Dementia | — | 2021 | https://doi.org/10.1002/alz.12358 |
| Marin, R. S., Biedrzycki, R. C., & Firinciogullari, S | Psychiatry Research | — | 1991 | https://doi.org/10.1016/0165-1781(91)90040-V |
| Le Heron, C., Holroyd, C. B., Salamone, J., & Husain, M | Journal of Neurology, Neurosurgery & Psychiatry | — | 2019 | https://doi.org/10.1136/jnnp-2018-318265 |
| Clarke, D. E., Ko, J. Y., Lyketsos, C., Rebok, G. W., & Eaton, W. W | International Psychogeriatrics | — | 2010 | https://doi.org/10.1017/S1041610209991402 |
| Ayers, E., Shapiro, M., Holtzer, R., Barzilai, N., Milman, S., & Verghese, J | The Journal of Clinical Psychiatry | — | 2017 | https://doi.org/10.4088/JCP.15m10113 |
| Connors, M. H., Teixeira-Pinto, A., Ames, D., Woodward, M., & Brodaty, H | Australian & New Zealand Journal of Psychiatry | — | 2023 | https://doi.org/10.1177/00048674221114597 |
| Reid, K. F., & Fielding, R. A | Exercise and Sport Sciences Reviews | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3245773/ |
| Alcazar, J., Kamper, R. S., Aagaard, P., et al | Scientific Reports | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/33004970/ |
| Alcazar, J., Alegre, L. M., Suetta, C., et al | Medicine & Science in Sports & Exercise | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34107507/ |
| Hunter, S. K., Pereira, H. M., & Keenan, K. G | Journal of Applied Physiology | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5142309/ |
| Portegijs, E., et al | BMC Research Notes | — | 2014 | https://doi.org/10.1186/1756-0500-7-323 |
| Hinrichs, T., et al | European Review of Aging and Physical Activity | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7700712/ |
| Yamasoba, T., et al | Hearing Research | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3723756/ |
| Shukla, A., et al | Otolaryngology-Head and Neck Surgery | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8292986/ |
| Spector, W. D., Katz, S., Murphy, J. B., & Fulton, J. P | Journal of Chronic Diseases | — | 1987 | https://pubmed.ncbi.nlm.nih.gov/3597653/ |
| Jekel, K., Damian, M., Wattmo, C., et al | Alzheimer's Research & Therapy | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4374414/ |
| Pashmdarfard, M., & Azad, A | Medical Journal of the Islamic Republic of Iran | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7320974/ |
| Bravell, M. E., Zarit, S. H., & Johansson, B | European Journal of Ageing | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5547338/ |
| Romero-Ayuso, D., Castillero-Perea, A., González, P., et al | Disability and Rehabilitation | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/31549907/ |
| Gaugler, J. E., Yu, F., Krichbaum, K., & Wyman, J. F | Medical Care | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19169120/ |
| Lucas, R. E | Journal of Personality and Social Psychology | — | 2007 | https://doi.org/10.1037/0022-3514.92.4.717 |
| Szanton, S. L., Xue, Q.-L., Leff, B., et al | JAMA Internal Medicine | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6439640/ |
| Rosenwohl-Mack, A., Schumacher, K., Fang, M.-L., & Fukuoka, Y | International Journal of Nursing Studies | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7556794/ |
| Bell, T. M., Wang, J., Nolly, R., Ozdenerol, E., Relyea, G., & Zarzaur, B. L | Annals of Epidemiology | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26481503/ |
| Gavrila Laic, R. A., Bogaert, L., Vander Sloten, J., & Depreitere, B | Brain & Spine | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9560680/ |
| Rafaqat, W., Panossian, V. S., Abiad, M., et al | Surgery | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/39107141/ |
| Al Hanna, R., Amatya, B., Lizama, L. E., Galea, M. P., & Khan, F | Journal of Rehabilitation Medicine | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32940713/ |
| Larose, J., Wright, H. E., Stapleton, J., et al | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23883671/ |
| Takeda, R., Imai, D., Suzuki, A., et al | European Journal of Applied Physiology | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27015984/ |
| Meade, R. D., Akerman, A. P., Notley, S. R., et al | Environmental Health Perspectives | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10852046/ |
| Vandentorren, S., Bretin, P., Zeghnoun, A., et al | European Journal of Public Health | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/17028103/ |
| Hospers, L., Dillon, G. A., McLachlan, A. J., et al | EClinicalMedicine | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11541675/ |
| Günsche, S., Borg, M. A., Anikeeva, O., et al | Environment International | — | 2026 | https://pubmed.ncbi.nlm.nih.gov/41679084/ |
| Zhang, R., Sun, L., Jia, A., et al | The Lancet Regional Health – Western Pacific | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11490898/ |
| Gagnon, D., & Kenny, G. P | Journal of Physiology | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3530110/ |
| Pollak, C., et al | Research in Gerontological Nursing | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10926714/ |
| Shankar, A., et al | Health Psychology | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/27786518/ |
| Pan, C., & Yu, L | Journal of Global Health | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10811563/ |
| Stauder, R., Valent, P., & Theurl, I | Blood | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29141943/ |
| Poole, D. C., & Jones, A. M | Comprehensive Physiology | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/23798293/ |
| Dominelli, P. B., et al | Mayo Clinic Proceedings | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8026750/ |
| den Elzen, W. P. J., Willems, J. M., Westendorp, R. G. J., et al | Canadian Medical Association Journal | — | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2717683/ |
| Wacka, E., et al | Journal of Clinical Medicine | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11012269/ |
| Cecchi, F., et al | Internal and Emergency Medicine | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5691100/ |
| Agrawal, Y., et al | Journal of Vestibular Research | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9249286/ |
| Bosmans, J., et al | Ear and Hearing | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/33974775/ |
| Harun, A., et al | The Patient | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4925240/ |
| Dieteren, C. M., Samson, L. D., Schipper, M., et al | Preventive Medicine | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32653354/ |
| Glynn, N. W., & Qiao, Y | Fatigue: Biomedicine, Health & Behavior | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10707490/ |
| Eldadah, B. A | PM&R | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20656622/ |
| Lin, F. V | The American Journal of Geriatric Psychiatry | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10653728/ |
| Bu, Z., et al | Brain and Behavior | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7821586/ |
| Erdinest, N., et al | Vision | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8544709/ |
| Saftari, L. N., & Kwon, O. S | Journal of Physiological Anthropology | — | 2018 | https://jphysiolanthropol.biomedcentral.com/articles/10.1186/s40101-018-0170-1 |
| Swenor, B. K., Munoz, B., & West, S. K | Investigative Ophthalmology & Visual Science | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3835273/ |
| Christ, S. L., et al | JAMA Ophthalmology | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7894742/ |
| GBD 2019 Blindness and Vision Impairment Collaborators | The Lancet Global Health | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7820390/ |
| Marson, D. C | Archives of Clinical Neuropsychology | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5007080/ |
| Niccolai, L. M., Triebel, K. L., Gerstenecker, A., et al | Clinical Gerontologist | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5412082/ |
| Gamble, K. J., Boyle, P. A., Yu, L., & Bennett, D. A | Management Science | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4662381/ |
| Sudo, F. K., & Laks, J | Aging & Mental Health | — | 2017 | https://doi.org/10.1080/13607863.2016.1226761 |
| Wild, K., Marcoe, J., Mattek, N., et al | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8911546/ |
| Widera, E., Steenpass, V., Marson, D., & Sudore, R | He didn't want me to take over. | JAMA | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3799787/ |
| Verleden, S. E., Kirby, M., Everaerts, S., et al | The Lancet Respiratory Medicine | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/33031747/ |
| Schneider, J. L., Rowe, J. H., Garcia-de-Alba, C., et al | Cell | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8052295/ |
| Bailey, K. L | Advances in Geriatric Medicine and Research | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9435381/ |
| Bertels, X., Ross, J. C., Faner, R., et al | ERJ Open Research | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10851953/ |
| GBD 2021 Low Back Pain Collaborators | The Lancet Rheumatology | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37273833/ |
| Haagsma, J. A., Polinder, S., Cassini, A., Colzani, E., & Havelaar, A. H | Population Health Metrics | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4445691/ |
| Imai, K., & Soneji, S | Journal of the American Statistical Association | — | 2007 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4533834/ |
| Valentijn, F. A., Falke, L. L., Nguyen, T. Q., & Goldschmeding, R | Journal of Cell Communication and Signaling | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5842195/ |
| Rex, N., Melk, A., & Schmitt, R | Clinical Science | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10739085/ |
| Healthy aging and chronic kidney disease | Kidney Research and Clinical Practice | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9731776/ |
| Ageing meets kidney disease | Clinical Kidney Journal | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9976735/ |
| Buchanan, S., Combet, E., Stenvinkel, P., & Shiels, P. G | Frontiers in Endocrinology | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7481361/ |
| Zhang, F., Wang, H., Bai, Y., et al | BMC Nephrology | — | 2023 | https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-023-03303-1 |
| Shankland, S. J., Rule, A. D., Kutz, J. N., Pippin, J. W., & Wessely, O | Kidney360 | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10758523/ |
| Singh-Manoux, A., Martikainen, P., Ferrie, J., et al | Journal of Epidemiology & Community Health | — | 2006 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2566175/ |
| Salomon, J. A., Tandon, A., & Murray, C. J. L | BMJ | — | 2004 | https://pmc.ncbi.nlm.nih.gov/articles/PMC324453/ |
| Idler, E. L., & Benyamini, Y | Journal of Health and Social Behavior | — | 1997 | https://pubmed.ncbi.nlm.nih.gov/9097506/ |
| Puthoff, M. L | Cardiopulmonary Physical Therapy Journal | — | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2845214/ |
| Kameniar, K., Mackintosh, S., Van Kessel, G., & Kumar, S | Journal of Geriatric Physical Therapy | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/35442231/ |
| Hallowell, E. S., Sullivan, K. L., Davis, J. D., et al | Neuropsychology | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35587411/ |
| Patel, T., McDougall, A., Ivo, J., et al | Pharmacy | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8167785/ |
| Beckman, A., Bernsten, C., Parker, M. G., Thorslund, M., & Fastbom, J | Pharmacy World & Science | — | 2005 | https://pubmed.ncbi.nlm.nih.gov/16341746/ |
| Elliott, R. A., Goeman, D., Beanland, C., & Koch, S | Current Clinical Pharmacology | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5396255/ |
| Campbell, N. L., Boustani, M. A., Skopelja, E. N., Gao, S., Unverzagt, F. W., & Murray, M. D | American Journal of Geriatric Pharmacotherapy | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22657941/ |
| Chun, S., Shin, D. W., Han, K., et al | European Journal of Preventive Cardiology | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/33838038/ |
| Ortega-Bastidas, P., Gómez, B., Aqueveque, P., Luarte-Martínez, S., & Cano-de-la-Cuerda, R | Sensors | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37050485/ |
| Promislow, D., Anderson, R. M., Scheffer, M., et al | iScience | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9044173/ |
| Lei, H., Huffman, D. M., Salmon, A. B., et al | Aging Pathobiology and Therapeutics | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9038086/ |
| Muhle, P., et al | Der Nervenarzt | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25833400/ |
| Baijens, L. W. J., et al | Clinical Interventions in Aging | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5063605/ |
| Namasivayam-MacDonald, A. M., and Riquelme, L. F | Seminars in Speech and Language | — | 2019 | https://doi.org/10.1055/s-0039-1688837 |
| Abu-Ghanem, S., et al | Dysphagia | — | 2022 | https://doi.org/10.1007/s00455-021-10371-8 |
| van der Maarel-Wierink, C. D., et al | Journal of Dental Research | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21940518/ |
| Cock, C., and Omari, T | Current Gastroenterology Reports | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6371098/ |
| Mann, W. C., et al | Archives of Family Medicine | — | 1999 | https://pubmed.ncbi.nlm.nih.gov/10333815/ |
| Hoenig, H., et al | American Journal of Public Health | — | 2003 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1447739/ |
| Larsen, S. M., et al | Disability and Rehabilitation: Assistive Technology | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/29683014/ |
| Fotteler, M. L., et al | JMIR Aging | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9016506/ |
| Jones, C. J., Rikli, R. E., & Beam, W. C | Research Quarterly for Exercise and Sport | — | 1999 | https://pubmed.ncbi.nlm.nih.gov/10380242/ |
| Sadeh, S., et al | Clinical Biomechanics | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37639862/ |
| Cooper, R., Strand, B. H., Hardy, R., Patel, K. V., & Kuh, D | BMJ | — | 2014 | https://www.bmj.com/content/348/bmj.g2219 |
| Muñoz-Bermejo, L., et al | Biology | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8228261/ |
| Rockwood, K., Song, X., MacKnight, C., et al | CMAJ | — | 2005 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1188185/ |
| Pugh, R. J., Ellison, A., Pye, K., et al | Anaesthesia | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30793278/ |
| Surkan, M., Rajabali, N., Bagshaw, S. M., et al | Canadian Geriatrics Journal | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7458598/ |
| Rueegg, M., Nissen, S. K., Brabrand, M., et al | Academic Emergency Medicine | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9320818/ |
| Ryff, C. D | Psychotherapy and Psychosomatics | — | 2014 | https://doi.org/10.1159/000353263 |
| Steptoe, A., de Oliveira, C., Demakakos, P., & Zaninotto, P | CMAJ | — | 2014 | https://doi.org/10.1503/cmaj.131155 |
| Keyes, C. L. M | Journal of Consulting and Clinical Psychology | — | 2005 | https://doi.org/10.1037/0022-006X.73.3.539 |
| Debès, C., et al | Nature | — | 2023 | https://www.nature.com/articles/s41586-023-05922-y |
| Stein, K. C., et al | Nature | — | 2022 | https://www.nature.com/articles/s41586-021-04295-4 |
| Nunomura, A., et al | Journal of Neuropathology & Experimental Neurology | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3288284/ |
| Picca, A. et al. “Mitophagy in human health, ageing and disease.” Nature Metabolism | Nature Metabolism | — | 2023 | https://www.nature.com/articles/s42255-023-00930-8 |
| Aman, Y. et al. “Autophagy in healthy aging and disease.” Nature Aging | Nature Aging | — | 2021 | https://www.nature.com/articles/s43587-021-00098-4 |
| Cappola, A. R. et al. "Hormones and Aging: An Endocrine Society Scientific Statement." The Journal of Clinical Endocrinology & Metabolism | Hormones and Aging: An Endocrine Society Scientific Statement. | The Journal of Clinical Endocrinology & Metabolism | 2023 | https://pubmed.ncbi.nlm.nih.gov/37326526/ |
| van den Beld, A. W. et al. "The physiology of endocrine systems with ageing." The Lancet Diabetes & Endocrinology | The physiology of endocrine systems with ageing. | The Lancet Diabetes & Endocrinology | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6089223/ |
| Stuenkel, C. A. et al. "Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline." The Journal of Clinical Endocrinology & Metabolism | Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. | The Journal of Clinical Endocrinology & Metabolism | 2015 | https://pubmed.ncbi.nlm.nih.gov/26444994/ |
| Matsumoto, A. M., & Bremner, W. J. "Age-Related Changes in the Male Reproductive System." Endotext | Age-Related Changes in the Male Reproductive System. | Endotext | 2021 | https://www.ncbi.nlm.nih.gov/books/NBK278998/ |
| Cowen, L. E., Hodak, S. P., & Verbalis, J. G. "Age-Associated Abnormalities of Water Homeostasis." Endocrinology and Metabolism Clinics of North America | Age-Associated Abnormalities of Water Homeostasis. | Endocrinology and Metabolism Clinics of North America | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3682932/ |
| Demanelis, K. et al. “Determinants of telomere length across human tissues.” Science | Science | — | 2020 | https://www.science.org/doi/10.1126/science.aaz6876 |
| Yang, J.-H. et al. "Loss of epigenetic information as a cause of mammalian aging." Cell | Loss of epigenetic information as a cause of mammalian aging. | Cell | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10166133/ |
| Enge, M. et al. "Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns." Cell | Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns. | Cell | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6047899/ |
| Kimmel, J. C. et al. "Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging." Genome Research | Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging. | Genome Research | 2019 | https://genome.cshlp.org/content/29/12/2088 |
| Li, J. et al. "A single-cell transcriptomic atlas of primate pancreatic islet aging." National Science Review | A single-cell transcriptomic atlas of primate pancreatic islet aging. | National Science Review | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8288398/ |
| Oberdoerffer, P. et al. "SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging." Cell | SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. | Cell | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2853975/ |
| Kumari, R., Jat, P. "Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype." Frontiers in Cell and Developmental Biology | Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype. | Frontiers in Cell and Developmental Biology | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8039141/ |
| Cohn, R. L. et al. "The heterogeneity of cellular senescence: insights at the single-cell level." Trends in Cell Biology | The heterogeneity of cellular senescence: insights at the single-cell level. | Trends in Cell Biology | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9812642/ |
| Idda, M. L. et al. "Survey of senescent cell markers with age in human tissues." Aging | Survey of senescent cell markers with age in human tissues. | Aging | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7093180/ |
| Norden, D. M., & Godbout, J. P | Neuropathology and Applied Neurobiology | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3553257/ |
| Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I | Cell | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29775591/ |
| Ximerakis, M., et al | Nature Neuroscience | — | 2019 | https://www.nature.com/articles/s41593-019-0491-3 |
| Heneka, M. T., Golenbock, D. T., & Latz, E | Nature Immunology | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25689443/ |
| Gorbunova, V. et al. "The role of retrotransposable elements in ageing and age-associated diseases." Nature | The role of retrotransposable elements in ageing and age-associated diseases. | Nature | 2021 | https://www.nature.com/articles/s41586-021-03542-y |
| De Cecco, M. et al. "Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues." Aging | Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. | Aging | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3883704/ |
| Simon, M. et al. "LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation." Cell Metabolism | LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation. | Cell Metabolism | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6449196/ |
| Schneider, B. K. et al. "Expression of retrotransposons contributes to aging in Drosophila." Genetics | Expression of retrotransposons contributes to aging in Drosophila. | Genetics | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10213499/ |
| Pabis, K. et al. "A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence." eLife | A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence. | eLife | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10990488/ |
| Tsai, Y.-T. et al. "Expression of most retrotransposons in human blood correlates with biological aging." eLife | Expression of most retrotransposons in human blood correlates with biological aging. | eLife | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11486490/ |
| Cohen, S., Janicki-Deverts, D., & Miller, G. E. "Psychological stress and disease." JAMA | Psychological stress and disease. | JAMA | 2007 | https://pubmed.ncbi.nlm.nih.gov/17925521/ |
| Picard, M., & McEwen, B. S. "Psychological stress and mitochondria: A systematic review." Psychosomatic Medicine | Psychological stress and mitochondria: A systematic review. | Psychosomatic Medicine | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5901654/ |
| Bobba-Alves, N., Juster, R. P., & Picard, M. "The energetic cost of allostasis and allostatic load." Psychoneuroendocrinology | The energetic cost of allostasis and allostatic load. | Psychoneuroendocrinology | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10082134/ |
| Lim, S., Nzegwu, D., & Wright, M. L. "The Impact of Psychosocial Stress from Life Trauma and Racial Discrimination on Epigenetic Aging-A Systematic Review." Biological Research for Nursing | The Impact of Psychosocial Stress from Life Trauma and Racial Discrimination on Epigenetic Aging-A Systematic Review. | Biological Research for Nursing | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9096197/ |
| Shevelyov, Y. Y., & Ulianov, S. V | Cells | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6406483/ |
| Freund, A., et al | Molecular Biology of the Cell | — | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3364172/ |
| Dou, Z., et al | Nature | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4824414/ |
| Eriksson, M., et al | Nature | — | 2003 | https://pubmed.ncbi.nlm.nih.gov/12714972/ |
| Scaffidi, P., & Misteli, T | Science | — | 2006 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1855250/ |
| Kristiani, L., et al | Cells | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7140666/ |
| Klionsky, D. J. et al. “Guidelines for the use and interpretation of assays for monitoring autophagy.” Autophagy | Autophagy | — | 2021 | https://doi.org/10.1080/15548627.2020.1797280 |
| Wahl, M. C., Will, C. L., & Luhrmann, R. "The spliceosome: design principles of a dynamic RNP machine." Cell | The spliceosome: design principles of a dynamic RNP machine. | Cell | 2009 | https://pubmed.ncbi.nlm.nih.gov/19239890/ |
| Heintz, C. et al. "Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans." Nature | Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. | Nature | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5361225/ |
| Bhadra, M. et al. "Alternative splicing in aging and longevity." Human Genetics | Alternative splicing in aging and longevity. | Human Genetics | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8176884/ |
| Ghosh, T. S., Shanahan, F., & O'Toole, P. W | Nature Reviews Gastroenterology & Hepatology | — | 2022 | https://www.nature.com/articles/s41575-022-00605-x |
| O'Toole, P. W., & Jeffery, I. B | Science | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26785481/ |
| Galkin, F., et al | Genes & Immunity | — | 2021 | https://www.nature.com/articles/s41435-021-00126-8 |
| Thevaranjan, N., et al | Cell Host & Microbe | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28407483/ |
| Sato, Y., et al | Nature | — | 2021 | https://www.nature.com/articles/s41586-021-03832-5 |
| Claesson, M. J., et al | Nature | — | 2012 | https://www.nature.com/articles/nature11319 |
| Jeffery, I. B., et al | The ISME Journal | — | 2016 | https://www.nature.com/articles/ismej201588 |
| Kumar, R., et al | The peroxisome: an update on mysteries 3.0. | Histochemistry and Cell Biology | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10822820/ |
| Titorenko, V. I., and Terlecky, S. R | Peroxisome metabolism and cellular aging. | Traffic | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3077116/ |
| Narayan, V., et al | Deep proteome analysis identifies age-related processes in C. elegans . | C. elegans | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5003814/ |
| Uzor, N. E., et al | Aging lowers PEX5 levels in cortical neurons in male and female mouse brains. | Molecular and Cellular Neuroscience | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7484460/ |
| Pascual-Ahuir, A., et al | Pro- and antioxidant functions of the peroxisome-mitochondria connection and its impact on aging and disease. | Oxidative Medicine and Cellular Longevity | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5546064/ |
| Périchon, R., et al | The role of peroxisomes in aging. | Cellular and Molecular Life Sciences | 1998 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11147293/ |
| Steensma, D. P., et al | Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. | Blood | 2015 | https://pubmed.ncbi.nlm.nih.gov/25931582/ |
| Fabre, M. A., et al | The longitudinal dynamics and natural history of clonal haematopoiesis. | Nature | 2022 | https://www.nature.com/articles/s41586-022-04785-z |
| Mitchell, E., et al | Clonal dynamics of haematopoiesis across the human lifespan. | Nature | 2022 | https://www.nature.com/articles/s41586-022-04786-y |
| Fuster, J. J., et al | Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. | Science | 2017 | https://pubmed.ncbi.nlm.nih.gov/28104796/ |
| Bick, A. G., et al | Inherited causes of clonal haematopoiesis in 97,691 whole genomes. | Nature | 2020 | https://www.nature.com/articles/s41586-020-2819-2 |
| Bolton, K. L., et al | Cancer therapy shapes the fitness landscape of clonal hematopoiesis. | Nature Genetics | 2020 | https://www.nature.com/articles/s41588-020-00710-0 |
| Sato, S., et al | Cell | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7792549/ |
| Solanas, G., et al | Cell | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28802040/ |
| Martincorena, I. et al. "Somatic mutant clones colonize the human esophagus with age." Science | Somatic mutant clones colonize the human esophagus with age. | Science | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6298579/ |
| Colom, B. et al. "Mutant clones in normal epithelium outcompete and eliminate emerging tumours." Nature | Mutant clones in normal epithelium outcompete and eliminate emerging tumours. | Nature | 2021 | https://www.nature.com/articles/s41586-021-03965-7 |
| Menthena, A. et al. "Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats." Gastroenterology | Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats. | Gastroenterology | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3087123/ |
| Steffen, K. K. et al. "Yeast life span extension by depletion of 60S ribosomal subunits is mediated by Gcn4." Cell | Yeast life span extension by depletion of 60S ribosomal subunits is mediated by Gcn4. | Cell | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2749658/ |
| Janssens, G. E. et al. "Protein biogenesis machinery is a driver of replicative aging in yeast." eLife | Protein biogenesis machinery is a driver of replicative aging in yeast. | eLife | 2015 | https://elifesciences.org/articles/08527 |
| Turi, Z., Lacey, M., Mistrik, M., & Moudry, P. "Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging." Aging | Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging. | Aging | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6520011/ |
| Jones, D. P., and Sies, H | Antioxidants & Redox Signaling | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4580308/ |
| Zhang, H., Davies, K. J. A., and Forman, H. J | Free Radical Biology and Medicine | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4628850/ |
| Rebrin, I., and Sohal, R. S | Advanced Drug Delivery Reviews | — | 2008 | https://pubmed.ncbi.nlm.nih.gov/18652861/ |
| Sies, H., Berndt, C., and Jones, D. P | Annual Review of Biochemistry | — | 2017 | https://www.annualreviews.org/content/journals/10.1146/annurev-biochem-061516-045037 |
| Forman, H. J., and Zhang, H | Nature Reviews Drug Discovery | — | 2021 | https://www.nature.com/articles/s41573-021-00233-1 |
| Hagg, S., & Jylhava, J. "Sex differences in biological aging with a focus on human studies." eLife | Sex differences in biological aging with a focus on human studies. | eLife | 2021 | https://elifesciences.org/articles/63425 |
| Junker, A. et al. "Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis." The FASEB Journal | Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis. | The FASEB Journal | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9885138/ |
| Fritz Garcia, J. H. G., Keller Valsecchi, C. I., & Basilicata, M. F. "Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks." Open Biology | Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks. | Open Biology | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11521605/ |
| Clayton, J. A., & Collins, F. S. "Policy: NIH to balance sex in cell and animal studies." Nature | Policy: NIH to balance sex in cell and animal studies. | Nature | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5101948/ |
| Moorad, J., Promislow, D., & Silvertown, J. "Evolutionary ecology of senescence and a reassessment of Williams' 'extrinsic mortality' hypothesis." Trends in Ecology & Evolution | Evolutionary ecology of senescence and a reassessment of Williams' 'extrinsic mortality' hypothesis. | Trends in Ecology & Evolution | 2019 | https://pubmed.ncbi.nlm.nih.gov/30857756/ |
| Gluckman, P. D., et al | A conceptual framework for the developmental origins of health and disease. | Journal of Developmental Origins of Health and Disease | 2010 | https://pubmed.ncbi.nlm.nih.gov/25142928/ |
| Boots, A., et al | Longitudinal changes in late-life brain health after prenatal exposure to the Dutch famine. | NeuroImage | 2025 | https://pubmed.ncbi.nlm.nih.gov/41046062/ |
| Low Birth Weight and Nephron Number Working Group | The impact of kidney development on the life course: A consensus document for action. | Nephron | 2017 | https://pubmed.ncbi.nlm.nih.gov/28319949/ |
| de Rooij, S. R., et al | Prenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study. | The American Journal of Clinical Nutrition | 2015 | https://pubmed.ncbi.nlm.nih.gov/26178721/ |
| Langley-Evans, S. C., & Sculley, D. V | The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life. | FEBS Letters | 2006 | https://pubmed.ncbi.nlm.nih.gov/16828754/ |
| Raffington, L., et al | Socioeconomic disadvantage and the pace of biological aging in children. | Pediatrics | 2021 | https://pubmed.ncbi.nlm.nih.gov/34001641/ |
| Bahar, R., et al | Nature | — | 2006 | https://www.nature.com/articles/nature04844 |
| Martinez-Jimenez, C. P., et al | Science | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5405862/ |
| Ibañez-Solé, O., et al | eLife | — | 2022 | https://elifesciences.org/articles/80380 |
| Gyenis, A., et al | Nature Genetics | — | 2023 | https://www.nature.com/articles/s41588-022-01279-6 |
| Dixon, S. J., et al | Ferroptosis: an iron-dependent form of nonapoptotic cell death. | Cell | 2012 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3367386/ |
| Bersuker, K., et al | The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. | Nature | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6883167/ |
| Feng, Y., et al | Iron retardation in lysosomes protects senescent cells from ferroptosis. | Aging | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11131988/ |
| Hambright, W. S., et al | Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. | Redox Biology | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5312549/ |
| Schumacher, B. et al. “The central role of DNA damage in the ageing process.” Nature | Nature | — | 2021 | https://www.nature.com/articles/s41586-021-03307-7 |
| Vijg, J. & Dong, X. “Pathogenic mechanisms of somatic mutation and genome mosaicism in aging.” Cell | Cell | — | 2020 | https://doi.org/10.1016/j.cell.2020.06.024 |
| Moore, L. et al. “The mutational landscape of human somatic and germline cells.” Nature | Nature | — | 2021 | https://www.nature.com/articles/s41586-021-03822-7 |
| Masfiah, S., Kurnialandi, A., Meij, J. J., & Maier, A. B | Definitions of healthspan: A systematic review | — | 2025 | https://doi.org/10.1016/j.arr.2025.102806 |
| Hansen, M., & Kennedy, B. K | Does Longer Lifespan Mean Longer Healthspan? | — | 2016 | https://doi.org/10.1016/j.tcb.2016.05.002 |
| Campisi, J., Kapahi, P., Lithgow, G. J., et al | From discoveries in ageing research to therapeutics for healthy ageing | — | 2019 | https://doi.org/10.1038/s41586-019-1365-2 |
| Bansal, A., & Zhu, L. J | Alive and well? Exploring disease by studying lifespan | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4253307/ |
| Cox, D. R | Regression Models and Life-Tables | Journal of the Royal Statistical Society: Series B | 1972 | https://doi.org/10.1111/j.2517-6161.1972.tb00899.x |
| Zwiener, I., et al | Survival Analysis: Part 15 of a Series on Evaluation of Scientific Publications | Deutsches Ärzteblatt International | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3071962/ |
| Spruance, S. L., et al | Hazard Ratio in Clinical Trials | Antimicrobial Agents and Chemotherapy | 2004 | https://pmc.ncbi.nlm.nih.gov/articles/PMC478551/ |
| Stensrud, M. J., & Hernán, M. A | Why Test for Proportional Hazards? | JAMA | 2020 | https://doi.org/10.1001/jama.2020.1267 |
| Uno, H., et al | Moving Beyond the Hazard Ratio in Quantifying the Between-Group Difference in Survival Analysis | Journal of Clinical Oncology | 2014 | https://doi.org/10.1200/JCO.2014.55.2208 |
| Han, S. K., et al | OASIS 2: Online Application for Survival Analysis 2 with Features for the Analysis of Maximal Lifespan and Healthspan in Aging Research | Oncotarget | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5302902/ |
| Frieden, T. R | The New England Journal of Medicine | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28636846/ |
| Lyall, D. M., et al | Brain Communications | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9150072/ |
| Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G | BMJ | — | 2003 | https://www.bmj.com/content/327/7414/557 |
| Bland, J. M., & Altman, D. G | BMJ | — | 1994 | https://www.bmj.com/content/309/6957/780 |
| Vickers, A. J., & Altman, D. G | BMJ | — | 2001 | https://www.bmj.com/content/323/7321/1123 |
| Croswell, J. M., et al | Principles of cancer screening: lessons from history and study design issues | Seminars in Oncology | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2921618/ |
| Pinsky, P. F | Principles of Cancer Screening | Surgical Clinics of North America | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4555845/ |
| Carter, J. L., et al | Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods | BMJ | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4332263/ |
| Marcus, P. M | Assessment of Cancer Screening: A Primer | National Cancer Institute | 2019 | https://www.ncbi.nlm.nih.gov/books/NBK550219/ |
| Lévesque, L. E., et al | Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes | BMJ | 2010 | https://www.bmj.com/content/340/bmj.b5087 |
| Shintani, A. K., et al | Immortal time bias in critical care research: application of time-varying Cox regression for observational cohort studies | Critical Care Medicine | 2009 | https://pubmed.ncbi.nlm.nih.gov/19770737/ |
| Giobbie-Hurder, A., et al | Challenges of guarantee-time bias | Journal of Clinical Oncology | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3732313/ |
| Scheel, A. M., et al | Advances in Methods and Practices in Psychological Science | — | 2021 | https://journals.sagepub.com/doi/10.1177/25152459211007467 |
| Claesen, A., et al | Royal Society Open Science | — | 2021 | https://royalsocietypublishing.org/doi/10.1098/rsos.211037 |
| Moher, D., Hopewell, S., Schulz, K. F., et al | BMJ | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2844943/ |
| White, I. R., Horton, N. J., Carpenter, J., and Pocock, S. J | BMJ | — | 2011 | https://www.bmj.com/content/342/bmj.d40 |
| Kang, M., Kendall, M. A., Ribaudo, H., et al | Clinical Trials | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9232859/ |
| Kraus, W. E., Bhapkar, M., Huffman, K. M., et al | The Lancet Diabetes & Endocrinology | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31303390/ |
| Piaggio, G., Elbourne, D. R., Pocock, S. J., Evans, S. J. W., and Altman, D. G | JAMA | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/23268518/ |
| VanderWeele, T. J | Annual Review of Public Health | — | 2016 | https://www.annualreviews.org/content/journals/10.1146/annurev-publhealth-032315-021402 |
| Imai, K., Keele, L., & Tingley, D | Psychological Methods | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20954780/ |
| Harries, L. W., et al | Age | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4600657/ |
| Jiang, R., et al | Clinical Epigenetics | — | 2022 | https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-022-01380-x |
| Hopewell, S., Chan, A.-W., Collins, G. S., et al | BMJ | — | 2025 | https://www.bmj.com/content/389/bmj-2024-081124 |
| Hróbjartsson, A., and Gøtzsche, P. C | Cochrane Database of Systematic Reviews | — | 2010 | https://doi.org/10.1002/14651858.CD003974.pub3 |
| Wood, L., Egger, M., Gluud, L. L., et al | BMJ | — | 2008 | https://www.bmj.com/content/336/7644/601 |
| Hróbjartsson, A., Thomsen, A. S. S., Emanuelsson, F., et al | BMJ | — | 2012 | https://www.bmj.com/content/344/bmj.e1119 |
| Moustgaard, H., Clayton, G. L., Jones, H. E., et al | BMJ | — | 2020 | https://www.bmj.com/content/368/bmj.l6802 |
| Holm, S | Scandinavian Journal of Statistics | — | 1979 | https://www.jstor.org/stable/4615733 |
| Benjamini, Y., & Hochberg, Y | Journal of the Royal Statistical Society: Series B | — | 1995 | https://doi.org/10.1111/j.2517-6161.1995.tb02031.x |
| Simmons, J. P., Nelson, L. D., & Simonsohn, U | Psychological Science | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/22006061/ |
| Sun, X., Briel, M., Walter, S. D., & Guyatt, G. H | BMJ | — | 2010 | https://www.bmj.com/content/340/bmj.c117.long |
| Sun, X., et al | BMJ | — | 2012 | https://www.bmj.com/content/344/bmj.e1553 |
| Kent, D. M., Rothwell, P. M., Ioannidis, J. P. A., Altman, D. G., & Hayward, R. A | Trials | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2928211/ |
| Schandelmaier, S., et al | BMJ | — | 2014 | https://www.bmj.com/content/349/bmj.g4539 |
| Sterne, J. A. C., et al | BMJ | — | 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2714692/ |
| Wolbers, M., et al | Competing risks analyses: objectives and approaches | European Heart Journal | 2014 | https://academic.oup.com/eurheartj/article/35/42/2936/784255 |
| Kim, H. T | Cumulative Incidence in Competing Risks Data and Competing Risks Regression Analysis | Clinical Cancer Research | 2007 | https://aacrjournals.org/clincancerres/article/13/2/559/178178/Cumulative-Incidence-in-Competing-Risks-Data-and |
| Chan, A. W., et al | BMJ | — | 2025 | https://www.bmj.com/content/389/bmj-2024-081660 |
| Chan, A. W., Hrobjartsson, A., Haahr, M. T., Gotzsche, P. C., and Altman, D. G | JAMA | — | 2004 | https://jamanetwork.com/journals/jama/fullarticle/198809 |
| Goldacre, B., et al | Trials | — | 2019 | https://link.springer.com/article/10.1186/s13063-019-3173-2 |
| Kirkham, J. J., et al | BMJ | — | 2018 | https://www.bmj.com/content/362/bmj.k3802 |
| Rubin, D. B | Biometrika | — | 1976 | https://doi.org/10.1093/biomet/63.3.581 |
| Sterne, J. A. C., White, I. R., Carlin, J. B., et al | BMJ | — | 2009 | https://www.bmj.com/content/338/bmj.b2393 |
| Wen, L., Muniz Terrera, G., and Seaman, S. R | Biostatistics | — | 2018 | https://doi.org/10.1093/biostatistics/kxx045 |
| Kurland, B. F., Johnson, L. L., Egleston, B. L., and Diehr, P. H | Statistical Science | — | 2009 | https://doi.org/10.1214/09-STS293 |
| Biomarkers Definitions Working Group | Biomarkers and surrogate endpoints: preferred definitions and conceptual framework | Clinical Pharmacology & Therapeutics | 2001 | https://pubmed.ncbi.nlm.nih.gov/11240971/ |
| Manyara, A. M., et al | Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration | BMJ | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11231881/ |
| Ciani, O., et al | Comparison of treatment effect sizes associated with surrogate and final patient relevant outcomes in randomised controlled trials: meta-epidemiological study | BMJ | 2013 | https://pubmed.ncbi.nlm.nih.gov/23360719/ |
| Buyse, M., & Molenberghs, G | Criteria for the validation of surrogate endpoints in randomized experiments | Biometrics | 1998 | https://pubmed.ncbi.nlm.nih.gov/9840970/ |
| Hoffmann, T. C., Glasziou, P. P., Boutron, I., et al | BMJ | — | 2014 | https://www.bmj.com/content/348/bmj.g1687 |
| Borrelli, B | Journal of Public Health Dentistry | — | 2011 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3194367/ |
| Matai, I. et al | Biomaterials | — | 2020 | https://doi.org/10.1016/j.biomaterials.2019.119536 |
| Grigoryan, B. et al | Science | — | 2019 | https://doi.org/10.1126/science.aav9750 |
| Noor, N. et al | Advanced Science | — | 2019 | https://doi.org/10.1002/advs.201900344 |
| Lee, A. et al | Science | — | 2019 | https://doi.org/10.1126/science.aav9051 |
| Mandrycky, C. et al | Biotechnology Advances | — | 2016 | https://doi.org/10.1016/j.biotechadv.2015.12.011 |
| US Food and Drug Administration. "Important Information About Young Donor Plasma Infusions for Profit" | Important Information About Young Donor Plasma Infusions for Profit | — | 2019 | https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/important-information-about-young-donor-plasma-infusions-profit |
| Amor, C. et al. "Senolytic CAR T cells reverse senescence-associated pathologies." Nature | Senolytic CAR T cells reverse senescence-associated pathologies. | Nature | 2020 | https://doi.org/10.1038/s41586-020-2403-9 |
| Zhou, Q. et al. "In vivo reprogramming of adult pancreatic exocrine cells to beta-cells." Nature | In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. | Nature | 2008 | https://doi.org/10.1038/nature07314 |
| Qian, L. et al. "In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes." Nature | In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. | Nature | 2012 | https://doi.org/10.1038/nature11044 |
| Rurik, J. G. et al. "CAR T cells produced in vivo to treat cardiac injury." Science | CAR T cells produced in vivo to treat cardiac injury. | Science | 2022 | https://doi.org/10.1126/science.abm0594 |
| Savage, S. A., & Bertuch, A. A | Genetics in Medicine | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3825100/ |
| Jaskelioff, M., et al | Nature | — | 2011 | https://doi.org/10.1038/nature09603 |
| Stern, J. L., et al | Oncogenesis | — | 2015 | https://doi.org/10.1038/oncsis.2015.39 |
| Jäger, K., & Walter, M | Genes | — | 2016 | https://doi.org/10.3390/genes7070039 |
| Telomeres Mendelian Randomization Collaboration, et al | JAMA Oncology | — | 2017 | https://doi.org/10.1001/jamaoncol.2016.5945 |
| Tomás-Loba, A., et al | Cell | — | 2008 | https://doi.org/10.1016/j.cell.2008.09.034 |
| Kitada, T. et al. "Programming gene and engineered-cell therapies with synthetic biology." Science | Programming gene and engineered-cell therapies with synthetic biology. | Science | 2018 | https://doi.org/10.1126/science.aad1067 |
| Xie, Z. et al. "Multi-input RNAi-based logic circuit for identification of specific cancer cells." Science | Multi-input RNAi-based logic circuit for identification of specific cancer cells. | Science | 2011 | https://doi.org/10.1126/science.1205527 |
| Gonzalez-Gualda, E. et al. "A guide to assessing cellular senescence in vitro and in vivo." FEBS Journal | A guide to assessing cellular senescence in vitro and in vivo. | FEBS Journal | 2021 | https://doi.org/10.1111/febs.15570 |
| Mizushima, N. and Komatsu, M | Cell | — | 2011 | https://doi.org/10.1016/j.cell.2011.10.026 |
| Amaravadi, R. K. et al | Clinical Cancer Research | — | 2019 | https://doi.org/10.1158/1078-0432.CCR-18-1227 |
| Settembre, C. et al | Science | — | 2011 | https://doi.org/10.1126/science.1204592 |
| Kim, K. et al. "Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells." Aging | Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells. | Aging | 2022 | https://doi.org/10.18632/aging.203931 |
| Draghici, C. et al. "Concise total synthesis of glucosepane." Science | Concise total synthesis of glucosepane. | Science | 2015 | https://doi.org/10.1126/science.aac9655 |
| Birch, H. L. "Extracellular Matrix and Ageing." Subcellular Biochemistry | Extracellular Matrix and Ageing. | Subcellular Biochemistry | 2018 | https://pubmed.ncbi.nlm.nih.gov/30779010/ |
| Vojta, A. et al. "Repurposing the CRISPR-Cas9 system for targeted DNA methylation." Nucleic Acids Research | Repurposing the CRISPR-Cas9 system for targeted DNA methylation. | Nucleic Acids Research | 2016 | https://doi.org/10.1093/nar/gkw159 |
| Xu, X. et al. "A CRISPR-based approach for targeted DNA demethylation." Cell Discovery | A CRISPR-based approach for targeted DNA demethylation. | Cell Discovery | 2016 | https://doi.org/10.1038/celldisc.2016.9 |
| Nuñez, J. K. et al. "Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing." Cell | Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. | Cell | 2021 | https://doi.org/10.1016/j.cell.2021.03.025 |
| Lin, L. et al. "Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases." GigaScience | Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases. | GigaScience | 2018 | https://doi.org/10.1093/gigascience/giy011 |
| Kulkarni, J. A. et al. "The current landscape of nucleic acid therapeutics." Nature Nanotechnology | The current landscape of nucleic acid therapeutics. | Nature Nanotechnology | 2021 | https://doi.org/10.1038/s41565-021-00898-0 |
| Bi, Y. et al. "Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells." Cell Metabolism | Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells. | Cell Metabolism | 2025 | https://doi.org/10.1016/j.cmet.2024.11.013 |
| Artika, I. M. "Allotopic expression of mitochondrial genes: Basic strategy and progress." Genes & Diseases | Allotopic expression of mitochondrial genes: Basic strategy and progress. | Genes & Diseases | 2020 | https://doi.org/10.1016/j.gendis.2019.08.001 |
| Hou, X. et al. "Lipid nanoparticles for mRNA delivery." Nature Reviews Materials | Lipid nanoparticles for mRNA delivery. | Nature Reviews Materials | 2021 | https://doi.org/10.1038/s41578-021-00358-0 |
| Dammes, N. et al. "Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics." Nature Nanotechnology | Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics. | Nature Nanotechnology | 2021 | https://doi.org/10.1038/s41565-021-00928-x |
| Chaudhari, A. P. et al. "The status of extracellular vesicles as drug carriers and therapeutics." Nature Reviews Bioengineering | The status of extracellular vesicles as drug carriers and therapeutics. | Nature Reviews Bioengineering | 2026 | https://doi.org/10.1038/s44222-026-00405-x |
| Bondeson, D. P. et al | Nature Chemical Biology | — | 2015 | https://doi.org/10.1038/nchembio.1858 |
| Silva, M. C. et al | eLife | — | 2019 | https://doi.org/10.7554/eLife.45457 |
| Banik, S. M. et al | Nature | — | 2020 | https://doi.org/10.1038/s41586-020-2545-9 |
| Kalluri, R. & LeBleu, V. S. "The biology, function, and clinical translation of exosomes." Science | The biology, function, and clinical translation of exosomes. | Science | 2020 | https://doi.org/10.1126/science.aau6977 |
| Komor, A. C. et al. "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage." Nature | Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. | Nature | 2016 | https://doi.org/10.1038/nature17946 |
| Gaudelli, N. M. et al. "Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage." Nature | Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. | Nature | 2017 | https://doi.org/10.1038/nature24644 |
| Anzalone, A. V. et al. "Search-and-replace genome editing without double-strand breaks or donor DNA." Nature | Search-and-replace genome editing without double-strand breaks or donor DNA. | Nature | 2019 | https://doi.org/10.1038/s41586-019-1711-4 |
| Koblan, L. W. et al. "In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice." Nature | In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice. | Nature | 2021 | https://doi.org/10.1038/s41586-020-03086-7 |
| Welsh, J. A. et al | Journal of Extracellular Vesicles | — | 2024 | https://doi.org/10.1002/jev2.12404 |
| de Abreu, R. C. et al | Nature Reviews Cardiology | — | 2020 | https://doi.org/10.1038/s41569-020-0389-5 |
| Liu, B. et al | Nature Biomedical Engineering | — | 2018 | https://doi.org/10.1038/s41551-018-0229-7 |
| Kim, J. et al | Nature Reviews Methods Primers | — | 2022 | https://doi.org/10.1038/s43586-022-00174-y |
| Takebe, T. et al | Nature | — | 2013 | https://doi.org/10.1038/nature12271 |
| Nam, S. A. et al | Experimental & Molecular Medicine | — | 2019 | https://doi.org/10.1038/s12276-019-0336-x |
| Chilibeck, P. D., et al | Open Access Journal of Sports Medicine | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/29138605/ |
| Kreider, R. B., et al | Journal of the International Society of Sports Nutrition | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28615996/ |
| Baker, L. D. et al. "Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial." JAMA | Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial. | JAMA | 2025 | https://pubmed.ncbi.nlm.nih.gov/40720610/ |
| Richard, E. et al. "Healthy ageing through internet counselling in the elderly (HATICE): a multinational, randomised controlled trial." The Lancet Digital Health | Healthy ageing through internet counselling in the elderly (HATICE): a multinational, randomised controlled trial. | The Lancet Digital Health | 2019 | https://pubmed.ncbi.nlm.nih.gov/33323224/ |
| Cummings, S. R., et al | JAMA | — | 1998 | https://pubmed.ncbi.nlm.nih.gov/9875874/ |
| Black, D. M., et al | JAMA | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/17190893/ |
| Wu, C. H., et al | Bone | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29555309/ |
| Faridi, S., Allen, R. W., Brook, R. D., et al | Ecotoxicology and Environmental Safety | — | 2023 | https://doi.org/10.1016/j.ecoenv.2023.115227 |
| Newman, J. D., Bhatt, D. L., Rajagopalan, S., et al | American Heart Journal Plus | — | 2023 | https://doi.org/10.1016/j.ahjo.2022.100182 |
| Dockery, D. W., Rich, D. Q., Goodman, P. G., et al | Research Report (Health Effects Institute) | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/24024358/ |
| Lin, F. R., et al | Archives of Neurology | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21320988/ |
| Yeo, B. S. H., et al | JAMA Neurology | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/36469314/ |
| Peelle, J. E., & Wingfield, A | Trends in Neurosciences | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/26710892/ |
| Sutton, E. F., et al | Cell Metabolism | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29754952/ |
| Chen, Y.-E., Tsai, H.-L., Tu, Y.-K., & Chen, L.-W | BMJ Medicine | — | 2026 | https://pubmed.ncbi.nlm.nih.gov/41586347/ |
| Acosta-Rodríguez, V., et al | Science | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35511946/ |
| Manson, J. E., et al | JAMA | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28898378/ |
| Wassertheil-Smoller, S., et al | JAMA | — | 2003 | https://pubmed.ncbi.nlm.nih.gov/12771114/ |
| Cushman, M., et al | JAMA | — | 2004 | https://pubmed.ncbi.nlm.nih.gov/15467059/ |
| Chlebowski, R. T., et al | JAMA | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32721007/ |
| Cauley, J. A., et al | JAMA | — | 2003 | https://pubmed.ncbi.nlm.nih.gov/14519707/ |
| Shumaker, S. A., et al | JAMA | — | 2003 | https://pubmed.ncbi.nlm.nih.gov/12771112/ |
| Weindruch, R., Walford, R. L., Fligiel, S., & Guthrie, D | The Journal of Nutrition | — | 1986 | https://pubmed.ncbi.nlm.nih.gov/3958810/ |
| Colman, R. J., et al | Science | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19590001/ |
| Mattison, J. A., et al | Nature | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22932268/ |
| Racette, S. B., et al | Oncotarget | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4991370/ |
| Soltani, S., et al | Nutrition Journal | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7178992/ |
| Daniel, G. D., et al | Clinical Nutrition ESPEN | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34857201/ |
| Struijk, E. A., et al | The American Journal of Clinical Nutrition | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7138663/ |
| Maddocks, M., et al | Thorax | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5099190/ |
| Beauchamp, M. K., et al | Chest | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23429931/ |
| Jenkins, A. R., et al | International Journal of Chronic Obstructive Pulmonary Disease | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5768431/ |
| Sherrington, C. et al. "Exercise for preventing falls in older people living in the community: an abridged Cochrane systematic review." British Journal of Sports Medicine | Exercise for preventing falls in older people living in the community: an abridged Cochrane systematic review. | British Journal of Sports Medicine | 2020 | https://pubmed.ncbi.nlm.nih.gov/31792067/ |
| Lesinski, M. et al. "Effects of Balance Training on Balance Performance in Healthy Older Adults: A Systematic Review and Meta-analysis." Sports Medicine | Effects of Balance Training on Balance Performance in Healthy Older Adults: A Systematic Review and Meta-analysis. | Sports Medicine | 2015 | https://pubmed.ncbi.nlm.nih.gov/26325622/ |
| Pšeničnik Sluga, S., Kozinc, Ž. "Sensorimotor and proprioceptive exercise programs to improve balance in older adults: a systematic review with meta-analysis." European Journal of Translational Myology | Sensorimotor and proprioceptive exercise programs to improve balance in older adults: a systematic review with meta-analysis. | European Journal of Translational Myology | 2024 | https://pubmed.ncbi.nlm.nih.gov/38213185/ |
| Clemson, L. et al. "Integration of balance and strength training into daily life activity to reduce rate of falls in older people (the LiFE study): randomised parallel trial." BMJ | Integration of balance and strength training into daily life activity to reduce rate of falls in older people (the LiFE study): randomised parallel trial. | BMJ | 2012 | https://www.bmj.com/content/345/bmj.e4547 |
| Trichopoulou, A., et al | BMJ | — | 2005 | https://pmc.ncbi.nlm.nih.gov/articles/PMC557144/ |
| Urpi-Sarda, M., et al | Biomedicines | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34440065/ |
| Schwingshackl, L., Morze, J., & Hoffmann, G | British Journal of Pharmacology | — | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7056467/ |
| Ciabattini, A. et al. "Vaccination in the elderly: The challenge of immune changes with aging." Seminars in Immunology | Vaccination in the elderly: The challenge of immune changes with aging. | Seminars in Immunology | 2018 | https://pubmed.ncbi.nlm.nih.gov/30501873/ |
| Branche, A. R. et al. "Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults." Influenza and Other Respiratory Viruses | Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults. | Influenza and Other Respiratory Viruses | 2022 | https://pubmed.ncbi.nlm.nih.gov/36069297/ |
| Eyting, M. et al. "A natural experiment on the effect of herpes zoster vaccination on dementia." Nature | A natural experiment on the effect of herpes zoster vaccination on dementia. | Nature | 2025 | https://pubmed.ncbi.nlm.nih.gov/40175543/ |
| Look AHEAD Research Group | Diabetes Care | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9174966/ |
| Foster, H. M. E., et al | BMC Medicine | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37946218/ |
| Cené, C. W., et al | Journal of the American Heart Association | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35924775/ |
| Hakulinen, C., et al | Heart | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29588329/ |
| Berkman, L. F., et al | JAMA | — | 2003 | https://pubmed.ncbi.nlm.nih.gov/12813116/ |
| Nicholls, S. J., et al | JAMA | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/33190147/ |
| Calder, P. C | Biochimie | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/31866423/ |
| Stockwell, T., et al | Journal of Studies on Alcohol and Drugs | — | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4803651/ |
| Millwood, I. Y., et al | The Lancet Public Health | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/38000378/ |
| Rumgay, H., et al | The Lancet Oncology | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34270924/ |
| Topiwala, A., et al | BMJ | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28588063/ |
| Ference, B. A., et al | European Heart Journal | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28444290/ |
| Silverman, M. G., et al | JAMA | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27673306/ |
| Clyne, B. et al. "Effectiveness of a Multifaceted Intervention for Potentially Inappropriate Prescribing in Older Patients in Primary Care: A Cluster-Randomized Controlled Trial (OPTI-SCRIPT Study)." Annals of Family Medicine | Effectiveness of a Multifaceted Intervention for Potentially Inappropriate Prescribing in Older Patients in Primary Care: A Cluster-Randomized Controlled Trial (OPTI-SCRIPT Study). | Annals of Family Medicine | 2015 | https://pubmed.ncbi.nlm.nih.gov/26553894/ |
| Blum, M. R. et al. "Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial." BMJ | Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial. | BMJ | 2021 | https://pubmed.ncbi.nlm.nih.gov/34257088/ |
| Fava, C., et al | Chest | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24077181/ |
| Bratton, D. J., et al | JAMA | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26624827/ |
| Sánchez-de-la-Torre, M., et al | JAMA | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37787793/ |
| Yaffe, K., et al | JAMA | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21828324/ |
| Saunders, T. J. et al. "The Acute Metabolic and Vascular Impact of Interrupting Prolonged Sitting: A Systematic Review and Meta-Analysis." Sports Medicine | The Acute Metabolic and Vascular Impact of Interrupting Prolonged Sitting: A Systematic Review and Meta-Analysis. | Sports Medicine | 2018 | https://pubmed.ncbi.nlm.nih.gov/30078066/ |
| Loh, R. et al. "Effects of Interrupting Prolonged Sitting with Physical Activity Breaks on Blood Glucose, Insulin and Triacylglycerol Measures: A Systematic Review and Meta-analysis." Sports Medicine | Effects of Interrupting Prolonged Sitting with Physical Activity Breaks on Blood Glucose, Insulin and Triacylglycerol Measures: A Systematic Review and Meta-analysis. | Sports Medicine | 2020 | https://pubmed.ncbi.nlm.nih.gov/31552570/ |
| Buffey, A. J. et al. "The Acute Effects of Interrupting Prolonged Sitting Time in Adults with Standing and Light-Intensity Walking on Biomarkers of Cardiometabolic Health in Adults: A Systematic Review and Meta-analysis." Sports Medicine | The Acute Effects of Interrupting Prolonged Sitting Time in Adults with Standing and Light-Intensity Walking on Biomarkers of Cardiometabolic Health in Adults: A Systematic Review and Meta-analysis. | Sports Medicine | 2022 | https://pubmed.ncbi.nlm.nih.gov/35147898/ |
| Climie, R. E. et al. "Acute Effects of Interrupting Prolonged Sitting on Vascular Function in Type 2 Diabetes." American Journal of Physiology-Heart and Circulatory Physiology | Acute Effects of Interrupting Prolonged Sitting on Vascular Function in Type 2 Diabetes. | American Journal of Physiology-Heart and Circulatory Physiology | 2021 | https://pubmed.ncbi.nlm.nih.gov/33164575/ |
| Diaz, K. M. et al. "Optimal Frequency of Interrupting Prolonged Sitting for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Crossover Trials." Scandinavian Journal of Medicine & Science in Sports | Optimal Frequency of Interrupting Prolonged Sitting for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Crossover Trials. | Scandinavian Journal of Medicine & Science in Sports | 2024 | https://pubmed.ncbi.nlm.nih.gov/39630056/ |
| Wheeler, M. J. et al. "Distinct Effects of Acute Exercise and Breaks in Sitting on Working Memory and Executive Function in Older Adults: A Three-Arm, Randomised Cross-Over Trial." British Journal of Sports Medicine | Distinct Effects of Acute Exercise and Breaks in Sitting on Working Memory and Executive Function in Older Adults: A Three-Arm, Randomised Cross-Over Trial. | British Journal of Sports Medicine | 2020 | https://pubmed.ncbi.nlm.nih.gov/31036563/ |
| Kaltenbach, T., et al | JAMA | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38583868/ |
| Wooldrage, K., et al | The Lancet Gastroenterology & Hepatology | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/39038482/ |
| Black, W. C., et al | Journal of the National Cancer Institute | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/11830606/ |
| Hubbell, E., et al | Cancer Medicine | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31422585/ |
| Jacklyn, G., et al | British Journal of Cancer | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27124337/ |
| Miller, A. B., et al | BMJ | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24519768/ |
| Chan, A. K. Y., et al | Journal of Dentistry | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/36058347/ |
| Peng, J., et al | Bioscience Reports | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30530864/ |
| Juthani-Mehta, M., et al | Clinical Infectious Diseases | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25520333/ |
| Sen, S., et al | Stroke | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37548008/ |
| Unutzer, J., et al | JAMA | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/12472325/ |
| Hunkeler, E. M., et al | BMJ | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/16428253/ |
| Alexopoulos, G. S., et al | American Journal of Psychiatry | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19528195/ |
| Gallo, J. J., et al | BMJ | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23738992/ |
| Kim, J.-M., et al | JAMA | — | 2018 | https://jamanetwork.com/journals/jama/fullarticle/2688569 |
| Ball, K., et al | JAMA | — | 2002 | https://doi.org/10.1001/jama.288.18.2271 |
| Simons, D. J., et al | Psychological Science in the Public Interest | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27697851/ |
| Huang, L., et al | BMJ | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32094151/ |
| Cook, N. R., et al | BMJ | — | 2007 | https://pubmed.ncbi.nlm.nih.gov/17449506/ |
| Campbell, N. R. C., et al | The Journal of Clinical Hypertension | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31087778/ |
| Oparil, S., et al | Nature Reviews Disease Primers | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29565029/ |
| Bischoff-Ferrari, H. A., et al | JAMA | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/33170239/ |
| Sanders, K. M., et al | JAMA | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20460620/ |
| Bouillon, R., et al | Endocrine Reviews | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30321335/ |
| Pahor, M. et al. "Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial." JAMA | Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. | JAMA | 2014 | https://pubmed.ncbi.nlm.nih.gov/24866862/ |
| Bernabei, R. et al. "Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project)." BMJ | Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project). | BMJ | 2022 | https://pubmed.ncbi.nlm.nih.gov/35545258/ |
| Cadore, E. L. et al. "Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review." Rejuvenation Research | Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. | Rejuvenation Research | 2013 | https://pubmed.ncbi.nlm.nih.gov/23327448/ |
| Campbell, A. J. et al. "Randomised controlled trial of prevention of falls in people aged 75 or older with severe visual impairment: the VIP trial." BMJ | Randomised controlled trial of prevention of falls in people aged 75 or older with severe visual impairment: the VIP trial. | BMJ | 2005 | https://www.bmj.com/content/331/7520/817 |
| Edwards, J. J., et al | Sports Medicine | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37204620/ |
| Bouaziz, W., et al | International Journal of Clinical Practice | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32083390/ |
| Stensvold, D., et al | BMJ | — | 2020 | https://www.bmj.com/content/371/bmj.m3485 |
| Weston, K. S., Wisløff, U., & Coombes, J. S | British Journal of Sports Medicine | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24144531/ |
| Santos, A., et al | International Journal of Behavioral Nutrition and Physical Activity | — | 2023 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10664287/ |
| Hussain, J., & Cohen, M | Evidence-Based Complementary and Alternative Medicine | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29849692/ |
| Hamaya, R., et al | American Journal of Preventive Cardiology | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/41049507/ |
| Pizzey, F. K., et al | Experimental Physiology | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/33866630/ |
| Ylikahri, R., et al | Annals of Clinical Research | — | 1988 | https://pubmed.ncbi.nlm.nih.gov/3218903/ |
| SPRINT MIND Investigators for the SPRINT Research Group | JAMA | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30688979/ |
| Muntner, P., et al | Hypertension | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30827125/ |
| West, R. R., Jones, D. A., & Henderson, A. H | Heart | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22194152/ |
| Suaya, J. A., et al | Journal of the American College of Cardiology | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19555836/ |
| Dunlay, S. M., et al | American Journal of Medicine | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24556195/ |
| Taylor, R. S., et al | European Journal of Heart Failure | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/30255969/ |
| Wu, G., et al | Global Heart | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/36578919/ |
| Dalal, H. M., et al | BMJ | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20085991/ |
| Doll, R., Peto, R., Boreham, J., & Sutherland, I | BMJ | — | 2004 | https://pubmed.ncbi.nlm.nih.gov/15213107/ |
| Cho, E. R., et al | NEJM Evidence | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/38329816/ |
| Duncan, M. S., et al | JAMA | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31429895/ |
| Fry, J. S., et al | Annals of the American Thoracic Society | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32603182/ |
| Gellert, C., et al | American Journal of Preventive Medicine | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26188685/ |
| Dugué, P.-A., et al | Epigenetics | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/31552803/ |
| Golbidi, S., Edvinsson, L., & Laher, I | Current Vascular Pharmacology | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/30210003/ |
| Huang, G., et al | Preventive Cardiology | — | 2005 | https://pubmed.ncbi.nlm.nih.gov/16230876/ |
| Abrego-Guandique, D. M., et al | Biomolecular Concepts | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/40459444/ |
| Michael, R., & Bron, A. J | Philosophical Transactions of the Royal Society B: Biological Sciences | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21402586/ |
| Mangione, C. M., et al | Archives of Ophthalmology | — | 1994 | https://pubmed.ncbi.nlm.nih.gov/7980131/ |
| Han, X., et al | British Journal of Ophthalmology | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/35410876/ |
| Lundstrom, M., et al | American Journal of Ophthalmology | — | 2004 | https://pubmed.ncbi.nlm.nih.gov/14700658/ |
| Liu, X., et al | European Journal of Clinical Investigation | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/37874275/ |
| Nambiar, A. M., et al | EBioMedicine | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/36857968/ |
| Unity Biotechnology, Inc | ClinicalTrials.gov | — | 2021 | https://clinicaltrials.gov/study/NCT04129944 |
| Lee, E., and Burns, M | Alternative Therapies in Health and Medicine | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/39269340/ |
| de Souza, R. J., et al | BMJ | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26268692/ |
| Ramsden, C. E., et al | BMJ | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/27071971/ |
| Aroda, V. R., et al | Journal of Clinical Endocrinology & Metabolism | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/26900641/ |
| Shan, Z., et al | European Journal of Nutrition | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/34379193/ |
| Termannsen, A.-D., et al | Obesity Reviews | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35672940/ |
| Tong, T. Y. N., et al | BMJ | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31484644/ |
| Edinger, J. D., et al | Journal of Clinical Sleep Medicine | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/33164742/ |
| Huang, K., et al | Australasian Psychiatry | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35968818/ |
| Sivertsen, B., et al | JAMA | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/16804151/ |
| Lovato, N., et al | Sleep | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24470701/ |
| Irwin, M. R., et al | Sleep | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/25142571/ |
| Ritterband, L. M., et al | npj Digital Medicine | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/40681664/ |
| Yang, J., et al | World Journal of Gastroenterology | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/23326148/ |
| Yang, Y., et al | British Journal of Nutrition | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22313809/ |
| Tu, D.-Y., et al | Healthcare | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/34072617/ |
| Naghshi, S., et al | BMJ | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32699048/ |
| Moel, M., et al | Aging | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/40188830/ |
| Tedesco-Silva, H., et al | Transplantation | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/30801548/ |
| Mahalati, K., and Kahan, B. D | Clinical Pharmacokinetics | — | 2001 | https://pubmed.ncbi.nlm.nih.gov/11523724/ |
| Pawelec, G | The human immunosenescence phenotype: does it exist? | Seminars in Immunopathology | 2020 | https://link.springer.com/article/10.1007/s00281-020-00810-3 |
| Turner, J. E., et al | Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults | Age | 2014 | https://pubmed.ncbi.nlm.nih.gov/23846127/ |
| Ritchie, S. J., et al | Predictors of ageing-related decline across multiple cognitive functions | Intelligence | 2016 | https://pubmed.ncbi.nlm.nih.gov/27932854/ |
| Zelazo, P. D., et al | NIH Toolbox Cognition Battery (CB): validation of executive function measures in adults | Journal of the International Neuropsychological Society | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4601803/ |
| Cooney, M. T., Vartiainen, E., Laatikainen, T., Juolevi, A., Dudina, A., & Graham, I. M | American Heart Journal | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20362720/ |
| Zhang, D., Shen, X., & Qi, X | CMAJ | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/26598376/ |
| Wen, C. P., Chen, C. H., Nauman, J., et al | Progress in Cardiovascular Diseases | — | 2025 | https://pubmed.ncbi.nlm.nih.gov/39894380/ |
| Alhalabi, L., Singleton, M. J., Oseni, A. O., et al | American Journal of Cardiology | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28132682/ |
| Vazir, A., Claggett, B., Cheng, S., et al | JAMA Cardiology | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29365021/ |
| Wu, L., et al | Integrated multi-omics for novel aging biomarkers and antiaging targets | Biomolecules | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8773837/ |
| Jiang, Y., et al | StackAge: an ensemble-based clock for precise quantification of biological age using multi-omics data | Briefings in Bioinformatics | 2026 | https://academic.oup.com/bib/article/27/3/bbag271/8698819 |
| Argelaguet, R., et al | Multi-Omics Factor Analysis—a framework for unsupervised integration of multi-omics data sets | Molecular Systems Biology | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6010767/ |
| Ying, K., et al | High-dimensional Ageome representations of biological aging across functional modules | bioRxiv | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11429788/ |
| Baier, D., Teren, A., Wirkner, K., Loeffler, M., & Scholz, M | Clinical Research in Cardiology | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6208658/ |
| Zhong, Q., Hu, M. J., Cui, Y. J., Liang, L., Zhou, M. M., Yang, Y. W., & Huang, F | Angiology | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29172654/ |
| Charlton, P. H., Mariscal Harana, J., Vennin, S., Li, Y., Chowienczyk, P., & Alastruey, J | American Journal of Physiology-Heart and Circulatory Physiology | — | 2023 | https://pubmed.ncbi.nlm.nih.gov/37000606/ |
| Evans, T. C., & Jehle, D | The red blood cell distribution width | Journal of Emergency Medicine | 1991 | https://pubmed.ncbi.nlm.nih.gov/1955687/ |
| Orces, C. H | The association between red cell distribution width and grip strength in older adults | Cureus | 2022 | https://pubmed.ncbi.nlm.nih.gov/36721603/ |
| Constantino, B. T | Red cell distribution width, revisited | Laboratory Medicine | 2013 | https://academic.oup.com/labmed/article/44/2/e2/2657684 |
| Cheng, C. K., et al | Complete blood count reference interval diagrams derived from NHANES III: stratification by age, sex, and race | Laboratory Hematology | 2004 | https://pubmed.ncbi.nlm.nih.gov/15070217/ |
| Tanaka, T., et al | Plasma proteomic biomarker signature of age predicts health and life span | eLife | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7723412/ |
| Oh, H. S. H., et al | Organ aging signatures in the plasma proteome track health and disease | Nature | 2023 | https://www.nature.com/articles/s41586-023-06802-1 |
| Alonso, A. K. M., et al | Definitions of digital biomarkers: a systematic mapping of the biomedical literature | BMJ Health & Care Informatics | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11015196/ |
| Zhou, H., Razjouyan, J., Halder, K., et al | Digital biomarkers of cognitive frailty: the value of detailed sensor-based gait assessment | Brain Sciences | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8578566/ |
| Le Goallec, A., et al | Machine learning approaches to predict age from accelerometer records of physical activity at biobank scale | PLOS Digital Health | 2023 | https://journals.plos.org/digitalhealth/article?id=10.1371/journal.pdig.0000176 |
| Franke, K., et al | Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: exploring the influence of various parameters | NeuroImage | 2010 | https://doi.org/10.1016/j.neuroimage.2010.01.005 |
| Cole, J. H., et al | Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker | NeuroImage | 2017 | https://doi.org/10.1016/j.neuroimage.2017.07.059 |
| Smith, S. M., et al | Estimation of brain age delta from brain imaging | NeuroImage | 2019 | https://doi.org/10.1016/j.neuroimage.2019.06.017 |
| Vidal-Piñeiro, D., et al | Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change | eLife | 2021 | https://elifesciences.org/articles/69995 |
| Dular, L., et al | Extensive T1-weighted MRI preprocessing improves generalizability of deep brain age prediction models | Computers in Biology and Medicine | 2024 | https://doi.org/10.1016/j.compbiomed.2024.108320 |
| Butler, E. R., et al | Pitfalls in brain age analyses | Human Brain Mapping | 2021 | https://doi.org/10.1002/hbm.25733 |
| Aging Biomarker Consortium, Jiang, M., Zheng, Z., Wang, X., Chen, Y., Qu, J., et al | Life Medicine | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11749002/ |
| Le Couteur, D. G., Blyth, F. M., Creasey, H. M., Handelsman, D. J., Naganathan, V., Sambrook, P. N., et al | Journal of Gerontology: Medical Sciences | — | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4085878/ |
| Koehler, E. M., Sanna, D., Hansen, B. E., van Rooij, F. J. A., Heeringa, J., Hofman, A., et al | Liver International | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24219360/ |
| Klemera, P., & Doubal, S | Mechanisms of Ageing and Development | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/16318865/ |
| Mayeux, R | NeuroRx | — | 2004 | https://pmc.ncbi.nlm.nih.gov/articles/PMC534923/ |
| Obuchowski, N. A., et al | Translational Oncology | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9667479/ |
| Vaught, J. B | Cancer Epidemiology, Biomarkers & Prevention | — | 2006 | https://aacrjournals.org/cebp/article/15/9/1582/174993/Blood-Collection-Shipment-Processing-and-Storage |
| Hardikar, S., et al | Cancer Causes & Control | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4169209/ |
| Weir, J. P | Journal of Strength and Conditioning Research | — | 2005 | https://pubmed.ncbi.nlm.nih.gov/15705040/ |
| Denic, A., Glassock, R. J., & Rule, A. D | Structural and functional changes with the aging kidney | Advances in Chronic Kidney Disease | 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4693148/ |
| Foster, M. C., et al | Non-GFR determinants of low-molecular-weight serum protein filtration markers in the elderly: AGES-Kidney and MESA-Kidney | American Journal of Kidney Diseases | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5572311/ |
| Juraschek, S. P., et al | Comparison of serum concentrations of beta-trace protein, beta-2 microglobulin, cystatin C, and creatinine in the US population | Clinical Journal of the American Society of Nephrology | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3613960/ |
| Hastings, W. J., et al | Psychoneuroendocrinology | — | 2019 | https://doi.org/10.1016/j.psyneuen.2019.03.012 |
| Kodama, S., Saito, K., Tanaka, S., et al | JAMA | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19454641/ |
| Betik, A. C., & Hepple, R. T | Applied Physiology, Nutrition, and Metabolism | — | 2008 | https://pubmed.ncbi.nlm.nih.gov/18347663/ |
| Peterman, J. E., Harber, M. P., Imboden, M. T., et al | Medicine and Science in Sports and Exercise | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/32472836/ |
| Grimbly, M. J., et al | Estimating biological age from retinal imaging: a scoping review | BMJ Open Ophthalmology | 2024 | https://bmjophth.bmj.com/content/9/1/e001794 |
| Ahadi, S., et al | Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock | eLife | 2023 | https://elifesciences.org/articles/82364 |
| Buckley, M. T., et al | A transcriptome-based single-cell biological age model and resource for tissue-specific aging measures | Genome Research | 2023 | https://genome.cshlp.org/content/33/9/1503 |
| Billman, G. E | Frontiers in Physiology | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23431279/ |
| Kuo, T. B. J., Lin, T., Yang, C. C. H., Li, C. L., Chen, C. F., & Chou, P | American Journal of Physiology | — | 1999 | https://pubmed.ncbi.nlm.nih.gov/10600841/ |
| Fang, S. C., Wu, Y. L., & Tsai, P. S | Biological Research for Nursing | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/31558032/ |
| Georgiou, K., Larentzakis, A. V., Khamis, N. N., Alsuhaibani, G. I., Alaska, Y. A., & Giallafos, E. J | Folia Medica | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29668452/ |
| Rocha, A. S. L., Siqueira, V. B., Maduro, P. A., Batista, L. S. P., & Schwingel, P. A | Psychophysiology | — | 2024 | https://pubmed.ncbi.nlm.nih.gov/39073173/ |
| Avolio, A | Pulse | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/26587425/ |
| Benetos, A | Journal of Hypertension Supplement | — | 1999 | https://pubmed.ncbi.nlm.nih.gov/10706321/ |
| Kikuya, M., Asayama, K., & Ohkubo, T | Kardiologia Polska | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31125026/ |
| Cuspidi, C., Sala, C., Tadic, M., Gherbesi, E., De Giorgi, A., Grassi, G., & Mancia, G | Journal of Clinical Hypertension | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28692165/ |
| Dimsdale, J. E., von Kanel, R., Profant, J., Nelesen, R., Ancoli-Israel, S., & Ziegler, M | Blood Pressure Monitoring | — | 2000 | https://pubmed.ncbi.nlm.nih.gov/11035863/ |
| Adav, S. S., & Wang, Y | Metabolomics Signatures of Aging: Recent Advances | Aging and Disease | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7990359/ |
| Sharma, R., & Ramanathan, A | The Aging Metabolome-Biomarkers to Hub Metabolites | Proteomics | 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7117067/ |
| de Haan, G., & Lazare, S. S | Aging of hematopoietic stem cells | Blood | 2018 | https://pubmed.ncbi.nlm.nih.gov/29141947/ |
| Tettamanti, M., et al | Prevalence, incidence and types of mild anemia in the elderly: the Health and Anemia population-based study | Haematologica | 2010 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2966906/ |
| Masuch, A., Friedrich, N., Roth, J., Nauck, M., Müller, U. A., & Petersmann, A | BMC Endocrine Disorders | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6371438/ |
| Chonchol, M., Katz, R., Fried, L. F., Sarnak, M. J., Siscovick, D. S., Newman, A. B., et al | Nutrition, Metabolism and Cardiovascular Diseases | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/19364638/ |
| Jung, M. H., Yi, S. W., An, S. J., Balkau, B., Yi, J. J., & Kim, H | Diabetologia | — | 2020 | https://pubmed.ncbi.nlm.nih.gov/32424541/ |
| Magnussen, C., Ojeda, F. M., Rzayeva, N., et al | International Journal of Cardiology | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28214081/ |
| Bogen, B., Aaslund, M. K., Ranhoff, A. H., & Moe-Nilssen, R | Gait & Posture | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31200293/ |
| Gamwell, H. E., Wait, S. O., Royster, J. T., Ritch, B. L., Powell, S. C., & Skinner, J. W | Gerontology and Geriatric Medicine | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8882934/ |
| Vanhooren, V., et al | Rejuvenation Research | — | 2007 | https://pubmed.ncbi.nlm.nih.gov/18047421/ |
| Parekh, R., Roitt, I., Isenberg, D., Dwek, R., & Rademacher, T | Journal of Experimental Medicine | — | 1988 | https://pubmed.ncbi.nlm.nih.gov/3133487/ |
| Ercan, A., et al | JCI Insight | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28239652/ |
| Mijakovac, A., et al | Frontiers in Cell and Developmental Biology | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/36619858/ |
| Harley, C. B., Futcher, A. B., & Greider, C. W | Telomeres shorten during ageing of human fibroblasts | — | 1990 | https://doi.org/10.1038/345458a0 |
| Cesari, M., et al | Biomarkers of aging and physical function | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19414544/ |
| Efeyan, A., Comb, W. C., & Sabatini, D. M | Nutrient-sensing mechanisms and pathways | — | 2015 | https://doi.org/10.1038/nature14190 |
| Hardie, D. G., Ross, F. A., & Hawley, S. A | AMPK: a nutrient and energy sensor that maintains energy homeostasis | — | 2012 | https://doi.org/10.1038/nrm3311 |
| Kennedy, B. K., Lamming, D. W., & Hekimi, S | Making sense of dietary restriction and ageing | — | 2022 | https://doi.org/10.1038/s41586-022-05283-y |
| Balch, W. E., et al | Adapting proteostasis for disease intervention | — | 2008 | https://pubmed.ncbi.nlm.nih.gov/18413248/ |
| Powers, E. T., et al | Biological and chemical approaches to diseases of proteostasis deficiency | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19625408/ |
| Hipp, M. S., et al | Proteostasis impairment in protein-misfolding and aggregation diseases | — | 2019 | https://pubmed.ncbi.nlm.nih.gov/31388181/ |
| Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., & Elledge, S. J | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases | — | 1993 | https://doi.org/10.1016/0092-8674(93)90499-G |
| El-Deiry, W. S., Tokino, T., Velculescu, V. E., et al | WAF1, a potential mediator of p53 tumor suppression | — | 1993 | https://doi.org/10.1016/0092-8674(93)90500-P |
| Sherr, C. J., & Roberts, J. M | CDK inhibitors: positive and negative regulators of G1-phase progression | — | 1999 | https://doi.org/10.1101/gad.13.12.1501 |
| Hernandez-Segura, A., Nehme, J., & Demaria, M | Hallmarks of Cellular Senescence | — | 2018 | https://doi.org/10.1016/j.tcb.2018.02.001 |
| Moore, L. D., Le, T., & Fan, G | DNA methylation and its basic function | — | 2013 | https://doi.org/10.1038/npp.2012.112 |
| Doyle, L. M., & Wang, M. Z | Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis | — | 2019 | https://doi.org/10.3390/cells8070727 |
| Théry, C., et al | Minimal information for studies of extracellular vesicles 2018: a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | — | 2018 | https://doi.org/10.1080/20013078.2018.1535750 |
| Xu, R., Rai, A., Chen, M., Suwakulsiri, W., Greening, D. W., & Simpson, R. J | Extracellular vesicles in cancer — implications for future improvements in cancer care | — | 2018 | https://doi.org/10.1038/s41571-018-0036-9 |
| Borras, F. E., & Edelman, E. R | Extracellular Vesicles and Aging: A Decade of Discovery and Potential Therapeutic Applications | — | 2021 | https://doi.org/10.3390/cells10082077 |
| Kumar, M. A., et al | Extracellular vesicles as tools and targets in therapy for diseases | — | 2024 | https://doi.org/10.1038/s41392-024-01735-1 |
| Moskalev, A., Chernyagina, E., Kudryavtseva, A., & Shaposhnikov, M | Aging and Disease | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5440114/ |
| Moskalev, A., Chernyagina, E., de Magalhães, J. P., & Zhavoronkov, A | Aging | — | 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4600621/ |
| Beard, J. R., Officer, A., de Carvalho, I. A., et al | The World report on ageing and health: a policy framework for healthy ageing | — | 2016 | https://doi.org/10.1016/S0140-6736(15)00516-4 |
| Cesari, M., Araujo de Carvalho, I., Amuthavalli Thiyagarajan, J., et al | Evidence for the Domains Supporting the Construct of Intrinsic Capacity | — | 2018 | https://doi.org/10.1093/gerona/gly011 |
| Beard, J. R., Jotheeswaran, A. T., Cesari, M., & Araujo de Carvalho, I | The structure and predictive value of intrinsic capacity in a longitudinal study of ageing | — | 2019 | https://doi.org/10.1136/bmjopen-2018-026119 |
| U.S. Food and Drug Administration | Clinical Outcome Assessment Compendium | — | 2018 | https://www.fda.gov/drugs/development-resources/clinical-outcome-assessment-compendium |
| Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., & Barzilai, N | A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: Report from the TAME Biomarkers Workgroup | — | 2018 | https://doi.org/10.1007/s11357-018-0042-y |
| Gerdes, H. H., & Carvalho, R. N | Intercellular transfer mediated by tunneling nanotubes | — | 2008 | https://doi.org/10.1016/j.ceb.2008.03.005 |
| Buganim, Y., Faddah, D. A., & Jaenisch, R | Mechanisms and models of somatic cell reprogramming | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23906219/ |
| Mahmoudi, S., & Brunet, A | Aging and reprogramming: A two-way street | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22794222/ |
| Gill, D., et al | Multi-omic rejuvenation of human cells by maturation phase transient reprogramming | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35418301/ |
| Halliwell, B | Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life | — | 2006 | https://doi.org/10.1104/pp.106.077073 |
| Murphy, M. P | How mitochondria produce reactive oxygen species | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19061483/ |
| Sena, L. A., & Chandel, N. S | Physiological roles of mitochondrial reactive oxygen species | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/23102266/ |
| Sies, H., Berndt, C., & Jones, D. P | Oxidative stress | — | 2017 | https://pubmed.ncbi.nlm.nih.gov/28441057/ |
| Martinon, F., Burns, K., & Tschopp, J | The Inflammasome: A Molecular Platform Triggering Activation of Inflammatory Caspases and Processing of proIL-β | — | 2002 | https://doi.org/10.1016/S1097-2765(02)00599-3 |
| Schroder, K., & Tschopp, J | The Inflammasomes | — | 2010 | https://doi.org/10.1016/j.cell.2010.01.040 |
| Broz, P., & Dixit, V. M | Inflammasomes: mechanism of assembly, regulation and signalling | — | 2016 | https://doi.org/10.1038/nri.2016.58 |
| Youm, Y. H., et al | Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging | — | 2013 | https://doi.org/10.1016/j.cell.2013.09.028 |
| Latz, E., Xiao, T. S., & Stutz, A | Activation and regulation of the inflammasomes | — | 2013 | https://doi.org/10.1038/nri3452 |
| Ferreira-González, I., Busse, J. W., Heels-Ansdell, D., Montori, V. M., Akl, E. A., Bryant, D. M., Alonso-Coello, P., Alonso, J., Worster, A., Upadhye, S., Jaeschke, R., Schünemann, H. J., Permanyer-Miralda, G., Pacheco-Huergo, V., Domingo-Salvany, A., Wu, P., Mills, E. J., & Guyatt, G. H | Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials | — | 2007 | https://doi.org/10.1136/bmj.39136.682083.AE |
| Rockwood, K., & Mitnitski, A | Frailty in relation to the accumulation of deficits | — | 2007 | https://doi.org/10.1093/gerona/62.7.722 |
| Rockwood, K., Song, X., MacKnight, C., Bergman, H., Hogan, D. B., McDowell, I., & Mitnitski, A | A global clinical measure of fitness and frailty in elderly people | — | 2005 | https://doi.org/10.1503/cmaj.050051 |
| Gordon, S., & Taylor, P. R | Monocyte and macrophage heterogeneity | — | 2005 | https://doi.org/10.1038/nri1733 |
| Wynn, T. A., Chawla, A., & Pollard, J. W | Macrophage biology in development, homeostasis and disease | — | 2013 | https://doi.org/10.1038/nature12034 |
| Franceschi, C., & Campisi, J | Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases | — | 2014 | https://doi.org/10.1093/gerona/glu057 |
| Fulop, T., Larbi, A., Dupuis, G., et al | Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? | — | 2017 | https://doi.org/10.3389/fimmu.2017.01960 |
| Nikolich-Zugich, J | The twilight of immunity: emerging concepts in aging of the immune system | — | 2018 | https://doi.org/10.1038/s41590-017-0006-x |
| Gruver, A. L., Hudson, L. L., & Sempowski, G. D | Immunosenescence of ageing | — | 2007 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1931833/ |
| Lee, K. A., et al | Immune Senescence, Immunosenescence and Aging | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9261375/ |
| Aiello, A., et al | Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? | — | 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6773825/ |
| Goyani, P., et al | Immunosenescence: Aging and Immune System Decline | — | 2024 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11680340/ |
| Reiser, K., McCormick, R. J., & Rucker, R. B | Enzymatic and nonenzymatic cross-linking of collagen and elastin | — | 1992 | https://pubmed.ncbi.nlm.nih.gov/1541331/ |
| Bailey, A. J | Molecular mechanisms of ageing in connective tissues | — | 2001 | https://pubmed.ncbi.nlm.nih.gov/11771701/ |
| McEwen, B. S., & Wingfield, J. C | The concept of allostasis in biology and biomedicine | — | 2003 | https://pubmed.ncbi.nlm.nih.gov/12749634/ |
| Seeman, T. E., et al | Allostatic load as a marker of cumulative biological risk | — | 2001 | https://pubmed.ncbi.nlm.nih.gov/11730249/ |
| Kale, A., Sharma, A., Stolzing, A., Desprez, P. Y., & Campisi, J | Role of immune cells in the removal of deleterious senescent cells | — | 2020 | https://doi.org/10.1111/imr.12820 |
| Vijg, J., & Suh, Y | Genome instability and aging | — | 2013 | https://pubmed.ncbi.nlm.nih.gov/23454761/ |
| Maynard, S., et al | DNA damage, DNA repair, aging, and neurodegeneration | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26385091/ |
| Powell, D., et al | Harnessing the power of digital biomarkers in healthcare | — | 2024 | https://doi.org/10.1038/s41746-024-01023-w |
| Klionsky, D. J., & Emr, S. D | Autophagy as a Regulated Pathway of Cellular Degradation | — | 2000 | https://doi.org/10.1126/science.290.5497.1717 |
| Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J | Autophagy fights disease through cellular self-digestion | — | 2008 | https://doi.org/10.1038/nature06639 |
| Rubinsztein, D. C., Marino, G., & Kroemer, G | Autophagy and Aging | — | 2011 | https://doi.org/10.1016/j.cell.2011.07.030 |
| Hansen, M., Rubinsztein, D. C., & Walker, D. W | Autophagy as a promoter of longevity: insights from model organisms | — | 2018 | https://doi.org/10.1038/s41580-018-0033-y |
| Prentice, R. L | Surrogate endpoints in clinical trials: Definition and operational criteria | — | 1989 | https://doi.org/10.1002/sim.4780080407 |
| Califf, R. M | Biomarker definitions and their applications | — | 2018 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5813875/ |
| Sauve, A. A., Wolberger, C., Schramm, V. L., & Boeke, J. D | The Biochemistry of Sirtuins | — | 2006 | https://doi.org/10.1146/annurev.biochem.74.082803.133500 |
| Michan, S., & Sinclair, D | Sirtuins in mammals: insights into their biological function | — | 2007 | https://doi.org/10.1042/BJ20070140 |
| Longo, V. D., & Kennedy, B. K | Sirtuins in Aging and Age-Related Disease | — | 2006 | https://doi.org/10.1016/j.cell.2006.09.002 |
| Bonkowski, M. S., & Sinclair, D. A | Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds | — | 2016 | https://doi.org/10.1038/nrm.2016.93 |
| Brownlee, M | Advanced protein glycosylation in diabetes and aging | — | 1995 | https://doi.org/10.1146/annurev.med.46.1.223 |
| Semba, R. D., et al | Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19448391/ |
| Ramasamy, R., Yan, S. F., & Schmidt, A. M | Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/22211895/ |
| Murray, P. J., Allen, J. E., Biswas, S. K., et al | Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines | — | 2014 | https://doi.org/10.1016/j.immuni.2014.06.008 |
| Italiani, P., & Boraschi, D | From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation | — | 2014 | https://doi.org/10.3389/fimmu.2014.00514 |
| Soliman, G. A | The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses | — | 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3725503/ |
| Szwed, A., Kim, E., & Jacinto, E | Regulation and metabolic functions of mTORC1 and mTORC2 | — | 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8424549/ |
| Wang, G., et al | Mechanistic target of rapamycin complex 1: From a nutrient sensor to a central regulator of metabolism | — | 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9526850/ |
| Sies, H | Oxidative stress: Introductory remarks | — | 1985 | https://pubmed.ncbi.nlm.nih.gov/3901401/ |
| Finkel, T., & Holbrook, N. J | Oxidants, oxidative stress and the biology of ageing | — | 2000 | https://pubmed.ncbi.nlm.nih.gov/10935633/ |
| — | NIH Human Microbiome Project | — | — | https://commonfund.nih.gov/hmp |
| Ciechanover, A | Proteolysis: from the lysosome to ubiquitin and the proteasome | — | 2005 | https://doi.org/10.1038/nrm1552 |
| Finley, D | Recognition and processing of ubiquitin-protein conjugates by the proteasome | — | 2009 | https://doi.org/10.1146/annurev.biochem.78.081507.101607 |
| Kaushik, S., & Cuervo, A. M | Proteostasis and aging | — | 2015 | https://doi.org/10.1038/nm.4001 |
| Vilchez, D., Saez, I., & Dillin, A | The role of protein clearance mechanisms in organismal ageing and age-related diseases | — | 2014 | https://doi.org/10.1038/nrm3827 |
| Dikic, I., & Elazar, Z | Mechanism and medical implications of mammalian autophagy | — | 2018 | https://doi.org/10.1038/s41580-018-0003-4 |
| Coller, H. A., Sang, L., & Roberts, J. M | A new description of cellular quiescence | — | 2006 | https://pubmed.ncbi.nlm.nih.gov/16554874/ |
| Yao, G | Modelling mammalian cellular quiescence | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24731628/ |
| Urbán, N., & Cheung, T. H | Stem cell quiescence: The challenging path to activation | — | 2021 | https://pubmed.ncbi.nlm.nih.gov/33513359/ |
| Carling, D | AMPK signalling in health and disease | — | 2017 | https://doi.org/10.1016/j.cub.2017.05.074 |
| Salminen, A., & Kaarniranta, K | AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network | — | 2012 | https://doi.org/10.1016/j.arr.2011.12.005 |
| van den Akker, M., Buntinx, F., & Knottnerus, J. A | Comorbidity or multimorbidity: What's in a name? | — | 1996 | https://pubmed.ncbi.nlm.nih.gov/8911007/ |
| The Academy of Medical Sciences | Multimorbidity: A priority for global health research | — | 2018 | https://acmedsci.ac.uk/file-download/82222577 |
| Fabbri, E., et al | Aging and multimorbidity: New tasks, priorities, and frontiers for integrated gerontological and clinical research | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25724969/ |
| Shreffler, J., & Huecker, M. R | StatPearls | — | 2023 | https://www.ncbi.nlm.nih.gov/books/NBK560604/ |
| Sashegyi, A., & Ferry, D | The Oncologist | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5388384/ |
| Bodnar, A. G., et al | Extension of life-span by introduction of telomerase into normal human cells | — | 1998 | https://doi.org/10.1126/science.279.5349.349 |
| Fraga, M. F., et al | Epigenetic differences arise during the lifetime of monozygotic twins | — | 2005 | https://doi.org/10.1073/pnas.0500398102 |
| Feinberg, A. P., & Irizarry, R. A | Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease | — | 2010 | https://doi.org/10.1073/pnas.1006183107 |
| Fleg, J. L., et al | Accelerated longitudinal decline of aerobic capacity in healthy older adults | — | 2005 | https://pubmed.ncbi.nlm.nih.gov/15687341/ |
| Aspenes, S. T., et al | Peak oxygen uptake and cardiovascular risk factors in 4631 healthy women and men | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21208929/ |
| Searle, S. D., et al | A standard procedure for creating a frailty index | — | 2008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2573877/ |
| Hubbard, R. E., et al | Frailty in the face of COVID-19 | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/26018884/ |
| Fraser, C. G | AACC Press | — | 2001 | https://www.aacc.org/science-and-research/scientific-shorts/2018/biological-variation |
| Jinek, M., et al | A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity | — | 2012 | https://doi.org/10.1126/science.1225829 |
| Doudna, J. A., & Charpentier, E | The new frontier of genome engineering with CRISPR-Cas9 | — | 2014 | https://doi.org/10.1126/science.1258096 |
| Hsu, P. D., Lander, E. S., & Zhang, F | Development and Applications of CRISPR-Cas9 for Genome Engineering | — | 2014 | https://doi.org/10.1016/j.cell.2014.05.010 |
| Anzalone, A. V., Koblan, L. W., & Liu, D. R | Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors | — | 2020 | https://doi.org/10.1038/s41587-020-0561-9 |
| Wang, J. Y., Doudna, J. A., & Liu, D. R | CRISPR technology: A decade of genome editing is only the beginning | — | 2023 | https://doi.org/10.1126/science.add8643 |
| Frangoul, H., et al | CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia | — | 2021 | https://doi.org/10.1056/NEJMoa2031054 |
| Petersen, C., & Round, J. L | Defining dysbiosis and its influence on host immunity and disease | — | 2014 | https://doi.org/10.1111/cmi.12308 |
| Hooks, K. B., & O'Malley, M. A | Dysbiosis and Its Discontents | — | 2017 | https://doi.org/10.1128/mBio.01492-17 |
| Sommer, F., & Bäckhed, F | The gut microbiota — masters of host development and physiology | — | 2013 | https://doi.org/10.1038/nrmicro2974 |
| Ghosh, T. S., et al | Microbial signatures of healthy aging | — | 2022 | https://doi.org/10.1038/s43587-021-00151-2 |
| Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M | Senescent cells: An emerging target for diseases of ageing | — | 2017 | https://www.nature.com/articles/nrd.2017.116 |
| Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M. S., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T., Passos, J. F., Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T., Kirkland, J. L., & Robbins, P. D | Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease | — | 2019 | https://www.ebiomedicine.com/article/S2352-3964(19)30427-1/fulltext |
| Oh, J., Lee, Y. D., & Wagers, A. J | Stem cell aging: Mechanisms, regulators and therapeutic opportunities | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/24484927/ |
| Oblak, L., van der Zaag, J., Higgins-Chen, A. T., Levine, M. E., & Boks, M. P | A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration | — | 2021 | https://doi.org/10.1016/j.arr.2021.101348 |
| Kornberg, R. D | Chromatin Structure: A Repeating Unit of Histones and DNA | — | 1974 | https://doi.org/10.1126/science.184.4139.868 |
| Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J | Crystal structure of the nucleosome core particle at 2.8 Å resolution | — | 1997 | https://doi.org/10.1038/389251a0 |
| de Duve, C | The lysosome turns fifty | — | 2005 | https://doi.org/10.1038/ncb1205-847 |
| Settembre, C., Fraldi, A., Medina, D. L., & Ballabio, A | Signals from the lysosome: a control centre for cellular clearance and energy metabolism | — | 2013 | https://doi.org/10.1038/nrm3565 |
| Ballabio, A., & Bonifacino, J. S | Lysosomes as dynamic regulators of cell and organismal homeostasis | — | 2020 | https://doi.org/10.1038/s41580-020-0256-3 |
| Cuervo, A. M., & Dice, J. F | Age-related decline in chaperone-mediated autophagy | — | 2000 | https://doi.org/10.1073/pnas.97.19.10687 |
| Carmona-Gutierrez, D., et al | The cell biology of lysosomal aging: From function to dysfunction | — | 2016 | https://doi.org/10.1111/acel.12499 |
| Rattan, S. I. S | Biogerontology: research status, challenges and opportunities | — | 2018 | https://doi.org/10.23750/abm.v89i2.7403 |
| Jackson, S. P., & Bartek, J | The DNA-damage response in human biology and disease | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19847258/ |
| Ciccia, A., & Elledge, S. J | The DNA damage response: Making it safe to play with knives | — | 2010 | https://pubmed.ncbi.nlm.nih.gov/20832717/ |
| Lord, C. J., & Ashworth, A | The DNA damage response and cancer therapy | — | 2012 | https://pubmed.ncbi.nlm.nih.gov/22193477/ |
| Lemasters, J. J | Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging | — | 2005 | https://pubmed.ncbi.nlm.nih.gov/15811512/ |
| Pickles, S., Vigié, P., & Youle, R. J | Mitophagy and quality control mechanisms in mitochondrial maintenance | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29358636/ |
| Palikaras, K., Lionaki, E., & Tavernarakis, N | Mechanisms of mitophagy in cellular homeostasis, physiology and pathology | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29620996/ |
| Palmer, R. D | Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age | — | 2022 | https://pubmed.ncbi.nlm.nih.gov/35783114/ |
| Hynes, R. O | The extracellular matrix: Not just pretty fibrils | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19854164/ |
| Theocharis, A. D., et al | Extracellular matrix structure | — | 2016 | https://pubmed.ncbi.nlm.nih.gov/26923902/ |
| Bonnans, C., Chou, J., & Werb, Z | Remodelling the extracellular matrix in development and disease | — | 2014 | https://pubmed.ncbi.nlm.nih.gov/25415508/ |
| Booth, L. N., & Brunet, A | The Aging Epigenome | — | 2016 | https://doi.org/10.1016/j.molcel.2016.05.013 |
| Serrano, M., Hannon, G. J., & Beach, D | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 | — | 1993 | https://doi.org/10.1038/366704a0 |
| Collado, M., Blasco, M. A., & Serrano, M | Cellular Senescence in Cancer and Aging | — | 2007 | https://doi.org/10.1016/j.cell.2007.07.003 |
| Krishnamurthy, J., Torrice, C., Ramsey, M. R., et al | Ink4a/Arf expression is a biomarker of aging | — | 2004 | https://doi.org/10.1172/JCI22475 |
| Genovese, G., et al | Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence | — | 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4290021/ |
| Jan, M., Ebert, B. L., and Jaiswal, S | Clonal hematopoiesis | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8045769/ |
| Shlush, L. I | Age-related clonal hematopoiesis | — | 2018 | https://pubmed.ncbi.nlm.nih.gov/29141946/ |
| Acuna-Hidalgo, R., et al | Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life | — | 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5501773/ |
| — | OpenStax | — | — | https://openstax.org/books/anatomy-and-physiology-2e/pages/1-5-homeostasis |
| Kerr, J. F. R., Wyllie, A. H., & Currie, A. R | Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics | — | 1972 | https://pubmed.ncbi.nlm.nih.gov/4561027/ |
| Elmore, S | Apoptosis: A review of programmed cell death | — | 2007 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2117903/ |
| Fuchs, Y., & Steller, H | Programmed cell death in animal development and disease | — | 2011 | https://pubmed.ncbi.nlm.nih.gov/21763611/ |
| Tower, J | Programmed cell death in aging | — | 2015 | https://pubmed.ncbi.nlm.nih.gov/25862945/ |
| Coppé, J. P., et al | Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor | — | 2008 | https://pubmed.ncbi.nlm.nih.gov/19053174/ |
| Kuilman, T., & Peeper, D. S | Senescence-messaging secretome: SMS-ing cellular stress | — | 2009 | https://pubmed.ncbi.nlm.nih.gov/19596272/ |
| Vlassara, H., & Palace, M. R | Diabetes and advanced glycation endproducts | — | 2002 | https://pubmed.ncbi.nlm.nih.gov/11834475/ |
| Ramasamy, R., et al | Receptor for advanced glycation end products: Fundamental roles in the inflammatory response | — | 2005 | https://pubmed.ncbi.nlm.nih.gov/15994272/ |
| Wernig, M., et al | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state | — | 2007 | https://pubmed.ncbi.nlm.nih.gov/17554336/ |
| Greider, C. W., & Blackburn, E. H | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts | — | 1985 | https://doi.org/10.1016/0092-8674(85)90170-9 |
| Schmidt, J. C., & Cech, T. R | Human telomerase: biogenesis, trafficking, recruitment, and activation | — | 2015 | https://doi.org/10.1101/gad.263863.115 |
| Shay, J. W., & Wright, W. E | Telomeres and telomerase: three decades of progress | — | 2019 | https://doi.org/10.1038/s41576-019-0099-1 |
| — | Lapierre, L. R. et al. (2013). The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans . Nature Communications . https://doi.org/10.1038/ncomms3267 | — | — | https://doi.org/10.1038/ncomms3267 |
| — | Decressac, M. et al. (2013). TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1305623110 | — | — | https://doi.org/10.1073/pnas.1305623110 |
| — | Aman, Y. et al. (2021). Autophagy in healthy aging and disease. Nature Aging . https://doi.org/10.1038/s43587-020-00013-8 | — | — | https://doi.org/10.1038/s43587-020-00013-8 |
| — | Ballabio, A. and Bonifacino, J. S. (2020). Lysosomes as dynamic regulators of cell and organismal homeostasis. Nature Reviews Molecular Cell Biology . https://doi.org/10.1038/s41580-019-0185-4 | — | — | https://doi.org/10.1038/s41580-019-0185-4 |
| — | Pyo, J.-O. et al. (2013). Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nature Communications . https://doi.org/10.1038/ncomms3300 | — | — | https://doi.org/10.1038/ncomms3300 |
| — | Zhang, C. and Cuervo, A. M. (2008). Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nature Medicine . https://doi.org/10.1038/nm.1851 | — | — | https://doi.org/10.1038/nm.1851 |
| — | Kolesky, D. B. et al. (2016). Three-dimensional bioprinting of thick vascularized tissues. Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1521342113 | — | — | https://doi.org/10.1073/pnas.1521342113 |
| — | Murphy, S. V. & Atala, A. (2014). 3D bioprinting of tissues and organs. Nature Biotechnology . https://doi.org/10.1038/nbt.2958 | — | — | https://doi.org/10.1038/nbt.2958 |
| — | Richards, D. et al. (2017). 3D bioprinting for vascularized tissue fabrication. Annals of Biomedical Engineering . https://doi.org/10.1007/s10439-016-1653-z | — | — | https://doi.org/10.1007/s10439-016-1653-z |
| — | Oh, J. et al. (2014). Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nature Medicine . https://doi.org/10.1038/nm.3651 | — | — | https://doi.org/10.1038/nm.3651 |
| — | Skylar-Scott, M. A. et al. (2019). Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels. Science Advances . https://doi.org/10.1126/sciadv.aaw2459 | — | — | https://doi.org/10.1126/sciadv.aaw2459 |
| — | Schene, I. F. et al. "Prime editing for functional repair in patient-derived disease models." Nature Communications (2020). https://doi.org/10.1038/s41467-020-19136-7 | — | — | https://doi.org/10.1038/s41467-020-19136-7 |
| — | Davis, J. R. et al. "Efficient prime editing in mouse brain, liver and heart with dual AAVs." Nature Biotechnology (2024). https://doi.org/10.1038/s41587-023-01758-z | — | — | https://doi.org/10.1038/s41587-023-01758-z |
| — | Lee, J. et al. "Prime editing with genuine Cas9 nickases minimizes unwanted indels." Nature Communications (2023). https://doi.org/10.1038/s41467-023-37507-8 | — | — | https://doi.org/10.1038/s41467-023-37507-8 |
| — | Gehrke, J. M. et al. "An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities." Nature Biotechnology (2018). https://doi.org/10.1038/nbt.4199 | — | — | https://doi.org/10.1038/nbt.4199 |
| — | Merideth, M. A. et al. "Phenotype and course of Hutchinson–Gilford progeria syndrome." New England Journal of Medicine (2008). https://doi.org/10.1056/NEJMoa0706898 | — | — | https://doi.org/10.1056/NEJMoa0706898 |
| — | Heinz, A. "Elastic fibers during aging and disease." Ageing Research Reviews (2021), 66, 101255. https://pubmed.ncbi.nlm.nih.gov/33434682/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33434682/ |
| — | Monnier, V. M. et al. "Skin Collagen Advanced Glycation End Products (AGEs) and the Diabetic Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort." Diabetes (2018). https://doi.org/10.2337/db18-0520 | — | — | https://doi.org/10.2337/db18-0520 |
| — | Ibrahim, A. G.-E. et al. (2019). Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories. Nature Biomedical Engineering . https://doi.org/10.1038/s41551-019-0448-6 | — | — | https://doi.org/10.1038/s41551-019-0448-6 |
| — | Lener, T. et al. (2015). Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper. Journal of Extracellular Vesicles . https://doi.org/10.3402/jev.v4.30087 | — | — | https://doi.org/10.3402/jev.v4.30087 |
| — | Alvarez-Erviti, L. et al. (2011). Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nature Biotechnology . https://doi.org/10.1038/nbt.1807 | — | — | https://doi.org/10.1038/nbt.1807 |
| — | Yang, Z. et al. (2020). Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. Nature Biomedical Engineering . https://doi.org/10.1038/s41551-019-0485-1 | — | — | https://doi.org/10.1038/s41551-019-0485-1 |
| — | Sagiv, A. et al. "NKG2D ligands mediate immunosurveillance of senescent cells." Aging (2016). https://doi.org/10.18632/aging.100897 | — | — | https://doi.org/10.18632/aging.100897 |
| — | Baker, D. J. et al. "Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders." Nature (2011). https://doi.org/10.1038/nature10600 | — | — | https://doi.org/10.1038/nature10600 |
| — | Demaria, M. et al. "An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA." Developmental Cell (2014). https://doi.org/10.1016/j.devcel.2014.11.012 | — | — | https://doi.org/10.1016/j.devcel.2014.11.012 |
| — | Schuster, S. J. et al. "Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma." New England Journal of Medicine (2019). https://doi.org/10.1056/NEJMoa1804980 | — | — | https://doi.org/10.1056/NEJMoa1804980 |
| — | Kim, K. M. et al. "Identification of senescent cell surface targetable protein DPP4." Genes & Development (2017). https://doi.org/10.1101/gad.302570.117 | — | — | https://doi.org/10.1101/gad.302570.117 |
| — | Amor, C. et al. "Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction." Nature Aging (2024). https://doi.org/10.1038/s43587-023-00560-5 | — | — | https://doi.org/10.1038/s43587-023-00560-5 |
| — | Day, K. et al. "Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape." Genome Biology (2013). https://doi.org/10.1186/gb-2013-14-9-r102 | — | — | https://doi.org/10.1186/gb-2013-14-9-r102 |
| — | Ueda, J., Yamazaki, T. & Funakoshi, H. "Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges." International Journal of Molecular Sciences (2023). https://doi.org/10.3390/ijms24054778 | — | — | https://doi.org/10.3390/ijms24054778 |
| — | Kantor, B. et al. "The therapeutic implications of all-in-one AAV-delivered epigenome-editing platform in neurodegenerative disorders." Nature Communications (2024). https://doi.org/10.1038/s41467-024-50515-6 | — | — | https://doi.org/10.1038/s41467-024-50515-6 |
| — | Saunderson, E. A. et al. "CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny." Proceedings of the National Academy of Sciences (2023). https://doi.org/10.1073/pnas.2300224120 | — | — | https://doi.org/10.1073/pnas.2300224120 |
| — | Tremblay, F. et al. "A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels." Nature Medicine (2025). https://doi.org/10.1038/s41591-025-03508-x | — | — | https://doi.org/10.1038/s41591-025-03508-x |
| — | Liesenfelder, S. et al. "Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape." Nature Aging (2025). https://doi.org/10.1038/s43587-025-00841-1 | — | — | https://doi.org/10.1038/s43587-025-00841-1 |
| — | Kota, J. et al. "Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates." Science Translational Medicine (2009). https://pmc.ncbi.nlm.nih.gov/articles/PMC2852878/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2852878/ |
| — | Conboy, I. M. et al. "Rejuvenation of aged progenitor cells by exposure to a young systemic environment." Nature (2005). https://doi.org/10.1038/nature03260 | — | — | https://doi.org/10.1038/nature03260 |
| — | Boada, M. et al. "A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study." Alzheimer's & Dementia (2020). https://doi.org/10.1002/alz.12137 | — | — | https://doi.org/10.1002/alz.12137 |
| — | Mehdipour, M. et al. "Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin." Aging (2020). https://doi.org/10.18632/aging.103418 | — | — | https://doi.org/10.18632/aging.103418 |
| — | Liang, Z., Dong, X., Zhang, Z., Zhang, Q., & Zhao, Y. (2022). Age-related thymic involution: mechanisms and functional impact. Aging Cell , 21(8), e13671. https://pubmed.ncbi.nlm.nih.gov/35822239/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35822239/ |
| — | Fahy, G. M. et al. "Reversal of epigenetic aging and immunosenescent trends in humans." Aging Cell (2019). https://doi.org/10.1111/acel.13028 | — | — | https://doi.org/10.1111/acel.13028 |
| — | Wang, H. et al. "Direct cell reprogramming: approaches, mechanisms and progress." Nature Reviews Molecular Cell Biology (2021). https://doi.org/10.1038/s41580-021-00335-z | — | — | https://doi.org/10.1038/s41580-021-00335-z |
| — | Torper, O. et al. "Generation of induced neurons via direct conversion in vivo." Proceedings of the National Academy of Sciences (2013). https://doi.org/10.1073/pnas.1303829110 | — | — | https://doi.org/10.1073/pnas.1303829110 |
| — | Song, G. et al. "Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis." Cell Stem Cell (2016). https://doi.org/10.1016/j.stem.2016.01.010 | — | — | https://doi.org/10.1016/j.stem.2016.01.010 |
| — | Heinrich, C., Spagnoli, F. M. & Berninger, B. "In vivo reprogramming for tissue repair." Nature Cell Biology (2015). https://doi.org/10.1038/ncb3108 | — | — | https://doi.org/10.1038/ncb3108 |
| — | Miyamoto, K. et al. "Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction." Cell Stem Cell (2018). https://doi.org/10.1016/j.stem.2017.11.010 | — | — | https://doi.org/10.1016/j.stem.2017.11.010 |
| — | Islam, M. N. et al. "Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury." Nature Medicine (2012). https://doi.org/10.1038/nm.2736 | — | — | https://doi.org/10.1038/nm.2736 |
| — | Mansour, A. A. et al. (2018). An in vivo model of functional and vascularized human brain organoids. Nature Biotechnology . https://doi.org/10.1038/nbt.4127 | — | — | https://doi.org/10.1038/nbt.4127 |
| — | van den Berg, C. W. et al. (2018). Renal subcapsular transplantation of PSC-derived kidney organoids induces neo-vasculogenesis and significant glomerular and tubular maturation in vivo. Stem Cell Reports . https://doi.org/10.1016/j.stemcr.2018.01.041 | — | — | https://doi.org/10.1016/j.stemcr.2018.01.041 |
| — | Cao, S.-Y. et al. (2023). Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke. npj Regenerative Medicine . https://doi.org/10.1038/s41536-023-00301-7 | — | — | https://doi.org/10.1038/s41536-023-00301-7 |
| — | Yui, S. et al. (2012). Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nature Medicine . https://doi.org/10.1038/nm.2695 | — | — | https://doi.org/10.1038/nm.2695 |
| — | Shirai, H. et al. (2016). Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1512590113 | — | — | https://doi.org/10.1073/pnas.1512590113 |
| — | Ye, Z. et al. "Regulation of miR-181a expression in T cell aging." Nature Communications (2018). https://doi.org/10.1038/s41467-018-05552-3 | — | — | https://doi.org/10.1038/s41467-018-05552-3 |
| — | Paunovska, K., Loughrey, D. & Dahlman, J. E. "Drug delivery systems for RNA therapeutics." Nature Reviews Genetics (2022). https://doi.org/10.1038/s41576-021-00439-4 | — | — | https://doi.org/10.1038/s41576-021-00439-4 |
| — | Morelli, K. H. et al. "An RNA-targeting CRISPR–Cas13d system alleviates disease-related phenotypes in Huntington's disease models." Nature Neuroscience (2023). https://doi.org/10.1038/s41593-022-01207-1 | — | — | https://doi.org/10.1038/s41593-022-01207-1 |
| — | Winkle, M. et al. "Noncoding RNA therapeutics — challenges and potential solutions." Nature Reviews Drug Discovery (2021). https://doi.org/10.1038/s41573-021-00219-z | — | — | https://doi.org/10.1038/s41573-021-00219-z |
| — | Della Valle, F. et al. "LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes." Science Translational Medicine (2022). https://doi.org/10.1126/scitranslmed.abl6057 | — | — | https://doi.org/10.1126/scitranslmed.abl6057 |
| — | Chen, S. et al. "Using RNA therapeutics to promote healthy aging." Nature Aging (2025). https://doi.org/10.1038/s43587-025-00895-1 | — | — | https://doi.org/10.1038/s43587-025-00895-1 |
| — | Li, Y. et al. "Transient introduction of human telomerase mRNA improves hallmarks of progeria cells." Aging Cell (2019). https://doi.org/10.1111/acel.12979 | — | — | https://doi.org/10.1111/acel.12979 |
| — | Phinney, D. G. & Pittenger, M. F. "Concise Review: MSC-Derived Exosomes for Cell-Free Therapy." Stem Cells (2017). https://doi.org/10.1002/stem.2575 | — | — | https://doi.org/10.1002/stem.2575 |
| — | Parkhitko, A. A. & Cracan, V. "Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases." Science Advances (2025). https://doi.org/10.1126/sciadv.adu1710 | — | — | https://doi.org/10.1126/sciadv.adu1710 |
| — | Baker, D. J. et al. "Naturally occurring p16Ink4a-positive cells shorten healthy lifespan." Nature (2016). https://doi.org/10.1038/nature16932 | — | — | https://doi.org/10.1038/nature16932 |
| — | High, K. A. & Roncarolo, M. G. "Gene Therapy." New England Journal of Medicine (2019). https://doi.org/10.1056/NEJMra1706910 | — | — | https://doi.org/10.1056/NEJMra1706910 |
| — | Li, C. & Samulski, R. J. "Engineering adeno-associated virus vectors for gene therapy." Nature Reviews Genetics (2020). https://doi.org/10.1038/s41576-019-0205-4 | — | — | https://doi.org/10.1038/s41576-019-0205-4 |
| — | Wang, D., Tai, P. W. L., & Gao, G. "Adeno-associated virus vector as a platform for gene therapy delivery." Nature Reviews Drug Discovery (2019). https://doi.org/10.1038/s41573-019-0012-9 | — | — | https://doi.org/10.1038/s41573-019-0012-9 |
| — | Cheng, L. & Hill, A. F. "Therapeutically harnessing extracellular vesicles." Nature Reviews Drug Discovery (2022). https://doi.org/10.1038/s41573-022-00410-w | — | — | https://doi.org/10.1038/s41573-022-00410-w |
| — | Sakamoto, K. M. et al. (2001). Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.141230798 | — | — | https://doi.org/10.1073/pnas.141230798 |
| — | Tsai, J. M. et al. (2024). Targeted protein degradation: from mechanisms to clinic. Nature Reviews Molecular Cell Biology . https://doi.org/10.1038/s41580-024-00729-9 | — | — | https://doi.org/10.1038/s41580-024-00729-9 |
| — | Ackerman, L. et al. (2023). IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial. Nature Medicine . https://doi.org/10.1038/s41591-023-02635-7 | — | — | https://doi.org/10.1038/s41591-023-02635-7 |
| — | He, Y. et al. (2020). Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. Nature Communications . https://doi.org/10.1038/s41467-020-15838-0 | — | — | https://doi.org/10.1038/s41467-020-15838-0 |
| — | Chang, J. et al. (2016). Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicine . https://doi.org/10.1038/nm.4010 | — | — | https://doi.org/10.1038/nm.4010 |
| — | Békés, M., Langley, D. R. and Crews, C. M. (2022). PROTAC targeted protein degraders: the past is prologue. Nature Reviews Drug Discovery . https://doi.org/10.1038/s41573-021-00371-6 | — | — | https://doi.org/10.1038/s41573-021-00371-6 |
| — | Ji, C. H. et al. (2022). The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nature Communications . https://doi.org/10.1038/s41467-022-28520-4 | — | — | https://doi.org/10.1038/s41467-022-28520-4 |
| — | Savage, S. A., & Bertuch, A. A. (2010). The genetics and clinical manifestations of telomere biology disorders. Genetics in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC3825100/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3825100/ |
| — | Chang, S., et al. (2003). Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes & Development . https://pmc.ncbi.nlm.nih.gov/articles/PMC195968/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC195968/ |
| — | Ramunas, J., et al. (2015). Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells. FASEB Journal . https://doi.org/10.1096/fj.14-259531 | — | — | https://doi.org/10.1096/fj.14-259531 |
| — | Jones-Weinert, C., Mainz, L., & Karlseder, J. (2025). Telomere function and regulation from mouse models to human ageing and disease. Nature Reviews Molecular Cell Biology . https://doi.org/10.1038/s41580-024-00800-5 | — | — | https://doi.org/10.1038/s41580-024-00800-5 |
| — | Debès, C., et al. (2023). Ageing-associated changes in transcriptional elongation influence longevity. Nature . https://www.nature.com/articles/s41586-023-05922-y | — | — | https://www.nature.com/articles/s41586-023-05922-y |
| — | Lee, J., et al. (2025). Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC12358915/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12358915/ |
| — | Isken, O., & Maquat, L. E. (2007). Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes & Development . https://genesdev.cshlp.org/content/21/15/1833.long | — | — | https://genesdev.cshlp.org/content/21/15/1833.long |
| — | Son, H. G., et al. (2017). RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2 /insulin/IGF-1 mutant C. elegans . Nature Communications . https://www.nature.com/articles/ncomms14749 | — | — | https://www.nature.com/articles/ncomms14749 |
| — | Vermulst, M., et al. (2015). Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nature Communications . https://www.nature.com/articles/ncomms9065 | — | — | https://www.nature.com/articles/ncomms9065 |
| — | Sudmant, P. H., et al. (2018). Widespread accumulation of ribosome-associated isolated 3′ UTRs in neuronal cell populations of the aging brain. Cell Reports . https://pmc.ncbi.nlm.nih.gov/articles/PMC6354779/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6354779/ |
| — | Han, X., et al. (2024). Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence. Cell Stem Cell . https://doi.org/10.1016/j.stem.2024.03.015 | — | — | https://doi.org/10.1016/j.stem.2024.03.015 |
| — | Stein, K. C., et al. (2022). Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis. Nature . https://www.nature.com/articles/s41586-021-04295-4 | — | — | https://www.nature.com/articles/s41586-021-04295-4 |
| — | Lopez-Otin, C. et al. "The Hallmarks of Aging." Cell (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ |
| — | Chen, L. et al. "Associations between biological ageing and the risk of, and reduced life
expectancy in, rheumatoid arthritis." The Lancet Healthy Longevity (2024). https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00220-9/fulltext | — | — | https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00220-9/fulltext |
| — | WHO ICD-11 ageing-related coding discussed in: He, Q. et al. Frontiers in Public
Health (2024). https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1451737/full | — | — | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1451737/full |
| — | He, Q. et al. "The association between accelerated biological aging and osteoarthritis." Frontiers in Public Health (2024). https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1451737/full | — | — | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1451737/full |
| — | Genovese, G. et al. "Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence." New England Journal of Medicine (2014). https://www.nejm.org/doi/full/10.1056/NEJMoa1409405 | — | — | https://www.nejm.org/doi/full/10.1056/NEJMoa1409405 |
| — | Baker, N. E. "Emerging mechanisms of cell competition." Nature Reviews Genetics (2020). https://www.nature.com/articles/s41576-020-0262-8 | — | — | https://www.nature.com/articles/s41576-020-0262-8 |
| — | Jaiswal, S. et al. "Age-related clonal hematopoiesis associated with adverse outcomes." New England Journal of Medicine (2014). https://www.nejm.org/doi/full/10.1056/NEJMoa1408617 | — | — | https://www.nejm.org/doi/full/10.1056/NEJMoa1408617 |
| — | Brunet, A., Goodell, M. A. & Rando, T. A. "Ageing and rejuvenation of tissue stem cells and their niches." Nature Reviews Molecular Cell Biology (2023). https://www.nature.com/articles/s41580-022-00510-w | — | — | https://www.nature.com/articles/s41580-022-00510-w |
| — | van Neerven, S. M. & Vermeulen, L. "Cell competition in development, homeostasis and cancer." Nature Reviews Molecular Cell Biology (2023). https://www.nature.com/articles/s41580-022-00538-y | — | — | https://www.nature.com/articles/s41580-022-00538-y |
| — | Ermolaeva, M. et al. "Cellular and epigenetic drivers of stem cell ageing." Nature Reviews Molecular Cell Biology (2018). https://www.nature.com/articles/s41580-018-0020-3 | — | — | https://www.nature.com/articles/s41580-018-0020-3 |
| — | Holmström, K. M., and Finkel, T. (2014). “Cellular mechanisms and physiological consequences of redox-dependent signalling.” Nature Reviews Molecular Cell Biology . https://www.nature.com/articles/nrm3801 | — | — | https://www.nature.com/articles/nrm3801 |
| — | Schmidlin, C. J., et al. (2019). “Redox regulation by NRF2 in aging and disease.” Free Radical Biology and Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC6588470/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6588470/ |
| — | Sies, H., and Jones, D. P. (2020). “Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.” Nature Reviews Molecular Cell Biology . https://www.nature.com/articles/s41580-020-0230-3 | — | — | https://www.nature.com/articles/s41580-020-0230-3 |
| — | Birch, J., Gil, J. "Senescence and the SASP: many therapeutic avenues." Genes &
Development (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7706700/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7706700/ |
| — | Kamat, P. et al. "Single-cell morphology encodes functional subtypes of senescence in
aging human dermal fibroblasts." Science Advances (2024). https://pmc.ncbi.nlm.nih.gov/articles/PMC11118441/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11118441/ |
| — | Wechter, N. et al. "Single-cell transcriptomic analysis uncovers diverse and dynamic
senescent cell populations." Aging (2023). https://pubmed.ncbi.nlm.nih.gov/37086265/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37086265/ |
| — | Hernandez-Segura, A. et al. "Unmasking Transcriptional Heterogeneity in Senescent
Cells." Current Biology (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5788810/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5788810/ |
| — | Saul, D. et al. "Distinct senotypes in p16- and p21-positive cells across human and
mouse aging tissues." The EMBO Journal (2025). https://pubmed.ncbi.nlm.nih.gov/41162753/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41162753/ |
| — | Settembre, C. et al. "Signals for the lysosome: a control center for cellular clearance and energy metabolism." Nature Reviews Molecular Cell Biology (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC4387238/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4387238/ |
| — | Aman, Y. et al. "Autophagy in healthy aging and disease." Nature Aging (2021). https://pmc.ncbi.nlm.nih.gov/articles/PMC8659158/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8659158/ |
| — | Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. "Epigenetic Mechanisms of Longevity and Aging." Cell (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5821249/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5821249/ |
| — | Pal, S., & Tyler, J. K. "Epigenetics and aging." Science Advances (2016). https://www.science.org/doi/10.1126/sciadv.1600584 | — | — | https://www.science.org/doi/10.1126/sciadv.1600584 |
| — | Moskalev, A. A. et al. "The role of DNA damage and repair in aging through the prism of Koch-like criteria." Ageing Research Reviews (2013). https://pubmed.ncbi.nlm.nih.gov/22353384/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22353384/ |
| — | Furman, D. et al. “Chronic inflammation in the etiology of disease across the life span.” Nature Medicine (2019). https://www.nature.com/articles/s41591-019-0675-0 | — | — | https://www.nature.com/articles/s41591-019-0675-0 |
| — | Ferrucci, L. & Fabbri, E. “Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.” Nature Reviews Cardiology (2018). https://www.nature.com/articles/s41569-018-0064-2 | — | — | https://www.nature.com/articles/s41569-018-0064-2 |
| — | Franceschi, C. et al. “Inflammaging: a new immune–metabolic viewpoint for age-related diseases.” Nature Reviews Endocrinology (2018). https://www.nature.com/articles/s41574-018-0059-4 | — | — | https://www.nature.com/articles/s41574-018-0059-4 |
| — | Terekhova, M. & Artyomov, M. “Rethinking inflammaging across human diversity.” Nature Aging (2025). https://www.nature.com/articles/s43587-025-00933-y | — | — | https://www.nature.com/articles/s43587-025-00933-y |
| — | Slavich, G. M., & Irwin, M. R. "From stress to inflammation and major depressive disorder: A social signal transduction theory of depression." Psychological Bulletin (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4006295/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4006295/ |
| — | Epel, E. S. et al. "Accelerated telomere shortening in response to life stress." Proceedings of the National Academy of Sciences (2004). https://pmc.ncbi.nlm.nih.gov/articles/PMC534658/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC534658/ |
| — | Franceschi, C. et al. "Inflammaging: a new immune-metabolic viewpoint for age-related diseases." Nature Reviews Endocrinology (2018). https://www.nature.com/articles/s41574-018-0059-4 | — | — | https://www.nature.com/articles/s41574-018-0059-4 |
| — | McEwen, B. S. "Protective and damaging effects of stress mediators." New England Journal of Medicine (1998). https://pubmed.ncbi.nlm.nih.gov/9428819/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9428819/ |
| — | Juster, R. P., McEwen, B. S., & Lupien, S. J. "Allostatic load biomarkers of chronic stress and impact on health and cognition." Neuroscience & Biobehavioral Reviews (2010). https://pubmed.ncbi.nlm.nih.gov/19822172/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19822172/ |
| — | Sato, S., et al. (2017). Circadian Reprogramming in the Liver Identifies Metabolic
Pathways of Aging. Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC7792549/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7792549/ |
| — | Chen, C.-Y., et al. (2016). Effects of aging on circadian patterns of gene expression
in the human prefrontal cortex. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC4711850/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4711850/ |
| — | Scheer, F. A. J. L., et al. (2009). Adverse metabolic and cardiovascular consequences
of circadian misalignment. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC2657421/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2657421/ |
| — | Mortimer, T., et al. (2025). Circadian clock communication during homeostasis and
ageing. Nature Reviews Molecular Cell Biology . https://www.nature.com/articles/s41580-024-00802-3 | — | — | https://www.nature.com/articles/s41580-024-00802-3 |
| — | Musiek, E. S., et al. (2013). Circadian clock proteins regulate neuronal redox
homeostasis and neurodegeneration. Journal of Clinical Investigation . https://pmc.ncbi.nlm.nih.gov/articles/PMC3859381/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3859381/ |
| — | Kondratov, R. V., et al. (2006). Early aging and age-related pathologies in mice
deficient in BMAL1, the core component of the circadian clock. Genes & Development . https://genesdev.cshlp.org/content/20/14/1868.long | — | — | https://genesdev.cshlp.org/content/20/14/1868.long |
| — | Davidson, A. J., et al. (2006). Chronic jet-lag increases mortality in aged mice. Current Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC1635966/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1635966/ |
| — | Takahashi, J. S. (2017). Transcriptional architecture of the mammalian circadian clock. Nature Reviews Genetics . https://pmc.ncbi.nlm.nih.gov/articles/PMC5501165/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5501165/ |
| — | Solanas, G., et al. (2017). Aged Stem Cells Reprogram Their Daily Rhythmic Functions
to Adapt to Stress. Cell . https://pubmed.ncbi.nlm.nih.gov/28802040/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28802040/ |
| — | Hood, S., & Amir, S. (2017). The aging clock: circadian rhythms and later life. Journal of Clinical Investigation . https://pmc.ncbi.nlm.nih.gov/articles/PMC5272178/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5272178/ |
| — | Robertson, N. A., et al. (2022). "Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects." Nature Medicine . https://www.nature.com/articles/s41591-022-01883-3 | — | — | https://www.nature.com/articles/s41591-022-01883-3 |
| — | Jakobsen, N. A., et al. (2024). "Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging." Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/38917807/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38917807/ |
| — | Jaiswal, S., et al. (2014). "Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes." New England Journal of Medicine . https://www.nejm.org/doi/full/10.1056/NEJMoa1408617 | — | — | https://www.nejm.org/doi/full/10.1056/NEJMoa1408617 |
| — | Genovese, G., et al. (2014). "Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence." New England Journal of Medicine . https://www.nejm.org/doi/full/10.1056/NEJMoa1409405 | — | — | https://www.nejm.org/doi/full/10.1056/NEJMoa1409405 |
| — | Jaiswal, S., et al. (2017). "Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease." New England Journal of Medicine . https://www.nejm.org/doi/abs/10.1056/NEJMoa1701719 | — | — | https://www.nejm.org/doi/abs/10.1056/NEJMoa1701719 |
| — | Kirkwood, T. B. L. "Systems biology of ageing and longevity." Philosophical Transactions of the Royal Society B (2005). | — | — | — |
| — | Rose, M. R. Evolutionary Biology of Aging (book). | — | — | — |
| — | Blagosklonny, M. V. "Aging is quasi-programmed: from growth to hyperfunction to death." Aging (2006). | — | — | — |
| — | Kirkwood, T. B. L. "Evolution of ageing." Nature (1977). | — | — | — |
| — | Harman, D. "Aging: a theory based on free radical and radiation chemistry." Journal of Gerontology (1956). | — | — | — |
| — | Kirkwood, T. B. L., Melov, S. "On the programmed/non-programmed nature of ageing within
the life history." Current Biology (2011). | — | — | — |
| — | Kirkwood, T. B. L., Austad, S. N. "Why do we age?" Nature (2000). | — | — | — |
| — | Heijmans, B. T., et al. (2008). "Persistent epigenetic differences associated with prenatal exposure to famine in humans." Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/18955703/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18955703/ |
| — | Huang, X., et al. (2022). "Birth weight and the risk of cardiovascular outcomes: A report from the large population-based UK Biobank cohort study." Frontiers in Cardiovascular Medicine . https://pubmed.ncbi.nlm.nih.gov/35402571/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35402571/ |
| — | Eriksson, M., et al. (2004). "The impact of birth weight on coronary heart disease morbidity and mortality in a birth cohort followed up for 85 years: a population-based study of men born in 1913." Journal of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/15554948/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15554948/ |
| — | Belsky, D. W., et al. (2022). "DunedinPACE, a DNA methylation biomarker of the pace of aging." eLife . https://pubmed.ncbi.nlm.nih.gov/35029144/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35029144/ |
| — | Cheng, M., et al. (2024). "Accelerated biological aging six decades after prenatal famine exposure." Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/38833467/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38833467/ |
| — | Aman, Y. et al. “Autophagy in healthy aging and disease.” Nature Aging (2021). https://www.nature.com/articles/s43587-021-00098-4 | — | — | https://www.nature.com/articles/s43587-021-00098-4 |
| — | Kitada, M. & Koya, D. “Autophagy in metabolic disease and ageing.” Nature Reviews Endocrinology (2021). https://www.nature.com/articles/s41574-021-00551-9 | — | — | https://www.nature.com/articles/s41574-021-00551-9 |
| — | Russell, S. J., & Kahn, C. R. "Endocrine regulation of ageing." Nature Reviews Molecular Cell Biology (2007). https://www.nature.com/articles/nrm2234 | — | — | https://www.nature.com/articles/nrm2234 |
| — | Xing, Y. et al. "Aging under endocrine hormone regulation." Frontiers in Endocrinology (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC10433899/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10433899/ |
| — | Kenyon, C. et al. "A C. elegans mutant that lives twice as long as wild type." Nature (1993). https://pubmed.ncbi.nlm.nih.gov/8247153/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8247153/ |
| — | Veldhuis, J. D. "Changes in pituitary function with ageing and implications for patient care." Nature Reviews Endocrinology (2013). https://www.nature.com/articles/nrendo.2013.38 | — | — | https://www.nature.com/articles/nrendo.2013.38 |
| — | Hannum, G. et al. "Genome-wide methylation profiles reveal quantitative views of human
aging rates." Genome Research (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC3780611/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3780611/ |
| — | Horvath, S., & Raj, K. "DNA methylation-based biomarkers and the epigenetic clock
theory of ageing." Nature Reviews Genetics (2018). https://www.nature.com/articles/s41576-018-0004-3 | — | — | https://www.nature.com/articles/s41576-018-0004-3 |
| — | Olova, N. et al. "Partial reprogramming induces a steady decline in epigenetic age
before loss of somatic identity." Aging Cell (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6351826/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6351826/ |
| — | Horvath, S. "DNA methylation age of human tissues and cell types." Genome Biology (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC4015143/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4015143/ |
| — | Lu, A. T. et al. "Universal DNA methylation age across mammalian tissues." Nature Aging (2023). https://www.nature.com/articles/s43587-023-00462-6 | — | — | https://www.nature.com/articles/s43587-023-00462-6 |
| — | Kirkwood, T. B. L., Holliday, R. "The evolution of ageing and longevity." Proceedings of the Royal Society of London B (1979). | — | — | — |
| — | Medawar, P. B. An Unsolved Problem of Biology (1952). | — | — | — |
| — | Rose, M. R. Evolutionary Biology of Aging (1991). | — | — | — |
| — | Williams, G. C. "Pleiotropy, natural selection, and the evolution of senescence." Evolution (1957). | — | — | — |
| — | Hamilton, W. D. "The moulding of senescence by natural selection." Journal of Theoretical Biology (1966). | — | — | — |
| — | Frantz, C., Stewart, K. M., & Weaver, V. M. "The extracellular matrix at a glance." Journal of Cell Science (2010). https://pmc.ncbi.nlm.nih.gov/articles/PMC2995612/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2995612/ |
| — | Wu, L., et al. (2024). "Macrophage iron dyshomeostasis promotes aging-related renal fibrosis." Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC11561705/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11561705/ |
| — | Sun, D. Y., et al. (2024). "Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence." Nature Communications . https://pmc.ncbi.nlm.nih.gov/articles/PMC10873425/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10873425/ |
| — | Ding, H., et al. (2021). "Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis." Journal of Cachexia, Sarcopenia and Muscle . https://pmc.ncbi.nlm.nih.gov/articles/PMC8200440/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8200440/ |
| — | Du, K., et al. (2024). "Aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress." Nature Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC12810195/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12810195/ |
| — | Jiang, X., Stockwell, B. R., and Conrad, M. (2021). "Ferroptosis: mechanisms, biology and role in disease." Nature Reviews Molecular Cell Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC8142022/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8142022/ |
| — | Zeidan, R. S., et al. (2021). "Iron homeostasis and organismal aging." Ageing Research Reviews . https://pmc.ncbi.nlm.nih.gov/articles/PMC8620744/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8620744/ |
| — | Moore, L. et al. “The mutational landscape of human somatic and germline cells.” Nature (2021). https://www.nature.com/articles/s41586-021-03822-7 | — | — | https://www.nature.com/articles/s41586-021-03822-7 |
| — | Schumacher, B. et al. “The central role of DNA damage in the ageing process.” Nature (2021). https://www.nature.com/articles/s41586-021-03307-7 | — | — | https://www.nature.com/articles/s41586-021-03307-7 |
| — | Villeda, S. A. et al. "Young blood reverses age-related impairments in cognitive
function and synaptic plasticity in mice." Nature Medicine (2014). https://pubmed.ncbi.nlm.nih.gov/24793238/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24793238/ |
| — | Conboy, I. M. et al. "Rejuvenation of aged progenitor cells by exposure to a young
systemic environment." Nature (2005). https://pubmed.ncbi.nlm.nih.gov/15716955/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15716955/ |
| — | Connolly, E. et al. "Loss of immune cell identity with age inferred from large atlases of single cell transcriptomes." Aging Cell (2024). https://pmc.ncbi.nlm.nih.gov/articles/PMC11634704/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11634704/ |
| — | Shrestha, S. et al. "Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress." Science Advances (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC9534504/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9534504/ |
| — | Olova, N. et al. "Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity." Aging Cell (2019). https://pubmed.ncbi.nlm.nih.gov/30450724/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30450724/ |
| — | Lu, Y. et al. "Reprogramming to recover youthful epigenetic information and restore vision." Nature (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7752134/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7752134/ |
| — | Angelidis, I. et al. "An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics." Nature Communications (2019). https://www.nature.com/articles/s41467-019-08831-9 | — | — | https://www.nature.com/articles/s41467-019-08831-9 |
| — | Moskalev, A. A. et al. "The role of DNA damage and repair in aging through the prism of Koch-like criteria." Ageing Res Rev (2013). https://pubmed.ncbi.nlm.nih.gov/22353384/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22353384/ |
| — | Carmona-Gutierrez, D. et al. “The crucial impact of lysosomes in aging and longevity.” Ageing Research Reviews (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5081277/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5081277/ |
| — | Lawrence, R. E. & Zoncu, R. “The lysosome as a cellular centre for signalling, metabolism and quality control.” Nature Cell Biology (2019). https://www.nature.com/articles/s41556-018-0244-7 | — | — | https://www.nature.com/articles/s41556-018-0244-7 |
| — | Nixon, R. A. & Rubinsztein, D. C. “Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases.” Nature Reviews Molecular Cell Biology (2024). https://www.nature.com/articles/s41580-024-00757-5 | — | — | https://www.nature.com/articles/s41580-024-00757-5 |
| — | Picca, A. et al. “Mitophagy in human health, ageing and disease.” Nature Metabolism (2023). https://www.nature.com/articles/s42255-023-00930-8 | — | — | https://www.nature.com/articles/s42255-023-00930-8 |
| — | Guilbaud, E., Sarosiek, K. A. & Galluzzi, L. “Inflammation and mitophagy are mitochondrial checkpoints to aging.” Nature Communications (2024). https://www.nature.com/articles/s41467-024-47840-1 | — | — | https://www.nature.com/articles/s41467-024-47840-1 |
| — | Palikaras, K., Lionaki, E. & Tavernarakis, N. “Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.” Nature Cell Biology (2018). https://www.nature.com/articles/s41556-018-0176-2 | — | — | https://www.nature.com/articles/s41556-018-0176-2 |
| — | Martinez-Jimenez, C. P., et al. (2017). “Aging increases cell-to-cell transcriptional variability upon immune stimulation.” Science . https://pmc.ncbi.nlm.nih.gov/articles/PMC5405862/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5405862/ |
| — | Sen, P., et al. (2023). “Spurious intragenic transcription is a feature of mammalian cellular senescence and tissue aging.” Nature Aging . https://www.nature.com/articles/s43587-023-00384-3 | — | — | https://www.nature.com/articles/s43587-023-00384-3 |
| — | Hernando-Herraez, I., et al. (2019). “Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells.” Nature Communications . https://www.nature.com/articles/s41467-019-12293-4 | — | — | https://www.nature.com/articles/s41467-019-12293-4 |
| — | Debès, C., et al. (2023). “Ageing-associated changes in transcriptional elongation influence longevity.” Nature . https://www.nature.com/articles/s41586-023-05922-y | — | — | https://www.nature.com/articles/s41586-023-05922-y |
| — | Gyenis, A., et al. (2023). “Genome-wide RNA polymerase stalling shapes the transcriptome during aging.” Nature Genetics . https://www.nature.com/articles/s41588-022-01279-6 | — | — | https://www.nature.com/articles/s41588-022-01279-6 |
| — | Bahar, R., et al. (2006). “Increased cell-to-cell variation in gene expression in ageing mouse heart.” Nature . https://www.nature.com/articles/nature04844 | — | — | https://www.nature.com/articles/nature04844 |
| — | Ibañez-Solé, O., et al. (2022). “Lack of evidence for increased transcriptional noise in aged tissues.” eLife . https://elifesciences.org/articles/80380 | — | — | https://elifesciences.org/articles/80380 |
| — | Angelidis, I., et al. (2019). “An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics.” Nature Communications . https://www.nature.com/articles/s41467-019-08831-9 | — | — | https://www.nature.com/articles/s41467-019-08831-9 |
| — | Sarnoski, E. A., et al. (2017). “Noise reduction as an emergent property of single-cell aging.” Nature Communications . https://www.nature.com/articles/s41467-017-00752-9 | — | — | https://www.nature.com/articles/s41467-017-00752-9 |
| — | Vermulst, M., et al. (2015). “Transcription errors induce proteotoxic stress and shorten cellular lifespan.” Nature Communications . https://www.nature.com/articles/ncomms9065 | — | — | https://www.nature.com/articles/ncomms9065 |
| — | McCauley, B. S., et al. (2021). “Altered chromatin states drive cryptic transcription in aging mammalian stem cells.” Nature Aging . https://www.nature.com/articles/s43587-021-00091-x | — | — | https://www.nature.com/articles/s43587-021-00091-x |
| — | The Tabula Muris Consortium. (2020). “A single-cell transcriptomic atlas characterizes ageing tissues in the mouse.” Nature . https://www.nature.com/articles/s41586-020-2496-1 | — | — | https://www.nature.com/articles/s41586-020-2496-1 |
| — | Marschallinger, J., et al. (2020). Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nature Neuroscience . https://www.nature.com/articles/s41593-019-0566-1 | — | — | https://www.nature.com/articles/s41593-019-0566-1 |
| — | Banks, W. A., Reed, M. J., Logsdon, A. F., et al. (2021). Healthy aging and the blood-brain barrier. Nature Aging . https://www.nature.com/articles/s43587-021-00043-5 | — | — | https://www.nature.com/articles/s43587-021-00043-5 |
| — | Heneka, M. T., et al. (2015). Neuroinflammation in Alzheimer's disease. The Lancet Neurology . https://pubmed.ncbi.nlm.nih.gov/25792098/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25792098/ |
| — | Clarke, L. E., et al. (2018). Normal aging induces A1-like astrocyte reactivity. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC5828643/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5828643/ |
| — | Zlokovic, B. V. (2011). Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nature Reviews Neuroscience . https://pmc.ncbi.nlm.nih.gov/articles/PMC4036520/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4036520/ |
| — | Franceschi, C., et al. (2018). Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology . https://www.nature.com/articles/s41574-018-0059-4 | — | — | https://www.nature.com/articles/s41574-018-0059-4 |
| — | Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018). Disease-associated microglia: a universal immune sensor of neurodegeneration. Cell . https://pubmed.ncbi.nlm.nih.gov/29775591/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29775591/ |
| — | Heneka, M. T., Golenbock, D. T., & Latz, E. (2015). Innate immunity in Alzheimer's disease. Nature Immunology . https://pubmed.ncbi.nlm.nih.gov/25689443/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25689443/ |
| — | Ximerakis, M., et al. (2019). Single-cell transcriptomic profiling of the aging mouse brain. Nature Neuroscience . https://www.nature.com/articles/s41593-019-0491-3 | — | — | https://www.nature.com/articles/s41593-019-0491-3 |
| — | Sadaie, M., et al. (2013). “Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.” Genes & Development . https://pmc.ncbi.nlm.nih.gov/articles/PMC3759696/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3759696/ |
| — | Eriksson, M., et al. (2003). “Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome.” Nature . https://pubmed.ncbi.nlm.nih.gov/12714972/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12714972/ |
| — | Scaffidi, P., & Misteli, T. (2006). “Lamin A-dependent nuclear defects in human aging.” Science . https://pmc.ncbi.nlm.nih.gov/articles/PMC1855250/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1855250/ |
| — | Goldman, R. D., et al. (2004). “Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome.” Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC428455/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC428455/ |
| — | Shevelyov, Y. Y., & Ulianov, S. V. (2019). “The Nuclear Lamina as an Organizer of Chromosome Architecture.” Cells . https://pmc.ncbi.nlm.nih.gov/articles/PMC6406483/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6406483/ |
| — | Dou, Z., et al. (2017). “Cytoplasmic chromatin triggers inflammation in senescence and cancer.” Nature . https://pmc.ncbi.nlm.nih.gov/articles/PMC5850938/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5850938/ |
| — | Dou, Z., et al. (2015). “Autophagy mediates degradation of nuclear lamina.” Nature . https://pmc.ncbi.nlm.nih.gov/articles/PMC4824414/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4824414/ |
| — | Kristiani, L., et al. (2020). “Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation.” Cells . https://pmc.ncbi.nlm.nih.gov/articles/PMC7140666/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7140666/ |
| — | Shimi, T., et al. (2011). “The role of nuclear lamin B1 in cell proliferation and senescence.” Genes & Development . https://pmc.ncbi.nlm.nih.gov/articles/PMC3248680/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3248680/ |
| — | Martins, F., et al. (2020). “Nuclear envelope dysfunction and its contribution to the aging process.” Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC7253059/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7253059/ |
| — | Legakis, J. E., et al. (2002). "Peroxisome senescence in human fibroblasts." Molecular Biology of the Cell . https://pubmed.ncbi.nlm.nih.gov/12475949/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12475949/ |
| — | Dolese, D. A., et al. (2022). "Degradative tubular lysosomes link pexophagy to starvation and early aging in C. elegans ." Autophagy . https://pubmed.ncbi.nlm.nih.gov/34689720/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34689720/ |
| — | Cipolla, C. M., and Lodhi, I. J. (2017). "Peroxisomal dysfunction in age-related diseases." Trends in Endocrinology & Metabolism . https://pubmed.ncbi.nlm.nih.gov/28063767/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28063767/ |
| — | Klinge, S., & Woolford, J. L. Jr. "Ribosome assembly coming into focus." Nature Reviews Molecular Cell Biology (2019). https://www.nature.com/articles/s41580-018-0078-y | — | — | https://www.nature.com/articles/s41580-018-0078-y |
| — | Lessard, F. et al. "Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway." Nature Cell Biology (2018). https://www.nature.com/articles/s41556-018-0127-y | — | — | https://www.nature.com/articles/s41556-018-0127-y |
| — | Xiao, F.-H. et al. "ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity." Science Advances (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC9045719/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9045719/ |
| — | Buchwalter, A., & Hetzer, M. W. "Nucleolar expansion and elevated protein translation in premature aging." Nature Communications (2017). https://www.nature.com/articles/s41467-017-00322-z | — | — | https://www.nature.com/articles/s41467-017-00322-z |
| — | Tiku, V. et al. "Small nucleoli are a cellular hallmark of longevity." Nature Communications (2017). https://www.nature.com/articles/ncomms16083 | — | — | https://www.nature.com/articles/ncomms16083 |
| — | Anisimova, A. S. et al. "Multifaceted deregulation of gene expression and protein synthesis with age." Proceedings of the National Academy of Sciences (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7354943/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7354943/ |
| — | Gutierrez, J. I., & Tyler, J. K. "A mortality timer based on nucleolar size triggers nucleolar integrity loss and catastrophic genomic instability." Nature Aging (2024). https://www.nature.com/articles/s43587-024-00754-5 | — | — | https://www.nature.com/articles/s43587-024-00754-5 |
| — | Kwon, S. M. et al. "Global spliceosome activity regulates entry into cellular senescence." FASEB Journal (2021). https://pubmed.ncbi.nlm.nih.gov/33337569/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33337569/ |
| — | Wang, K. et al. "Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases." Scientific Reports (2018). https://pmc.ncbi.nlm.nih.gov/articles/PMC6053367/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6053367/ |
| — | Harries, L. W. et al. "Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing." Aging Cell (2011). https://pmc.ncbi.nlm.nih.gov/articles/PMC3173580/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3173580/ |
| — | Garcia-Ruiz, S. et al. "Splicing accuracy varies across human introns, tissues, age and disease." Nature Communications (2025). https://pmc.ncbi.nlm.nih.gov/articles/PMC11772838/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11772838/ |
| — | Yao, J. et al. "Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence." Aging Cell (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7744961/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7744961/ |
| — | Adusumalli, S. et al. "Increased intron retention is a post-transcriptional signature associated with progressive aging and Alzheimer's disease." Aging Cell (2019). https://pubmed.ncbi.nlm.nih.gov/30868713/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30868713/ |
| — | Debes, C. et al. "Ageing-associated changes in transcriptional elongation influence longevity." Nature (2023). https://www.nature.com/articles/s41586-023-05922-y | — | — | https://www.nature.com/articles/s41586-023-05922-y |
| — | Hanahan, D. "Hallmarks of Cancer: New Dimensions." Cancer Discovery (2022). https://pubmed.ncbi.nlm.nih.gov/35022204/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35022204/ |
| — | Campisi, J. "Aging, cellular senescence, and cancer." Annual Review of Physiology (2013). https://pubmed.ncbi.nlm.nih.gov/23140366/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23140366/ |
| — | Demaria, M. et al. "Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer
Relapse." Cancer Discovery (2017). https://aacrjournals.org/cancerdiscovery/article/7/2/165/6158/Cellular-Senescence-Promotes-Adverse-Effects-of | — | — | https://aacrjournals.org/cancerdiscovery/article/7/2/165/6158/Cellular-Senescence-Promotes-Adverse-Effects-of |
| — | Austad, S. N., & Fischer, K. E. "Sex Differences in Lifespan." Cell Metabolism (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC4932837/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4932837/ |
| — | Lemaitre, J.-F. et al. "Sex differences in adult lifespan and aging rates of mortality across wild mammals." Proceedings of the National Academy of Sciences (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7165438/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7165438/ |
| — | Mauvais-Jarvis, F. et al. "Sex and gender: modifiers of health, disease, and medicine." The Lancet (2020). https://pubmed.ncbi.nlm.nih.gov/32828189/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32828189/ |
| — | Horvath, S. et al. "An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease." Genome Biology (2016). https://pubmed.ncbi.nlm.nih.gov/27511193/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27511193/ |
| — | Marquez, E. J. et al. "Sexual-dimorphism in human immune system aging." Nature Communications (2020). https://www.nature.com/articles/s41467-020-14396-9 | — | — | https://www.nature.com/articles/s41467-020-14396-9 |
| — | Phyo, A. Z. Z. et al. "Sex differences in biological aging and the association with clinical measures in older adults." GeroScience (2024). https://pmc.ncbi.nlm.nih.gov/articles/PMC10828143/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10828143/ |
| — | Luecken, M. D. et al. "Benchmarking atlas-level data integration in single-cell genomics." Nature Methods (2022). https://www.nature.com/articles/s41592-021-01336-8 | — | — | https://www.nature.com/articles/s41592-021-01336-8 |
| — | Tabula Muris Consortium. "A single-cell transcriptomic atlas characterizes ageing tissues in the mouse." Nature (2020). https://www.nature.com/articles/s41586-020-2496-1 | — | — | https://www.nature.com/articles/s41586-020-2496-1 |
| — | Jones, O. R. et al. "Diversity of ageing across the tree of life." Nature (2014). | — | — | — |
| — | Valenzuela-Sanchez, A. et al. "Variable rate of ageing within species." (2023). https://discovery.ucl.ac.uk/id/eprint/10172184/3/Cunningham_Manuscript%2030-03-2022_submitted.pdf | — | — | https://discovery.ucl.ac.uk/id/eprint/10172184/3/Cunningham_Manuscript%2030-03-2022_submitted.pdf |
| — | Lemaitre, J. F., Gaillard, J. M. "Reproductive senescence: new perspectives in the wild." Biological Reviews (2017). https://pubmed.ncbi.nlm.nih.gov/28374548/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28374548/ |
| — | Morrison, S. J., Spradling, A. C. "Stem cell niches: mechanisms that promote stem cell
maintenance throughout life." Cell (2008). https://www.cell.com/fulltext/S0092-8674(08)00139-6 | — | — | https://www.cell.com/fulltext/S0092-8674(08)00139-6 |
| — | Conboy, I. M., Rando, T. A. "Aging, stem cells and tissue regeneration: lessons from muscle." Cell Stem Cell (2012). https://www.tandfonline.com/doi/abs/10.4161/cc.4.3.1518 | — | — | https://www.tandfonline.com/doi/abs/10.4161/cc.4.3.1518 |
| — | Ye, Q. et al. “Telomere length and chronological age across the human lifespan: a systematic review and meta-analysis.” Ageing Research Reviews (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC10529491/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10529491/ |
| — | Rossiello, F. et al. “Telomere dysfunction in ageing and age-related diseases.” Nature Cell Biology (2022). https://www.nature.com/articles/s41556-022-00842-x | — | — | https://www.nature.com/articles/s41556-022-00842-x |
| — | Savage, S. A. “Beginning at the ends: telomeres and human disease.” F1000Research (2018). https://pmc.ncbi.nlm.nih.gov/articles/PMC5931273/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5931273/ |
| — | Demanelis, K. et al. “Determinants of telomere length across human tissues.” Science (2020). https://www.science.org/doi/10.1126/science.aaz6876 | — | — | https://www.science.org/doi/10.1126/science.aaz6876 |
| — | Thevaranjan, N., et al. (2017). Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction. Cell Host & Microbe . https://pubmed.ncbi.nlm.nih.gov/28407483/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28407483/ |
| — | Claesson, M. J., et al. (2012). Gut microbiota composition correlates with diet and health in the elderly. Nature . https://www.nature.com/articles/nature11319 | — | — | https://www.nature.com/articles/nature11319 |
| — | O'Toole, P. W., & Jeffery, I. B. (2015). Gut microbiota and aging. Science . https://pubmed.ncbi.nlm.nih.gov/26785481/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26785481/ |
| — | Galkin, F., et al. (2021). The aging gut microbiome and its impact on host immunity. Genes & Immunity . https://www.nature.com/articles/s41435-021-00126-8 | — | — | https://www.nature.com/articles/s41435-021-00126-8 |
| — | Fransen, F., et al. (2017). Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice. Frontiers in Immunology . https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01385/full | — | — | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01385/full |
| — | Wilmanski, T., et al. (2021). Gut microbiome pattern reflects healthy ageing and predicts survival in humans. Nature Metabolism . https://www.nature.com/articles/s42255-021-00348-0 | — | — | https://www.nature.com/articles/s42255-021-00348-0 |
| — | Sato, Y., et al. (2021). Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. Nature . https://www.nature.com/articles/s41586-021-03832-5 | — | — | https://www.nature.com/articles/s41586-021-03832-5 |
| — | Jeffery, I. B., et al. (2016). Composition and temporal stability of the gut microbiota in older persons. The ISME Journal . https://www.nature.com/articles/ismej201588 | — | — | https://www.nature.com/articles/ismej201588 |
| — | Wu, L., et al. (2023). Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures. Nature Aging . https://www.nature.com/articles/s43587-023-00389-y | — | — | https://www.nature.com/articles/s43587-023-00389-y |
| — | De Cecco, M. et al. "L1 drives IFN in senescent cells and promotes age-associated
inflammation." Nature (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6519963/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6519963/ |
| — | LaRocca, T. J. et al. "Repetitive elements as a transcriptomic marker of aging:
Evidence in multiple datasets and models." Aging Cell (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7412685/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7412685/ |
| — | Van Meter, M. et al. "SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but
this repression fails with stress and age." Nature Communications (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4185372/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4185372/ |
| — | Wood, J. G. et al. "Chromatin-modifying genetic interventions suppress age-associated
transposable element activation and extend life span in Drosophila." Proceedings of the
National Academy of Sciences (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5056045/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5056045/ |
| — | Li, W. et al. "Activation of transposable elements during aging and neuronal decline
in Drosophila." Nature Neuroscience (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC3821974/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3821974/ |
| — | Kirkwood, T. B. L., & Holliday, R. "The evolution of ageing and longevity." Proceedings of the Royal Society of London. Series B, Biological Sciences (1979). https://pubmed.ncbi.nlm.nih.gov/42059/ | — | — | https://pubmed.ncbi.nlm.nih.gov/42059/ |
| — | Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., et al. (2006). Expert consensus document on arterial stiffness: methodological issues and clinical applications. European Heart Journal . https://pubmed.ncbi.nlm.nih.gov/17000623/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17000623/ |
| — | Sequi-Dominguez, I., Cavero-Redondo, I., Alvarez-Bueno, C., Pozuelo-Carrascosa, D. P., Nunez de Arenas-Arroyo, S., & Martinez-Vizcaino, V. (2020). Accuracy of pulse wave velocity predicting cardiovascular and all-cause mortality. A systematic review and meta-analysis. Journal of Clinical Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC7408852/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7408852/ |
| — | Safar, M. E., Levy, B. I., & Struijker-Boudier, H. (2003). Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation . https://pubmed.ncbi.nlm.nih.gov/12538439/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12538439/ |
| — | O'Rourke, M. F., & Hashimoto, J. (2007). Mechanical factors in arterial aging: a clinical perspective. Journal of the American College of Cardiology . https://pubmed.ncbi.nlm.nih.gov/17692727/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17692727/ |
| — | Mitchell, G. F. (2014). Arterial stiffness and hypertension: chicken or egg? Hypertension . https://pubmed.ncbi.nlm.nih.gov/24799614/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24799614/ |
| — | Vlachopoulos, C., Aznaouridis, K., & Stefanadis, C. (2010). Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. Journal of the American College of Cardiology . https://pubmed.ncbi.nlm.nih.gov/20117448/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20117448/ |
| — | Mitchell, G. F., Parise, H., Benjamin, E. J., Larson, M. G., Keyes, M. J., Vita, J. A., Vasan, R. S., & Levy, D. (2004). Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension . https://pubmed.ncbi.nlm.nih.gov/15123572/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15123572/ |
| — | Sun, Z. (2015). Aging, arterial stiffness, and hypertension. Hypertension . https://pubmed.ncbi.nlm.nih.gov/25941331/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25941331/ |
| — | Nilsson, P. M., Boutouyrie, P., & Laurent, S. (2009). Vascular aging: a tale of EVA and ADAM in cardiovascular risk assessment and prevention. Hypertension . https://pubmed.ncbi.nlm.nih.gov/19652083/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19652083/ |
| — | North, B. J., & Sinclair, D. A. (2012). The intersection between aging and cardiovascular disease. Circulation Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC3366686/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3366686/ |
| — | Townsend, R. R., Wilkinson, I. B., Schiffrin, E. L., Avolio, A. P., Chirinos, J. A., Cockcroft, J. R., et al. (2015). Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association. Hypertension . https://pubmed.ncbi.nlm.nih.gov/26160955/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26160955/ |
| — | Zhong, Q., Hu, M. J., Cui, Y. J., Liang, L., Zhou, M. M., Yang, Y. W., & Huang, F. (2018). Carotid-femoral pulse wave velocity in the prediction of cardiovascular events and mortality: an updated systematic review and meta-analysis. Angiology . https://pubmed.ncbi.nlm.nih.gov/29172654/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29172654/ |
| — | Bland, J. M., & Altman, D. G. (1986). Statistical methods for assessing agreement between two methods of clinical measurement. The Lancet , 327(8476), 307-310. https://pubmed.ncbi.nlm.nih.gov/2868172/ | — | — | https://pubmed.ncbi.nlm.nih.gov/2868172/ |
| — | Jones, G. R. D., & Aarsand, A. K. (2024). A new concept for reference change values—regression to the population mean. Clinical Chemistry , 70(8), 1076-1084. https://academic.oup.com/clinchem/article/70/8/1076/7679834 | — | — | https://academic.oup.com/clinchem/article/70/8/1076/7679834 |
| — | Jones, G. R. D., et al. (2025). Estimating reference change values using routine patient data: a novel pathology database approach. Clinical Chemistry , 71(2), 307-317. https://academic.oup.com/clinchem/article/71/2/307/7874401 | — | — | https://academic.oup.com/clinchem/article/71/2/307/7874401 |
| — | Hardikar, S., et al. (2014). Intraindividual variability over time in plasma biomarkers of inflammation and effects of long-term storage. Cancer Causes & Control , 25(8), 969-976. https://pmc.ncbi.nlm.nih.gov/articles/PMC4169209/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4169209/ |
| — | Lacher, D. A., Hughes, J. P., & Carroll, M. D. (2005). Estimate of biological variation of laboratory analytes based on the Third National Health and Nutrition Examination Survey. Clinical Chemistry , 51(2), 450-452. https://pubmed.ncbi.nlm.nih.gov/15681571/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15681571/ |
| — | Moqri, M., Herzog, C., Poganik, J. R., et al. (2024). Validation of biomarkers of aging. Nature Medicine , 30(2), 360-372. https://www.nature.com/articles/s41591-023-02784-9 | — | — | https://www.nature.com/articles/s41591-023-02784-9 |
| — | Mayeux, R. (2004). Biomarkers: potential uses and limitations. NeuroRx , 1(2), 182-188. https://pmc.ncbi.nlm.nih.gov/articles/PMC534923/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC534923/ |
| — | Guralnik, J. M., et al. (2004). Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia . Blood . https://pubmed.ncbi.nlm.nih.gov/15238427/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15238427/ |
| — | Levine, M. E., et al. (2018). An epigenetic biomarker of aging for lifespan and healthspan . Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ |
| — | Leng, S. X., et al. (2005). Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older women . Experimental Gerontology . https://pubmed.ncbi.nlm.nih.gov/16183235/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16183235/ |
| — | Herklotz, R., et al. (2020). Reference intervals for platelet counts in the elderly: results from the prospective SENIORLAB study . Journal of Clinical Medicine . https://pubmed.ncbi.nlm.nih.gov/32899382/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32899382/ |
| — | Kwon, D., & Belsky, D. W. (2021). A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge . GeroScience . https://pubmed.ncbi.nlm.nih.gov/34725754/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34725754/ |
| — | Patel, K. V., et al. (2010). Red cell distribution width and mortality in older adults: a meta-analysis . The Journals of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/19880817/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19880817/ |
| — | Pyrkov, T. V., et al. (2021). Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit . Nature Communications . https://pubmed.ncbi.nlm.nih.gov/34035236/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34035236/ |
| — | Fest, J., et al. (2019). The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: the Rotterdam Study . European Journal of Epidemiology . https://pubmed.ncbi.nlm.nih.gov/30569368/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30569368/ |
| — | Franklin, S. S., Gustin, W., Wong, N. D., Larson, M. G., Weber, M. A., Kannel, W. B., & Levy, D. (1997). Hemodynamic patterns of age-related changes in blood pressure: the Framingham Heart Study. Circulation . https://doi.org/10.1161/01.CIR.96.1.308 | — | — | https://doi.org/10.1161/01.CIR.96.1.308 |
| — | Vaccarino, V., Holford, T. R., & Krumholz, H. M. (2000). Pulse pressure and risk for myocardial infarction and heart failure in the elderly. Journal of the American College of Cardiology . https://pubmed.ncbi.nlm.nih.gov/10898424/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10898424/ |
| — | Kikuya, M., Asayama, K., & Ohkubo, T. (2019). Blood pressure variability and arterial stiffness parameters derived from ambulatory blood pressure monitoring. Kardiologia Polska . https://pubmed.ncbi.nlm.nih.gov/31125026/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31125026/ |
| — | Sequi-Dominguez, I., Cavero-Redondo, I., Alvarez-Bueno, C., Pozuelo-Carrascosa, D. P., Nunez de Arenas-Arroyo, S., & Martinez-Vizcaino, V. (2020). Accuracy of pulse wave velocity predicting cardiovascular and all-cause mortality. A systematic review and meta-analysis. Journal of Clinical Medicine . https://pubmed.ncbi.nlm.nih.gov/32630671/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32630671/ |
| — | O'Rourke, M. F., & Nichols, W. W. (2005). Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension. Hypertension . https://pubmed.ncbi.nlm.nih.gov/15699456/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15699456/ |
| — | Lu, Y., Kiechl, S. J., Wang, J., Xu, Q., Kiechl, S., Pechlaner, R., et al. (2023). Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participants. EBioMedicine . https://pubmed.ncbi.nlm.nih.gov/37229905/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37229905/ |
| — | Avolio, A. (2013). Arterial stiffness. Pulse . https://pubmed.ncbi.nlm.nih.gov/26587425/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26587425/ |
| — | Brach, J. S., et al. (2023). The Health, Aging, and Body Composition (Health ABC)
Study-Ground-Breaking Science for 25 Years and Counting. Journal of Gerontology Series A . https://pubmed.ncbi.nlm.nih.gov/37431156/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37431156/ |
| — | Lee, C. G., et al. (2017). Body Composition Remodeling and Mortality: The Health Aging
and Body Composition Study. Journals of Gerontology Series A , 72(4), 513-519. https://pubmed.ncbi.nlm.nih.gov/27567109/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27567109/ |
| — | Donini, L. M., et al. (2022). Definition and Diagnostic Criteria for Sarcopenic
Obesity: ESPEN and EASO Consensus Statement. Obesity Facts , 15(3), 321-335. https://pmc.ncbi.nlm.nih.gov/articles/PMC9210010/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9210010/ |
| — | Woo, J., Leung, J., & Kwok, T. (2007). BMI, body composition, and physical
functioning in older adults. Obesity , 15(7), 1886-1894. https://pubmed.ncbi.nlm.nih.gov/17636108/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17636108/ |
| — | Miljkovic, I., et al. (2021). Body Composition by Computed Tomography vs Dual-Energy
X-ray Absorptiometry: Long-Term Prediction of All-Cause Mortality in the Health ABC Cohort. Journals of Gerontology Series A , 76(6), 1042-1049. https://pubmed.ncbi.nlm.nih.gov/33835154/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33835154/ |
| — | Maeyens, L. T., Nelson, J. F., & Zhao, S. (2026). Visceral adiposity, metabolic
health and aging. Nature Aging . https://pubmed.ncbi.nlm.nih.gov/41714834/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41714834/ |
| — | Cole, J. H., & Franke, K. (2017). Predicting age using neuroimaging: innovative brain ageing biomarkers . Trends in Neurosciences . https://doi.org/10.1016/j.tins.2017.10.001 | — | — | https://doi.org/10.1016/j.tins.2017.10.001 |
| — | Kaufmann, T., et al. (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain . Nature Neuroscience . https://www.nature.com/articles/s41593-019-0471-7 | — | — | https://www.nature.com/articles/s41593-019-0471-7 |
| — | Cole, J. H., et al. (2018). Brain age predicts mortality . Molecular Psychiatry . https://www.nature.com/articles/mp201762 | — | — | https://www.nature.com/articles/mp201762 |
| — | Mandsager, K., Harb, S., Cremer, P., Phelan, D., Nissen, S. E., & Jaber, W.
(2018). Association of cardiorespiratory fitness with long-term mortality among adults undergoing
exercise treadmill testing. JAMA Network Open , 1(6), e183605. https://pubmed.ncbi.nlm.nih.gov/30646252/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30646252/ |
| — | Kodama, S., Saito, K., Tanaka, S., et al. (2009). Cardiorespiratory fitness as a
quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women:
a meta-analysis. JAMA , 301(19), 2024-2035. https://pubmed.ncbi.nlm.nih.gov/19454641/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19454641/ |
| — | Fleg, J. L., Morrell, C. H., Bos, A. G., et al. (2005). Accelerated longitudinal
decline of aerobic capacity in healthy older adults. Circulation , 112(5), 674-682. https://pubmed.ncbi.nlm.nih.gov/16043637/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16043637/ |
| — | Loe, H., Rognmo, O., Saltin, B., & Wisloff, U. (2013). Aerobic capacity reference
data in 3816 healthy men and women 20-90 years. PLoS ONE , 8(5), e64319. https://pubmed.ncbi.nlm.nih.gov/23691196/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23691196/ |
| — | Ross, R., Blair, S. N., Arena, R., et al. (2016). Importance of assessing
cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign. Circulation , 134(24), e653-e699. https://pubmed.ncbi.nlm.nih.gov/27881567/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27881567/ |
| — | Kaminsky, L. A., Arena, R., & Myers, J. (2015). Reference standards for
cardiorespiratory fitness measured with cardiopulmonary exercise testing: data from the Fitness
Registry and the Importance of Exercise National Database. Mayo Clinic Proceedings , 90(11),
1515-1523. https://pubmed.ncbi.nlm.nih.gov/26455884/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26455884/ |
| — | Ferrucci, L., & Fabbri, E. (2018). Inflammation: a key to understanding age-related
diseases. Journal of Internal Medicine , 283(6), 573-591. https://pmc.ncbi.nlm.nih.gov/articles/PMC6882952/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6882952/ |
| — | Fried, L. P., Tangen, C. M., Walston, J., et al. (2001). Frailty in older adults: evidence
for a phenotype. The Journals of Gerontology: Series A , 56(3), M146-M157. https://academic.oup.com/biomedgerontology/article/56/3/M146/545770 | — | — | https://academic.oup.com/biomedgerontology/article/56/3/M146/545770 |
| — | Aging Biomarker Consortium, Bao, H., Cao, J., Chen, M., et al. (2023). Biomarkers of aging. Science China Life Sciences , 66(5), 893-1066. https://pmc.ncbi.nlm.nih.gov/articles/PMC10115486/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10115486/ |
| — | Rantanen, T., Guralnik, J. M., Foley, D., et al. (1999). Midlife hand grip strength as a
predictor of old age disability. JAMA , 281(6), 558-560. https://jamanetwork.com/journals/jama/fullarticle/188699 | — | — | https://jamanetwork.com/journals/jama/fullarticle/188699 |
| — | Cesari, M., Kritchevsky, S. B., Penninx, B. W., et al. (2009). Prognostic value of usual
gait speed in well-functioning older people. JAMA , 301(17), 1782-1790. https://pmc.ncbi.nlm.nih.gov/articles/PMC2676397/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2676397/ |
| — | Kennedy, B. K., Berger, S. L., Brunet, A., et al. (2014). Geroscience: linking aging to
chronic disease. Cell , 159(4), 709-713. https://pmc.ncbi.nlm.nih.gov/articles/PMC4292892/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4292892/ |
| — | Horvath, S., & Raj, K. (2018). DNA methylation-based biomarkers and the epigenetic
clock theory of ageing. Nature Reviews Genetics , 19(2), 101-113. https://www.nature.com/articles/nrg.2017.115 | — | — | https://www.nature.com/articles/nrg.2017.115 |
| — | Levine, M. E., Lu, A. T., Quach, A., et al. (2018). An epigenetic biomarker of aging for
lifespan and healthspan. Aging (Albany NY) , 10(4), 573-591. https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ |
| — | Hartmann, A., Hartmann, C., Secci, R., et al. (2021). Ranking biomarkers of aging by
citation profiling and effort scoring. Frontiers in Genetics , 12, 686320. https://pmc.ncbi.nlm.nih.gov/articles/PMC8176216/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8176216/ |
| — | Perri, G., Poganik, J. R., Levine, M. E., et al. (2025). An expert consensus statement on
biomarkers of aging for use in intervention studies. Journal of Gerontology: Biological Sciences , 80(5), glae297. https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 | — | — | https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 |
| — | Poganik, J. R., Perri, G., Belsky, D. W., et al. (2024). Framework to standardize
biomarkers of aging and accelerate clinical translation. Nature Aging . https://www.nature.com/articles/s43587-024-00550-7 | — | — | https://www.nature.com/articles/s43587-024-00550-7 |
| — | Sanderson-Cimino, M. E., et al. (2025). Practice effects persist over two decades of cognitive testing: Implications for longitudinal research . Archives of Clinical Neuropsychology . https://pubmed.ncbi.nlm.nih.gov/40585136/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40585136/ |
| — | Weintraub, S., et al. (2013). Cognition assessment using the NIH Toolbox . Neurology . https://pubmed.ncbi.nlm.nih.gov/23479546/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23479546/ |
| — | Deary, I. J., et al. (2009). Age-associated cognitive decline . British Medical Bulletin . https://doi.org/10.1093/bmb/ldp033 | — | — | https://doi.org/10.1093/bmb/ldp033 |
| — | Ganguli, M., et al. (2010). Age and education effects and norms on a cognitive test battery from a population-based cohort: The Monongahela-Youghiogheny Healthy Aging Team . Aging & Mental Health . https://pmc.ncbi.nlm.nih.gov/articles/PMC2828360/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2828360/ |
| — | Wilson, R. S., et al. (2007). Terminal cognitive decline: accelerated loss of cognition in the last years of life . Neurology . https://pubmed.ncbi.nlm.nih.gov/17327212/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17327212/ |
| — | Lavery, L. L., et al. (2009). Cognitive decline and mortality in a community-based cohort: the Monongahela Valley Independent Elders Survey . Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC2768614/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2768614/ |
| — | Searle, S. D., et al. (2015). A proposed panel of biomarkers of healthy ageing . BMC Medicine . https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0470-9 | — | — | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0470-9 |
| — | Stern, Y. (2009). Cognitive reserve . Neuropsychologia . https://pmc.ncbi.nlm.nih.gov/articles/PMC2739591/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2739591/ |
| — | Belsky, D. W., et al. (2018). Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing? American Journal of Epidemiology . https://doi.org/10.1093/aje/kwx346 | — | — | https://doi.org/10.1093/aje/kwx346 |
| — | Nakamura, E., and Miyao, K. (2007). A method for identifying biomarkers of aging and constructing an index of biological age in humans. Journal of Gerontology: Medical Sciences . https://doi.org/10.1093/gerona/62.10.1096 | — | — | https://doi.org/10.1093/gerona/62.10.1096 |
| — | Belsky, D. W., et al. (2015). Quantification of biological aging in young adults. Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1506264112 | — | — | https://doi.org/10.1073/pnas.1506264112 |
| — | Klemera, P., and Doubal, S. (2006). A new approach to the concept and computation of biological age. Mechanisms of Ageing and Development . https://doi.org/10.1016/j.mad.2005.10.004 | — | — | https://doi.org/10.1016/j.mad.2005.10.004 |
| — | Li, X., et al. (2020). Association of blood chemistry quantifications of biological aging with disability and mortality in older adults. Journal of Gerontology: Medical Sciences . https://doi.org/10.1093/gerona/glz219 | — | — | https://doi.org/10.1093/gerona/glz219 |
| — | Levine, M. E., et al. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging . https://doi.org/10.18632/aging.101414 | — | — | https://doi.org/10.18632/aging.101414 |
| — | Levine, M. E. (2013). Modeling the rate of senescence: Can estimated biological age predict mortality more accurately than chronological age? Journal of Gerontology: Medical Sciences . https://doi.org/10.1093/gerona/gls233 | — | — | https://doi.org/10.1093/gerona/gls233 |
| — | Herzog, C. M. S., et al. (2024). Challenges and recommendations for the translation of
biomarkers of aging. Nature Aging , 4(11), 1231-1241. https://www.nature.com/articles/s43587-024-00550-7 | — | — | https://www.nature.com/articles/s43587-024-00550-7 |
| — | McGlinchey, E., et al. (2024). Biomarkers of neurodegeneration across the Global South. The Lancet Healthy Longevity , 5(9), e611-e627. https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00132-6/fulltext | — | — | https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00132-6/fulltext |
| — | Doherty, A., et al. (2017). Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study . PLOS ONE . https://pmc.ncbi.nlm.nih.gov/articles/PMC5287488/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5287488/ |
| — | Coravos, A., Khozin, S., & Mandl, K. D. (2019). Developing and adopting safe and effective digital biomarkers to improve patient outcomes . npj Digital Medicine . https://pubmed.ncbi.nlm.nih.gov/30868107/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30868107/ |
| — | FDA-NIH Biomarker Working Group. (2016). BEST (Biomarkers, EndpointS, and other Tools) Resource . https://www.ncbi.nlm.nih.gov/books/NBK326791/ | — | — | https://www.ncbi.nlm.nih.gov/books/NBK326791/ |
| — | Strain, T., et al. (2020). Wearable-device-measured physical activity and future health risk . Nature Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC7116559/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7116559/ |
| — | Hicks, J. L., et al. (2019). Best practices for analyzing large-scale health data from wearables and smartphone apps . npj Digital Medicine . https://www.nature.com/articles/s41746-019-0121-1 | — | — | https://www.nature.com/articles/s41746-019-0121-1 |
| — | Khurshid, S., et al. (2022). Wearable accelerometer-derived physical activity and incident disease . npj Digital Medicine . https://www.nature.com/articles/s41746-022-00676-9 | — | — | https://www.nature.com/articles/s41746-022-00676-9 |
| — | Liu, J., et al. (2024). Quantification of epigenetic aging in population studies. Clinical Epigenetics , 16(1), 175. https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-024-01818-8 | — | — | https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-024-01818-8 |
| — | Levine, M. E., et al. (2018). An epigenetic biomarker of aging for lifespan and
healthspan. Aging (Albany NY) , 10(4), 573-591. https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ |
| — | Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology , 14(10), R115. https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-10-r115 | — | — | https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-10-r115 |
| — | Hannum, G., et al. (2013). Genome-wide methylation profiles reveal quantitative views of
human aging rates. Genome Research , 23(12), 2124-2132. https://pmc.ncbi.nlm.nih.gov/articles/PMC3856243/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3856243/ |
| — | Higgins-Chen, A. T., et al. (2022). A computational solution for bias and noise in
epigenetic clocks. Clinical Epigenetics , 14(1), 117. https://pmc.ncbi.nlm.nih.gov/articles/PMC9270895/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9270895/ |
| — | Lu, A. T., et al. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY) , 11(4), 1183-1199. https://pmc.ncbi.nlm.nih.gov/articles/PMC6366976/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6366976/ |
| — | Chen, B. H., et al. (2016). DNA methylation-based measures of biological age: meta-analysis
predicting mortality. Aging Cell , 15(4), 686-698. https://onlinelibrary.wiley.com/doi/10.1111/acel.13229 | — | — | https://onlinelibrary.wiley.com/doi/10.1111/acel.13229 |
| — | Horvath, S., & Raj, K. (2018). DNA methylation-based biomarkers and the epigenetic
clock theory of ageing. Nature Reviews Genetics , 19(6), 371-384. https://www.nature.com/articles/nrg.2017.115 | — | — | https://www.nature.com/articles/nrg.2017.115 |
| — | Belsky, D. W., et al. (2022). DunedinPACE, a DNA methylation biomarker of the pace of
aging. Nature Medicine , 28(10), 2086-2095. https://pmc.ncbi.nlm.nih.gov/articles/PMC8853656/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8853656/ |
| — | Callisaya, M. L., Blizzard, L., Schmidt, M. D., McGinley, J. L., & Srikanth, V. K.
(2010). Ageing and gait variability: a population-based study of older people. Age and Ageing , 39(2), 191-197. https://pubmed.ncbi.nlm.nih.gov/20083617/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20083617/ |
| — | Tian, Q., Chastan, N., Bair, W.-N., Resnick, S. M., Ferrucci, L., & Studenski, S. A.
(2017). The brain map of gait variability in aging, cognitive impairment and dementia: a systematic review. Neuroscience & Biobehavioral Reviews , 74(Pt A), 149-162. https://pmc.ncbi.nlm.nih.gov/articles/PMC5303129/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5303129/ |
| — | Martin, K. L., Blizzard, L., Wood, A. G., Srikanth, V., Thomson, R., Sanders, L. M., & Callisaya, M. L. (2013).
Cognitive function, gait, and gait variability in older people: a population-based study. Journal of Gerontology: Biological Sciences , 68(6), 726-732. https://pubmed.ncbi.nlm.nih.gov/23112113/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23112113/ |
| — | Bogen, B., Aaslund, M. K., Ranhoff, A. H., & Moe-Nilssen, R. (2019). Two-year changes
in gait variability in community-living older adults. Gait & Posture , 72, 142-147. https://pubmed.ncbi.nlm.nih.gov/31200293/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31200293/ |
| — | Brach, J. S., Studenski, S. A., Perera, S., VanSwearingen, J. M., & Newman, A. B. (2007).
Gait variability and the risk of incident mobility disability in community-dwelling older adults. Journal of Gerontology: Biological Sciences , 62(9), 983-988. https://pmc.ncbi.nlm.nih.gov/articles/PMC2858390/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2858390/ |
| — | Doi, T., Nakakubo, S., Tsutsumimoto, K., Kurita, S., Ishii, H., & Shimada, H. (2021).
Spatiotemporal gait characteristics and risk of mortality in community-dwelling older adults. Maturitas , 151, 31-35. https://pubmed.ncbi.nlm.nih.gov/34446276/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34446276/ |
| — | Brach, J. S., Berthold, R., Craik, R., VanSwearingen, J. M., & Newman, A. B. (2001).
Gait variability in community-dwelling older adults. Journal of the American Geriatrics Society , 49(12), 1646-1650. https://pubmed.ncbi.nlm.nih.gov/11843998/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11843998/ |
| — | Brach, J. S., Perera, S., Studenski, S., Katz, M., Hall, C., & Verghese, J. (2010).
Meaningful change in measures of gait variability in older adults. Gait & Posture , 31(2), 175-179. https://pmc.ncbi.nlm.nih.gov/articles/PMC2818277/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2818277/ |
| — | Palta, P., Huang, E. S., Kalyani, R. R., Golden, S. H., & Yeh, H. C. (2017). Hemoglobin A1c and mortality in older adults with and without diabetes: results from the National Health and Nutrition Examination Surveys (1988–2011). Diabetes Care . https://pubmed.ncbi.nlm.nih.gov/28223299/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28223299/ |
| — | Bermingham, K. M., Smith, H. A., Duncan, E. L., Gonzalez, J. T., Valdes, A. M., Franks, P. W., et al. (2026). Associations of continuous glucose monitor derived time in range and glycaemic variability with diet, lifestyle and demographics. Nature Communications . https://pmc.ncbi.nlm.nih.gov/articles/PMC13187318/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC13187318/ |
| — | Kalyani, R. R., Varadhan, R., Weiss, C. O., Fried, L. P., & Cappola, A. R. (2012). Frailty status and altered glucose-insulin dynamics. Journal of Gerontology: Medical Sciences . https://pubmed.ncbi.nlm.nih.gov/21873592/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21873592/ |
| — | Daya, N. R., Fang, M., Wang, D., Valint, A., Windham, B. G., Coresh, J., et al. (2025). Glucose abnormalities detected by continuous glucose monitoring in very old adults with and without diabetes. Diabetes Care . https://pubmed.ncbi.nlm.nih.gov/39705138/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39705138/ |
| — | Jung, M. H., Yi, S. W., An, S. J., Balkau, B., Yi, J. J., & Kim, H. (2020). Complex interaction of fasting glucose, body mass index, age and sex on all-cause mortality: a cohort study in 15 million Korean adults. Diabetologia . https://pubmed.ncbi.nlm.nih.gov/32424541/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32424541/ |
| — | Basu, R., Breda, E., Oberg, A. L., Powell, C. C., Dalla Man, C., Basu, A., et al. (2003). Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes . https://pubmed.ncbi.nlm.nih.gov/12829641/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12829641/ |
| — | Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., et al. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ |
| — | Shah, V. N., DuBose, S. N., Li, Z., Beck, R. W., Peters, A. L., Weinstock, R. S., et al. (2019). Continuous glucose monitoring profiles in healthy nondiabetic participants: a multicenter prospective study. Journal of Clinical Endocrinology & Metabolism . https://pubmed.ncbi.nlm.nih.gov/31127824/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31127824/ |
| — | Ercan, A., et al. (2017). Estrogens regulate glycosylation of IgG in women and men. JCI Insight . https://pubmed.ncbi.nlm.nih.gov/28239652/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28239652/ |
| — | Merleev, A. A., et al. (2020). A site-specific map of the human plasma glycome and its age and gender-associated alterations. Scientific Reports . https://www.nature.com/articles/s41598-020-73588-x | — | — | https://www.nature.com/articles/s41598-020-73588-x |
| — | Paton, B., Suarez, M., Herrero, P., & Canela, N. (2021). Glycosylation biomarkers associated with age-related diseases and current methods for glycan analysis. International Journal of Molecular Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC8198018/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8198018/ |
| — | Krištić, J., et al. (2014). Glycans are a novel biomarker of chronological and biological ages. The Journals of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/24325898/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24325898/ |
| — | Rantanen, T., Volpato, S., Ferrucci, L., et al. (2003). Handgrip strength and cause-specific
and total mortality in older disabled women: exploring the mechanism. Journal of the American
Geriatrics Society , 51(5), 636-641. https://pubmed.ncbi.nlm.nih.gov/12752838/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12752838/ |
| — | Cheung, C.-L., Nguyen, U.-S. D. T., Au, E., Tan, K. C., & Kung, A. W. C. (2013).
Association of handgrip strength with chronic diseases and multimorbidity. Age (Dordr) , 35(3), 929-941. https://pmc.ncbi.nlm.nih.gov/articles/PMC3633344/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3633344/ |
| — | Bohannon, R. W. (2017). Test-retest reliability of hand-held dynamometry for grip
strength: a systematic review. Isokinetics and Exercise Science , 25(1), 1-9. https://doi.org/10.3233/IES-160624 | — | — | https://doi.org/10.3233/IES-160624 |
| — | Frontiers in Medicine. (2025). Handgrip strength as a potential indicator of aging:
insights from its association with aging-related laboratory biomarkers. Frontiers in Medicine , 10, 1491584. https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1491584/full | — | — | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1491584/full |
| — | Bohannon, R. W. (2019). Grip strength: an indispensable biomarker for older adults. Clinical Interventions in Aging , 14, 1681-1691. https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| — | Sayer, A. A., & Kirkwood, T. B. L. (2015). Grip strength and mortality: a biomarker of
ageing? The Lancet , 386(9990), 226-227. https://pubmed.ncbi.nlm.nih.gov/26090667/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26090667/ |
| — | Roberts, H. C., Denison, H. J., Martin, H. J., et al. (2011). A review of the measurement
of grip strength in clinical and epidemiological studies: towards a standardized approach. Age and Ageing , 40(4), 423-429. https://pubmed.ncbi.nlm.nih.gov/21624928/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21624928/ |
| — | Alley, D. E., Shardell, M. D., Peters, K. W., et al. (2014). Grip strength cutpoints for
the identification of clinically relevant weakness. Journal of Gerontology: Biological Sciences , 69(5), 559-566. https://pmc.ncbi.nlm.nih.gov/articles/PMC3991141/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3991141/ |
| — | Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (1996). Heart rate variability: standards of measurement, physiological interpretation and clinical use. European Heart Journal , 17(3), 354-381. https://pubmed.ncbi.nlm.nih.gov/8737210/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8737210/ |
| — | Umetani, K., Singer, D. H., McCraty, R., & Atkinson, M. (1998). Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. Journal of the American College of Cardiology , 31(3), 593-601. https://pubmed.ncbi.nlm.nih.gov/9502641/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9502641/ |
| — | Rocha, A. S. L., Siqueira, V. B., Maduro, P. A., Batista, L. S. P., & Schwingel, P. A. (2024). Reference values for heart rate variability in older adults: a systematic review. Psychophysiology , 61(12), e14661. https://pubmed.ncbi.nlm.nih.gov/39073173/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39073173/ |
| — | Jarczok, M. N., Weimer, K., Braun, C., et al. (2022). Heart rate variability in the prediction of mortality: a systematic review and meta-analysis of healthy and patient populations. Neuroscience & Biobehavioral Reviews , 143, 104907. https://pubmed.ncbi.nlm.nih.gov/36243195/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36243195/ |
| — | Georgiou, K., Larentzakis, A. V., Khamis, N. N., Alsuhaibani, G. I., Alaska, Y. A., & Giallafos, E. J. (2018). Can wearable devices accurately measure heart rate variability? A systematic review. Folia Medica , 60(1), 7-20. https://pubmed.ncbi.nlm.nih.gov/29668452/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29668452/ |
| — | Tsuji, H., Venditti, F. J., Manders, E. S., et al. (1996). Determinants of heart rate variability. Journal of the American College of Cardiology , 28(6), 1539-1546. https://pubmed.ncbi.nlm.nih.gov/8917269/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8917269/ |
| — | Laborde, S., Mosley, E., & Thayer, J. F. (2017). Heart rate variability and cardiac vagal tone in psychophysiological research: recommendations for experiment planning, data analysis, and data reporting. Frontiers in Psychology , 8, 213. https://pubmed.ncbi.nlm.nih.gov/28265249/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28265249/ |
| — | Fulop, T., et al. (2018). Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? . Frontiers in Immunology . https://pmc.ncbi.nlm.nih.gov/articles/PMC5767595/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5767595/ |
| — | Filippov, I., Schauser, L., & Peterson, P. (2024). An integrated single-cell atlas of blood immune cells in aging . npj Aging . https://www.nature.com/articles/s41514-024-00185-x | — | — | https://www.nature.com/articles/s41514-024-00185-x |
| — | Mogilenko, D. A., Shchukina, I., & Artyomov, M. N. (2022). Immune ageing at single-cell resolution . Nature Reviews Immunology . https://www.nature.com/articles/s41577-021-00646-4 | — | — | https://www.nature.com/articles/s41577-021-00646-4 |
| — | Nikolich-Zugich, J. (2018). The twilight of immunity: emerging concepts in aging of the immune system . Nature Immunology . https://www.nature.com/articles/s41590-017-0006-x | — | — | https://www.nature.com/articles/s41590-017-0006-x |
| — | Luo, O. J., et al. (2022). Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty . Nature Aging . https://www.nature.com/articles/s43587-022-00198-9 | — | — | https://www.nature.com/articles/s43587-022-00198-9 |
| — | Rodriguez, I. J., et al. (2021). Immunosenescence Study of T Cells: A Systematic Review . Frontiers in Immunology . https://pmc.ncbi.nlm.nih.gov/articles/PMC7843425/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7843425/ |
| — | Sayed, N., et al. (2021). An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging . Nature Aging . https://www.nature.com/articles/s43587-021-00082-y | — | — | https://www.nature.com/articles/s43587-021-00082-y |
| — | Alpert, A., et al. (2019). A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring . Nature Medicine . https://www.nature.com/articles/s41591-019-0381-y | — | — | https://www.nature.com/articles/s41591-019-0381-y |
| — | Franck, M., et al. (2025). Nonuniversality of inflammaging across human populations . Nature Aging . https://pubmed.ncbi.nlm.nih.gov/40588649/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40588649/ |
| — | Andonian, B. J., et al. (2025). Inflammation and aging-related disease: A transdisciplinary inflammaging framework . Geroscience . https://pubmed.ncbi.nlm.nih.gov/39352664/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39352664/ |
| — | Kwon, D., Belsky, D. W., & Achenbach, C. J. (2021). A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge . GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC8602613/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8602613/ |
| — | Inker, L. A., et al. (2012). Estimating glomerular filtration rate from serum creatinine and cystatin C . The New England Journal of Medicine . https://www.nejm.org/doi/full/10.1056/NEJMoa1114248 | — | — | https://www.nejm.org/doi/full/10.1056/NEJMoa1114248 |
| — | Bachmann, L. M., et al. (2017). Beta trace protein does not outperform creatinine and cystatin C in estimating glomerular filtration rate in older adults . Scientific Reports . https://pmc.ncbi.nlm.nih.gov/articles/PMC5627233/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5627233/ |
| — | Matias-Garcia, P. R., et al. (2021). DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function . Clinical Epigenetics . https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01082-w | — | — | https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01082-w |
| — | Kooman, J. P., et al. (2014). Chronic kidney disease and premature ageing . Nature Reviews Nephrology . https://pubmed.ncbi.nlm.nih.gov/24686460/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24686460/ |
| — | Chronic Kidney Disease Prognosis Consortium. (2010). Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality . The Lancet . https://pmc.ncbi.nlm.nih.gov/articles/PMC3993088/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3993088/ |
| — | Sarnak, M. J., et al. (2008). Cystatin C and aging success . Archives of Internal Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC2871318/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2871318/ |
| — | Shlipak, M. G., et al. (2013). Cystatin C versus creatinine in determining risk based on kidney function . The New England Journal of Medicine . https://www.nejm.org/doi/full/10.1056/NEJMoa1214234 | — | — | https://www.nejm.org/doi/full/10.1056/NEJMoa1214234 |
| — | Matsushita, K., et al. (2015). Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: A collaborative meta-analysis . The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/26028594/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26028594/ |
| — | Bolignano, D., Mattace-Raso, F., Sijbrands, E. J. G., & Zoccali, C. (2014). The aging kidney revisited: A systematic review . Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/24280505/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24280505/ |
| — | Inker, L. A., et al. (2021). New creatinine- and cystatin C-based equations to estimate GFR without race . The New England Journal of Medicine . https://www.nejm.org/doi/full/10.1056/NEJMoa2102953 | — | — | https://www.nejm.org/doi/full/10.1056/NEJMoa2102953 |
| — | Perri, G., et al. (2025). An expert consensus statement on biomarkers of aging for use in
intervention studies. The Journals of Gerontology: Series A , 80(5), glae297. https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 | — | — | https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 |
| — | Spoto, B., Mattace-Raso, F., Sijbrands, E. J., D'Arrigo, G., Tripepi, G., Volpato, S., et al. (2017). Oxidized LDL, gamma-glutamyltransferase and adverse outcomes in older adults. Journal of the American Geriatrics Society . https://pubmed.ncbi.nlm.nih.gov/28422277/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28422277/ |
| — | Koehler, E. M., Sanna, D., Hansen, B. E., van Rooij, F. J. A., Heeringa, J., Hofman, A., et al. (2014). Serum liver enzymes are associated with all-cause mortality in an elderly population. Liver International . https://pubmed.ncbi.nlm.nih.gov/24219360/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24219360/ |
| — | Wynne, H. A., Cope, L. H., Mutch, E., Rawlins, M. D., Woodhouse, K. W., & James, O. F. W. (1989). The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology . https://pubmed.ncbi.nlm.nih.gov/2643548/ | — | — | https://pubmed.ncbi.nlm.nih.gov/2643548/ |
| — | Kim, I. H., Kisseleva, T., & Brenner, D. A. (2013). Liver physiology and liver diseases in the elderly. World Journal of Gastroenterology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3870491/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3870491/ |
| — | Kwon, D., & Belsky, D. W. (2021). A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge. GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC8602613/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8602613/ |
| — | Aging Biomarker Consortium, Jiang, M., Zheng, Z., Wang, X., Chen, Y., Qu, J., et al. (2024). A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement. Life Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC11749002/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11749002/ |
| — | Ruhl, C. E., & Everhart, J. E. (2013). Serum gamma-glutamyltransferase predicts all-cause, cardiovascular and liver mortality in older adults. Journal of Clinical Epidemiology . https://pubmed.ncbi.nlm.nih.gov/23997501/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23997501/ |
| — | Corti, M. C., Guralnik, J. M., Salive, M. E., & Sorkin, J. D. (1994). Serum albumin level and physical disability as predictors of mortality in older persons. JAMA . https://pubmed.ncbi.nlm.nih.gov/8089886/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8089886/ |
| — | Dong, M. H., Bettencourt, R., Barrett-Connor, E., Loomba, R. (2010). Alanine aminotransferase decreases with age: the Rancho Bernardo Study. PLoS ONE . https://pmc.ncbi.nlm.nih.gov/articles/PMC2999530/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2999530/ |
| — | Duong, M., Islam, S., Rangarajan, S., et al. (2019). Mortality and cardiovascular and
respiratory morbidity in individuals with impaired FEV 1 (PURE): an international,
community-based cohort study. The Lancet Global Health , 7(5), e613-e623. https://pubmed.ncbi.nlm.nih.gov/31000131/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31000131/ |
| — | Vaz Fragoso, C. A., Beavers, D. P., Hankinson, J. L., et al. (2019). Relative and
absolute lung function change in a general population aged 60-102 years. European Respiratory
Journal , 53(3), 1701812. https://pubmed.ncbi.nlm.nih.gov/30578401/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30578401/ |
| — | Janssens, J. P., Pache, J. C., & Nicod, L. P. (1999). Physiological changes in
respiratory function associated with ageing. European Respiratory Journal , 13(1), 197-205. https://pubmed.ncbi.nlm.nih.gov/10836348/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10836348/ |
| — | Lange, P., Celli, B., Agustí, A., et al. (2015). Lung-function trajectories leading to
chronic obstructive pulmonary disease. New England Journal of Medicine , 373(2), 111-122. https://pubmed.ncbi.nlm.nih.gov/26154786/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26154786/ |
| — | Quanjer, P. H., Stanojevic, S., Cole, T. J., et al. (2012). Multi-ethnic reference
values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. European Respiratory Journal , 40(6), 1324-1343. https://pubmed.ncbi.nlm.nih.gov/22743675/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22743675/ |
| — | Vaz Fragoso, C. A., & Gill, T. M. (2012). Respiratory impairment and the aging lung:
a novel paradigm for assessing pulmonary function. The Journals of Gerontology: Series A ,
67(3), 264-275. https://pubmed.ncbi.nlm.nih.gov/22138206/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22138206/ |
| — | Graham, B. L., Steenbruggen, I., Miller, M. R., et al. (2019). Standardization of
spirometry 2019 update: an official American Thoracic Society and European Respiratory Society
technical statement. American Journal of Respiratory and Critical Care Medicine , 200(8),
e70-e88. https://pubmed.ncbi.nlm.nih.gov/31613151/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31613151/ |
| — | Janssens, G. E., et al. (2023). A metabolomic signature of decelerated physiological aging in human plasma . GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC10643795/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10643795/ |
| — | Sebastiani, P., et al. (2024). Metabolite signatures of chronological age, aging, survival, and longevity . Cell Reports . https://pmc.ncbi.nlm.nih.gov/articles/PMC11656345/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11656345/ |
| — | Wang, F., et al. (2023). Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals . Nature Communications . https://www.nature.com/articles/s41467-023-41515-z | — | — | https://www.nature.com/articles/s41467-023-41515-z |
| — | Robinson, O., et al. (2020). Determinants of accelerated metabolomic and epigenetic aging in a UK cohort . Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC7294785/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7294785/ |
| — | Gonzalez-Freire, M., et al. (2019). Targeted Metabolomics Shows Low Plasma Lysophosphatidylcholine 18:2 Predicts Greater Decline of Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging . The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC6298185/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6298185/ |
| — | Panyard, D. J., Yu, B., & Snyder, M. P. (2022). The metabolomics of human aging: Advances, challenges, and opportunities . Science Advances . https://pmc.ncbi.nlm.nih.gov/articles/PMC9581477/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9581477/ |
| — | Ahadi, S., et al. (2020). Personal aging markers and ageotypes revealed by deep longitudinal profiling . Nature Medicine . https://www.nature.com/articles/s41591-019-0719-5 | — | — | https://www.nature.com/articles/s41591-019-0719-5 |
| — | Chen, Q., et al. (2026). OMICmAge quantifies biological age by integrating multi-omics with electronic medical records . Nature Aging . https://www.nature.com/articles/s43587-026-01073-7 | — | — | https://www.nature.com/articles/s43587-026-01073-7 |
| — | Rutledge, J., Oh, H. S., & Wyss-Coray, T. (2022). Measuring biological age using omics data . Nature Reviews Genetics . https://www.nature.com/articles/s41576-022-00511-7 | — | — | https://www.nature.com/articles/s41576-022-00511-7 |
| — | Higgins-Chen, A. T., et al. (2022). A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking. Nature Aging . https://doi.org/10.1038/s43587-022-00248-2 | — | — | https://doi.org/10.1038/s43587-022-00248-2 |
| — | Belsky, D. W., et al. (2020). Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. eLife . https://doi.org/10.7554/eLife.54870 | — | — | https://doi.org/10.7554/eLife.54870 |
| — | Lu, A. T., et al. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging . https://doi.org/10.18632/aging.101684 | — | — | https://doi.org/10.18632/aging.101684 |
| — | Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology . https://doi.org/10.1186/gb-2013-14-10-r115 | — | — | https://doi.org/10.1186/gb-2013-14-10-r115 |
| — | Belsky, D. W., et al. (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife . https://doi.org/10.7554/eLife.73420 | — | — | https://doi.org/10.7554/eLife.73420 |
| — | Hartmann, A., Hartmann, C., Secci, R., et al. (2021). Ranking biomarkers of aging by citation
profiling and effort scoring. Frontiers in Genetics , 12, 686320. https://pmc.ncbi.nlm.nih.gov/articles/PMC8176216/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8176216/ |
| — | Johnson, A. A., Shokhirev, M. N., Wyss-Coray, T., & Lehallier, B. (2020). Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age . Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/32311500/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32311500/ |
| — | Kuo, C.-L., et al. (2024). Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults . Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC11320350/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11320350/ |
| — | Argentieri, M. A., et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations . Nature Medicine . https://www.nature.com/articles/s41591-024-03164-7 | — | — | https://www.nature.com/articles/s41591-024-03164-7 |
| — | Lehallier, B., et al. (2019). Undulating changes in human plasma proteome profiles across the lifespan . Nature Medicine . https://www.nature.com/articles/s41591-019-0673-2 | — | — | https://www.nature.com/articles/s41591-019-0673-2 |
| — | An, D. W., Hansen, T. W., Aparicio, L. S., Chori, B., Huang, Q. F., Wei, F. F., et al. (2023). Derivation of an outcome-driven threshold for aortic pulse wave velocity: an individual-participant meta-analysis. Hypertension . https://pmc.ncbi.nlm.nih.gov/articles/PMC10424824/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10424824/ |
| — | Vlachopoulos, C., Aznaouridis, K., & Stefanadis, C. (2010). Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. Journal of the American College of Cardiology . https://pubmed.ncbi.nlm.nih.gov/20338492/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20338492/ |
| — | Reference Values for Arterial Stiffness' Collaboration. (2010). Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: establishing normal and reference values. European Heart Journal . https://pmc.ncbi.nlm.nih.gov/articles/PMC2948201/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2948201/ |
| — | Ben-Shlomo, Y., Spears, M., Boustred, C., May, M., Anderson, S. G., Benjamin, E. J., et al. (2014). Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. Journal of the American College of Cardiology . https://pubmed.ncbi.nlm.nih.gov/24239664/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24239664/ |
| — | Salvagno, G. L., et al. (2015). Red blood cell distribution width: a simple parameter with multiple clinical applications . Critical Reviews in Clinical Laboratory Sciences . https://pubmed.ncbi.nlm.nih.gov/25535770/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25535770/ |
| — | Pilling, L. C., et al. (2018). Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years . PLoS ONE . https://pubmed.ncbi.nlm.nih.gov/30212481/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30212481/ |
| — | Kim, K. M., et al. (2021). Association between variation in red cell size and multiple aging-related outcomes . The Journals of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/32894755/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32894755/ |
| — | Higgins, J. M., & Mahadevan, L. (2010). Physiological and pathological population dynamics of circulating human red blood cells . Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/20823246/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20823246/ |
| — | Cruz-Jentoft, A. J., Bahat, G., Bauer, J., et al. (2019). Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing , 48(1), 16-31. https://pmc.ncbi.nlm.nih.gov/articles/PMC6322506/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6322506/ |
| — | Studenski, S., Perera, S., Patel, K., et al. (2011). Gait speed and survival in older adults. JAMA , 305(1), 50-58. https://pmc.ncbi.nlm.nih.gov/articles/PMC3080184/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3080184/ |
| — | Miller, W. G., Horowitz, G. L., Ceriotti, F., Fleming, J. K., Greenberg, N., Katayev, A., et al. (2016). Reference intervals: strengths, weaknesses, and challenges. Clinical Chemistry , 62(7), 916-923. https://academic.oup.com/clinchem/article/62/7/916/5611870 | — | — | https://academic.oup.com/clinchem/article/62/7/916/5611870 |
| — | Apsley, A. T., Etzel, L., Ye, Q., & Shalev, I. (2025). From population science to the clinic? Limits of epigenetic clocks as personal biomarkers. Epigenomics , 17(18), 1447-1461. https://pmc.ncbi.nlm.nih.gov/articles/PMC12714307/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12714307/ |
| — | Perri, G., Poganik, J. R., Levine, M. E., et al. (2025). An expert consensus statement on biomarkers of aging for use in intervention studies. Journal of Gerontology: Biological Sciences , 80(5), glae297. https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 | — | — | https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 |
| — | Horowitz, G. L. (2008). Reference intervals: practical aspects. eJIFCC , 19(2), 95-105. https://pmc.ncbi.nlm.nih.gov/articles/PMC4975204/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4975204/ |
| — | Gaye, B., Valentin, E., Xanthakis, V., et al. (2024). Association between change in heart rate over years and life span in the Paris Prospective 1, the Whitehall 1, and Framingham studies. Scientific Reports , 14, 20052. https://pubmed.ncbi.nlm.nih.gov/39209972/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39209972/ |
| — | Vazir, A., Claggett, B., Cheng, S., et al. (2018). Association of resting heart rate and temporal changes in heart rate with outcomes in participants of the Atherosclerosis Risk in Communities Study. JAMA Cardiology , 3(3), 200-206. https://pubmed.ncbi.nlm.nih.gov/29365021/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29365021/ |
| — | Zhang, D., Shen, X., & Qi, X. (2016). Resting heart rate and all-cause and cardiovascular mortality in the general population: a meta-analysis. CMAJ , 188(3), E53-E63. https://pubmed.ncbi.nlm.nih.gov/26598376/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26598376/ |
| — | Fox, K., Borer, J. S., Camm, A. J., et al. (2007). Resting heart rate in cardiovascular disease. Journal of the American College of Cardiology , 50(9), 823-830. https://pubmed.ncbi.nlm.nih.gov/17719466/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17719466/ |
| — | Jensen, M. T., Marott, J. L., Allin, K. H., Nordestgaard, B. G., & Jensen, G. B. (2012). Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: the Copenhagen City Heart Study. European Journal of Preventive Cardiology , 19(1), 102-108. https://pubmed.ncbi.nlm.nih.gov/21525123/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21525123/ |
| — | He, D., Zhang, J., Zhang, Y., et al. (2024). Association between resting heart rate and machine learning-based brain age in middle- and older-age. Journal of Alzheimer's Disease , 100(3), 997-1007. https://pubmed.ncbi.nlm.nih.gov/39044526/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39044526/ |
| — | O'Neil, A., et al. (2025). Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging . Investigative Ophthalmology & Visual Science . https://pmc.ncbi.nlm.nih.gov/articles/PMC11895846/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11895846/ |
| — | Nusinovici, S., et al. (2022). Retinal photograph-based deep learning predicts biological age, and stratifies morbidity and mortality risk . Age and Ageing . https://doi.org/10.1093/ageing/afac065 | — | — | https://doi.org/10.1093/ageing/afac065 |
| — | Patel, N. B., et al. (2014). Age-Associated Changes in the Retinal Nerve Fiber Layer and Optic Nerve Head . Investigative Ophthalmology & Visual Science . https://pmc.ncbi.nlm.nih.gov/articles/PMC4137486/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4137486/ |
| — | Poplin, R., et al. (2018). Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning . Nature Biomedical Engineering . https://www.nature.com/articles/s41551-018-0195-0 | — | — | https://www.nature.com/articles/s41551-018-0195-0 |
| — | Zhu, Z., et al. (2023). Retinal age gap as a predictive biomarker for mortality risk . British Journal of Ophthalmology . https://bjo.bmj.com/content/107/4/547 | — | — | https://bjo.bmj.com/content/107/4/547 |
| — | Zhu, Z., et al. (2022). Retinal age gap as a predictive biomarker of stroke risk . BMC Medicine . https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02620-w | — | — | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02620-w |
| — | Aubert, G., & Lansdorp, P. M. (2008). Telomeres and aging . Physiological Reviews . https://pubmed.ncbi.nlm.nih.gov/18391173/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18391173/ |
| — | Lopez-Otin, C., et al. (2013). The Hallmarks of Aging . Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ |
| — | Fleischer, J. G., et al. (2018). Predicting age from the transcriptome of human dermal fibroblasts . Genome Biology . https://genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1599-6 | — | — | https://genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1599-6 |
| — | Peters, M. J., et al. (2015). The transcriptional landscape of age in human peripheral blood . Nature Communications . https://www.nature.com/articles/ncomms9570 | — | — | https://www.nature.com/articles/ncomms9570 |
| — | Ren, X., & Kuan, P. F. (2020). RNAAgeCalc: A multi-tissue transcriptional age calculator . PLOS ONE . https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237006 | — | — | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237006 |
| — | Meyer, D. H., & Schumacher, B. (2021). BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy . Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC7963339/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7963339/ |
| — | Palmer, D., et al. (2022). Measuring biological age using a functionally interpretable multi-tissue RNA clock . Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC10186600/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10186600/ |
| — | Expert consensus statement on biomarkers of ageing for use in intervention studies. Journal of Gerontology: Biological Sciences (2025). https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 | — | — | https://academic.oup.com/biomedgerontology/article/80/5/glae297/7930267 |
| — | Baker, G. T., & Sprott, R. L. (1988). Biomarkers of aging. Experimental
Gerontology , 23(4-5), 223-239. https://pubmed.ncbi.nlm.nih.gov/3058488/ | — | — | https://pubmed.ncbi.nlm.nih.gov/3058488/ |
| — | Singh, R., et al. (2001). Advanced glycation end-products: A review . https://pubmed.ncbi.nlm.nih.gov/11241802/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11241802/ |
| — | Semba, R. D., et al. (2010). Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women . https://pubmed.ncbi.nlm.nih.gov/20176874/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20176874/ |
| — | Semba, R. D., et al. (2010). Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women . https://pubmed.ncbi.nlm.nih.gov/20019188/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20019188/ |
| — | Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition . https://pubmed.ncbi.nlm.nih.gov/19822172/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19822172/ |
| — | McEwen, B. S. (1998). Protective and damaging effects of stress mediators . https://pubmed.ncbi.nlm.nih.gov/9634234/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9634234/ |
| — | Laplante, M., & Sabatini, D. M. (2012). mTOR signaling in growth control and disease . https://doi.org/10.1016/j.cell.2012.03.017 | — | — | https://doi.org/10.1016/j.cell.2012.03.017 |
| — | Lopez-Otin, C., et al. (2013). The Hallmarks of Aging . https://doi.org/10.1016/j.cell.2013.05.039 | — | — | https://doi.org/10.1016/j.cell.2013.05.039 |
| — | Hardie, D. G. (2011). AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function . https://doi.org/10.1101/gad.17420111 | — | — | https://doi.org/10.1101/gad.17420111 |
| — | Campisi, J. (2013). Aging, cellular senescence, and cancer . https://pubmed.ncbi.nlm.nih.gov/23140366/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23140366/ |
| — | Klionsky, D.J., et al. (2022). Autophagy: A Key Regulator of Homeostasis and Disease . https://pmc.ncbi.nlm.nih.gov/articles/PMC9329718/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9329718/ |
| — | Kirkwood, T. B. L., & Austad, S. N. (2000). Why do we age? https://doi.org/10.1038/35041682 | — | — | https://doi.org/10.1038/35041682 |
| — | Kennedy, B. K., et al. (2014). Geroscience: Linking Aging to Chronic Disease . https://doi.org/10.1016/j.cell.2014.10.039 | — | — | https://doi.org/10.1016/j.cell.2014.10.039 |
| — | Kirkwood, T. B. L. (2005). Understanding the Odd Science of Aging . https://doi.org/10.1016/j.cell.2005.01.027 | — | — | https://doi.org/10.1016/j.cell.2005.01.027 |
| — | Rollandi, G. A., et al. (2019). Biological age versus chronological age in the prevention of age-related diseases . https://www.lidsen.com/journals/geriatrics/geriatrics-03-02-051 | — | — | https://www.lidsen.com/journals/geriatrics/geriatrics-03-02-051 |
| — | Hamczyk, M. R., et al. (2020). Biological Versus Chronological Aging: JACC Focus Seminar . https://pubmed.ncbi.nlm.nih.gov/32130928/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32130928/ |
| — | Ferrucci, L., Levine, M. E., Kuo, P. L., & Simonsick, E. M. (2018). Time and the metrics of aging. Circulation Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC6380373/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6380373/ |
| — | Cohen, A. A., Kennedy, B. K., Anglas, U., et al. (2020). Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development . https://pmc.ncbi.nlm.nih.gov/articles/PMC7564088/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7564088/ |
| — | Fraser, C. G. (2001). Biological variation: From principles to practice. AACC Press . https://www.aacc.org/science-and-research/scientific-shorts/2018/biological-variation | — | — | https://www.aacc.org/science-and-research/scientific-shorts/2018/biological-variation |
| — | Justice, J. N., et al. (2018). A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: Report from the TAME Biomarkers Workgroup . https://pubmed.ncbi.nlm.nih.gov/30151729/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30151729/ |
| — | Baker, G. T., & Sprott, R. L. (1988). Biomarkers of aging . https://pubmed.ncbi.nlm.nih.gov/3058488/ | — | — | https://pubmed.ncbi.nlm.nih.gov/3058488/ |
| — | Moqri, M., et al. (2023). Biomarkers of aging for the identification and evaluation of longevity interventions . https://www.cell.com/cell/fulltext/S0092-8674(23)00857-7 | — | — | https://www.cell.com/cell/fulltext/S0092-8674(23)00857-7 |
| — | Bao, H., et al. (2023). Biomarkers of aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC10115486/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10115486/ |
| — | Ocampo, A., et al. (2016). In vivo amelioration of age-associated hallmarks by partial reprogramming . https://pubmed.ncbi.nlm.nih.gov/27984723/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27984723/ |
| — | Franceschi, C., et al. (2018). Inflammaging: A new immune–metabolic viewpoint for age-related diseases . https://www.nature.com/articles/s41574-018-0059-4 | — | — | https://www.nature.com/articles/s41574-018-0059-4 |
| — | Muñoz-Espín, D., & Serrano, M. (2014). Cellular senescence: From physiology to pathology . https://www.nature.com/articles/nrm3823 | — | — | https://www.nature.com/articles/nrm3823 |
| — | Childs, B. G., et al. (2015). Cellular senescence in aging and age-related disease: From mechanisms to therapy . https://www.nature.com/articles/nm.4000 | — | — | https://www.nature.com/articles/nm.4000 |
| — | López-Otín, C., et al. (2013). The hallmarks of aging . https://www.cell.com/cell/fulltext/S0092-8674(13)00645-4 | — | — | https://www.cell.com/cell/fulltext/S0092-8674(13)00645-4 |
| — | Serrano, M., et al. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a . https://www.cell.com/cell/fulltext/S0092-8674(00)81890-4 | — | — | https://www.cell.com/cell/fulltext/S0092-8674(00)81890-4 |
| — | d’Adda di Fagagna, F. (2008). Living on a break: Cellular senescence as a DNA-damage response . https://www.nature.com/articles/nrc2440 | — | — | https://www.nature.com/articles/nrc2440 |
| — | Demaria, M., et al. (2014). An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA . https://www.sciencedirect.com/science/article/pii/S1534580714007690 | — | — | https://www.sciencedirect.com/science/article/pii/S1534580714007690 |
| — | Coppé, J. P., et al. (2010). The senescence-associated secretory phenotype: The dark side of tumor suppression . https://www.annualreviews.org/doi/10.1146/annurev-pathol-121808-102144 | — | — | https://www.annualreviews.org/doi/10.1146/annurev-pathol-121808-102144 |
| — | Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016). Epigenetic Mechanisms of Longevity and Aging . https://doi.org/10.1016/j.cell.2016.02.050 | — | — | https://doi.org/10.1016/j.cell.2016.02.050 |
| — | Allis, C. D., & Jenuwein, T. (2016). The molecular hallmarks of epigenetic control . https://doi.org/10.1038/nrm.2016.59 | — | — | https://doi.org/10.1038/nrm.2016.59 |
| — | Pal, S., & Tyler, J. K. (2016). Epigenetics and aging . https://doi.org/10.1126/sciadv.1600584 | — | — | https://doi.org/10.1126/sciadv.1600584 |
| — | Baars, J. (2013). Aging and Time . http://www.janbaars.nl/wp-content/uploads/Aging-and-Time-Chapter-01-Jan-Baars.pdf | — | — | http://www.janbaars.nl/wp-content/uploads/Aging-and-Time-Chapter-01-Jan-Baars.pdf |
| — | Witzel, D. D., et al. (2025). Age and inflammation: Insights on "age three ways" from population cohorts . https://www.sciencedirect.com/science/article/abs/pii/S0889159125001035 | — | — | https://www.sciencedirect.com/science/article/abs/pii/S0889159125001035 |
| — | Moqri, M., Herzog, C., Poganik, J. R., et al. (2023). Biomarkers of aging for the identification and evaluation of longevity interventions . https://doi.org/10.1016/j.cell.2023.08.003 | — | — | https://doi.org/10.1016/j.cell.2023.08.003 |
| — | Jaiswal, S. (2020). Clonal hematopoiesis and nonhematologic disorders . https://pmc.ncbi.nlm.nih.gov/articles/PMC8209629/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8209629/ |
| — | Jan, M., Ebert, B. L., and Jaiswal, S. (2017). Clonal hematopoiesis . https://pmc.ncbi.nlm.nih.gov/articles/PMC8045769/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8045769/ |
| — | Steensma, D. P., et al. (2015). Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes . https://pmc.ncbi.nlm.nih.gov/articles/PMC4624443/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4624443/ |
| — | Freemantle, N., Calvert, M., Wood, J., Eastaugh, J., & Griffin, C. (2003). Composite outcomes in randomized trials: greater precision but with greater uncertainty? https://doi.org/10.1001/jama.289.19.2554 | — | — | https://doi.org/10.1001/jama.289.19.2554 |
| — | Jones, P. A. (2012). Functions of DNA methylation: islands, start sites, gene bodies and beyond . https://doi.org/10.1038/nrg3230 | — | — | https://doi.org/10.1038/nrg3230 |
| — | Horvath, S. (2013). DNA methylation age of human tissues and cell types . https://doi.org/10.1186/gb-2013-14-10-r115 | — | — | https://doi.org/10.1186/gb-2013-14-10-r115 |
| — | Levine, M. E., et al. (2018). An epigenetic biomarker of aging for lifespan and healthspan . https://doi.org/10.18632/aging.101414 | — | — | https://doi.org/10.18632/aging.101414 |
| — | Horvath, S., & Raj, K. (2018). DNA methylation-based biomarkers and the epigenetic clock theory of ageing . https://doi.org/10.1038/s41576-018-0004-3 | — | — | https://doi.org/10.1038/s41576-018-0004-3 |
| — | Zhou, H., Razjouyan, J., Halder, K., et al. (2021). Digital biomarkers of cognitive frailty: the value of detailed sensor-based gait assessment . https://doi.org/10.3390/brainsci11111542 | — | — | https://doi.org/10.3390/brainsci11111542 |
| — | Alonso, A. K. M., et al. (2024). Definitions of digital biomarkers: a systematic mapping of the biomedical literature . https://doi.org/10.1038/s41746-024-01073-0 | — | — | https://doi.org/10.1038/s41746-024-01073-0 |
| — | López-Otín, C., et al. (2013). The hallmarks of aging . https://pubmed.ncbi.nlm.nih.gov/23746838/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23746838/ |
| — | Hoeijmakers, J. H. J. (2009). DNA damage, aging, and cancer . https://pubmed.ncbi.nlm.nih.gov/19418601/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19418601/ |
| — | O'Toole, P. W., & Jeffery, I. B. (2015). Gut microbiota and aging . https://doi.org/10.1126/science.aac8469 | — | — | https://doi.org/10.1126/science.aac8469 |
| — | Frantz, C., Stewart, K. M., & Weaver, V. M. (2010). The extracellular matrix at a glance . https://pubmed.ncbi.nlm.nih.gov/21123617/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21123617/ |
| — | Verzijl, N., et al. (2000). Effect of collagen turnover on the accumulation of advanced glycation end products . https://pubmed.ncbi.nlm.nih.gov/11076999/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11076999/ |
| — | Semba, R. D., Nicklett, E. J., & Ferrucci, L. (2010). Does accumulation of advanced glycation end products contribute to the aging phenotype? . https://pubmed.ncbi.nlm.nih.gov/20419234/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20419234/ |
| — | Lu, A. T., et al. (2022). PhenoAge and GrimAge clock associations with mortality and age-related diseases in 11 cohorts . https://doi.org/10.1038/s41467-022-34851-3 | — | — | https://doi.org/10.1038/s41467-022-34851-3 |
| — | Lu, A. T., et al. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan . https://doi.org/10.18632/aging.101800 | — | — | https://doi.org/10.18632/aging.101800 |
| — | Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016). Epigenetic Mechanisms of Longevity and Aging . https://doi.org/10.1016/j.cell.2016.07.050 | — | — | https://doi.org/10.1016/j.cell.2016.07.050 |
| — | Levine, M. E. (2020). Assessment of epigenetic clocks as biomarkers of aging in basic and population research . https://pmc.ncbi.nlm.nih.gov/articles/PMC7328198/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7328198/ |
| — | Levine, M. E., et al. (2018). An epigenetic biomarker of aging for lifespan and healthspan . https://pubmed.ncbi.nlm.nih.gov/29676998/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29676998/ |
| — | Horvath, S. (2013). DNA methylation age of human tissues and cell types . https://pubmed.ncbi.nlm.nih.gov/24138928/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24138928/ |
| — | Bell, C. G., et al. (2019). DNA methylation aging clocks: Challenges and recommendations . https://pmc.ncbi.nlm.nih.gov/articles/PMC6876109/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6876109/ |
| — | Belsky, D. W., et al. (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging . https://pubmed.ncbi.nlm.nih.gov/35029144/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35029144/ |
| — | Hannum, G., et al. (2013). Genome-wide methylation profiles reveal quantitative views of human aging rates . https://pubmed.ncbi.nlm.nih.gov/23177740/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23177740/ |
| — | Teschendorff, A. E., et al. (2013). Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer . https://doi.org/10.1186/gb-2010-11-10-r108 | — | — | https://doi.org/10.1186/gb-2010-11-10-r108 |
| — | Bird, A. (2007). Perceptions of epigenetics . https://doi.org/10.1038/nature05913 | — | — | https://doi.org/10.1038/nature05913 |
| — | Lopez-Otin, C., et al. (2013). The hallmarks of aging . https://doi.org/10.1016/j.cell.2013.05.039 | — | — | https://doi.org/10.1016/j.cell.2013.05.039 |
| — | Birch, H. L. (2018). Extracellular matrix and ageing . https://pubmed.ncbi.nlm.nih.gov/29452643/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29452643/ |
| — | Clegg, A., et al. (2013). Frailty in elderly people . https://pubmed.ncbi.nlm.nih.gov/23395245/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23395245/ |
| — | Rockwood, K., et al. (2005). A global clinical measure of fitness and frailty in elderly people . https://pubmed.ncbi.nlm.nih.gov/16129869/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16129869/ |
| — | Searle, S. D., Mitnitski, A., Gahbauer, E. A., Gill, T. M., & Rockwood, K. (2008). A standard procedure for creating a frailty index . https://doi.org/10.1186/1471-2318-8-24 | — | — | https://doi.org/10.1186/1471-2318-8-24 |
| — | Mitnitski, A. B., Mogilner, A. J., & Rockwood, K. (2001). Accumulation of deficits as a proxy measure of aging . https://doi.org/10.1101/gr.133801 | — | — | https://doi.org/10.1101/gr.133801 |
| — | Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013). Frailty in elderly people . https://doi.org/10.1016/S0140-6736(12)62167-9 | — | — | https://doi.org/10.1016/S0140-6736(12)62167-9 |
| — | Fried, L. P., Tangen, C. M., Walston, J., et al. (2001). Frailty in older adults: evidence for a phenotype . https://doi.org/10.1093/gerona/56.3.M146 | — | — | https://doi.org/10.1093/gerona/56.3.M146 |
| — | Kirkwood, T. B. L. (2005). Understanding the odd science of aging . https://pubmed.ncbi.nlm.nih.gov/15784673/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15784673/ |
| — | Bohannon, R. W. (2008). Hand-grip dynamometry predicts future outcomes in aging adults . https://pubmed.ncbi.nlm.nih.gov/18790810/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18790810/ |
| — | Rasmussen University. What is gerontology? https://www.rasmussen.edu/degrees/nursing/blog/what-is-gerontology/ | — | — | https://www.rasmussen.edu/degrees/nursing/blog/what-is-gerontology/ |
| — | ScienceDirect Topics. Gerontology. https://www.sciencedirect.com/topics/neuroscience/gerontology | — | — | https://www.sciencedirect.com/topics/neuroscience/gerontology |
| — | Moskalev, A., Chernyagina, E., Kudryavtseva, A., & Shaposhnikov, M. (2017). Geroprotectors: A unified concept and screening approaches. Aging and Disease . https://pmc.ncbi.nlm.nih.gov/articles/PMC5440114/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5440114/ |
| — | Trendelenburg, A. U., Scheuren, A. C., Potter, P., Müller, R., & Bellantuono, I. (2019). Geroprotectors: A role in the treatment of frailty. Mechanisms of Ageing and Development . https://www.sciencedirect.com/science/article/pii/S0047637419300363 | — | — | https://www.sciencedirect.com/science/article/pii/S0047637419300363 |
| — | Moskalev, A., Chernyagina, E., de Magalhães, J. P., & Zhavoronkov, A. (2015). Geroprotectors.org: A new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC4600621/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4600621/ |
| — | Ferrucci, L., et al. (2024). Geroscience hypothesis and multimorbidity. The Journals of Gerontology: Series A . https://academic.oup.com/biomedgerontology/article/79/9/glae179/7744984 | — | — | https://academic.oup.com/biomedgerontology/article/79/9/glae179/7744984 |
| — | National Institute on Aging. The intersection of basic aging biology, chronic disease,
and health (GeroScience Interest Group). https://www.nia.nih.gov/research/dab/geroscience-intersection-basic-aging-biology-chronic-disease-and-health | — | — | https://www.nia.nih.gov/research/dab/geroscience-intersection-basic-aging-biology-chronic-disease-and-health |
| — | Rolland, Y., et al. (2023). Challenges in developing geroscience trials. Nature Communications . https://www.nature.com/articles/s41467-023-39786-7 | — | — | https://www.nature.com/articles/s41467-023-39786-7 |
| — | Mandelblatt, J. S., et al. (2024). Gerotherapeutics: aging mechanism-based pharmaceutical discovery and development. GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC11884862/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11884862/ |
| — | Newman, J. C., et al. (2024). Role of the National Institute on Aging in transforming geroscience research. Innovation in Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC12314534/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12314534/ |
| — | Singh, R., et al. (2001). Advanced glycation end-products: A review . https://pubmed.ncbi.nlm.nih.gov/11270668/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11270668/ |
| — | Hillary, R. F., Stevenson, A. J., McCartney, D. L., Campbell, A., Walker, R. M., Howard, D. M., Ritchie, C. W., Horvath, S., Hayward, C., McIntosh, A. M., Evans, K. L., Deary, I. J., & Marioni, R. E. (2021). An epigenetic predictor of death captures multi-modal measures of brain health . https://doi.org/10.1038/s41380-019-0616-9 | — | — | https://doi.org/10.1038/s41380-019-0616-9 |
| — | Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Ferrucci, L., & Horvath, S. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan . https://doi.org/10.18632/aging.101684 | — | — | https://doi.org/10.18632/aging.101684 |
| — | Lu, A. T., Binder, A. M., Zhang, J., Yan, Q., Reiner, A. P., Cox, S. R., Corley, J., Harris, S. E., Kuo, P. L., Moore, A. Z., Bandinelli, S., Stewart, J. D., Hou, L., Baccarelli, A. A., Whitsel, E. A., Assimes, T. L., Chen, B. H., Ferrucci, L., & Horvath, S. (2022). DNA methylation GrimAge version 2 . https://doi.org/10.18632/aging.204434 | — | — | https://doi.org/10.18632/aging.204434 |
| — | Campisi, J., & d'Adda di Fagagna, F. (2007). Cellular senescence: when bad things happen to good cells . https://doi.org/10.1038/nrm2233 | — | — | https://doi.org/10.1038/nrm2233 |
| — | Hayflick, L. (1965). The Limited in Vitro Lifetime of Human Diploid Cell Strains . https://doi.org/10.1016/0014-4827(65)90211-9 | — | — | https://doi.org/10.1016/0014-4827(65)90211-9 |
| — | Shreffler, J., & Huecker, M. R. (2023). Survival Analysis. StatPearls . NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK560604/ | — | — | https://www.ncbi.nlm.nih.gov/books/NBK560604/ |
| — | Sashegyi, A., & Ferry, D. (2017). On the interpretation of the hazard ratio and communication of survival benefit. The Oncologist . https://pmc.ncbi.nlm.nih.gov/articles/PMC5388384/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5388384/ |
| — | Hernán, M. A. (2010). The hazards of hazard ratios. Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3653612/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3653612/ |
| — | Kaeberlein, M. (2018). How healthy is the healthspan concept? GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC6136295/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6136295/ |
| — | Fries, J. F. (2016). The theory and practice of active aging. Current Gerontology and Geriatrics Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC4968910/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4968910/ |
| — | Rowe, J. W., & Kahn, R. L. (1987). Human aging: usual and successful. Science . https://pubmed.ncbi.nlm.nih.gov/3299702/ | — | — | https://pubmed.ncbi.nlm.nih.gov/3299702/ |
| — | Promislow, D. (2022). Resilience integrates concepts in aging research. iScience , 25(5), 104199. https://pmc.ncbi.nlm.nih.gov/articles/PMC9044173/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9044173/ |
| — | Billman, G. E. (2020). Homeostasis: The underappreciated and far too often ignored central organizing principle of physiology. Frontiers in Physiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC7076167/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7076167/ |
| — | OpenStax. Homeostasis. https://openstax.org/books/anatomy-and-physiology-2e/pages/1-5-homeostasis | — | — | https://openstax.org/books/anatomy-and-physiology-2e/pages/1-5-homeostasis |
| — | Ukraintseva, S., Yashin, A. I., Arbeev, K. G., et al. (2021). Decline in biological resilience as key manifestation of aging. Mechanisms of Ageing and Development . https://www.sciencedirect.com/science/article/pii/S0047637420302141 | — | — | https://www.sciencedirect.com/science/article/pii/S0047637420302141 |
| — | Promislow, D., Anderson, R. M., Scheffer, M., et al. (2022). Resilience integrates concepts in aging research. iScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC9044173/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9044173/ |
| — | Whitson, H. E., Duan-Porter, W., Schmader, K. E., et al. (2016). Physical resilience in older adults: systematic review and development of an emerging construct. The Journals of Gerontology: Series A . https://academic.oup.com/biomedgerontology/article/71/4/489/2605404 | — | — | https://academic.oup.com/biomedgerontology/article/71/4/489/2605404 |
| — | Fulop, T., et al. (2018). Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? . https://pmc.ncbi.nlm.nih.gov/articles/PMC5767595/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5767595/ |
| — | Aw, D., Silva, A. B., & Palmer, D. B. (2007). Immunosenescence: emerging challenges for an ageing population . https://pmc.ncbi.nlm.nih.gov/articles/PMC2265901/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2265901/ |
| — | Franceschi, C., et al. (2000). Inflamm-aging: An evolutionary perspective on immunosenescence . https://pubmed.ncbi.nlm.nih.gov/10911963/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10911963/ |
| — | Franceschi, C., et al. (2017). Inflammaging and human longevity in the omics era . https://pubmed.ncbi.nlm.nih.gov/28038993/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28038993/ |
| — | Franceschi, C., et al. (2018). Inflammaging: a new immune-metabolic viewpoint for age-related diseases . https://doi.org/10.1038/s41574-018-0059-4 | — | — | https://doi.org/10.1038/s41574-018-0059-4 |
| — | Alberts, B., et al. (2015). Molecular Biology of the Cell . https://www.ncbi.nlm.nih.gov/books/NBK21054/ | — | — | https://www.ncbi.nlm.nih.gov/books/NBK21054/ |
| — | Campisi, J. (2013). Aging, Cellular Senescence, and Cancer . https://doi.org/10.1146/annurev-physiol-030212-183653 | — | — | https://doi.org/10.1146/annurev-physiol-030212-183653 |
| — | World Health Organization. (2015). World report on ageing and health . https://www.who.int/publications/i/item/9789241565042 | — | — | https://www.who.int/publications/i/item/9789241565042 |
| — | World Health Organization. (2017). Integrated care for older people: guidelines on community-level interventions to manage declines in intrinsic capacity . https://www.who.int/publications/i/item/9789241550109 | — | — | https://www.who.int/publications/i/item/9789241550109 |
| — | World Health Organization. (2020). Decade of healthy ageing: baseline report . https://www.who.int/publications/i/item/9789240017900 | — | — | https://www.who.int/publications/i/item/9789240017900 |
| — | Baylor OpenBooks. Lifespan, life expectancy, and healthy aging. https://openbooks.library.baylor.edu/lifespanhumandevelopment/chapter/22-1-lifespan-life-expectancy-healthy-aging/ | — | — | https://openbooks.library.baylor.edu/lifespanhumandevelopment/chapter/22-1-lifespan-life-expectancy-healthy-aging/ |
| — | ScienceDirect Topics. Lifespan. https://www.sciencedirect.com/topics/medicine-and-dentistry/lifespan | — | — | https://www.sciencedirect.com/topics/medicine-and-dentistry/lifespan |
| — | Murray, P. J., & Wynn, T. A. (2011). Protective and pathogenic functions of macrophage subsets . https://doi.org/10.1038/nri3073 | — | — | https://doi.org/10.1038/nri3073 |
| — | Xue, J., Schmidt, S. V., Sander, J., et al. (2014). Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation . https://doi.org/10.1016/j.immuni.2014.01.006 | — | — | https://doi.org/10.1016/j.immuni.2014.01.006 |
| — | Wynn, T. A., & Vannella, K. M. (2016). Macrophages in Tissue Repair, Regeneration, and Fibrosis . https://doi.org/10.1016/j.immuni.2016.02.015 | — | — | https://doi.org/10.1016/j.immuni.2016.02.015 |
| — | Galkin, F., Mamoshina, P., Aliper, A., et al. (2020). Human gut microbiome aging clock based on taxonomic profiling and deep learning. iScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC7037303/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7037303/ |
| — | O'Toole, P. W., & Jeffery, I. B. (2015). Gut microbiota and aging. Science . https://www.science.org/doi/10.1126/science.aac8469 | — | — | https://www.science.org/doi/10.1126/science.aac8469 |
| — | Bratic, A., & Larsson, N. G. (2013). The role of mitochondria in aging . https://doi.org/10.1172/JCI64125 | — | — | https://doi.org/10.1172/JCI64125 |
| — | Youle, R. J., & Narendra, D. P. (2011). Mechanisms of mitophagy . https://pubmed.ncbi.nlm.nih.gov/21779032/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21779032/ |
| — | Sun, N., Youle, R. J., & Finkel, T. (2016). The mitochondrial basis of aging . https://pubmed.ncbi.nlm.nih.gov/27108561/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27108561/ |
| — | Fries, J. F. (2011). Compression of morbidity 1980-2011. Clinical Orthopaedics and Related Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC3163136/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3163136/ |
| — | Barnett, K., et al. (2012). Epidemiology of multimorbidity and implications for health care, research, and medical education. The Lancet . https://pubmed.ncbi.nlm.nih.gov/22579043/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22579043/ |
| — | Hessler, R. M., et al. (2003). The compression of morbidity debate. Archives of Gerontology and Geriatrics . https://www.sciencedirect.com/science/article/abs/pii/S0167494303000487 | — | — | https://www.sciencedirect.com/science/article/abs/pii/S0167494303000487 |
| — | Blaum, C. (American Geriatrics Society). Morbidity, comorbidity, and multimorbidity. https://www.americangeriatrics.org/sites/default/files/inline-files/caroline_blaum.pdf | — | — | https://www.americangeriatrics.org/sites/default/files/inline-files/caroline_blaum.pdf |
| — | Mannick, J. B., et al. (2023). Targeting the biology of aging with mTOR inhibitors . https://pmc.ncbi.nlm.nih.gov/articles/PMC10330278/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10330278/ |
| — | Kennedy, B. K., & Lamming, D. W. (2016). The mechanistic target of rapamycin: The grand conducTOR of metabolism and aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC4910876/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4910876/ |
| — | López-Otín, C., et al. (2013). The hallmarks of aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ |
| — | Lamming, D. W. (2016). Inhibition of the mechanistic target of rapamycin (mTOR)-rapamycin and beyond . https://pmc.ncbi.nlm.nih.gov/articles/PMC4852795/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4852795/ |
| — | Barnett, K., et al. (2012). Epidemiology of multimorbidity and implications for health care, research, and medical education . https://pubmed.ncbi.nlm.nih.gov/22579043/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22579043/ |
| — | World Health Organization. (2016). Multimorbidity: Technical Series on Safer Primary Care . https://iris.who.int/handle/10665/252275 | — | — | https://iris.who.int/handle/10665/252275 |
| — | Sies, H., Berndt, C., & Jones, D. P. (2017). Oxidative stress . https://pubmed.ncbi.nlm.nih.gov/28441057/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28441057/ |
| — | Baker, D. J., Wijshake, T., Tchkonia, T., et al. (2011). Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders . https://doi.org/10.1038/nature10600 | — | — | https://doi.org/10.1038/nature10600 |
| — | Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015). Cellular senescence in aging and age-related disease: from mechanisms to therapy . https://doi.org/10.1038/nm.4000 | — | — | https://doi.org/10.1038/nm.4000 |
| — | Katsimpardi, L., et al. (2014). Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science . https://pmc.ncbi.nlm.nih.gov/articles/PMC4123747/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4123747/ |
| — | Baht, G. S., et al. (2015). Exposure to a youthful circulation rejuvenates bone repair through modulation of beta-catenin. Nature Communications . https://pmc.ncbi.nlm.nih.gov/articles/PMC4479006/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4479006/ |
| — | Villeda, S. A., et al. (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC4224436/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4224436/ |
| — | Conboy, I. M., et al. (2005). Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature . https://pubmed.ncbi.nlm.nih.gov/15716955/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15716955/ |
| — | Mehdipour, M., et al. (2020). Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin. Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC7288913/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7288913/ |
| — | Yousefzadeh, M. J., Robbins, P. D., & Huffman, D. M. (2022). Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging. Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC9037264/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9037264/ |
| — | Rebo, J., et al. (2016). A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nature Communications . https://pmc.ncbi.nlm.nih.gov/articles/PMC5121415/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5121415/ |
| — | Conboy, M. J., Conboy, I. M., & Rando, T. A. (2013). Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC4072458/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4072458/ |
| — | Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., Whitsel, E. A., Wilson, J. G., Reiner, A. P., Aviv, A., Lohman, K., Liu, Y., Ferrucci, L., & Horvath, S. (2018). An epigenetic biomarker of aging for lifespan and healthspan . https://doi.org/10.18632/aging.101414 | — | — | https://doi.org/10.18632/aging.101414 |
| — | Liu, Z., Kuo, P. L., Horvath, S., Crimmins, E., Ferrucci, L., & Levine, M. (2018). A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study . https://doi.org/10.1371/journal.pmed.1002718 | — | — | https://doi.org/10.1371/journal.pmed.1002718 |
| — | Hershko, A., & Ciechanover, A. (1998). The ubiquitin system . https://doi.org/10.1146/annurev.biochem.67.1.425 | — | — | https://doi.org/10.1146/annurev.biochem.67.1.425 |
| — | Labbadia, J., & Morimoto, R. I. (2015). The biology of proteostasis in aging and disease . https://pubmed.ncbi.nlm.nih.gov/25710535/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25710535/ |
| — | Li, J., & Clevers, H. (2010). Coexistence of quiescent and active adult stem cells in mammals . https://pubmed.ncbi.nlm.nih.gov/20519528/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20519528/ |
| — | Cheung, T. H., & Rando, T. A. (2013). Molecular regulation of stem cell quiescence . https://pubmed.ncbi.nlm.nih.gov/23962845/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23962845/ |
| — | Finkel, T. (2011). Signal transduction by reactive oxygen species . https://pubmed.ncbi.nlm.nih.gov/21746850/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21746850/ |
| — | d'Adda di Fagagna, F., et al. (2003). A DNA damage checkpoint response in telomere-initiated senescence . https://doi.org/10.1038/nature02118 | — | — | https://doi.org/10.1038/nature02118 |
| — | Cruz-Jentoft, A. J. et al. "Sarcopenia: Revised European consensus on definition and
diagnosis (EWGSOP2)." Age and Ageing (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6322506/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6322506/ |
| — | Cruz-Jentoft, A. J. et al. "Sarcopenia: European consensus on definition and diagnosis." Age and Ageing (2010). https://pmc.ncbi.nlm.nih.gov/articles/PMC2886201/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2886201/ |
| — | Childs, B. G., et al. (2015). Cellular senescence in aging and age-related disease: From mechanisms to therapy . https://pubmed.ncbi.nlm.nih.gov/25936745/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25936745/ |
| — | Gorgoulis, V., et al. (2019). Cellular senescence: Defining a path forward . https://pubmed.ncbi.nlm.nih.gov/31577934/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31577934/ |
| — | van Deursen, J. M. (2014). The role of senescent cells in ageing . https://www.nature.com/articles/nature13193 | — | — | https://www.nature.com/articles/nature13193 |
| — | Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015). Cellular senescence in aging and age-related disease: From mechanisms to therapy. Nature Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC4748967/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4748967/ |
| — | Gorgoulis, V., Adams, P. D., Alimonti, A., et al. (2019). Cellular senescence: Defining a path forward. Cell . https://www.cell.com/cell/fulltext/S0092-8674(19)31304-2 | — | — | https://www.cell.com/cell/fulltext/S0092-8674(19)31304-2 |
| — | Campisi, J., & d'Adda di Fagagna, F. (2007). Cellular senescence: When bad things happen to good cells. Nature Reviews Molecular Cell Biology . https://www.nature.com/articles/nrm2233 | — | — | https://www.nature.com/articles/nrm2233 |
| — | Krizhanovsky, V., Yon, M., Dickins, R. A., et al. (2008). Senescence of Activated Stellate Cells Limits Liver Fibrosis . https://doi.org/10.1016/j.cell.2008.06.049 | — | — | https://doi.org/10.1016/j.cell.2008.06.049 |
| — | Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T., & Kirkland, J. L. (2018). Senescent cell clearance by the immune system: Emerging therapeutic opportunities . https://doi.org/10.1016/j.semcancer.2018.05.003 | — | — | https://doi.org/10.1016/j.semcancer.2018.05.003 |
| — | Ovadya, Y., & Krizhanovsky, V. (2014). Senescent cells: SASPected drivers of age-related pathologies . https://doi.org/10.1016/j.bbamcr.2014.10.016 | — | — | https://doi.org/10.1016/j.bbamcr.2014.10.016 |
| — | Munoz-Espin, D., & Serrano, M. (2014). Cellular senescence: from physiology to pathology . https://doi.org/10.1038/nrm3823 | — | — | https://doi.org/10.1038/nrm3823 |
| — | Xue, W., Zender, L., Miething, C., et al. (2007). Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas . https://doi.org/10.1038/nature05529 | — | — | https://doi.org/10.1038/nature05529 |
| — | Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E., Hoeijmakers, J. H. J., de Bruin, A., Hara, E., & Campisi, J. (2014). An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA . https://www.sciencedirect.com/science/article/pii/S1534580714007690 | — | — | https://www.sciencedirect.com/science/article/pii/S1534580714007690 |
| — | López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging . https://www.cell.com/cell/fulltext/S0092-8674(13)00645-4 | — | — | https://www.cell.com/cell/fulltext/S0092-8674(13)00645-4 |
| — | Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019). Cellular senescence: Aging, cancer, and injury . https://journals.physiology.org/doi/full/10.1152/physrev.00020.2018 | — | — | https://journals.physiology.org/doi/full/10.1152/physrev.00020.2018 |
| — | Haigis, M. C., & Sinclair, D. A. (2010). Mammalian sirtuins: biological insights and disease relevance . https://doi.org/10.1146/annurev.pathol.4.110807.092250 | — | — | https://doi.org/10.1146/annurev.pathol.4.110807.092250 |
| — | Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease . https://doi.org/10.1016/j.tcb.2014.04.002 | — | — | https://doi.org/10.1016/j.tcb.2014.04.002 |
| — | Goodell, M. A., & Rando, T. A. (2015). Stem cells and healthy aging . https://pubmed.ncbi.nlm.nih.gov/25710536/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25710536/ |
| — | Brunet, A., & Rando, T. A. (2017). Interaction between epigenetic and metabolism in aging stem cells . https://pubmed.ncbi.nlm.nih.gov/28388419/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28388419/ |
| — | U.S. Food and Drug Administration. (2018). Surrogate Endpoint Resources for Drug and Biologic Development . https://www.fda.gov/drugs/development-resources/surrogate-endpoint-resources-drug-and-biologic-development | — | — | https://www.fda.gov/drugs/development-resources/surrogate-endpoint-resources-drug-and-biologic-development |
| — | Palm, W., & de Lange, T. (2008). How Shelterin Protects Mammalian Telomeres . https://doi.org/10.1146/annurev.genet.41.110306.130350 | — | — | https://doi.org/10.1146/annurev.genet.41.110306.130350 |
| — | Kodama, S., et al. (2009). Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women . https://pubmed.ncbi.nlm.nih.gov/19454641/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19454641/ |
| — | Ross, R., et al. (2016). Importance of assessing cardiorespiratory fitness in clinical practice: A case for fitness as a clinical vital sign . https://pubmed.ncbi.nlm.nih.gov/27881567/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27881567/ |
| — | Poole, D. C., & Jones, A. M. (2017). Measurement of the maximum oxygen uptake VO2max: VO2peak is no longer acceptable . https://pubmed.ncbi.nlm.nih.gov/28153947/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28153947/ |
| — | Guralnik, J. M., et al. (1994). A short physical performance battery assessing lower extremity
function: association with self-reported disability and prediction of mortality and nursing home
admission. Journal of Gerontology , 49(2), M85-M94. https://pubmed.ncbi.nlm.nih.gov/8126356/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8126356/ |
| — | Gill, T. M. (2010). Assessment of function and disability in longitudinal studies. Journal of the American Geriatrics Society , 58 Suppl 2, S308-S312. https://pubmed.ncbi.nlm.nih.gov/21029059/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21029059/ |
| — | Lawton, M. P., & Brody, E. M. (1969). Assessment of older people: self-maintaining and
instrumental activities of daily living. Gerontologist , 9(3), 179-186. https://academic.oup.com/gerontologist/article-abstract/9/3_Part_1/179/552696 | — | — | https://academic.oup.com/gerontologist/article-abstract/9/3_Part_1/179/552696 |
| — | Katz, S., et al. (1963). Studies of illness in the aged. The index of ADL: a standardized measure of
biological and psychosocial function. JAMA , 185(12), 914-919. https://jamanetwork.com/journals/jama/article-abstract/666768 | — | — | https://jamanetwork.com/journals/jama/article-abstract/666768 |
| — | Rogers, W. A., Ramadhani, W. A., & Harris, M. T. (2020). Defining aging in place:
the intersectionality of space, person, and time. Innovation in Aging , 4(4), igaa036. https://pmc.ncbi.nlm.nih.gov/articles/PMC7595274/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7595274/ |
| — | Wahl, H.-W., Iwarsson, S., & Oswald, F. (2012). Aging well and the environment:
toward an integrative model and research agenda for the future. The Gerontologist , 52(3),
306-316. https://doi.org/10.1093/geront/gnr154 | — | — | https://doi.org/10.1093/geront/gnr154 |
| — | Wiles, J. L., Leibing, A., Guberman, N., Reeve, J., & Allen, R. E. S. (2012). The
meaning of “aging in place” to older people. The Gerontologist , 52(3), 357-366. https://doi.org/10.1093/geront/gnr098 | — | — | https://doi.org/10.1093/geront/gnr098 |
| — | Oswald, F., Wahl, H.-W., Schilling, O., et al. (2007). Relationships between housing and
healthy aging in very old age. The Gerontologist , 47(1), 96-107. https://doi.org/10.1093/geront/47.1.96 | — | — | https://doi.org/10.1093/geront/47.1.96 |
| — | Gitlin, L. N., Winter, L., Dennis, M. P., Corcoran, M., Schinfeld, S., & Hauck, W. W.
(2006). A randomized trial of a multicomponent home intervention to reduce functional difficulties
in older adults. Journal of the American Geriatrics Society , 54(5), 809-816. https://doi.org/10.1111/j.1532-5415.2006.00703.x | — | — | https://doi.org/10.1111/j.1532-5415.2006.00703.x |
| — | Stineman, M. G., Xie, D., Streim, J. E., et al. (2012). Home accessibility, living
circumstances, stage of activity limitation, and nursing home use. Archives of Physical Medicine and Rehabilitation , 93(9), 1609-1616. https://pmc.ncbi.nlm.nih.gov/articles/PMC3461316/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3461316/ |
| — | Stark, S., Keglovits, M., Somerville, E., et al. (2021). Home hazard removal to reduce
falls among community-dwelling older adults: a randomized clinical trial. JAMA Network Open ,
4(8), e2122044. https://pmc.ncbi.nlm.nih.gov/articles/PMC8408671/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8408671/ |
| — | Werngren-Elgström, M., Carlsson, G., & Iwarsson, S. (2008). Changes in
person-environmental fit and ADL dependence among older Swedish adults: a 10-year follow-up. Aging Clinical and Experimental Research , 20(5), 469-478. https://doi.org/10.1007/BF03325154 | — | — | https://doi.org/10.1007/BF03325154 |
| — | Lawton, M. P., & Brody, E. M. (1969). Assessment of older people: self-maintaining
and instrumental activities of daily living. The Gerontologist , 9(3 Part 1), 179-186. https://doi.org/10.1093/geront/9.3_Part_1.179 | — | — | https://doi.org/10.1093/geront/9.3_Part_1.179 |
| — | Penninx, B. W. J. H., Guralnik, J. M., Onder, G., et al. (2003). Anemia and decline in physical performance among older persons. The American Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/12893395/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12893395/ |
| — | Guralnik, J., Ershler, W. B., Artz, A. S., et al. (2022). Unexplained anemia of aging: etiology, health consequences, and diagnostic criteria. Journal of the American Geriatrics Society . https://pubmed.ncbi.nlm.nih.gov/34796957/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34796957/ |
| — | Thein, M., Ershler, W. B., Artz, A. S., et al. (2009). Diminished quality of life and physical function in community-dwelling elderly with anemia. Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC2893336/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2893336/ |
| — | Guralnik, J. M., Eisenstaedt, R. S., Ferrucci, L., Klein, H. G., & Woodman, R. C. (2004). Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood . https://pubmed.ncbi.nlm.nih.gov/15238427/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15238427/ |
| — | Palmer, K., Vetrano, D. L., Marengoni, A., et al. (2018). The relationship between anaemia and frailty: a systematic review and meta-analysis of observational studies. Journal of Nutrition, Health & Aging . https://pubmed.ncbi.nlm.nih.gov/30272101/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30272101/ |
| — | Stauder, R., Valent, P., & Theurl, I. (2018). Anemia at older age: etiologies, clinical implications, and management. Blood . https://pubmed.ncbi.nlm.nih.gov/29141943/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29141943/ |
| — | Penninx, B. W. J. H., Pahor, M., Cesari, M., et al. (2004). Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. Journal of the American Geriatrics Society . https://pubmed.ncbi.nlm.nih.gov/15086651/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15086651/ |
| — | Ferrucci, L., Guralnik, J. M., Bandinelli, S., et al. (2007). Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. British Journal of Haematology . https://pmc.ncbi.nlm.nih.gov/articles/PMC2669300/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2669300/ |
| — | Radakovic, R., & Abrahams, S. (2014). Developing a new apathy measurement scale:
Dimensional Apathy Scale. Psychiatry Research , 219(3), 658-663. https://doi.org/10.1016/j.psychres.2014.06.010 | — | — | https://doi.org/10.1016/j.psychres.2014.06.010 |
| — | Starkstein, S. E., Jorge, R., Mizrahi, R., & Robinson, R. G. (2006). A prospective
longitudinal study of apathy in Alzheimer's disease. Journal of Neurology, Neurosurgery &
Psychiatry , 77(1), 8-11. https://doi.org/10.1136/jnnp.2005.069575 | — | — | https://doi.org/10.1136/jnnp.2005.069575 |
| — | Henstra, M. J., Rhebergen, D., Stek, M. L., et al. (2019). The association between
apathy, decline in physical performance, and falls in older persons. Aging Clinical and
Experimental Research , 31(10), 1491-1499. https://doi.org/10.1007/s40520-018-1096-5 | — | — | https://doi.org/10.1007/s40520-018-1096-5 |
| — | Robert, P. H., Clairet, S., Benoit, M., et al. (2002). The Apathy Inventory:
assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive
impairment. International Journal of Geriatric Psychiatry , 17(12), 1099-1105. https://doi.org/10.1002/gps.755 | — | — | https://doi.org/10.1002/gps.755 |
| — | Lanctôt, K. L., Ismail, Z., Bawa, K. K., Cummings, J. L., Husain, M., Mortby,
M. E., & Robert, P. (2023). Distinguishing apathy from depression: a review differentiating the
behavioral, neuroanatomic, and treatment-related aspects of apathy from depression in
neurocognitive disorders. International Journal of Geriatric Psychiatry , 38(2), e5882. https://doi.org/10.1002/gps.5882 | — | — | https://doi.org/10.1002/gps.5882 |
| — | Wilson, S. A., et al. (2022). A systematic review of smartphone and tablet use by older
adults with and without cognitive impairment. Innovation in Aging , 6(2), igac002. https://pmc.ncbi.nlm.nih.gov/articles/PMC8889997/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8889997/ |
| — | Howard, R., et al. (2021). The effectiveness and cost-effectiveness of assistive
technology and telecare for independent living in dementia: a randomised controlled trial. Age and Ageing , 50(3), 882-890. https://pmc.ncbi.nlm.nih.gov/articles/PMC8099012/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8099012/ |
| — | Bateni, H., & Maki, B. E. (2005). Assistive devices for balance and mobility:
benefits, demands, and adverse consequences. Archives of Physical Medicine and Rehabilitation ,
86(1), 134-145. https://pubmed.ncbi.nlm.nih.gov/15641004/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15641004/ |
| — | Fotteler, M. L., et al. (2022). The effectiveness of assistive technologies for older
adults and the influence of frailty: systematic literature review of randomized controlled trials. JMIR Aging , 5(2), e31916. https://pmc.ncbi.nlm.nih.gov/articles/PMC9016506/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9016506/ |
| — | Salminen, A. L., et al. (2009). Mobility devices to promote activity and participation:
a systematic review. Journal of Rehabilitation Medicine , 41(9), 697-706. https://pubmed.ncbi.nlm.nih.gov/19774301/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19774301/ |
| — | Gell, N. M., et al. (2015). Mobility device use in older adults and incidence of falls
and worry about falling: findings from the 2011-2012 National Health and Aging Trends Study. Journal of the American Geriatrics Society , 63(5), 853-859. https://pmc.ncbi.nlm.nih.gov/articles/PMC4439269/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4439269/ |
| — | Agree, E. M., & Freedman, V. A. (2003). A comparison of assistive technology and
personal care in alleviating disability and unmet need. The Gerontologist , 43(3), 335-344. https://pubmed.ncbi.nlm.nih.gov/12810897/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12810897/ |
| — | Ambrose, A. F., Paul, G., & Hausdorff, J. M. (2013). Risk factors for falls among older adults: a review of the literature. Maturitas , 75(1), 51-61. https://pubmed.ncbi.nlm.nih.gov/23523272/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23523272/ |
| — | Guralnik, J. M., Simonsick, E. M., Ferrucci, L., et al. (1994). A short physical performance battery assessing lower extremity function. Journal of Gerontology , 49(2), M85-M94. https://pubmed.ncbi.nlm.nih.gov/8126356/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8126356/ |
| — | Horak, F. B. (2006). Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Age and Ageing , 35 Suppl 2, ii7-ii11. https://pubmed.ncbi.nlm.nih.gov/16926210/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16926210/ |
| — | Tinetti, M. E. (1986). Performance-oriented assessment of mobility problems in elderly patients. Journal of the American Geriatrics Society , 34(2), 119-126. https://pubmed.ncbi.nlm.nih.gov/3944402/ | — | — | https://pubmed.ncbi.nlm.nih.gov/3944402/ |
| — | Barry, E., Galvin, R., Keogh, C., Horgan, F., & Fahey, T. (2014). Is the Timed Up and Go test a useful predictor of risk of falls in community dwelling older adults? BMC Geriatrics , 14, 14. https://pmc.ncbi.nlm.nih.gov/articles/PMC3924230/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3924230/ |
| — | Rubenstein, L. Z. (2006). Falls in older people: epidemiology, risk factors and strategies for prevention. Age and Ageing , 35 Suppl 2, ii37-ii41. https://pubmed.ncbi.nlm.nih.gov/16926202/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16926202/ |
| — | Moreland, J. D., Richardson, J. A., Goldsmith, C. H., & Clase, C. M. (2004). Muscle weakness and falls in older adults: a systematic review and meta-analysis. Journal of the American Geriatrics Society , 52(7), 1121-1129. https://pubmed.ncbi.nlm.nih.gov/15209650/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15209650/ |
| — | Deandrea, S., Lucenteforte, E., Bravi, F., Foschi, R., La Vecchia, C., & Negri, E. (2010). Risk factors for falls in community-dwelling older people: a systematic review and meta-analysis. Epidemiology , 21(5), 658-668. https://pubmed.ncbi.nlm.nih.gov/20585256/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20585256/ |
| — | Tang, V. L., et al. (2017). Rates of recovery to pre-fracture function in older persons with hip fracture: an observational study. Journal of General Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/27605004/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27605004/ |
| — | Edwards, M. H., et al. (2013). Clinical risk factors, bone density and fall history in the prediction of incident fracture among men and women. Bone . https://pubmed.ncbi.nlm.nih.gov/23159464/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23159464/ |
| — | Balasubramanian, A., et al. (2019). Risk of subsequent fracture after prior fracture among older women. Osteoporosis International . https://pubmed.ncbi.nlm.nih.gov/30456571/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30456571/ |
| — | Farr, J. N., et al. (2017). Targeting cellular senescence prevents age-related bone loss in mice. Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/28825716/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28825716/ |
| — | Seeman, E., & Delmas, P. D. (2006). Bone quality—the material and structural basis of bone strength and fragility. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/16723616/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16723616/ |
| — | Compston, J. E., McClung, M. R., & Leslie, W. D. (2019). Osteoporosis. The Lancet . https://pubmed.ncbi.nlm.nih.gov/30696576/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30696576/ |
| — | Strait, J. B., & Lakatta, E. G. (2012). Heart Failure Clinics . https://pmc.ncbi.nlm.nih.gov/articles/PMC3223374/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3223374/ |
| — | Lakatta, E. G. (2002). Heart Failure Reviews . https://pubmed.ncbi.nlm.nih.gov/11790921/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11790921/ |
| — | Singam, N. S. V., Fine, C., & Fleg, J. L. (2020). Clinical Cardiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC7021646/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7021646/ |
| — | Donato, A. J., Machin, D. R., & Lesniewski, L. A. (2018). Circulation Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC6207260/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6207260/ |
| — | Cheng, S., Fernandes, V. R. S., Bluemke, D. A., et al. (2009). Circulation . https://pmc.ncbi.nlm.nih.gov/articles/PMC2744970/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2744970/ |
| — | Roh, J., Rhee, J., Chaudhari, V., & Rosenzweig, A. (2016). Circulation Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC4914047/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4914047/ |
| — | Ankuda, C. K., Levine, D. A., Langa, K. M., Ornstein, K. A., & Kelley, A. S. (2020).
Caregiving, recovery and death after incident ADL/IADL disability among older adults in the United
States. Journal of Applied Gerontology , 39(4), 393-397. https://pmc.ncbi.nlm.nih.gov/articles/PMC7105395/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7105395/ |
| — | Gill, T. M. (2010). Assessment of function and disability in longitudinal studies. Journal of the American Geriatrics Society , 58(S2), S308-S312. https://pmc.ncbi.nlm.nih.gov/articles/PMC2992435/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2992435/ |
| — | Hardy, S. E., Dubin, J. A., Holford, T. R., & Gill, T. M. (2005). Transitions
between states of disability and independence among older persons. American Journal of Epidemiology ,
161(6), 575-584. https://pubmed.ncbi.nlm.nih.gov/15746474/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15746474/ |
| — | Gaugler, J. E., Yu, F., Krichbaum, K., & Wyman, J. F. (2009). Predictors of nursing
home admission for persons with dementia. Medical Care , 47(2), 191-198. https://pubmed.ncbi.nlm.nih.gov/19169120/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19169120/ |
| — | Gill, T. M., Robison, J. T., & Tinetti, M. E. (1997). Predictors of recovery in
activities of daily living among disabled older persons living in the community. Journal of General Internal Medicine , 12(12), 757-762. https://pmc.ncbi.nlm.nih.gov/articles/PMC1497202/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1497202/ |
| — | Gaugler, J. E., Duval, S., Anderson, K. A., & Kane, R. L. (2007). Predicting nursing
home admission in the U.S.: a meta-analysis. BMC Geriatrics , 7, 13. https://pubmed.ncbi.nlm.nih.gov/17578574/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17578574/ |
| — | Katz, S., Ford, A. B., Moskowitz, R. W., Jackson, B. A., & Jaffe, M. W. (1963).
Studies of illness in the aged: the Index of ADL. JAMA , 185, 914-919. https://pubmed.ncbi.nlm.nih.gov/14044222/ | — | — | https://pubmed.ncbi.nlm.nih.gov/14044222/ |
| — | Ho, L., Pugh, C., Seth, S., et al. (2024). Predicting short- to medium-term care home
admission risk in older adults: a systematic review of externally validated models. Age and Ageing , 53(5), afae088. https://pubmed.ncbi.nlm.nih.gov/38727580/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38727580/ |
| — | Muñoz-Bermejo, L., et al. (2021). Test-retest reliability of Five Times Sit to Stand Test in adults: a systematic review and meta-analysis. Biology , 10(6), 510. https://pmc.ncbi.nlm.nih.gov/articles/PMC8228261/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8228261/ |
| — | Bohannon, R. W. (2006). Reference values for the five-repetition sit-to-stand test: a descriptive meta-analysis of data from elders. Perceptual and Motor Skills , 103(1), 215-222. https://pubmed.ncbi.nlm.nih.gov/17037663/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17037663/ |
| — | Cooper, R., Strand, B. H., Hardy, R., Patel, K. V., & Kuh, D. (2014). Physical capability in mid-life and survival over 13 years of follow-up: British birth cohort study. BMJ , 348, g2219. https://www.bmj.com/content/348/bmj.g2219 | — | — | https://www.bmj.com/content/348/bmj.g2219 |
| — | Janssen, W. G. M., Bussmann, H. B. J., & Stam, H. J. (2002). Determinants of the sit-to-stand movement: a review. Physical Therapy , 82(9), 866-879. https://pubmed.ncbi.nlm.nih.gov/12201801/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12201801/ |
| — | Mehmet, H., Yang, A. W. H., & Robinson, S. R. (2020). What is the optimal chair stand test protocol for older adults? A systematic review. Disability and Rehabilitation , 42(20), 2828-2835. https://pubmed.ncbi.nlm.nih.gov/30907166/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30907166/ |
| — | Guralnik, J. M., Simonsick, E. M., Ferrucci, L., et al. (1994). A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. Journal of Gerontology , 49(2), M85-M94. https://pubmed.ncbi.nlm.nih.gov/8126356/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8126356/ |
| — | Hörlin, E., Munir Ehrlington, S., Henricson, J., Toll John, R., & Wilhelms, D. (2022). Inter-rater reliability of the Clinical Frailty Scale by staff members in a Swedish emergency department setting. Academic Emergency Medicine , 29(12), 1431-1437. https://pmc.ncbi.nlm.nih.gov/articles/PMC10092290/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10092290/ |
| — | Pugh, R. J., Ellison, A., Pye, K., et al. (2019). Reliability of frailty assessment in the critically ill: a multicentre prospective observational study. Anaesthesia , 74(6), 758-764. https://pubmed.ncbi.nlm.nih.gov/30793278/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30793278/ |
| — | Lee, J. H., Park, Y. S., Kim, M. J., et al. (2022). Clinical Frailty Scale as a predictor of short-term mortality: a systematic review and meta-analysis of studies on diagnostic test accuracy. Academic Emergency Medicine , 29(11), 1347-1356. https://pubmed.ncbi.nlm.nih.gov/35349205/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35349205/ |
| — | Rockwood, K., Song, X., MacKnight, C., et al. (2005). A global clinical measure of fitness and frailty in elderly people. CMAJ , 173(5), 489-495. https://pmc.ncbi.nlm.nih.gov/articles/PMC1188185/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1188185/ |
| — | Cesari, M., Gambassi, G., van Kan, G. A., & Vellas, B. (2014). The frailty phenotype and the frailty index: different instruments for different purposes. Age and Ageing , 43(1), 10-12. https://pubmed.ncbi.nlm.nih.gov/24132852/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24132852/ |
| — | Church, S., Rogers, E., Rockwood, K., & Theou, O. (2020). A scoping review of the Clinical Frailty Scale. BMC Geriatrics , 20, 393. https://doi.org/10.1186/s12877-020-01801-7 | — | — | https://doi.org/10.1186/s12877-020-01801-7 |
| — | Stern, Y. (2012). Cognitive reserve in ageing and Alzheimer’s disease . https://pmc.ncbi.nlm.nih.gov/articles/PMC3507991/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3507991/ |
| — | Raz, N., & Rodrigue, K. M. (2006). Differential aging of the brain: patterns, cognitive correlates and modifiers . https://pubmed.ncbi.nlm.nih.gov/16919333/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16919333/ |
| — | Perneczky, R., Pohl, C., Sorg, C., et al. (2006). Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues . https://pubmed.ncbi.nlm.nih.gov/16513677/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16513677/ |
| — | Kelaiditi, E., et al. (2013). Cognitive frailty: rational and definition from an I.A.N.A./I.A.G.G. international consensus group. The Journal of Nutrition, Health & Aging . https://pubmed.ncbi.nlm.nih.gov/24154642/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24154642/ |
| — | Sargent, L., et al. (2018). Shared biological pathways for frailty and cognitive impairment: a systematic review. Ageing Research Reviews . https://pmc.ncbi.nlm.nih.gov/articles/PMC6376483/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6376483/ |
| — | Ruan, Q., et al. (2015). Cognitive frailty, a novel target for the prevention of elderly dependency. Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/25555677/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25555677/ |
| — | Halil, M., et al. (2015). Cognitive aspects of frailty: mechanisms behind the link between frailty and cognitive impairment. The Journal of Nutrition, Health & Aging . https://pubmed.ncbi.nlm.nih.gov/25732212/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25732212/ |
| — | Feng, L., et al. (2017). Cognitive frailty and adverse health outcomes: findings from the Singapore Longitudinal Ageing Studies. Journal of the American Medical Directors Association . https://pubmed.ncbi.nlm.nih.gov/27838339/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27838339/ |
| — | Tsutsumimoto, K., et al. (2020). Cognitive frailty as a risk factor for incident disability during late life: a 24-month follow-up longitudinal study. The Journal of Nutrition, Health & Aging . https://pubmed.ncbi.nlm.nih.gov/32346687/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32346687/ |
| — | Tang, K. F., et al. (2023). Cognitive frailty and functional disability among community-dwelling older adults: a systematic review. Innovation in Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC9999676/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9999676/ |
| — | Bu, Z., et al. (2021). Cognitive frailty as a predictor of adverse outcomes among older adults: a systematic review and meta-analysis. Brain and Behavior . https://pmc.ncbi.nlm.nih.gov/articles/PMC7821586/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7821586/ |
| — | Sargent, L. and Brown, R. (2017). Assessing the current state of cognitive frailty: measurement properties. The Journal of Nutrition, Health & Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC12879857/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12879857/ |
| — | Zhang, T., et al. (2022). Prevalence and associated risk factors of cognitive frailty: a systematic review and meta-analysis. Frontiers in Aging Neuroscience . https://pmc.ncbi.nlm.nih.gov/articles/PMC8832102/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8832102/ |
| — | Rantakokko, M., et al. (2016). Mobility modification alleviates environmental influence on incident mobility difficulty among community-dwelling older people: a two-year follow-up study. PLoS ONE , 11(4), e0154396. https://pmc.ncbi.nlm.nih.gov/articles/PMC4841513/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4841513/ |
| — | Brown, C. J., et al. (2009). Trajectories of life-space mobility after hospitalization. Annals of Internal Medicine , 150(6), 372-378. https://pmc.ncbi.nlm.nih.gov/articles/PMC2802817/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2802817/ |
| — | World Health Organization. (2015). World Report on Ageing and Health . https://www.who.int/publications/i/item/9789241565042 | — | — | https://www.who.int/publications/i/item/9789241565042 |
| — | Crowe, M., et al. (2008). Life-space and cognitive decline in a community-based sample of African American and Caucasian older adults. The Journals of Gerontology: Series A , 63(11), 1241-1245. https://doi.org/10.1093/gerona/63.11.1241 | — | — | https://doi.org/10.1093/gerona/63.11.1241 |
| — | Baker, P. S., Bodner, E. V., & Allman, R. M. (2003). Measuring life-space mobility in community-dwelling older adults. Journal of the American Geriatrics Society , 51(11), 1610-1614. https://pubmed.ncbi.nlm.nih.gov/14687391/ | — | — | https://pubmed.ncbi.nlm.nih.gov/14687391/ |
| — | Portegijs, E., Rantakokko, M., Mikkola, T. M., Viljanen, A., & Rantanen, T. (2014). Association between physical performance and sense of autonomy in outdoor activities and life-space mobility in community-dwelling older people. Journal of the American Geriatrics Society , 62(4), 615-621. https://doi.org/10.1111/jgs.12763 | — | — | https://doi.org/10.1111/jgs.12763 |
| — | Mackey, D. C., et al. (2014). Life-space mobility and mortality in older men: a prospective cohort study. Journal of the American Geriatrics Society , 62(7), 1288-1296. https://pmc.ncbi.nlm.nih.gov/articles/PMC4251711/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4251711/ |
| — | Viljanen, A., Mikkola, T. M., Rantakokko, M., Portegijs, E., & Rantanen, T. (2016). The association between transportation and life-space mobility in community-dwelling older people with or without walking difficulties. Journal of Aging and Health , 28(6), 1038-1054. https://pubmed.ncbi.nlm.nih.gov/26613926/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26613926/ |
| — | Geyer, S., & Eberhard, S. "Compression and expansion of morbidity—secular trends among cohorts of the same age." Deutsches Ärzteblatt International (2022), 119, 810-815. https://pmc.ncbi.nlm.nih.gov/articles/PMC9906028/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9906028/ |
| — | Crimmins, E. M., & Beltrán-Sánchez, H. "Mortality and morbidity trends: is there compression of morbidity?" Journals of Gerontology Series B (2011), 66B(1), 75-86. https://pmc.ncbi.nlm.nih.gov/articles/PMC3001754/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3001754/ |
| — | Fries, J. F. "Aging, natural death, and the compression of morbidity." New England Journal of Medicine (1980), 303(3), 130-135. https://pubmed.ncbi.nlm.nih.gov/7383070/ | — | — | https://pubmed.ncbi.nlm.nih.gov/7383070/ |
| — | Hubert, H. B. et al. "Lifestyle habits and compression of morbidity." Journals of Gerontology Series A (2002), 57(6), M347-M351. https://pubmed.ncbi.nlm.nih.gov/12023263/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12023263/ |
| — | Yang, Y. et al. "Compression of morbidity by interventions that steepen the survival curve." Nature Communications (2025), 16, 3348. https://pmc.ncbi.nlm.nih.gov/articles/PMC11978790/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11978790/ |
| — | Fries, J. F. "The compression of morbidity." Milbank Memorial Fund Quarterly: Health and Society (1983), 61(3), 397-419. https://pubmed.ncbi.nlm.nih.gov/6555590/ | — | — | https://pubmed.ncbi.nlm.nih.gov/6555590/ |
| — | Parker, M. G., & Thorslund, M. "Health trends in the elderly population: getting better and getting worse." The Gerontologist (2007), 47(2), 150-158. https://pubmed.ncbi.nlm.nih.gov/17440120/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17440120/ |
| — | van der Wiel, H. E., Lips, P., Nauta, J., Netelenbos, J. C., & Hazenberg, G. J.
(1991). Biochemical parameters of bone turnover during ten days of bed rest and subsequent
mobilization. Bone and Mineral , 13(2), 123-129. https://pubmed.ncbi.nlm.nih.gov/2059676/ | — | — | https://pubmed.ncbi.nlm.nih.gov/2059676/ |
| — | Dirks, M. L., Wall, B. T., van de Valk, B., et al. (2016). One week of bed rest leads
to substantial muscle atrophy and induces whole-body insulin resistance in the absence of skeletal
muscle lipid accumulation. Diabetes , 65(10), 2862-2875. https://pubmed.ncbi.nlm.nih.gov/27358494/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27358494/ |
| — | Hajj-Boutros, G., Sonjak, V., Faust, A., et al. (2023). Impact of 14 days of bed rest
in older adults and an exercise countermeasure on body composition, muscle strength, and
cardiovascular function: Canadian Space Agency standard measures. Gerontology , 69(11),
1284-1294. https://pubmed.ncbi.nlm.nih.gov/37717560/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37717560/ |
| — | Loyd, C., Markland, A. D., Zhang, Y., et al. (2020). Prevalence of hospital-associated
disability in older adults: a meta-analysis. Journal of the American Medical Directors
Association , 21(4), 455-461.e5. https://pmc.ncbi.nlm.nih.gov/articles/PMC7469431/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7469431/ |
| — | Kortebein, P., Symons, T. B., Ferrando, A., et al. (2008). Functional impact of 10 days
of bed rest in healthy older adults. The Journals of Gerontology: Series A , 63(10),
1076-1081. https://pubmed.ncbi.nlm.nih.gov/18948558/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18948558/ |
| — | Tanner, R. E., Brunker, L. B., Agergaard, J., et al. (2015). Age-related differences
in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise
rehabilitation. The Journal of Physiology , 593(18), 4259-4273. https://pmc.ncbi.nlm.nih.gov/articles/PMC4594296/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4594296/ |
| — | Brown, C. J., Redden, D. T., Flood, K. L., & Allman, R. M. (2009). The
underrecognized epidemic of low mobility during hospitalization of older adults. Journal of the
American Geriatrics Society , 57(9), 1660-1665. https://pubmed.ncbi.nlm.nih.gov/19682121/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19682121/ |
| — | Coker, R. H., Hays, N. P., Williams, R. H., Wolfe, R. R., & Evans, W. J. (2015).
Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older,
healthy adults. The Journals of Gerontology: Series A , 70(1), 91-96. https://pmc.ncbi.nlm.nih.gov/articles/PMC4342684/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4342684/ |
| — | Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R., & Evans, W. J. (2007).
Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA , 297(16),
1772-1774. https://pubmed.ncbi.nlm.nih.gov/17456818/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17456818/ |
| — | Motanova, E., Sarto, F., Negro, S., et al. (2026). Neuromuscular junction instability
with inactivity: morphological and functional changes after 10 days of bed rest in older adults. The Journal of Physiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC12810232/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12810232/ |
| — | Pišot, R., Marusic, U., Biolo, G., et al. (2016). Greater loss in muscle mass and
function but smaller metabolic alterations in older compared with younger men following 2 wk of bed
rest and recovery. Journal of Applied Physiology , 120(8), 922-929. https://pubmed.ncbi.nlm.nih.gov/26823343/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26823343/ |
| — | Lagacé, J.-C., St-Martin, P., Avino, M., et al. (2026). Impact of 14 days of
head-down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and
circulatory cytokines in older adults. Experimental Physiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC13394170/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC13394170/ |
| — | St-Martin, P., Lagacé, J.-C., Ruel, M., et al. (2026). Exercise during 14 days of
head down tilt bedrest attenuates motor unit impairments in older humans. The Journal of
Physiology . https://pubmed.ncbi.nlm.nih.gov/41719153/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41719153/ |
| — | Loyd, C., Markland, A. D., Zhang, Y., et al. (2020). Prevalence of
hospital-associated disability in older adults: a meta-analysis. Journal of the American Medical
Directors Association , 21(4), 455-461.e5. https://pmc.ncbi.nlm.nih.gov/articles/PMC7469431/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7469431/ |
| — | Crimmins, E. M., & Beltrán-Sánchez, H. "Mortality and morbidity trends: is there compression of morbidity?" Journals of Gerontology Series B (2011). https://pmc.ncbi.nlm.nih.gov/articles/PMC3001754/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3001754/ |
| — | Kaeberlein, M. "How healthy is the healthspan concept?" GeroScience (2018). https://pmc.ncbi.nlm.nih.gov/articles/PMC6136295/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6136295/ |
| — | Chihuri, S., et al. (2016). Driving cessation and health outcomes in older adults. Journal of the American Geriatrics Society , 64(2), 332-341. https://pmc.ncbi.nlm.nih.gov/articles/PMC5021147/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5021147/ |
| — | Curl, A. L., Stowe, J. D., Cooney, T. M., & Proulx, C. M. (2014). Giving up the keys: how driving cessation affects engagement in later life. The Gerontologist , 54(3), 423-433. https://pubmed.ncbi.nlm.nih.gov/23651920/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23651920/ |
| — | Dickerson, A. E., et al. (2024). A systematic review of effective interventions and strategies to support the transition of older adults from driving to driving retirement/cessation. Innovation in Aging , 8(6), igae054. https://pmc.ncbi.nlm.nih.gov/articles/PMC11212369/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11212369/ |
| — | Edwards, J. D., Lunsman, M., Perkins, M., Rebok, G. W., & Roth, D. L. (2009). Driving cessation and health trajectories in older adults. The Journals of Gerontology: Series A , 64(12), 1290-1295. https://pmc.ncbi.nlm.nih.gov/articles/PMC2773808/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2773808/ |
| — | Marottoli, R. A., et al. (1997). Driving cessation and increased depressive symptoms: prospective evidence from the New Haven EPESE. Journal of the American Geriatrics Society , 45(2), 202-206. https://pubmed.ncbi.nlm.nih.gov/9033520/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9033520/ |
| — | Qin, W., Xiang, X., & Taylor, H. (2020). Driving cessation and social isolation in older adults. Journal of Aging and Health , 32(9), 962-971. https://pmc.ncbi.nlm.nih.gov/articles/PMC7901288/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7901288/ |
| — | Ge, S., et al. (2021). Longitudinal association between hearing loss, vision loss, dual sensory loss, and cognitive decline. Journal of the American Geriatrics Society . https://pubmed.ncbi.nlm.nih.gov/33258497/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33258497/ |
| — | Garcia Morales, E. E., et al. (2024). Population prevalence of dual sensory loss in community-dwelling US adults 71 years and older: evidence from the National Health and Aging Trends Study. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC10922129/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10922129/ |
| — | Raina, P., Wong, M., & Massfeller, H. (2004). The relationship between sensory impairment and functional independence among elderly. BMC Geriatrics . https://pmc.ncbi.nlm.nih.gov/articles/PMC425581/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC425581/ |
| — | Urqueta Alfaro, A., et al. (2020). Older adults with dual sensory loss in rehabilitation show high functioning and may fare better than those with single sensory loss. PLoS ONE . https://pmc.ncbi.nlm.nih.gov/articles/PMC7398548/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7398548/ |
| — | Goh, H.-T., Pearce, M., & Vas, A. (2021). Task matters: an investigation on the effect of different secondary tasks on dual-task gait in older adults. BMC Geriatrics , 21, 510. https://pubmed.ncbi.nlm.nih.gov/34563129/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34563129/ |
| — | Montero-Odasso, M., Sarquis-Adamson, Y., Kamkar, N., et al. (2020). Dual-task gait speed assessments with an electronic walkway and a stopwatch in older adults: a reliability study. Experimental Gerontology , 142, 111102. https://pubmed.ncbi.nlm.nih.gov/33017671/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33017671/ |
| — | Kahya, M., Moon, S., Ranchet, M., et al. (2019). Brain activity during dual task gait and balance in aging and age-related neurodegenerative conditions: a systematic review. Experimental Gerontology , 128, 110756. https://pubmed.ncbi.nlm.nih.gov/31648005/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31648005/ |
| — | Asai, T., Yamamoto, J., Oshima, K., et al. (2025). Dual-task gait test provides limited additional value for fall prediction in care-requiring older adults: a prospective study. Geriatrics & Gerontology International , 25(5), 663-669. https://pubmed.ncbi.nlm.nih.gov/40135419/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40135419/ |
| — | Yogev-Seligmann, G., Hausdorff, J. M., & Giladi, N. (2008). The role of executive function and attention in gait. Movement Disorders , 23(3), 329-342. https://pubmed.ncbi.nlm.nih.gov/18058946/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18058946/ |
| — | Ramírez, F., & Gutiérrez, M. (2021). Dual-task gait as a predictive tool for cognitive impairment in older adults: a systematic review. Frontiers in Aging Neuroscience , 13, 769462. https://pubmed.ncbi.nlm.nih.gov/35002676/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35002676/ |
| — | Clarke, P., et al. (2009). Urban built environments and trajectories of mobility disability: findings from a national sample of community-dwelling American adults (1986–2001). Social Science & Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC2759178/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2759178/ |
| — | Rantakokko, M., et al. (2016). Mobility modification alleviates environmental influence on incident mobility difficulty among community-dwelling older people: a two-year follow-up study. PLoS ONE . https://pmc.ncbi.nlm.nih.gov/articles/PMC4841513/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4841513/ |
| — | Rantanen, T., et al. (2012). Individual and environmental factors underlying life space of older people: study protocol and design of a cohort study on life-space mobility in old age (LISPE). BMC Public Health . https://pmc.ncbi.nlm.nih.gov/articles/PMC3534010/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3534010/ |
| — | Julião, P. L., et al. (2023). A systematic review of reviews on the psychometric properties of measures of older persons' ability to build and maintain social relationships. Age and Ageing , 52(Suppl 4), iv133-iv137. https://pmc.ncbi.nlm.nih.gov/articles/PMC10615056/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10615056/ |
| — | World Health Organization. (2001). International Classification of Functioning, Disability and Health: ICF . https://iris.who.int/handle/10665/42407 | — | — | https://iris.who.int/handle/10665/42407 |
| — | Keysor, J. J., et al. (2010). Community environmental factors are associated with disability in older adults with functional limitations: the MOST study. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC2905834/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2905834/ |
| — | Lawton, M. P., & Brody, E. M. (1969). Assessment of older people: self-maintaining and
instrumental activities of daily living. The Gerontologist , 9(3 Part 1), 179-186. https://doi.org/10.1093/geront/9.3_Part_1.179 | — | — | https://doi.org/10.1093/geront/9.3_Part_1.179 |
| — | Royall, D. R., Palmer, R., Chiodo, L. K., & Polk, M. J. (2004). Declining executive
control in normal aging predicts change in functional status: the Freedom House Study. Journal of the American Geriatrics Society , 52(3), 346-352. https://doi.org/10.1111/j.1532-5415.2004.52104.x | — | — | https://doi.org/10.1111/j.1532-5415.2004.52104.x |
| — | Diehl, M., Marsiske, M., Horgas, A. L., Rosenberg, A., Saczynski, J. S., & Willis,
S. L. (2005). The revised Observed Tasks of Daily Living: a performance-based assessment of everyday
problem solving in older adults. Journal of Applied Gerontology , 24(3), 211-230. https://pmc.ncbi.nlm.nih.gov/articles/PMC2153442/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2153442/ |
| — | Eldadah, B. A. (2010). Fatigue and fatigability in older adults. PM&R . https://pubmed.ncbi.nlm.nih.gov/20656622/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20656622/ |
| — | Tian, H., Xin, Z., Lin, Z., et al. (2025). Prevalence of fatigue and perceived fatigability in older adults: a systematic review and meta-analysis. Scientific Reports . https://www.nature.com/articles/s41598-025-88961-x | — | — | https://www.nature.com/articles/s41598-025-88961-x |
| — | Ehrenkranz, R., Rosso, A. L., Sprague, B. N., et al. (2021). Functional correlates of self-reported energy levels in the Health, Aging and Body Composition Study. Aging Clinical and Experimental Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC8531104/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8531104/ |
| — | Schrack, J. A., Simonsick, E. M., & Glynn, N. W. (2020). Fatigability: a prognostic indicator of phenotypic aging. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC7749190/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7749190/ |
| — | Richardson, C. A., Glynn, N. W., Ferrucci, L. G., & Mackey, D. C. (2015). Walking energetics, fatigability, and fatigue in older adults: the Study of Energy and Aging Pilot. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC4447797/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4447797/ |
| — | Glynn, N. W., Santanasto, A. J., Simonsick, E. M., et al. (2015). The Pittsburgh Fatigability Scale for older adults: development and validation. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC4971882/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4971882/ |
| — | Simonsick, E. M., Glynn, N. W., Jerome, G. J., et al. (2016). Fatigued, but not frail: perceived fatigability as a marker of impending decline in mobility-intact older adults. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC4914474/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4914474/ |
| — | Zengarini, E., Ruggiero, C., Pérez-Zepeda, M. U., et al. (2015). Fatigue: relevance and implications in the aging population. Experimental Gerontology . https://pubmed.ncbi.nlm.nih.gov/26190478/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26190478/ |
| — | Renner, S. W., Bear, T. M., Brown, P. J., et al. (2021). Validation of perceived mental fatigability using the Pittsburgh Fatigability Scale. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC8127403/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8127403/ |
| — | Simonsick, E. M., Schrack, J. A., Glynn, N. W., & Ferrucci, L. (2014). Assessing fatigability in mobility-intact older adults. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC3947865/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3947865/ |
| — | Jørstad, E. C., Hauer, K., Becker, C., & Lamb, S. E. (2005). Measuring the psychological outcomes of falling: a systematic review. Journal of the American Geriatrics Society , 53(3), 501-510. https://pubmed.ncbi.nlm.nih.gov/15743297/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15743297/ |
| — | Deshpande, N., Metter, E. J., Lauretani, F., Bandinelli, S., Guralnik, J., & Ferrucci, L. (2008). Activity restriction induced by fear of falling and objective and subjective measures of physical function: a prospective cohort study. Journal of the American Geriatrics Society , 56(4), 615-620. https://pubmed.ncbi.nlm.nih.gov/18312314/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18312314/ |
| — | Hadjistavropoulos, T., Delbaere, K., & Fitzgerald, T. D. (2011). Reconceptualizing the role of fear of falling and balance confidence in fall risk. Journal of Aging and Health , 23(1), 3-23. https://pubmed.ncbi.nlm.nih.gov/20852012/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20852012/ |
| — | Scheffer, A. C., Schuurmans, M. J., van Dijk, N., van der Hooft, T., & de Rooij, S. E. (2008). Fear of falling: measurement strategy, prevalence, risk factors and consequences among older persons. Age and Ageing , 37(1), 19-24. https://pubmed.ncbi.nlm.nih.gov/18194967/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18194967/ |
| — | Liu, M., Hou, T., Li, Y., et al. (2021). Fear of falling is as important as multiple previous falls in terms of limiting daily activities: a longitudinal study. BMC Geriatrics , 21, 350. https://pubmed.ncbi.nlm.nih.gov/34098904/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34098904/ |
| — | Delbaere, K., Close, J. C. T., Brodaty, H., Sachdev, P., & Lord, S. R. (2010). Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study. BMJ , 341, c4165. https://www.bmj.com/content/341/bmj.c4165 | — | — | https://www.bmj.com/content/341/bmj.c4165 |
| — | Rochat, S., Büla, C. J., Martin, E., et al. (2010). What is the relationship between fear of falling and gait in well-functioning older persons aged 65 to 70 years? Archives of Physical Medicine and Rehabilitation , 91(6), 879-884. https://pubmed.ncbi.nlm.nih.gov/20510978/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20510978/ |
| — | Gamble, K. J., Boyle, P. A., Yu, L., & Bennett, D. A. (2015). Aging and financial
decision making. Management Science , 61(11), 2603-2610. https://pmc.ncbi.nlm.nih.gov/articles/PMC4662381/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4662381/ |
| — | Marson, D. C., Martin, R. C., Wadley, V., et al. (2009). Clinical interview assessment of
financial capacity in older adults with mild cognitive impairment and Alzheimer's disease. Journal of the American Geriatrics Society , 57(5), 806-814. https://pmc.ncbi.nlm.nih.gov/articles/PMC2714907/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2714907/ |
| — | Gerstenecker, A., Martin, R. C., Triebel, K., & Marson, D. (2019). Anosognosia of
financial ability in mild cognitive impairment. International Journal of Geriatric Psychiatry ,
34(8), 1200-1207. https://doi.org/10.1002/gps.5118 | — | — | https://doi.org/10.1002/gps.5118 |
| — | Triebel, K. L., Martin, R., Griffith, H. R., et al. (2009). Declining financial capacity
in mild cognitive impairment: a 1-year longitudinal study. Neurology , 73(12), 928-934. https://pmc.ncbi.nlm.nih.gov/articles/PMC2754335/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2754335/ |
| — | Marson, D. C., Sawrie, S. M., Snyder, S., et al. (2000). Assessing financial capacity in
patients with Alzheimer disease: a conceptual model and prototype instrument. Archives of Neurology , 57(6), 877-884. https://pubmed.ncbi.nlm.nih.gov/10867786/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10867786/ |
| — | Martin, R. C., Gerstenecker, A., Triebel, K. L., et al. (2019). Declining financial
capacity in mild cognitive impairment: a six-year longitudinal study. Archives of Clinical Neuropsychology , 34(2), 152-161. https://doi.org/10.1093/arclin/acy030 | — | — | https://doi.org/10.1093/arclin/acy030 |
| — | Lichtenberg, P. A., Stoltman, J., Ficker, L. J., Iris, M., & Mast, B. (2015). A
person-centered approach to financial capacity assessment: preliminary development of a new rating
scale. Clinical Gerontologist , 38(1), 49-67. https://pmc.ncbi.nlm.nih.gov/articles/PMC4392714/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4392714/ |
| — | Ghesquiere, A. R., McAfee, C., & Burnett, J. (2019). Measures of financial capacity:
a review. The Gerontologist , 59(2), e109-e129. https://doi.org/10.1093/geront/gnx045 | — | — | https://doi.org/10.1093/geront/gnx045 |
| — | Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. "Untangling the concepts of disability, frailty, and comorbidity." Journal of Gerontology: Series A (2004). https://pubmed.ncbi.nlm.nih.gov/15031310/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15031310/ |
| — | Afilalo, J., Alexander, K. P., Mack, M. J. et al. "Frailty assessment in the cardiovascular care of older adults." Journal of the American College of Cardiology (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4571179/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4571179/ |
| — | Sutton, J. L., Gould, R. L., Daley, S. et al. "Psychometric properties of multicomponent tools designed to assess frailty in older adults: a systematic review." BMC Geriatrics (2016), 16, 55. https://link.springer.com/article/10.1186/s12877-016-0225-2 | — | — | https://link.springer.com/article/10.1186/s12877-016-0225-2 |
| — | Theou, O., Cann, L., Blodgett, J., Wallace, L. M. K., Brothers, T. D., & Rockwood, K. "Modifications to the frailty phenotype criteria: systematic review of the current literature and investigation of 262 frailty phenotypes in the Survey of Health, Ageing, and Retirement in Europe." Ageing Research Reviews (2015), 21, 78-94. https://www.sciencedirect.com/science/article/pii/S1568163715000355 | — | — | https://www.sciencedirect.com/science/article/pii/S1568163715000355 |
| — | Rockwood, K., & Mitnitski, A. "Frailty in relation to the accumulation of deficits." Journal of Gerontology: Series A (2007), 62(7), 722-727. https://pubmed.ncbi.nlm.nih.gov/17634318/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17634318/ |
| — | Mitnitski, A. B., Mogilner, A. J., & Rockwood, K. "Accumulation of deficits as a proxy measure of aging." ScientificWorldJournal (2001), 1, 323-336. https://pubmed.ncbi.nlm.nih.gov/12806071/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12806071/ |
| — | Kojima, G., Iliffe, S., & Walters, K. "Frailty index as a predictor of mortality: a systematic review and meta-analysis." Age and Ageing (2018), 47(2), 193-200. https://academic.oup.com/ageing/article/47/2/193/4508819 | — | — | https://academic.oup.com/ageing/article/47/2/193/4508819 |
| — | Cigolle, C. T., Ofstedal, M. B., Tian, Z., & Blaum, C. S. "Comparing models of frailty: the Health and Retirement Study." Journal of the American Geriatrics Society (2009), 57(5), 830-839. https://pubmed.ncbi.nlm.nih.gov/19453306/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19453306/ |
| — | Guralnik, J. M., et al. (1994). A short physical performance battery assessing lower extremity
function: association with self-reported disability and prediction of mortality and nursing home
admission. Journal of Gerontology , 49(2), M85–M94. https://pubmed.ncbi.nlm.nih.gov/8126356/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8126356/ |
| — | Pavasini, R., et al. (2016). Short Physical Performance Battery and all-cause mortality:
systematic review and meta-analysis. BMC Medicine , 14, 215. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0763-7 | — | — | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0763-7 |
| — | Katz, S., et al. (1963). Studies of illness in the aged. The index of ADL: a standardized measure of
biological and psychosocial function. JAMA , 185(12), 914–919. https://jamanetwork.com/journals/jama/article-abstract/666768 | — | — | https://jamanetwork.com/journals/jama/article-abstract/666768 |
| — | Lawton, M. P., & Brody, E. M. (1969). Assessment of older people: Self-maintaining and
instrumental activities of daily living. Gerontologist , 9(3), 179–186. https://academic.oup.com/gerontologist/article-abstract/9/3_Part_1/179/552696 | — | — | https://academic.oup.com/gerontologist/article-abstract/9/3_Part_1/179/552696 |
| — | Frangos, E., Graf, C., & Samaras, N. (2023). Functional aging: Integrating functionality to a
multidimensional assessment of healthy aging. Current Gerontology and Geriatrics Research ,
2023, 9409918. https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ |
| — | Crimmins, E. M. (2015). Lifespan and healthspan: past, present, and promise. Gerontologist , 55(6), 901-911. | — | — | — |
| — | Aarden, J. J., van der Esch, M., Engelbert, R. H. H., van der Schaaf, M., de Rooij,
S. E., & Buurman, B. M. (2017). Hip fractures in older patients: trajectories of disability after
surgery. The Journal of Nutrition, Health & Aging , 21(7), 837-842. https://pubmed.ncbi.nlm.nih.gov/28717815/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28717815/ |
| — | Tang, V. L., Sudore, R., Cenzer, I. S., et al. (2017). Rates of recovery to pre-fracture
function in older persons with hip fracture: an observational study. Journal of General Internal
Medicine , 32(2), 153-158. https://pmc.ncbi.nlm.nih.gov/articles/PMC5264672/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5264672/ |
| — | Dakhil, S., Saltvedt, I., Benth, J. S., et al. (2023). Longitudinal trajectories of
functional recovery after hip fracture. PLOS ONE , 18(3), e0283551. https://pmc.ncbi.nlm.nih.gov/articles/PMC10057789/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10057789/ |
| — | Fischer, K., Trombik, M., Freystätter, G., Egli, A., Theiler, R., &
Bischoff-Ferrari, H. A. (2019). Timeline of functional recovery after hip fracture in seniors aged
65 and older: a prospective observational analysis. Osteoporosis International , 30(7),
1371-1381. https://pubmed.ncbi.nlm.nih.gov/30941485/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30941485/ |
| — | Gavrila Laic, R. A., Bogaert, L., Vander Sloten, J., & Depreitere, B. (2021).
Functional outcome, dependency and well-being after traumatic brain injury in the elderly population:
a systematic review and meta-analysis. Brain & Spine , 1, 100849. https://pmc.ncbi.nlm.nih.gov/articles/PMC9560680/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9560680/ |
| — | Alqarni, A. G., Gladman, J. R. F., Obasi, A. A., & Ollivere, B. (2023). Does frailty
status predict outcome in major trauma in older people? A systematic review and meta-analysis. Age and Ageing , 52(5), afad073. https://pmc.ncbi.nlm.nih.gov/articles/PMC10226729/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10226729/ |
| — | Magaziner, J., Hawkes, W., Hebel, J. R., et al. (2000). Recovery from hip fracture in
eight areas of function. The Journals of Gerontology: Series A , 55(9), M498-M507. https://doi.org/10.1093/gerona/55.9.M498 | — | — | https://doi.org/10.1093/gerona/55.9.M498 |
| — | Rafaqat, W., Panossian, V. S., Abiad, M., et al. (2024). The impact of frailty on
long-term functional outcomes in severely injured geriatric patients. Surgery , 176(4),
1148-1154. https://pubmed.ncbi.nlm.nih.gov/39107141/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39107141/ |
| — | Ek, S., Rizzuto, D., Xu, W., Calderón-Larrañaga, A., & Welmer, A.-K.
(2021). Predictors for functional decline after an injurious fall: a population-based cohort study. Aging Clinical and Experimental Research , 33(8), 2183-2190. https://pmc.ncbi.nlm.nih.gov/articles/PMC8302494/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8302494/ |
| — | Crimmins, E. M. "Lifespan and healthspan: past, present, and promise." The
Gerontologist (2015), 55(6), 901-911. https://pmc.ncbi.nlm.nih.gov/articles/PMC4861644/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4861644/ |
| — | Murray, C. J. L., & Lopez, A. D. (1996). The Global Burden of Disease . Harvard School of Public Health. | — | — | — |
| — | Fries, J. F. (1980). Aging, natural death, and the compression of morbidity. New England Journal of Medicine , 303(3), 130-135. https://pubmed.ncbi.nlm.nih.gov/7383070/ | — | — | https://pubmed.ncbi.nlm.nih.gov/7383070/ |
| — | Garmany, A., Yamada, S., & Terzic, A. "Longevity leap: mind the healthspan gap." npj Aging (2021). https://www.nature.com/articles/s41536-021-00169-5 | — | — | https://www.nature.com/articles/s41536-021-00169-5 |
| — | Frangos, E., Graf, C., & Samaras, N. "Functional aging: Integrating functionality to a
multidimensional assessment of healthy aging." Current Gerontology and Geriatrics Research (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ |
| — | Seals, D. R., Justice, J. N., & LaRocca, T. J. "Physiological geroscience: targeting
function to increase healthspan and achieve optimal longevity." The Journal of Physiology (2016). https://doi.org/10.1113/jphysiol.2014.282665 | — | — | https://doi.org/10.1113/jphysiol.2014.282665 |
| — | Fries, J. F. "Compression of morbidity." NBER Working Paper (2016). https://www.nber.org/system/files/working_papers/w22306/w22306.pdf | — | — | https://www.nber.org/system/files/working_papers/w22306/w22306.pdf |
| — | Bohannon, R. W. (2019). Grip strength: an indispensable biomarker for older adults. Journal of Strength and Conditioning Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6778477/ |
| — | Cosco, T. D., Prina, A. M., Perales, J., et al. (2014). Operational definitions of successful aging: a systematic review. International Psychogeriatrics . https://pubmed.ncbi.nlm.nih.gov/24308764/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24308764/ |
| — | Sanchez-Niubo, A., Forero, C. G., Wu, Y.-T., et al. (2021). Development of a common scale for measuring healthy ageing across the world: results from the ATHLOS consortium. International Journal of Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC8271194/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8271194/ |
| — | Lu, W., Pikhart, H., & Sacker, A. (2019). Domains and measurements of healthy aging in epidemiological studies: a review. The Gerontologist . https://pmc.ncbi.nlm.nih.gov/articles/PMC6630160/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6630160/ |
| — | Behr, L. C., Simm, A., Kluttig, A., & Großkopf, A. (2023). 60 years of healthy aging: on definitions, biomarkers, scores and challenges. Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/37059401/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37059401/ |
| — | Piriu, A. A., Bufali, M. V., Cappellaro, G., et al. (2025). Conceptualisation and measurement of healthy ageing: insights from a systematic literature review. Social Science & Medicine . https://pubmed.ncbi.nlm.nih.gov/40198967/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40198967/ |
| — | McCabe, E. L., Larson, M. G., Lunetta, K. L., et al. (2016). Association of an index of healthy aging with incident cardiovascular disease and mortality in a community-based sample of older adults. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC5106860/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5106860/ |
| — | Sanders, J. L., Minster, R. L., Barmada, M. M., et al. (2014). Heritability of and mortality prediction with a longevity phenotype: the Healthy Aging Index. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC3968826/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3968826/ |
| — | Dieteren, C. M., Samson, L. D., Schipper, M., et al. (2020). The Healthy Aging Index analyzed over 15 years in the general population: the Doetinchem Cohort Study. Preventive Medicine . https://pubmed.ncbi.nlm.nih.gov/32653354/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32653354/ |
| — | Menassa, M., Stronks, K., Khatmi, F., et al. (2023). Concepts and definitions of healthy ageing: a systematic review and synthesis of theoretical models. eClinicalMedicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC9852292/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9852292/ |
| — | Yeo, B. S. Y., et al. (2025). Hearing loss and falls: a systematic review and meta-analysis. JAMA Otolaryngology-Head & Neck Surgery . https://pmc.ncbi.nlm.nih.gov/articles/PMC11926736/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11926736/ |
| — | Tian, R., et al. (2021). Association between hearing loss and frailty: a systematic review and meta-analysis. BMC Geriatrics . https://pmc.ncbi.nlm.nih.gov/articles/PMC8147347/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8147347/ |
| — | Yamasoba, T., et al. (2013). Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hearing Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC3723756/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3723756/ |
| — | Bowl, M. R., & Dawson, S. J. (2019). Age-related hearing loss. Cold Spring Harbor Perspectives in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC6671929/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6671929/ |
| — | Armstrong, N. M., et al. (2020). Associations of hearing loss and depressive symptoms with incident disability in older adults: Health, Aging, and Body Composition Study. The Journals of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/30561511/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30561511/ |
| — | Loughrey, D. G., et al. (2018). Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis. JAMA Otolaryngology-Head & Neck Surgery . https://pmc.ncbi.nlm.nih.gov/articles/PMC5824986/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5824986/ |
| — | Dalton, D. S., et al. (2003). The impact of hearing loss on quality of life in older adults. The Gerontologist . https://pubmed.ncbi.nlm.nih.gov/14570962/ | — | — | https://pubmed.ncbi.nlm.nih.gov/14570962/ |
| — | Chen, D. S., et al. (2015). Association between hearing impairment and self-reported difficulty in physical functioning. Journal of the American Geriatrics Society . https://pubmed.ncbi.nlm.nih.gov/24779559/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24779559/ |
| — | Lin, F. R., et al. (2023). Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial. The Lancet . https://pubmed.ncbi.nlm.nih.gov/37478886/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37478886/ |
| — | Dhanda, N., et al. (2024). Does social isolation mediate the association between hearing loss and cognition in adults? A systematic review and meta-analysis of longitudinal studies. Frontiers in Public Health . https://pmc.ncbi.nlm.nih.gov/articles/PMC10824982/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10824982/ |
| — | Sierra, F., & Perez, V. (2026). Loss of molecular resilience as the ultimate outcome of aging biology. GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC12972337/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12972337/ |
| — | Hadley, E. C., Kuchel, G. A., Newman, A. B., et al. (2017). Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC5861884/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5861884/ |
| — | Whitson, H. E., Duan-Porter, W., Schmader, K. E., et al. (2016). Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC5014191/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5014191/ |
| — | Ferrante, L. E., Pisani, M. A., Murphy, T. E., et al. (2015). Functional trajectories among older persons before and after critical illness. JAMA Internal Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC4467795/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4467795/ |
| — | Gill, T. M., Allore, H. G., Gahbauer, E. A., & Murphy, T. E. (2010). Change in disability after hospitalization or restricted activity in older persons. JAMA . https://pmc.ncbi.nlm.nih.gov/articles/PMC3124926/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3124926/ |
| — | Ader, I., Pénicaud, L., Andrieu, S., et al. (2021). Healthy Aging Biomarkers: The INSPIRE's Contribution. The Journal of Frailty & Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC8081649/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8081649/ |
| — | Li, Q., Wang, S., Milot, E., et al. (2015). Homeostatic dysregulation proceeds in parallel in multiple physiological systems. Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC4693454/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4693454/ |
| — | Fimognari, F. L., Pierantozzi, A., De Alfieri, W., et al. (2017). The severity of acute
illness and functional trajectories in hospitalized older medical patients. The Journals of
Gerontology: Series A , 72(1), 102-108. https://pubmed.ncbi.nlm.nih.gov/27257216/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27257216/ |
| — | Boyd, C. M., Landefeld, C. S., Counsell, S. R., et al. (2008). Recovery of activities
of daily living in older adults after hospitalization for acute medical illness. Journal of the
American Geriatrics Society , 56(12), 2171-2179. https://pubmed.ncbi.nlm.nih.gov/19093915/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19093915/ |
| — | Inouye, S. K., Bogardus, S. T., Jr., Baker, D. I., Leo-Summers, L., & Cooney, L. M.,
Jr. (2000). The Hospital Elder Life Program: a model of care to prevent cognitive and functional
decline in older hospitalized patients. Journal of the American Geriatrics Society , 48(12),
1697-1706. https://pubmed.ncbi.nlm.nih.gov/11129764/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11129764/ |
| — | Creditor, M. C. (1993). Hazards of hospitalization of the elderly. Annals of
Internal Medicine , 118(3), 219-223. https://pubmed.ncbi.nlm.nih.gov/8417639/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8417639/ |
| — | Hao, X., Zhang, H., Zhao, X., Peng, X., & Li, K. (2024). Risk factors for
hospitalization-associated disability among older patients: a systematic review and meta-analysis. Ageing Research Reviews , 101, 102516. https://pubmed.ncbi.nlm.nih.gov/39332713/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39332713/ |
| — | Giacomino, K., Hilfiker, R., Beckwée, D., Taeymans, J., & Sattelmayer, K. M.
(2023). Assessment tools and incidence of hospital-associated disability in older adults: a rapid
systematic review. PeerJ , 11, e16036. https://pmc.ncbi.nlm.nih.gov/articles/PMC10590575/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10590575/ |
| — | Fox, M. T., Persaud, M., Maimets, I., et al. (2012). Effectiveness of acute geriatric
unit care using Acute Care for Elders components: a systematic review and meta-analysis. Journal of the American Geriatrics Society , 60(12), 2237-2245. https://pubmed.ncbi.nlm.nih.gov/23176020/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23176020/ |
| — | Brown, C. J., Redden, D. T., Flood, K. L., & Allman, R. M. (2009). The underrecognized
epidemic of low mobility during hospitalization of older adults. Journal of the American
Geriatrics Society , 57(9), 1660-1665. https://pubmed.ncbi.nlm.nih.gov/19682121/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19682121/ |
| — | Tu, W., & Rao, S. (2016). Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection . https://pmc.ncbi.nlm.nih.gov/articles/PMC5186782/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5186782/ |
| — | Weyand, C. M., & Goronzy, J. J. (2016). Aging of the Immune System. Mechanisms and Therapeutic Targets . https://pmc.ncbi.nlm.nih.gov/articles/PMC5291468/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5291468/ |
| — | Allen, J. C., Toapanta, F. R., Chen, W., & Tennant, S. M. (2020). Understanding immunosenescence and its impact on vaccination of older adults . https://pmc.ncbi.nlm.nih.gov/articles/PMC7719605/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7719605/ |
| — | Frasca, D., Blomberg, B. B., Paganelli, R., et al. (2020). B Cell Immunosenescence . https://pmc.ncbi.nlm.nih.gov/articles/PMC8060858/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8060858/ |
| — | Pinti, M., Appay, V., Campisi, J., Frasca, D., Fulop, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016). Aging of the immune system: Focus on inflammation and vaccination . https://pmc.ncbi.nlm.nih.gov/articles/PMC5156481/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5156481/ |
| — | Kingston, A., Collerton, J., Davies, K., et al. (2012). Losing the ability in activities
of daily living in the oldest old: a hierarchic disability scale from the Newcastle 85+ Study. PLOS ONE , 7(2), e31665. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031665 | — | — | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031665 |
| — | Sikkes, S. A. M., de Lange-de Klerk, E. S. M., Pijnenburg, Y. A. L., Scheltens, P.,
& Uitdehaag, B. M. J. (2009). A systematic review of instrumental activities of daily living scales
in dementia: room for improvement. Journal of Neurology, Neurosurgery & Psychiatry , 80(1), 7-12. https://pubmed.ncbi.nlm.nih.gov/19091706/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19091706/ |
| — | Sprung, J., Laporta, M., Knopman, D. S., et al. (2021). Gait speed and instrumental
activities of daily living in older adults after hospitalization: a longitudinal population-based
study. The Journals of Gerontology: Series A , 76(10), e272-e280. https://pmc.ncbi.nlm.nih.gov/articles/PMC8436979/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8436979/ |
| — | Pérès, K., Helmer, C., Amieva, H., et al. (2008). Natural history of decline in
instrumental activities of daily living performance over the 10 years preceding the clinical
diagnosis of dementia: a prospective population-based study. Journal of the American Geriatrics Society ,
56(1), 37-44. https://pubmed.ncbi.nlm.nih.gov/18028344/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18028344/ |
| — | Dufournet, M., Moutet, C., Achi, S., et al. (2021). Proposition of a corrected measure
of the Lawton instrumental activities of daily living score. BMC Geriatrics , 21, 39. https://pmc.ncbi.nlm.nih.gov/articles/PMC7802257/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7802257/ |
| — | Belloni, G., & Cesari, M. (2019). Frailty and intrinsic capacity: two distinct but related constructs. Frontiers in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC6591451/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6591451/ |
| — | Stolz, E., Mayerl, H., Freidl, W., et al. (2022). Intrinsic capacity predicts negative health outcomes in older adults. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC8751795/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8751795/ |
| — | Koivunen, K., Hoogendijk, E. O., Schaap, L. A., et al. (2023). Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach. Aging Clinical and Experimental Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC10115715/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10115715/ |
| — | Yu, R., Leung, J., Leung, G., & Woo, J. (2021). Validation of the construct of intrinsic capacity in a longitudinal Chinese cohort. The Journal of Nutrition, Health & Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC12876751/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12876751/ |
| — | World Health Organization. (2019). Integrated care for older people (ICOPE) implementation framework: guidance for systems and services . https://www.who.int/publications/i/item/9789241515993 | — | — | https://www.who.int/publications/i/item/9789241515993 |
| — | George, P. P., Lun, P., Ong, S. P., et al. (2021). A rapid review of the measurement of intrinsic capacity in older adults. The Journal of Nutrition, Health & Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC7966899/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7966899/ |
| — | Beard, J. R., Jotheeswaran, A. T., Cesari, M., & Araujo de Carvalho, I. (2019). The structure and predictive value of intrinsic capacity in a longitudinal study of ageing. BMJ Open . https://pmc.ncbi.nlm.nih.gov/articles/PMC6830681/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6830681/ |
| — | O'Sullivan, E. D., Hughes, J., & Ferenbach, D. A. (2017). Renal aging: causes and consequences. Journal of the American Society of Nephrology . https://pmc.ncbi.nlm.nih.gov/articles/PMC5280008/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5280008/ |
| — | Rex, N., Melk, A., & Schmitt, R. (2023). Cellular senescence and kidney aging. Clinical Science . https://pmc.ncbi.nlm.nih.gov/articles/PMC10739085/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10739085/ |
| — | Shankland, S. J., Rule, A. D., Kutz, J. N., Pippin, J. W., & Wessely, O. (2023). Podocyte senescence and aging. Kidney360 . https://pmc.ncbi.nlm.nih.gov/articles/PMC10758523/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10758523/ |
| — | Fang, Y., et al. (2020). The ageing kidney: molecular mechanisms and clinical implications. Ageing Research Reviews . https://pmc.ncbi.nlm.nih.gov/articles/PMC7595250/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7595250/ |
| — | Muglia, L., Di Dio, M., Filicetti, E., et al. (2024). Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis. Frontiers in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC11269154/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11269154/ |
| — | Hommos, M. S., Glassock, R. J., & Rule, A. D. (2017). Structural and functional changes in human kidneys with healthy aging. Journal of the American Society of Nephrology . https://pmc.ncbi.nlm.nih.gov/articles/PMC5619977/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5619977/ |
| — | Noronha, I. L., Santa-Catharina, G. P., Andrade, L., et al. (2022). Glomerular filtration in the aging population. Frontiers in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC9519889/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9519889/ |
| — | Zhang, F., Wang, H., Bai, Y., et al. (2023). Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis. BMC Nephrology . https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-023-03303-1 | — | — | https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-023-03303-1 |
| — | Kuspinar, A., et al. (2023). Assessing the measurement properties of life-space mobility measures in community-dwelling older adults: a systematic review. Age and Ageing , 52(Suppl 4), iv86-iv99. https://pmc.ncbi.nlm.nih.gov/articles/PMC10615067/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10615067/ |
| — | Peel, C., Sawyer Baker, P., Roth, D. L., Brown, C. J., Bodner, E. V., & Allman, R. M. (2005). Assessing mobility in older adults: the UAB Study of Aging Life-Space Assessment. Physical Therapy , 85(10), 1008-1019. https://pubmed.ncbi.nlm.nih.gov/16180950/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16180950/ |
| — | Crowe, M., Andel, R., Wadley, V. G., Okonkwo, O. C., Sawyer, P., & Allman, R. M. (2008). Life-space and cognitive decline in a community-based sample of African American and Caucasian older adults. The Journals of Gerontology: Series A , 63(11), 1241-1245. https://pmc.ncbi.nlm.nih.gov/articles/PMC2820830/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2820830/ |
| — | Portegijs, E., Rantakokko, M., Viljanen, A., Sipilä, S., & Rantanen, T. (2016). Identification of older people at risk of ADL disability using the Life-Space Assessment: a longitudinal cohort study. Journal of the American Medical Directors Association , 17(5), 410-414. https://pubmed.ncbi.nlm.nih.gov/26805752/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26805752/ |
| — | Alcazar, J., Kamper, R. S., Aagaard, P., et al. (2020). Relation between leg extension power and 30-s sit-to-stand muscle power in older adults: validation and translation to functional performance. Scientific Reports , 10, 16337. https://pubmed.ncbi.nlm.nih.gov/33004970/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33004970/ |
| — | Puthoff, M. L., & Nielsen, D. H. (2007). Relationships among impairments in lower-extremity strength and power, functional limitations, and disability in older adults. Physical Therapy , 87(10), 1334-1347. https://pubmed.ncbi.nlm.nih.gov/17684086/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17684086/ |
| — | Skelton, D. A., Greig, C. A., Davies, J. M., & Young, A. (1994). Strength, power and related functional ability of healthy people aged 65-89 years. Age and Ageing , 23(5), 371-377. https://pubmed.ncbi.nlm.nih.gov/7825481/ | — | — | https://pubmed.ncbi.nlm.nih.gov/7825481/ |
| — | Alcazar, J., Losa-Reyna, J., Rodriguez-Lopez, C., et al. (2018). The sit-to-stand muscle power test: an easy, inexpensive and portable procedure to assess muscle power in older people. Experimental Gerontology , 112, 38-43. https://pubmed.ncbi.nlm.nih.gov/30179662/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30179662/ |
| — | Foldvari, M., Clark, M., Laviolette, L. C., et al. (2000). Association of muscle power with functional status in community-dwelling elderly women. The Journals of Gerontology: Series A , 55(4), M192-M199. https://pubmed.ncbi.nlm.nih.gov/10811148/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10811148/ |
| — | Alcazar, J., Aagaard, P., Haddock, B., et al. (2020). Age- and sex-specific changes in lower-limb muscle power throughout the lifespan. The Journals of Gerontology: Series A , 75(7), 1369-1378. https://pubmed.ncbi.nlm.nih.gov/31943003/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31943003/ |
| — | Alcazar, J., Rodriguez-Lopez, C., Delecluse, C., Thomis, M., & Van Roie, E. (2023). Ten-year longitudinal changes in muscle power, force, and velocity in young, middle-aged, and older adults. Journal of Cachexia, Sarcopenia and Muscle , 14(2), 1019-1032. https://pubmed.ncbi.nlm.nih.gov/36788413/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36788413/ |
| — | Alcazar, J., Alegre, L. M., Van Roie, E., et al. (2021). Relative sit-to-stand power: aging trajectories, functionally relevant cut-off points, and normative data in a large European cohort. Journal of Cachexia, Sarcopenia and Muscle , 12(4), 921-932. https://pubmed.ncbi.nlm.nih.gov/34216098/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34216098/ |
| — | Bean, J. F., Kiely, D. K., LaRose, S., Alian, J., & Frontera, W. R. (2007). Is stair climb power a clinically relevant measure of leg power impairments in at-risk older adults? Archives of Physical Medicine and Rehabilitation , 88(5), 604-609. https://pubmed.ncbi.nlm.nih.gov/17466729/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17466729/ |
| — | Fávaro-Moreira, N. C., Krausch-Hofmann, S., Matthys, C., et al. (2016). Risk
factors for malnutrition in older adults: a systematic review of the literature based on
longitudinal data. Advances in Nutrition , 7(3), 507-522. https://pmc.ncbi.nlm.nih.gov/articles/PMC4863272/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4863272/ |
| — | Almohaisen, N., Gittins, M., Todd, C., et al. (2022). Prevalence of undernutrition,
frailty and sarcopenia in community-dwelling people aged 50 years and above: systematic review and
meta-analysis. Nutrients , 14(8), 1537. https://pmc.ncbi.nlm.nih.gov/articles/PMC9032775/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9032775/ |
| — | Mareschal, J., Genton, L., Collet, T.-H., & Graf, C. (2020). Nutritional
intervention to prevent the functional decline in community-dwelling older adults: a systematic
review. Nutrients , 12(9), 2820. https://pmc.ncbi.nlm.nih.gov/articles/PMC7551991/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7551991/ |
| — | Ligthart-Melis, G. C., Luiking, Y. C., Kakourou, A., et al. (2020). Frailty,
sarcopenia, and malnutrition frequently (co-)occur in hospitalized older adults: a systematic review
and meta-analysis. Journal of the American Medical Directors Association , 21(9), 1216-1228. https://pubmed.ncbi.nlm.nih.gov/32327302/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32327302/ |
| — | Sugiura, Y., Tanimoto, Y., Imbe, A., et al. (2016). Association between functional
capacity decline and nutritional status based on the Nutrition Screening Initiative Checklist: a
2-year cohort study of Japanese community-dwelling elderly. PLoS ONE , 11(11), e0166037. https://pubmed.ncbi.nlm.nih.gov/27824916/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27824916/ |
| — | Cederholm, T., Jensen, G. L., Correia, M. I. T. D., et al. (2019). GLIM criteria for
the diagnosis of malnutrition: a consensus report from the global clinical nutrition community. Clinical Nutrition , 38(1), 1-9. https://pubmed.ncbi.nlm.nih.gov/30181091/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30181091/ |
| — | Edelberg, H. K., Shallenberger, E., & Wei, J. Y. (1999). Medication management capacity
in highly functioning community-living older adults: detection of early deficits. Journal of the American Geriatrics Society , 47(5), 592-596. https://pubmed.ncbi.nlm.nih.gov/10323653/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10323653/ |
| — | Maidment, I., Lawson, S., Wong, G., et al. (2020). Towards an understanding of the
burdens of medication management affecting older people: the MEMORABLE realist synthesis. BMC Geriatrics , 20, 183. https://pmc.ncbi.nlm.nih.gov/articles/PMC7272211/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7272211/ |
| — | Sumida, C. A., Vo, T. T., Van Etten, E. J., & Schmitter-Edgecombe, M. (2019).
Medication management performance and associated cognitive correlates in healthy older adults and
older adults with amnestic mild cognitive impairment. Archives of Clinical Neuropsychology ,
34(3), 290-300. https://pmc.ncbi.nlm.nih.gov/articles/PMC6454840/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6454840/ |
| — | Patel, T., McDougall, A., Ivo, J., et al. (2021). Development and content validation of
an instrument to measure medication self-management in older adults. Pharmacy , 9(2), 78. https://pmc.ncbi.nlm.nih.gov/articles/PMC8167785/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8167785/ |
| — | Windham, B. G., Griswold, M. E., Fried, L. P., et al. (2005). Impaired vision and the
ability to take medications. Journal of the American Geriatrics Society , 53(7), 1179-1190. https://pubmed.ncbi.nlm.nih.gov/16108936/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16108936/ |
| — | Hallowell, E. S., Sullivan, K. L., Davis, J. D., et al. (2022). The complementary utility
of cognitive testing and the Medication Management Ability Assessment in older adults. Neuropsychology , 36(6), 528-539. https://pubmed.ncbi.nlm.nih.gov/35587411/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35587411/ |
| — | Luegering, A., Langner, R., Wilm, S., et al. (2023). Developing a novel tool to assess
the ability to self-administer medication: a systematic evaluation of patients' video recordings in
the ABLYMED study. Frontiers in Medicine , 10, 1040528. https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1040528/full | — | — | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1040528/full |
| — | Orwig, D., Brandt, N., & Gruber-Baldini, A. L. (2006). Medication management
assessment for older adults in the community. The Gerontologist , 46(5), 661-668. https://pubmed.ncbi.nlm.nih.gov/17050757/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17050757/ |
| — | Elliott, R. A., & Marriott, J. L. (2009). Standardised assessment of patients' capacity
to manage medications: a systematic review of published instruments. BMC Geriatrics , 9, 27. https://pmc.ncbi.nlm.nih.gov/articles/PMC2719637/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2719637/ |
| — | Edelberg, H. K., Shallenberger, E., Hausdorff, J. M., & Wei, J. Y. (2000). One-year
follow-up of medication management capacity in highly functioning older adults. The Journals of Gerontology: Series A , 55(10), M550-M553. https://pubmed.ncbi.nlm.nih.gov/11034226/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11034226/ |
| — | Stuck, A. E., Walthert, J. M., Nikolaus, T., Bula, C. J., Hohmann, C., & Beck, J. C.
(1999). Risk factors for functional status decline in community-living elderly people: a systematic
literature review. Social Science & Medicine , 48(4), 445-469. https://doi.org/10.1016/S0277-9536(98)00370-0 | — | — | https://doi.org/10.1016/S0277-9536(98)00370-0 |
| — | Pollak, C., Verghese, J., & Blumen, H. M. (2023). Loneliness and functional decline
in aging: a systematic review. Research in Gerontological Nursing , 16(4), 202-212. https://doi.org/10.3928/19404921-20230503-02 | — | — | https://doi.org/10.3928/19404921-20230503-02 |
| — | Boyle, P. A., Buchman, A. S., & Bennett, D. A. (2010). Purpose in life is associated
with a reduced risk of incident disability among community-dwelling older persons. The American
Journal of Geriatric Psychiatry , 18(12), 1093-1102. https://doi.org/10.1097/JGP.0b013e3181d6c259 | — | — | https://doi.org/10.1097/JGP.0b013e3181d6c259 |
| — | Verbrugge, L. M., & Jette, A. M. (1994). The disablement process. Social Science
& Medicine , 38(1), 1-14. https://doi.org/10.1016/0277-9536(94)90294-1 | — | — | https://doi.org/10.1016/0277-9536(94)90294-1 |
| — | Guralnik, J. M., Simonsick, E. M., Ferrucci, L., et al. (1994). A short physical
performance battery assessing lower extremity function: association with self-reported disability
and prediction of mortality and nursing home admission. The Journals of Gerontology , 49(2),
M85-M94. https://doi.org/10.1093/geronj/49.2.M85 | — | — | https://doi.org/10.1093/geronj/49.2.M85 |
| — | Steptoe, A., Deaton, A., & Stone, A. A. (2015). Subjective wellbeing, health, and
ageing. The Lancet , 385(9968), 640-648. https://doi.org/10.1016/S0140-6736(13)61489-0 | — | — | https://doi.org/10.1016/S0140-6736(13)61489-0 |
| — | Hajek, A., Brettschneider, C., Eisele, M., et al. (2017). Disentangling the complex
relation of disability and depressive symptoms in old age: findings of a multicenter prospective
cohort study in Germany. International Psychogeriatrics , 29(6), 885-895. https://doi.org/10.1017/S1041610216002507 | — | — | https://doi.org/10.1017/S1041610216002507 |
| — | Ormel, J., Rijsdijk, F. V., Sullivan, M., van Sonderen, E., & Kempen, G. I. J. M.
(2002). Temporal and reciprocal relationship between IADL/ADL disability and depressive symptoms in
late life. The Journals of Gerontology: Series B , 57(4), P338-P347. https://doi.org/10.1093/geronb/57.4.P338 | — | — | https://doi.org/10.1093/geronb/57.4.P338 |
| — | Swenor, B. K., Muñoz, B., & West, S. K. (2014). A longitudinal study of the association between visual impairment and mobility performance in older adults: the Salisbury Eye Evaluation Study. American Journal of Epidemiology , 179(3), 313-322. https://pmc.ncbi.nlm.nih.gov/articles/PMC3954103/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3954103/ |
| — | Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E., & Wallace, R. B. (1995). Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. The New England Journal of Medicine , 332(9), 556-561. https://pmc.ncbi.nlm.nih.gov/articles/PMC9828188/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9828188/ |
| — | Hardy, S. E., Kang, Y., Studenski, S. A., & Degenholtz, H. B. (2011). Ability to walk 1/4 mile predicts subsequent disability, mortality, and health care costs. Journal of General Internal Medicine , 26(2), 130-135. https://pmc.ncbi.nlm.nih.gov/articles/PMC3019329/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3019329/ |
| — | Pahor, M., Guralnik, J. M., Ambrosius, W. T., et al. (2014). Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA , 311(23), 2387-2396. https://pmc.ncbi.nlm.nih.gov/articles/PMC4266388/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4266388/ |
| — | Clarke, P., Ailshire, J. A., & Lantz, P. (2009). Urban built environments and trajectories of mobility disability: findings from a national sample of community-dwelling American adults (1986-2001). Social Science & Medicine , 69(6), 964-970. https://pmc.ncbi.nlm.nih.gov/articles/PMC2759178/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2759178/ |
| — | Schrack, J. A., Zipunnikov, V., Simonsick, E. M., Studenski, S., & Ferrucci, L. (2016). Rising energetic cost of walking predicts gait speed decline with aging. The Journals of Gerontology: Series A , 71(7), 947-953. https://pmc.ncbi.nlm.nih.gov/articles/PMC4906328/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4906328/ |
| — | Mackey, D. C., Cauley, J. A., Barrett-Connor, E., et al. (2014). Life-space mobility and mortality in older men: a prospective cohort study. Journal of the American Geriatrics Society , 62(7), 1288-1296. https://pmc.ncbi.nlm.nih.gov/articles/PMC4251711/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4251711/ |
| — | Ferrucci, L., Bandinelli, S., Benvenuti, E., et al. (2000). Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. Journal of the American Geriatrics Society , 48(12), 1618-1625. https://pubmed.ncbi.nlm.nih.gov/11129752/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11129752/ |
| — | Gill, T. M., Allore, H. G., Hardy, S. E., & Guo, Z. (2006). The dynamic nature of mobility disability in older persons. Journal of the American Geriatrics Society , 54(2), 248-254. https://pubmed.ncbi.nlm.nih.gov/16460375/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16460375/ |
| — | Ward, R. E., Boudreau, R. M., Caserotti, P., et al. (2014). Sensory and motor peripheral nerve function and incident mobility disability. Journal of the American Geriatrics Society , 62(12), 2273-2279. https://pmc.ncbi.nlm.nih.gov/articles/PMC4270855/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4270855/ |
| — | Cummings, S. R., Lui, L.-Y., Glynn, N. W., et al. (2024). Energetics and clinical factors for the time required to walk 400 m: the Study of Muscle, Mobility and Aging (SOMMA). Journal of the American Geriatrics Society , 72(4), 1035-1047. https://pubmed.ncbi.nlm.nih.gov/38243364/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38243364/ |
| — | He, Q., Xie, P., Hu, L., et al. (2024). The association between accelerated biological aging and osteoarthritis. Frontiers in Public Health , 12, 1451737. https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1451737/full | — | — | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1451737/full |
| — | Conboy, I. M., & Rando, T. A. (2012). Aging, stem cells and tissue regeneration: lessons from muscle. Cell Stem Cell , 10(6), 626-636. https://www.tandfonline.com/doi/abs/10.4161/cc.4.3.1518 | — | — | https://www.tandfonline.com/doi/abs/10.4161/cc.4.3.1518 |
| — | Compston, J. E., McClung, M. R., & Leslie, W. D. (2019). Osteoporosis. Lancet , 393(10169), 364-376. https://pubmed.ncbi.nlm.nih.gov/30696576/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30696576/ |
| — | Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018). Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology , 14(10), 576-590. https://www.nature.com/articles/s41574-018-0059-4 | — | — | https://www.nature.com/articles/s41574-018-0059-4 |
| — | Clark, D., Kotronia, E., Ramsay, S. E., et al. (2021). Frailty, aging, and periodontal disease: basic biological considerations. Periodontology 2000 . https://pmc.ncbi.nlm.nih.gov/articles/PMC8771712/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8771712/ |
| — | Hakeem, F. F., Bernabe, E., & Sabbah, W. (2019). Association between oral health and frailty: a systematic review of longitudinal studies. Gerodontology . https://pubmed.ncbi.nlm.nih.gov/31025772/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31025772/ |
| — | Chen, S., Zhou, D., Liu, O., Chen, H., Wang, Y., & Zhou, Y. (2022). Cellular senescence and periodontitis: mechanisms and therapeutics. Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC9598109/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9598109/ |
| — | Dibello, V., Lobbezoo, F., Lozupone, M., et al. (2023). Oral frailty indicators to target major adverse health-related outcomes in older age: a systematic review. GeroScience . https://pubmed.ncbi.nlm.nih.gov/36242694/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36242694/ |
| — | Asher, S., et al. (2022). Periodontal health, cognitive decline, and dementia: a systematic review and meta-analysis of longitudinal studies. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC9826143/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9826143/ |
| — | Mol, A., et al. (2018). Orthostatic hypotension and physical functioning in older adults:
A systematic review and meta-analysis. Ageing Research Reviews , 48, 122-144. https://pubmed.ncbi.nlm.nih.gov/30394339/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30394339/ |
| — | Wieling, W., et al. (2022). Diagnosis and treatment of orthostatic hypotension. The Lancet Neurology , 21(8), 735-746. https://pubmed.ncbi.nlm.nih.gov/35841911/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35841911/ |
| — | Saedon, N. I., et al. (2020). The prevalence of orthostatic hypotension: A systematic
review and meta-analysis. The Journals of Gerontology: Series A , 75(1), 117-122. https://pubmed.ncbi.nlm.nih.gov/30169579/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30169579/ |
| — | Duval, G. T., et al. (2024). Orthostatic hypotension and cognitive impairment: Systematic
review and meta-analysis of longitudinal studies. Maturitas , 185, 107866. https://pubmed.ncbi.nlm.nih.gov/38604094/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38604094/ |
| — | Tran, J., et al. (2021). Prevalence of initial orthostatic hypotension in older adults:
A systematic review and meta-analysis. Age and Ageing , 50(5), 1520-1528. https://pubmed.ncbi.nlm.nih.gov/34260686/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34260686/ |
| — | Mol, A., et al. (2020). Blood pressure drop rate after standing up is associated with
frailty and number of falls in geriatric outpatients. Journal of the American Heart Association ,
9(7), e014688. https://pubmed.ncbi.nlm.nih.gov/32223397/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32223397/ |
| — | The Consensus Committee of the American Autonomic Society and the American Academy of
Neurology. (1996). Consensus statement on the definition of orthostatic hypotension, pure autonomic
failure, and multiple system atrophy. Neurology , 46(5), 1470. https://www.neurology.org/doi/10.1212/WNL.46.5.1470 | — | — | https://www.neurology.org/doi/10.1212/WNL.46.5.1470 |
| — | Iseli, R., et al. (2019). Orthostatic hypotension and cognition in older adults: A
systematic review and meta-analysis. Experimental Gerontology , 120, 40-49. https://pubmed.ncbi.nlm.nih.gov/30825549/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30825549/ |
| — | Frangos, E., Graf, C., & Samaras, N. (2023). Functional aging: Integrating functionality to a multidimensional assessment of healthy aging. Current Gerontology and Geriatrics Research , 2023, 9409918. https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9899138/ |
| — | Bohannon, R. W., & Williams Andrews, A. (2011). Normal walking speed: a descriptive meta-analysis. Physiotherapy , 97(3), 182-189. https://pubmed.ncbi.nlm.nih.gov/21820535/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21820535/ |
| — | Al Rihani, S. B., et al. (2021). Quantifying anticholinergic burden and sedative load in
older adults with polypharmacy: A systematic review of risk scales and models. Drugs & Aging , 38, 977-994. https://pubmed.ncbi.nlm.nih.gov/34751922/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34751922/ |
| — | Yu, X., et al. (2024). Association between polypharmacy and cognitive impairment in older
adults: A systematic review and meta-analysis. Geriatric Nursing , 59, 330-337. https://pubmed.ncbi.nlm.nih.gov/39111065/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39111065/ |
| — | Roncal-Belzunce, V., et al. (2024). Systematic review and meta-analysis on the
effectiveness of multidisciplinary interventions to address polypharmacy in community-dwelling older
adults. Ageing Research Reviews , 98, 102317. https://pubmed.ncbi.nlm.nih.gov/38692414/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38692414/ |
| — | Masnoon, N., et al. (2017). What is polypharmacy? A systematic review of definitions. BMC Geriatrics , 17, 230. https://pubmed.ncbi.nlm.nih.gov/29017448/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29017448/ |
| — | Katsimpris, A., et al. (2019). The association between polypharmacy and physical function
in older adults: A systematic review. Journal of General Internal Medicine , 34, 1865-1873. https://pubmed.ncbi.nlm.nih.gov/31240604/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31240604/ |
| — | EuroQol Group. (1990). EuroQol: a new facility for the measurement of
health-related quality of life. Health Policy . https://pubmed.ncbi.nlm.nih.gov/10109801/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10109801/ |
| — | Weinstein, M. C., Torrance, G., & McGuire, A. (2009). QALYs: the basics. Value in Health . https://pubmed.ncbi.nlm.nih.gov/19250132/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19250132/ |
| — | Gill, T. M., Han, L., Gahbauer, E. A., Leo-Summers, L., Murphy, T. E., &
Ferrante, L. E. (2021). Functional effects of intervening illnesses and injuries after critical
illness in older persons. Critical Care Medicine , 49(6), 956-966. https://pmc.ncbi.nlm.nih.gov/articles/PMC8140984/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8140984/ |
| — | Gill, T. M., Gahbauer, E. A., Han, L., & Allore, H. G. (2015). The role of
intervening hospital admissions on trajectories of disability in the last year of life: prospective
cohort study of older people. BMJ , 350, h2361. https://pmc.ncbi.nlm.nih.gov/articles/PMC4443433/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4443433/ |
| — | Gill, T. M. (2014). Disentangling the disabling process: insights from the
Precipitating Events Project. The Gerontologist , 54(4), 533-549. https://pmc.ncbi.nlm.nih.gov/articles/PMC4155452/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4155452/ |
| — | Gill, T. M., Williams, C. S., & Tinetti, M. E. (1999). The combined effects of
baseline vulnerability and acute hospital events on the development of functional dependence among
community-living older persons. The Journals of Gerontology: Series A , 54(7), M377-M383. https://pubmed.ncbi.nlm.nih.gov/10462171/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10462171/ |
| — | Gill, T. M., Han, L., Gahbauer, E. A., Leo-Summers, L., & Murphy, T. E. (2020).
Risk factors and precipitants of severe disability among community-living older persons. JAMA Network Open , 3(6), e206021. https://pmc.ncbi.nlm.nih.gov/articles/PMC7267844/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7267844/ |
| — | Gill, T. M., Gahbauer, E. A., Han, L., & Allore, H. G. (2010). Trajectories of
disability in the last year of life. The New England Journal of Medicine , 362(13), 1173-1180. https://pmc.ncbi.nlm.nih.gov/articles/PMC2877372/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2877372/ |
| — | Gill, T. M., Allore, H. G., Gahbauer, E. A., & Murphy, T. E. (2010). Change in
disability after hospitalization or restricted activity in older persons. JAMA , 304(17),
1919-1928. https://pmc.ncbi.nlm.nih.gov/articles/PMC3124926/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3124926/ |
| — | Wang, J., Wang, J., Li, X., et al. (2022). Association of pulmonary function with motor function trajectories and disability progression among older adults: a long-term community-based cohort study. Journal of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/35512113/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35512113/ |
| — | Janssens, J. P., Pache, J. C., & Nicod, L. P. (1999). Physiological changes in respiratory function associated with ageing. European Respiratory Journal . https://pubmed.ncbi.nlm.nih.gov/10836348/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10836348/ |
| — | Roman, M. A., Rossiter, H. B., & Casaburi, R. (2016). Exercise, ageing and the lung. European Respiratory Journal . https://pubmed.ncbi.nlm.nih.gov/27799391/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27799391/ |
| — | Stanojevic, S., Kaminsky, D. A., Miller, M. R., et al. (2022). ERS/ATS technical standard on interpretive strategies for routine lung function tests. European Respiratory Journal . https://pubmed.ncbi.nlm.nih.gov/34949706/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34949706/ |
| — | Lange, P., Celli, B., Agusti, A., et al. (2015). Lung-function trajectories leading to chronic obstructive pulmonary disease. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/26154786/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26154786/ |
| — | Newnham, D. M., & Hamilton, S. J. (1997). Sensitivity of the cough reflex in young and elderly subjects. Age and Ageing . https://pubmed.ncbi.nlm.nih.gov/9223713/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9223713/ |
| — | Bertels, X., Ross, J. C., Faner, R., et al. (2024). Clinical relevance of lung function trajectory clusters in middle-aged and older adults. ERJ Open Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC10851953/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10851953/ |
| — | Enright, P. L., Kronmal, R. A., Manolio, T. A., Schenker, M. B., & Hyatt, R. E. (1994). Respiratory muscle strength in the elderly: correlates and reference values. American Journal of Respiratory and Critical Care Medicine . https://pubmed.ncbi.nlm.nih.gov/8306041/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8306041/ |
| — | Quanjer, P. H., Stanojevic, S., Cole, T. J., et al. (2012). Multi-ethnic reference values for spirometry for the 3-95-year age range: the Global Lung Function 2012 equations. European Respiratory Journal . https://pmc.ncbi.nlm.nih.gov/articles/PMC3786581/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3786581/ |
| — | Wang, J., Guo, J., Dove, A., et al. (2023). Pulmonary function trajectories preceding death among older adults: a long-term community-based cohort study. Journal of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC10329233/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10329233/ |
| — | Yang, X., Cheng, C., Ma, W., & Jia, C. (2023). Longitudinal association of lung function with frailty among older adults: the English Longitudinal Study of Ageing. European Geriatric Medicine . https://pubmed.ncbi.nlm.nih.gov/36536112/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36536112/ |
| — | Schneider, J. L., Rowe, J. H., Garcia-de-Alba, C., et al. (2021). The aging lung: physiology, disease, and immunity. Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC8052295/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8052295/ |
| — | Kirk, B., Cawthon, P. M., Arai, H., et al. (2024). The Conceptual Definition of
Sarcopenia: Delphi Consensus from the Global Leadership Initiative in Sarcopenia (GLIS). Age and Ageing , 53(3), afae052. https://academic.oup.com/ageing/article/53/3/afae052/7633681 | — | — | https://academic.oup.com/ageing/article/53/3/afae052/7633681 |
| — | Newman, A. B., Kupelian, V., Visser, M., et al. (2006). Strength, but not muscle mass,
is associated with mortality in the Health, Aging and Body Composition Study cohort. The Journals of Gerontology: Series A , 61(1), 72-77. https://pubmed.ncbi.nlm.nih.gov/16456196/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16456196/ |
| — | Westbury, L. D., Beaudart, C., Bruyère, O., et al. (2023). Recent sarcopenia
definitions—prevalence, agreement and mortality associations among men: Findings from
population-based cohorts. Journal of Cachexia, Sarcopenia and Muscle , 14(1), 565-575. https://pubmed.ncbi.nlm.nih.gov/36604970/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36604970/ |
| — | Larsson, L., Degens, H., Li, M., et al. (2019). Sarcopenia: Aging-Related Loss of
Muscle Mass and Function. Physiological Reviews , 99(1), 427-511. https://pubmed.ncbi.nlm.nih.gov/30427277/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30427277/ |
| — | Lan, L., Shao, S., & Zheng, X. (2024). Associations between sarcopenia and
trajectories of activities of daily living disability: a nationwide longitudinal study of
middle-aged and older adults in China from 2011 to 2018. Archives of Public Health , 82, 97. https://pubmed.ncbi.nlm.nih.gov/38918853/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38918853/ |
| — | Zhou, H., Ding, X., & Luo, M. (2024). The association between sarcopenia and
functional disability in older adults. The Journal of Nutrition, Health & Aging , 28(1),
100016. https://pubmed.ncbi.nlm.nih.gov/38267154/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38267154/ |
| — | Lunt, E., Ong, T., Gordon, A. L., Greenhaff, P. L., & Gladman, J. R. F. (2021).
The clinical usefulness of muscle mass and strength measures in older people: a systematic review. Age and Ageing , 50(1), 88-95. https://pubmed.ncbi.nlm.nih.gov/32706848/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32706848/ |
| — | Cruz-Jentoft, A. J., & Sayer, A. A. (2019). Sarcopenia. The Lancet ,
393(10191), 2636-2646. https://pubmed.ncbi.nlm.nih.gov/31171417/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31171417/ |
| — | Cruz-Jentoft, A. J., Bahat, G., Bauer, J., et al. (2019). Sarcopenia: revised European
consensus on definition and diagnosis. Age and Ageing , 48(1), 16-31. https://pubmed.ncbi.nlm.nih.gov/30312372/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30312372/ |
| — | Bamia, C., Orfanos, P., Juerges, H., et al. (2017). Self-rated health and all-cause and cause-specific mortality of older adults: individual data meta-analysis of prospective cohort studies in the CHANCES Consortium. Maturitas . https://pubmed.ncbi.nlm.nih.gov/28778331/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28778331/ |
| — | Lee, Y. (2000). The predictive value of self assessed general, physical, and mental health on functional decline and mortality in older adults. Journal of Epidemiology & Community Health . https://pmc.ncbi.nlm.nih.gov/articles/PMC1731623/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1731623/ |
| — | Jylhä, M. (2009). What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Social Science & Medicine . https://pubmed.ncbi.nlm.nih.gov/19520474/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19520474/ |
| — | Cullati, S., Bochatay, N., Rossier, C., et al. (2020). Does the single-item self-rated health measure the same thing across different wordings? Construct validity study. Quality of Life Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC7434800/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7434800/ |
| — | Salomon, J. A., Tandon, A., & Murray, C. J. L. (2004). Comparability of self rated health: cross sectional multi-country survey using anchoring vignettes. BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC324453/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC324453/ |
| — | Giltay, E. J., Vollaard, A. M., & Kromhout, D. (2012). Self-rated health and physician-rated health as independent predictors of mortality in elderly men. Age and Ageing . https://pubmed.ncbi.nlm.nih.gov/22180414/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22180414/ |
| — | Dramé, M., Cantegrit, E., & Godaert, L. (2023). Self-rated health as a predictor of mortality in older adults: a systematic review. International Journal of Environmental Research and Public Health . https://pmc.ncbi.nlm.nih.gov/articles/PMC10001164/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10001164/ |
| — | DeSalvo, K. B., Bloser, N., Reynolds, K., et al. (2006). Mortality prediction with a single general self-rated health question: a meta-analysis. Journal of General Internal Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC1828094/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1828094/ |
| — | Eriksson, I., Undén, A.-L., & Elofsson, S. (2001). Self-rated health. Comparisons between three different measures. Results from a population study. International Journal of Epidemiology . https://pubmed.ncbi.nlm.nih.gov/11369738/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11369738/ |
| — | Bergland, A., & Strand, B. H. (2019). Norwegian reference values for the Short Physical Performance Battery (SPPB): the Tromsø Study. BMC Geriatrics , 19, 216. https://pmc.ncbi.nlm.nih.gov/articles/PMC6686475/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6686475/ |
| — | Kwon, S., Perera, S., Pahor, M., et al. (2009). What is a meaningful change in physical performance? Findings from a clinical trial in older adults (the LIFE-P study). The Journal of Nutrition, Health & Aging , 13(6), 538-544. https://pmc.ncbi.nlm.nih.gov/articles/PMC3100159/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3100159/ |
| — | Pavasini, R., Guralnik, J., Brown, J. C., et al. (2016). Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis. BMC Medicine , 14, 215. https://pubmed.ncbi.nlm.nih.gov/28003033/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28003033/ |
| — | Guralnik, J. M., Ferrucci, L., Pieper, C. F., et al. (2000). Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the Short Physical Performance Battery. The Journals of Gerontology: Series A , 55(4), M221-M231. https://pubmed.ncbi.nlm.nih.gov/10811152/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10811152/ |
| — | Woo, J., Yau, F., Leung, J., & Chan, R. (2019). Peak oxygen uptake, six-minute walk distance, six-meter walk speed, and pulse pressure as predictors of seven year all-cause and cardiovascular mortality in community-living older adults. Experimental Gerontology , 124, 110645. https://pubmed.ncbi.nlm.nih.gov/31252159/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31252159/ |
| — | Harada, N. D., Chiu, V., & Stewart, A. L. (1999). Mobility-related function in older adults: assessment with a 6-minute walk test. Archives of Physical Medicine and Rehabilitation , 80(7), 837-841. https://pubmed.ncbi.nlm.nih.gov/10414771/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10414771/ |
| — | Ng, S. S., Yu, P. C., To, F. P., Chung, J. S., & Cheung, T. H. (2013). Effect of walkway length and turning direction on the distance covered in the 6-minute walk test among adults over 50 years of age: a cross-sectional study. Physiotherapy , 99(1), 63-70. https://pubmed.ncbi.nlm.nih.gov/23219645/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23219645/ |
| — | Chan, W. L. S., & Pin, T. W. (2019). Practice effect and cueing of 2-minute walk test, 6-minute walk test and 10-meter walk test in frail older adults with and without dementia: recommendations to walk tests protocols. Experimental Gerontology , 124, 110648. https://pubmed.ncbi.nlm.nih.gov/31279000/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31279000/ |
| — | Perera, S., Mody, S. H., Woodman, R. C., & Studenski, S. A. (2006). Meaningful change and responsiveness in common physical performance measures in older adults. Journal of the American Geriatrics Society , 54(5), 743-749. https://pubmed.ncbi.nlm.nih.gov/16696738/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16696738/ |
| — | Cazzoletti, L., Zanolin, M. E., Dorelli, G., et al. (2022). Six-minute walk distance in healthy subjects: reference standards from a general population sample. Respiratory Research , 23, 83. https://pubmed.ncbi.nlm.nih.gov/35382813/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35382813/ |
| — | Steffen, T. M., Hacker, T. A., & Mollinger, L. (2002). Age- and gender-related test performance in community-dwelling elderly people: Six-Minute Walk Test, Berg Balance Scale, Timed Up & Go Test, and gait speeds. Physical Therapy , 82(2), 128-137. https://pubmed.ncbi.nlm.nih.gov/11856064/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11856064/ |
| — | Bautmans, I., Lambert, M., & Mets, T. (2004). The six-minute walk test in community dwelling elderly: influence of health status. BMC Geriatrics , 4, 6. https://pubmed.ncbi.nlm.nih.gov/15272934/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15272934/ |
| — | Enright, P. L., & Sherrill, D. L. (1998). Reference equations for the six-minute walk in healthy adults. American Journal of Respiratory and Critical Care Medicine , 158(5), 1384-1387. https://pubmed.ncbi.nlm.nih.gov/9817683/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9817683/ |
| — | Troosters, T., Gosselink, R., & Decramer, M. (1999). Six minute walking distance in healthy elderly subjects. European Respiratory Journal , 14(2), 270-274. https://pubmed.ncbi.nlm.nih.gov/10515400/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10515400/ |
| — | Blackwell, T., Yaffe, K., Laffan, A., et al. (2014). Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS Sleep Study. Sleep . https://pmc.ncbi.nlm.nih.gov/articles/PMC4044750/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4044750/ |
| — | Mander, B. A., Winer, J. R., & Walker, M. P. (2017). Sleep and human aging. Neuron . https://pmc.ncbi.nlm.nih.gov/articles/PMC5810920/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5810920/ |
| — | Spira, A. P., Covinsky, K., Rebok, G. W., et al. (2012). Poor sleep quality and functional decline in older women. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC3375617/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3375617/ |
| — | National Academies of Sciences, Engineering, and Medicine. (2020). Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System . https://www.ncbi.nlm.nih.gov/books/NBK557974/ | — | — | https://www.ncbi.nlm.nih.gov/books/NBK557974/ |
| — | Makizako, H., et al. (2015). Social frailty in community-dwelling older adults as a risk factor for disability. Journal of the American Medical Directors Association . https://pubmed.ncbi.nlm.nih.gov/26482055/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26482055/ |
| — | Bunt, S., et al. (2017). Social frailty in older adults: a scoping review. European Journal of Ageing . https://pmc.ncbi.nlm.nih.gov/articles/PMC5587459/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5587459/ |
| — | Mehrabi, F., et al. (2024). The temporal sequence and reciprocal relationships of frailty, social isolation and loneliness in older adults across 21 years. Age and Ageing . https://pmc.ncbi.nlm.nih.gov/articles/PMC11447375/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11447375/ |
| — | Kastner, M., et al. (2024). Interventions that have potential to help older adults living with social frailty: a systematic scoping review. BMC Geriatrics . https://pmc.ncbi.nlm.nih.gov/articles/PMC11179268/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11179268/ |
| — | Goto, T., et al. (2024). Social frailty as a predictor of all-cause mortality and functional disability: a systematic review and meta-analysis. Scientific Reports . https://pmc.ncbi.nlm.nih.gov/articles/PMC10858956/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10858956/ |
| — | Makizako, H., et al. (2018). Social frailty leads to the development of physical frailty among physically non-frail adults: a four-year follow-up longitudinal cohort study. International Journal of Environmental Research and Public Health . https://pmc.ncbi.nlm.nih.gov/articles/PMC5877035/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5877035/ |
| — | Zhang, X.-M., et al. (2023). The prevalence of social frailty among older adults: a systematic review and meta-analysis. Journal of the American Medical Directors Association . https://pubmed.ncbi.nlm.nih.gov/36402197/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36402197/ |
| — | Webber, M., et al. (2025). The conceptualisation and measurement of social frailty in older people: an umbrella review. The Journal of Frailty & Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC12702443/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12702443/ |
| — | Shankar, A., et al. (2017). Social isolation and loneliness: prospective associations with functional status in older adults. Health Psychology . https://pubmed.ncbi.nlm.nih.gov/27786518/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27786518/ |
| — | Perissinotto, C. M., et al. (2012). Loneliness in older persons: a predictor of functional decline and death. Archives of Internal Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC4383762/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4383762/ |
| — | Lyu, C., et al. (2024). Social isolation changes and long-term outcomes among older adults. JAMA Network Open . https://pmc.ncbi.nlm.nih.gov/articles/PMC11270134/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11270134/ |
| — | Philip, K. E. J., et al. (2020). Social isolation, loneliness and physical performance in older-adults: fixed effects analyses of a cohort study. Scientific Reports . https://pmc.ncbi.nlm.nih.gov/articles/PMC7431531/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7431531/ |
| — | Ong, A. D., et al. (2016). Loneliness and health in older adults: a mini-review and synthesis. Gerontology . https://pmc.ncbi.nlm.nih.gov/articles/PMC6162046/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6162046/ |
| — | Doan, T.-N., et al. (2022). “Prevalence and methods for assessment of oropharyngeal dysphagia in older adults: a systematic review and meta-analysis.” Journal of Clinical Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC9104951/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9104951/ |
| — | Molfenter, S. M., et al. (2019). “Volumetric changes to the pharynx in healthy aging: consequence for pharyngeal swallow mechanics and function.” Dysphagia . https://pmc.ncbi.nlm.nih.gov/articles/PMC6344328/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6344328/ |
| — | Speyer, R., et al. (2022). “White paper by the European Society for Swallowing Disorders: screening and non-instrumental assessment for dysphagia in adults.” Dysphagia . https://doi.org/10.1007/s00455-021-10283-7 | — | — | https://doi.org/10.1007/s00455-021-10283-7 |
| — | Yoshimatsu, Y., et al. (2022). “The diagnosis of aspiration pneumonia in older persons: a systematic review.” European Geriatric Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC9409622/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9409622/ |
| — | Muhle, P., et al. (2015). “Age-related changes in swallowing: physiology and pathophysiology.” Der Nervenarzt . https://pubmed.ncbi.nlm.nih.gov/25833400/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25833400/ |
| — | Zhao, W. T., et al. (2018). “Systematic review and meta-analysis of the association between sarcopenia and dysphagia.” The Journal of Nutrition, Health & Aging . https://pubmed.ncbi.nlm.nih.gov/30272106/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30272106/ |
| — | Banda, K. J., et al. (2022). “Prevalence of oropharyngeal dysphagia and risk of pneumonia, malnutrition, and mortality in adults aged 60 years and older: a meta-analysis.” Gerontology . https://pubmed.ncbi.nlm.nih.gov/34903688/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34903688/ |
| — | Pinto, J. M., Wroblewski, K. E., Kern, D. W., Schumm, L. P., & McClintock, M. K. (2014). Olfactory dysfunction predicts 5-year mortality in older adults. PLOS ONE . https://pmc.ncbi.nlm.nih.gov/articles/PMC4182669/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4182669/ |
| — | Bothwell, A. R., Resnick, S. M., Ferrucci, L., & Tian, Q. (2023). Associations of olfactory function with brain structural and functional outcomes: a systematic review. Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/37913831/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37913831/ |
| — | Yuan, Y., Chamberlin, K. W., Li, C., et al. (2024). Olfaction and mobility in older adults. JAMA Otolaryngology-Head & Neck Surgery . https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2814085 | — | — | https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2814085 |
| — | Olofsson, J. K., Ekstrom, I., Larsson, M., & Nordin, S. (2021). Olfaction and aging: a review of the current state of research and future directions. i-Perception . https://journals.sagepub.com/doi/10.1177/20416695211020331 | — | — | https://journals.sagepub.com/doi/10.1177/20416695211020331 |
| — | Bauer, S., Blanar, V., Pospichal, J., & Eglseer, D. (2025). Association between taste disorders and malnutrition in older adults: a scoping review. Nutrition Reviews . https://pmc.ncbi.nlm.nih.gov/articles/PMC12793606/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12793606/ |
| — | Correia, C., Lopez, K. J., Wroblewski, K. E., et al. (2016). Global sensory impairment among older adults in the United States. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC4808743/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4808743/ |
| — | Choi, J. S., Jang, S. S., Kim, J., Hur, K., Ference, E., & Wrobel, B. (2021). Association between olfactory dysfunction and mortality in US adults. JAMA Otolaryngology-Head & Neck Surgery . https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2772028 | — | — | https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2772028 |
| — | Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004). Untangling the concepts of disability, frailty, and comorbidity. https://pubmed.ncbi.nlm.nih.gov/15031310/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15031310/ |
| — | Austad, S. N. (2016). The geroscience hypothesis: is it possible to change the rate of aging? In Advances in Geroscience . https://doi.org/10.1007/978-3-319-23246-1_1 | — | — | https://doi.org/10.1007/978-3-319-23246-1_1 |
| — | Albrecht, G. L., & Devlieger, P. J. (1999). The disability paradox: high quality
of life against all odds. Social Science & Medicine , 48(8), 977-988. https://doi.org/10.1016/S0277-9536(98)00411-0 | — | — | https://doi.org/10.1016/S0277-9536(98)00411-0 |
| — | Hutchinson, C., et al. (2022). Do we agree or disagree? A systematic review of the
application of preference-based instruments in self and proxy reporting of quality of life in older
people. Social Science & Medicine , 305, 115046. https://doi.org/10.1016/j.socscimed.2022.115046 | — | — | https://doi.org/10.1016/j.socscimed.2022.115046 |
| — | Schwartz, C. E., Andresen, E. M., Nosek, M. A., & Krahn, G. L. (2007). Response
shift theory: important implications for measuring quality of life in people with disability. Archives of Physical Medicine and Rehabilitation , 88(4), 529-536. https://doi.org/10.1016/j.apmr.2006.12.032 | — | — | https://doi.org/10.1016/j.apmr.2006.12.032 |
| — | Fellinghauer, B., Reinhardt, J. D., Stucki, G., & Bickenbach, J. (2012).
Explaining the disability paradox: a cross-sectional analysis of the Swiss general population. BMC Public Health , 12, 655. https://doi.org/10.1186/1471-2458-12-655 | — | — | https://doi.org/10.1186/1471-2458-12-655 |
| — | Sprangers, M. A. G., & Schwartz, C. E. (1999). Integrating response shift into
health-related quality of life research: a theoretical model. Social Science & Medicine ,
48(11), 1507-1515. https://doi.org/10.1016/S0277-9536(99)00045-3 | — | — | https://doi.org/10.1016/S0277-9536(99)00045-3 |
| — | van Loon, A. M., Depla, M. F. I. A., Hertogh, C. M. P. M., Huisman, M., & Kok,
A. A. L. (2023). The disability paradox? Trajectories of well-being in older adults with functional
decline. Journal of Aging and Health , 35(1-2), 125-137. https://doi.org/10.1177/08982643221108660 | — | — | https://doi.org/10.1177/08982643221108660 |
| — | Retel Helmrich, I. R. A., et al. (2022). Discrepancy between disability and reported
well-being after traumatic brain injury. Journal of Neurology, Neurosurgery & Psychiatry ,
93(7), 785-796. https://doi.org/10.1136/jnnp-2021-326615 | — | — | https://doi.org/10.1136/jnnp-2021-326615 |
| — | Köhler, T., & Vanhoutte, B. (2024). Temporary setback or lasting challenge? The
impact of transient and persistent functional disability on later-life well-being. The Journals
of Gerontology: Series B , 79(11), gbae159. https://doi.org/10.1093/geronb/gbae159 | — | — | https://doi.org/10.1093/geronb/gbae159 |
| — | The WHOQOL Group. (1995). The World Health Organization Quality of Life assessment
(WHOQOL): position paper from the World Health Organization. Social Science & Medicine ,
41(10), 1403-1409. https://doi.org/10.1016/0277-9536(95)00112-K | — | — | https://doi.org/10.1016/0277-9536(95)00112-K |
| — | Hospers, L., Dillon, G. A., McLachlan, A. J., et al. (2024). The effect of prescription and over-the-counter medications on core temperature in adults during heat stress: a systematic review and meta-analysis. EClinicalMedicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC11541675/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11541675/ |
| — | Kenney, W. L., & Chiu, P. (2001). Influence of age on thirst and fluid intake. Medicine & Science in Sports & Exercise . https://pubmed.ncbi.nlm.nih.gov/11528342/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11528342/ |
| — | Mack, G. W., Weseman, C. A., Langhans, G. W., et al. (1994). Body fluid balance in dehydrated healthy older men: thirst and renal osmoregulation. Journal of Applied Physiology . https://pubmed.ncbi.nlm.nih.gov/8045840/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8045840/ |
| — | Kenney, W. L., & Munce, T. A. (2003). Invited review: aging and human temperature regulation. Journal of Applied Physiology . https://pubmed.ncbi.nlm.nih.gov/14600165/ | — | — | https://pubmed.ncbi.nlm.nih.gov/14600165/ |
| — | Meade, R. D., Notley, S. R., Akerman, A. P., et al. (2023). Physiological responses to 9 hours of heat exposure in young and older adults. Part I: Body temperature and hemodynamic regulation. Journal of Applied Physiology . https://pubmed.ncbi.nlm.nih.gov/37439239/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37439239/ |
| — | Gagnon, D., & Kenny, G. P. (2012). Does sex have an independent effect on thermoeffector responses during exercise in the heat? Journal of Physiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3530110/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3530110/ |
| — | Ibrahim, A., Singh, D. K. A., & Shahar, S. (2017). “Timed Up and Go” test: age, gender and cognitive impairment stratified normative values of older adults. PLOS ONE , 12(10), e0185641. https://pubmed.ncbi.nlm.nih.gov/28972994/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28972994/ |
| — | Ortega-Bastidas, P., Gómez, B., Aqueveque, P., Luarte-Martínez, S., & Cano-de-la-Cuerda, R. (2023). Instrumented Timed Up and Go test (iTUG)—more than assessing time to predict falls: a systematic review. Sensors , 23(7), 3426. https://pubmed.ncbi.nlm.nih.gov/37050485/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37050485/ |
| — | Park, S. H. (2018). Tools for assessing fall risk in the elderly: a systematic review and meta-analysis. Aging Clinical and Experimental Research , 30(1), 1-16. https://pubmed.ncbi.nlm.nih.gov/28374345/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28374345/ |
| — | Bohannon, R. W. (2006). Reference values for the Timed Up and Go test: a descriptive meta-analysis. Journal of Geriatric Physical Therapy , 29(2), 64-68. https://pubmed.ncbi.nlm.nih.gov/16914068/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16914068/ |
| — | Barry, E., Galvin, R., Keogh, C., Horgan, F., & Fahey, T. (2014). Is the Timed Up and Go test a useful predictor of risk of falls in community-dwelling older adults: a systematic review and meta-analysis. BMC Geriatrics , 14, 14. https://pubmed.ncbi.nlm.nih.gov/24484314/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24484314/ |
| — | Low, D. C., & Walsh, G. S. (2022). The minimal important change for measures of balance and postural control in older adults: a systematic review. Age and Ageing , 51(12), afac284. https://pubmed.ncbi.nlm.nih.gov/36580388/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36580388/ |
| — | Podsiadlo, D., & Richardson, S. (1991). The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. Journal of the American Geriatrics Society , 39(2), 142-148. https://pubmed.ncbi.nlm.nih.gov/1991946/ | — | — | https://pubmed.ncbi.nlm.nih.gov/1991946/ |
| — | Honvo, G., et al. (2023). Measures of attributes of locomotor capacity in older people: a systematic literature review following the COSMIN methodology. Age and Ageing , 52(Suppl 4), iv44-iv66. https://pubmed.ncbi.nlm.nih.gov/37902521/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37902521/ |
| — | Jahn, K., et al. (2015). Dizziness and unstable gait in old age: etiology, diagnosis and treatment. Deutsches Arzteblatt International . https://pmc.ncbi.nlm.nih.gov/articles/PMC4498008/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4498008/ |
| — | Maheu, M., et al. (2015). The effects of aging on clinical vestibular evaluations. Frontiers in Neurology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4585272/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4585272/ |
| — | Semenov, Y. R., et al. (2016). Association between vestibular and cognitive function in US adults: data from the National Health and Nutrition Examination Survey. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC5864155/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5864155/ |
| — | Bosmans, J., et al. (2021). Vestibular function in older adults with cognitive impairment: a systematic review. Ear and Hearing . https://pubmed.ncbi.nlm.nih.gov/33974775/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33974775/ |
| — | Li, Y., et al. (2024). Association between dizziness and future falls and fall-related injuries in older adults: a systematic review and meta-analysis. Age and Ageing . https://pmc.ncbi.nlm.nih.gov/articles/PMC11410394/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11410394/ |
| — | Tighilet, B., & Chabbert, C. (2023). Cellular and molecular mechanisms of vestibular ageing. Journal of Clinical Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC10487907/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10487907/ |
| — | Arshad, Q., & Seemungal, B. M. (2016). Age-related vestibular loss: current understanding and future research directions. Frontiers in Neurology . https://pmc.ncbi.nlm.nih.gov/articles/PMC5165261/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5165261/ |
| — | Harun, A., et al. (2016). Understanding the experience of age-related vestibular loss in older individuals: a qualitative study. The Patient . https://pmc.ncbi.nlm.nih.gov/articles/PMC4925240/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4925240/ |
| — | Agrawal, Y., et al. (2009). Disorders of balance and vestibular function in US adults: data from the National Health and Nutrition Examination Survey, 2001-2004. Archives of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/19468085/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19468085/ |
| — | Nagarajan, N., et al. (2022). Vision impairment and cognitive decline among older adults: a systematic review. BMJ Open . https://bmjopen.bmj.com/content/12/1/e047929 | — | — | https://bmjopen.bmj.com/content/12/1/e047929 |
| — | Flaxman, S. R., et al. (2017). Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. The Lancet Global Health . https://doi.org/10.1016/S2214-109X(17)30393-5 | — | — | https://doi.org/10.1016/S2214-109X(17)30393-5 |
| — | Lam, B. L., et al. (2013). Longitudinal relationships among visual acuity and tasks of everyday life: the Salisbury Eye Evaluation Study. Investigative Ophthalmology & Visual Science . https://pmc.ncbi.nlm.nih.gov/articles/PMC3544421/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3544421/ |
| — | Tsang, J. Y., et al. (2024). Risk of falls and fractures in individuals with cataract, age-related macular degeneration, or glaucoma. JAMA Ophthalmology . https://pmc.ncbi.nlm.nih.gov/articles/PMC10870181/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10870181/ |
| — | Christ, S. L., et al. (2014). Longitudinal relationships among visual acuity, daily functional status, and mortality: the Salisbury Eye Evaluation Study. JAMA Ophthalmology . https://pmc.ncbi.nlm.nih.gov/articles/PMC7894742/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7894742/ |
| — | Swenor, B. K., et al. (2015). Visual impairment and incident mobility limitations: the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society . https://pubmed.ncbi.nlm.nih.gov/25536849/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25536849/ |
| — | Erdinest, N., et al. (2021). Vision through healthy aging eyes. Vision . https://pmc.ncbi.nlm.nih.gov/articles/PMC8544709/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8544709/ |
| — | Hou, C., et al. (2022). Bidirectional association between visual impairment and frailty among community-dwelling older adults: a longitudinal study. BMC Geriatrics . https://pmc.ncbi.nlm.nih.gov/articles/PMC9377125/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9377125/ |
| — | Vos, T., Flaxman, A. D., Naghavi, M., et al. (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet . https://pmc.ncbi.nlm.nih.gov/articles/PMC6350784/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6350784/ |
| — | Salomon, J. A., Vos, T., Hogan, D. R., et al. (2012). Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. The Lancet . https://pubmed.ncbi.nlm.nih.gov/23245605/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23245605/ |
| — | GBD 2017 DALYs and HALE Collaborators. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet . https://pmc.ncbi.nlm.nih.gov/articles/PMC6252083/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6252083/ |
| — | Hilderink, H. B. M., Plasmans, M. H. D., Snijders, B. E. P., et al. (2016). Accounting for multimorbidity can affect the estimation of the burden of disease: a comparison of approaches. Archives of Public Health . https://pmc.ncbi.nlm.nih.gov/articles/PMC4993005/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4993005/ |
| — | Salomon, J. A., Haagsma, J. A., Davis, A., et al. (2015). Disability weights for the Global Burden of Disease 2013 study. The Lancet Global Health . https://pubmed.ncbi.nlm.nih.gov/26475018/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26475018/ |
| — | GBD 2021 Diseases and Injuries Collaborators. (2024). Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet . https://pmc.ncbi.nlm.nih.gov/articles/PMC11122111/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11122111/ |
| — | Crimmins, E. M., Zhang, Y., & Saito, Y. (2016). Trends over 4 decades in disability-free life expectancy in the United States. American Journal of Public Health . https://pmc.ncbi.nlm.nih.gov/articles/PMC4984740/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4984740/ |
| — | Burstein, R., Fleming, T., Haagsma, J. A., et al. (2015). Estimating distributions of health state severity for the Global Burden of Disease study. Population Health Metrics . https://pmc.ncbi.nlm.nih.gov/articles/PMC4650517/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4650517/ |
| — | Cornelissen, V. A., & Smart, N. A. (2013). Exercise training for blood pressure: A
systematic review and meta-analysis. Journal of the American Heart Association . https://pubmed.ncbi.nlm.nih.gov/23525435/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23525435/ |
| — | An, J., Su, Z., & Meng, S. (2024). Effect of aerobic training versus resistance
training for improving cardiorespiratory fitness and body composition in middle-aged to older
adults: A systematic review and meta-analysis of randomized controlled trials. Archives of
Gerontology and Geriatrics . https://pubmed.ncbi.nlm.nih.gov/38878596/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38878596/ |
| — | Stensvold, D., et al. (2020). Effect of exercise training for five years on all cause
mortality in older adults—the Generation 100 study: Randomised controlled trial. BMJ . https://www.bmj.com/content/371/bmj.m3485 | — | — | https://www.bmj.com/content/371/bmj.m3485 |
| — | Han, M., et al. (2022). Cardiorespiratory fitness and mortality from all causes,
cardiovascular disease and cancer: Dose-response meta-analysis of cohort studies. British
Journal of Sports Medicine . https://pubmed.ncbi.nlm.nih.gov/35022163/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35022163/ |
| — | Garber, C. E., et al. (2011). Quantity and quality of exercise for developing and
maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy
adults: Guidance for prescribing exercise. Medicine & Science in Sports & Exercise . https://pubmed.ncbi.nlm.nih.gov/21694556/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21694556/ |
| — | Rebello, C. J., et al. (2023). Effect of exercise training on insulin-stimulated glucose
disposal: A systematic review and meta-analysis of randomized controlled trials. International
Journal of Obesity . https://pubmed.ncbi.nlm.nih.gov/36828899/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36828899/ |
| — | Garcia, L., et al. (2023). Non-occupational physical activity and risk of
cardiovascular disease, cancer and mortality outcomes: A dose-response meta-analysis of large
prospective studies. British Journal of Sports Medicine . https://pubmed.ncbi.nlm.nih.gov/36854652/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36854652/ |
| — | Lee, D. H., et al. (2022). Long-term leisure-time physical activity intensity and
all-cause and cause-specific mortality: A prospective cohort of US adults. Circulation . https://pubmed.ncbi.nlm.nih.gov/35876019/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35876019/ |
| — | Lepeule, J., Laden, F., Dockery, D., & Schwartz, J. (2012). Chronic exposure to fine particles and mortality: An extended follow-up of the Harvard Six Cities Study from 1974 to 2009. Environmental Health Perspectives , 120(7), 965–970. https://doi.org/10.1289/ehp.1104660 | — | — | https://doi.org/10.1289/ehp.1104660 |
| — | Ebenstein, A., Fan, M., Greenstone, M., He, G., & Zhou, M. (2017). New evidence on the impact of sustained exposure to air pollution on life expectancy from China's Huai River Policy. Proceedings of the National Academy of Sciences , 114(39), 10384–10389. https://doi.org/10.1073/pnas.1616784114 | — | — | https://doi.org/10.1073/pnas.1616784114 |
| — | Di, Q., Wang, Y., Zanobetti, A., et al. (2017). Air pollution and mortality in the Medicare population. New England Journal of Medicine , 376, 2513–2522. https://doi.org/10.1056/NEJMoa1702747 | — | — | https://doi.org/10.1056/NEJMoa1702747 |
| — | Clancy, L., Goodman, P., Sinclair, H., & Dockery, D. W. (2002). Effect of air-pollution control on death rates in Dublin, Ireland: An intervention study. The Lancet , 360(9341), 1210–1214. https://doi.org/10.1016/S0140-6736(02)11281-5 | — | — | https://doi.org/10.1016/S0140-6736(02)11281-5 |
| — | Pope, C. A. III, Ezzati, M., & Dockery, D. W. (2009). Fine-particulate air pollution and life expectancy in the United States. New England Journal of Medicine , 360, 376–386. https://doi.org/10.1056/NEJMsa0805646 | — | — | https://doi.org/10.1056/NEJMsa0805646 |
| — | Brook, R. D., Rajagopalan, S., Pope, C. A. III, et al. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation , 121(21), 2331–2378. https://doi.org/10.1161/CIR.0b013e3181dbece1 | — | — | https://doi.org/10.1161/CIR.0b013e3181dbece1 |
| — | Correia, A. W., Pope, C. A. III, Dockery, D. W., Wang, Y., Ezzati, M., & Dominici, F. (2013). Effect of air pollution control on life expectancy in the United States: An analysis of 545 US counties for the period from 2000 to 2007. Epidemiology , 24(1), 23–31. https://doi.org/10.1097/EDE.0b013e3182770237 | — | — | https://doi.org/10.1097/EDE.0b013e3182770237 |
| — | Biddinger, K. J., et al. (2022). Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease. JAMA Network Open . https://pmc.ncbi.nlm.nih.gov/articles/PMC8956974/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8956974/ |
| — | Wood, A. M., et al. (2018). Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies. The Lancet . https://pubmed.ncbi.nlm.nih.gov/29676281/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29676281/ |
| — | Rumgay, H., et al. (2021). Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study. The Lancet Oncology . https://pubmed.ncbi.nlm.nih.gov/34270924/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34270924/ |
| — | Roerecke, M., et al. (2017). The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis. The Lancet Public Health . https://pubmed.ncbi.nlm.nih.gov/29253389/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29253389/ |
| — | Zhao, J., et al. (2023). Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study. BMC Medicine . https://pubmed.ncbi.nlm.nih.gov/37286970/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37286970/ |
| — | Zhao, J., et al. (2023). Association Between Daily Alcohol Intake and Risk of All-Cause Mortality: A Systematic Review and Meta-analyses. JAMA Network Open . https://pmc.ncbi.nlm.nih.gov/articles/PMC10066463/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10066463/ |
| — | GBD 2020 Alcohol Collaborators. (2022). Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020. The Lancet . https://pmc.ncbi.nlm.nih.gov/articles/PMC9289789/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9289789/ |
| — | Topiwala, A., et al. (2017). Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. BMJ . https://pubmed.ncbi.nlm.nih.gov/28588063/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28588063/ |
| — | Mansfield, A. et al. "Does perturbation-based balance training prevent falls? Systematic review and meta-analysis of preliminary randomized controlled trials." Physical Therapy (2015). https://pubmed.ncbi.nlm.nih.gov/25524873/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25524873/ |
| — | Montero-Odasso, M. et al. "World guidelines for falls prevention and management for older adults: a global initiative." Age and Ageing (2022). https://pubmed.ncbi.nlm.nih.gov/36178003/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36178003/ |
| — | Lusardi, M. M. et al. "Determining Risk of Falls in Community Dwelling Older Adults: A Systematic Review and Meta-analysis Using Posttest Probability." Journal of Geriatric Physical Therapy (2017). https://pubmed.ncbi.nlm.nih.gov/27537070/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27537070/ |
| — | Sherrington, C. et al. "Evidence on physical activity and falls prevention for people aged 65+ years: systematic review to inform the WHO guidelines on physical activity and sedentary behaviour." International Journal of Behavioral Nutrition and Physical Activity (2020). https://pubmed.ncbi.nlm.nih.gov/33239019/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33239019/ |
| — | Sherrington, C. et al. "Exercise to prevent falls in older adults: an updated systematic review and meta-analysis." British Journal of Sports Medicine (2017). https://bjsm.bmj.com/content/51/24/1750 | — | — | https://bjsm.bmj.com/content/51/24/1750 |
| — | Hopewell, S. et al. "Multifactorial and multiple component interventions for preventing falls in older people living in the community." Cochrane Database of Systematic Reviews (2018). https://pubmed.ncbi.nlm.nih.gov/30035305/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30035305/ |
| — | SPRINT Research Group. (2021). Final report of a trial of intensive versus standard blood-pressure control. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/34010531/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34010531/ |
| — | Blood Pressure Lowering Treatment Trialists' Collaboration. (2021). Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis. The Lancet . https://pubmed.ncbi.nlm.nih.gov/34461040/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34461040/ |
| — | SPRINT MIND Investigators for the SPRINT Research Group. (2019). Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/30688979/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30688979/ |
| — | ACCORD Study Group. (2010). Effects of intensive blood-pressure control in type 2 diabetes mellitus. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/20228401/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20228401/ |
| — | Zhang, W., et al. (2021). Trial of intensive blood-pressure control in older patients with hypertension. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/34491661/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34491661/ |
| — | Ji, H., et al. (2021). Association of cumulative systolic blood pressure with long-term risk of cardiovascular disease and healthy longevity: findings from the Lifetime Risk Pooling Project cohorts. Circulation . https://pubmed.ncbi.nlm.nih.gov/33342241/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33342241/ |
| — | Muntner, P., et al. (2019). Measurement of blood pressure in humans: a scientific statement from the American Heart Association. Hypertension . https://pubmed.ncbi.nlm.nih.gov/30827125/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30827125/ |
| — | Ettehad, D., et al. (2016). Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. The Lancet . https://pubmed.ncbi.nlm.nih.gov/26724178/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26724178/ |
| — | Beckett, N. S., et al. (2008). Treatment of hypertension in patients 80 years of age or older. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/18378519/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18378519/ |
| — | SPRINT Research Group. (2015). A randomized trial of intensive versus standard blood-pressure control. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/26551272/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26551272/ |
| — | Kerr, J. et al. "Acute Glucoregulatory and Vascular Outcomes of Three Strategies for Interrupting Prolonged Sitting Time in Postmenopausal Women: A Pilot, Laboratory-Based, Randomized, Controlled, 4-Condition, 4-Period Crossover Trial." PLoS ONE (2017). https://pubmed.ncbi.nlm.nih.gov/29190761/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29190761/ |
| — | Dunstan, D. W. et al. "Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses." Diabetes Care (2012). https://pubmed.ncbi.nlm.nih.gov/22374636/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22374636/ |
| — | Yates, T. et al. "Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study." The Journals of Gerontology: Series A (2020). https://pubmed.ncbi.nlm.nih.gov/30403772/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30403772/ |
| — | Duran, A. T. et al. "Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose-Response Analysis of a Randomized Crossover Trial." Medicine & Science in Sports & Exercise (2023). https://pubmed.ncbi.nlm.nih.gov/36728338/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36728338/ |
| — | Peddie, M. C. et al. "The Effects of Prolonged Sitting, Prolonged Standing, and Activity Breaks on Vascular Function, and Postprandial Glucose and Insulin Responses: A Randomised Crossover Trial." PLoS ONE (2021). https://pubmed.ncbi.nlm.nih.gov/33395691/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33395691/ |
| — | Colman, R. J., et al. (2009). Caloric restriction delays disease onset and mortality in rhesus monkeys. Science . https://pubmed.ncbi.nlm.nih.gov/19590001/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19590001/ |
| — | Racette, S. B., et al. (2016). Safety of two-year caloric restriction in non-obese healthy individuals. Oncotarget . https://pmc.ncbi.nlm.nih.gov/articles/PMC4991370/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4991370/ |
| — | Liao, C.-Y., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010). Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell . https://pubmed.ncbi.nlm.nih.gov/19878144/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19878144/ |
| — | Ravussin, E., et al. (2015). A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity. The Journals of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/26187233/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26187233/ |
| — | Mattison, J. A., et al. (2012). Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature . https://pubmed.ncbi.nlm.nih.gov/22932268/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22932268/ |
| — | Redman, L. M., et al. (2018). Metabolic slowing and reduced oxidative damage with sustained caloric restriction supports the rate of living and oxidative damage theories of aging. Cell Metabolism . https://pmc.ncbi.nlm.nih.gov/articles/PMC5886711/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5886711/ |
| — | Fontana, L., & Partridge, L. (2015). Promoting health and longevity through diet: from model organisms to humans. Cell . https://pubmed.ncbi.nlm.nih.gov/25815989/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25815989/ |
| — | Belsky, D. W., et al. (2023). Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nature Aging . https://www.nature.com/articles/s43587-022-00357-y | — | — | https://www.nature.com/articles/s43587-022-00357-y |
| — | Dorling, J. L., et al. (2021). Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2. Nutrition Reviews . https://pubmed.ncbi.nlm.nih.gov/32940695/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32940695/ |
| — | Mattison, J. A., et al. (2017). Caloric restriction improves health and survival of rhesus monkeys. Nature Communications . https://www.nature.com/articles/ncomms14063 | — | — | https://www.nature.com/articles/ncomms14063 |
| — | Bretthauer, M., et al. (2022). Effect of colonoscopy screening on risks of colorectal cancer and related death. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/36214590/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36214590/ |
| — | Miller, E. A., et al. (2019). Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: long-term follow-up of the randomised US PLCO cancer screening trial. The Lancet Gastroenterology & Hepatology . https://pubmed.ncbi.nlm.nih.gov/30502933/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30502933/ |
| — | National Lung Screening Trial Research Team. (2011). Reduced lung-cancer mortality with low-dose computed tomographic screening. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/21714641/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21714641/ |
| — | de Vos, I. I., et al. (2025). European Study of Prostate Cancer Screening: 23-year follow-up. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/41160819/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41160819/ |
| — | Miller, A. B., et al. (2014). Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ . https://pubmed.ncbi.nlm.nih.gov/24519768/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24519768/ |
| — | Hubbell, E., et al. (2019). All-cause mortality versus cancer-specific mortality as outcome in cancer screening trials: a review and modeling study. Cancer Medicine . https://pubmed.ncbi.nlm.nih.gov/31422585/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31422585/ |
| — | Schoenborn, N. L., et al. (2018). Influence of age, health, and function on cancer screening in older adults with limited life expectancy. Journal of General Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/30402822/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30402822/ |
| — | Bretthauer, M., et al. (2023). Estimated lifetime gained with cancer screening tests: a meta-analysis of randomized clinical trials. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/37639247/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37639247/ |
| — | de Koning, H. J., et al. (2020). Reduced lung-cancer mortality with volume CT screening in a randomized trial. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/31995683/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31995683/ |
| — | Kaltenbach, T., et al. (2024). Cancer stage compared with mortality as end points in randomized clinical trials of cancer screening: a systematic review and meta-analysis. JAMA . https://pubmed.ncbi.nlm.nih.gov/38583868/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38583868/ |
| — | Hammill, B. G., et al. (2010). Relationship between cardiac rehabilitation and
long-term risks of death and myocardial infarction among elderly Medicare beneficiaries. Circulation . https://pubmed.ncbi.nlm.nih.gov/20026778/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20026778/ |
| — | Molloy, C., et al. (2024). Exercise-based cardiac rehabilitation for adults with
heart failure. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/38451843/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38451843/ |
| — | Dibben, G. O., et al. (2023). Exercise-based cardiac rehabilitation for coronary
heart disease: A meta-analysis. European Heart Journal . https://pubmed.ncbi.nlm.nih.gov/36746187/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36746187/ |
| — | Dalal, H. M., et al. (2010). Home based versus centre based cardiac rehabilitation:
Cochrane systematic review and meta-analysis. BMJ . https://pubmed.ncbi.nlm.nih.gov/20085991/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20085991/ |
| — | West, R. R., Jones, D. A., & Henderson, A. H. (2012). Rehabilitation after
myocardial infarction trial (RAMIT): Multi-centre randomised controlled trial of comprehensive
cardiac rehabilitation in patients following acute myocardial infarction. Heart . https://pubmed.ncbi.nlm.nih.gov/22194152/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22194152/ |
| — | Dibben, G., et al. (2021). Exercise-based cardiac rehabilitation for coronary heart
disease. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/34741536/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34741536/ |
| — | Brown, T. M., et al. (2024). Core components of cardiac rehabilitation programs:
2024 update. Circulation . https://pubmed.ncbi.nlm.nih.gov/39315436/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39315436/ |
| — | Wu, G., et al. (2022). The effect of cardiac rehabilitation on lipid levels in
patients with coronary heart disease: A systematic review and meta-analysis. Global Heart . https://pubmed.ncbi.nlm.nih.gov/36578919/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36578919/ |
| — | Harwood, R. H., et al. (2005). Falls and health status in elderly women following first eye cataract surgery: a randomised controlled trial. British Journal of Ophthalmology . https://pubmed.ncbi.nlm.nih.gov/15615747/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15615747/ |
| — | de Silva, S. R., et al. (2014). Phacoemulsification with posterior chamber intraocular lens versus extracapsular cataract extraction with posterior chamber intraocular lens for age-related cataract. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/24474622/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24474622/ |
| — | Lee, C. S., et al. (2022). Association between cataract extraction and development of dementia. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/34870676/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34870676/ |
| — | Pershing, S., et al. (2020). Endophthalmitis after cataract surgery in the United States: a report from the Intelligent Research in Sight Registry, 2013–2017. Ophthalmology . https://pubmed.ncbi.nlm.nih.gov/31611015/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31611015/ |
| — | Ritterband, L. M., et al. (2025). A randomized controlled trial of a digital cognitive behavioral therapy for insomnia for older adults. npj Digital Medicine . https://pubmed.ncbi.nlm.nih.gov/40681664/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40681664/ |
| — | Lovato, N., et al. (2014). Evaluation of a brief treatment program of cognitive behavior therapy for insomnia in older adults. Sleep . https://pubmed.ncbi.nlm.nih.gov/24470701/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24470701/ |
| — | Trauer, J. M., et al. (2015). Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysis. Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/26054060/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26054060/ |
| — | Irwin, M. R., et al. (2015). Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late-life insomnia: a randomized controlled trial. Biological Psychiatry . https://pubmed.ncbi.nlm.nih.gov/25748580/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25748580/ |
| — | McCurry, S. M., et al. (2021). Effect of telephone cognitive behavioral therapy for insomnia in older adults with osteoarthritis pain: a randomized clinical trial. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/33616613/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33616613/ |
| — | Siengsukon, C. F., et al. (2026). The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: a randomized controlled trial. Alzheimer's & Dementia . https://pubmed.ncbi.nlm.nih.gov/42298279/ | — | — | https://pubmed.ncbi.nlm.nih.gov/42298279/ |
| — | Irwin, M. R., et al. (2022). Prevention of incident and recurrent major depression in older adults with insomnia: a randomized clinical trial. JAMA Psychiatry . https://pubmed.ncbi.nlm.nih.gov/34817561/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34817561/ |
| — | Irwin, M. R., et al. (2014). Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep . https://pubmed.ncbi.nlm.nih.gov/25142571/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25142571/ |
| — | Sivertsen, B., et al. (2006). Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/16804151/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16804151/ |
| — | Coe, N. B., et al. (2026). Impact of cognitive training on claims-based diagnosed dementia over 20 years: evidence from the ACTIVE study. Alzheimer's & Dementia: Translational Research & Clinical Interventions . https://doi.org/10.1002/trc2.70197 | — | — | https://doi.org/10.1002/trc2.70197 |
| — | Lampit, A., Hallock, H., & Valenzuela, M. (2014). Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. PLOS Medicine . https://doi.org/10.1371/journal.pmed.1001756 | — | — | https://doi.org/10.1371/journal.pmed.1001756 |
| — | Gates, N. J., et al. (2019). Computerised cognitive training for maintaining cognitive function in cognitively healthy people in late life. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/30864187/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30864187/ |
| — | Kelly, M. E., et al. (2014). The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: a systematic review and meta-analysis. Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/24607830/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24607830/ |
| — | Rebok, G. W., et al. (2014). Ten-year effects of the Advanced Cognitive Training for Independent and Vital Elderly cognitive training trial on cognition and everyday functioning in older adults. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC4055506/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4055506/ |
| — | Edwards, J. D., et al. (2017). Speed of processing training results in lower risk of dementia. Alzheimer's & Dementia: Translational Research & Clinical Interventions . https://pubmed.ncbi.nlm.nih.gov/29201994/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29201994/ |
| — | Prokopidis, K., et al. (2023). Effects of creatine supplementation on memory in healthy individuals: A systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews . https://pubmed.ncbi.nlm.nih.gov/35984306/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35984306/ |
| — | Marshall, S., et al. (2026). Creatine and cognition in aging: A systematic review of evidence in older adults. Nutrition Reviews . https://pubmed.ncbi.nlm.nih.gov/40971619/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40971619/ |
| — | Sales, L. P., et al. (2020). Creatine supplementation (3 g/d) and bone health in older women: A 2-year, randomized, placebo-controlled trial. Journals of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/31257405/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31257405/ |
| — | Forbes, S. C., et al. (2021). Meta-analysis examining the importance of creatine ingestion strategies on lean tissue mass and strength in older adults. Nutrients . https://pubmed.ncbi.nlm.nih.gov/34199420/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34199420/ |
| — | Lobo, D. M., et al. (2015). Effects of long-term low-dose dietary creatine supplementation in older women. Experimental Gerontology . https://pubmed.ncbi.nlm.nih.gov/26192975/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26192975/ |
| — | Candow, D. G., et al. (2021). Efficacy of creatine supplementation and resistance training on area and density of bone and muscle in older adults. Medicine & Science in Sports & Exercise . https://pubmed.ncbi.nlm.nih.gov/34107512/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34107512/ |
| — | Bonilla, D. A., et al. (2021). Metabolic basis of creatine in health and disease: A bioinformatics-assisted review. Nutrients . https://pubmed.ncbi.nlm.nih.gov/33572884/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33572884/ |
| — | Kabiri Naeini, E., et al. (2025). Effect of creatine supplementation on kidney function: A systematic review and meta-analysis. BMC Nephrology . https://pubmed.ncbi.nlm.nih.gov/41199218/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41199218/ |
| — | Tangney, C. C., et al. (2014). Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4206157/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4206157/ |
| — | Sacks, F. M., et al. (2001). Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/11136953/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11136953/ |
| — | Blumenthal, J. A., et al. (2019). Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial. Neurology . https://pmc.ncbi.nlm.nih.gov/articles/PMC6340382/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6340382/ |
| — | Appel, L. J., et al. (1997). A clinical trial of the effects of dietary patterns on blood pressure. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/9099655/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9099655/ |
| — | Soltani, S., et al. (2020). Adherence to the dietary approaches to stop hypertension (DASH) diet in relation to all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Nutrition Journal . https://pmc.ncbi.nlm.nih.gov/articles/PMC7178992/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7178992/ |
| — | Filippou, C. D., et al. (2020). Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure Reduction in Adults with and without Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Advances in Nutrition . https://pmc.ncbi.nlm.nih.gov/articles/PMC7490167/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7490167/ |
| — | Berendsen, A. A. M., et al. (2017). The Dietary Approaches to Stop Hypertension Diet, Cognitive Function, and Cognitive Decline in American Older Women. Journal of the American Medical Directors Association . https://pubmed.ncbi.nlm.nih.gov/28108204/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28108204/ |
| — | Bensaaud, A., et al. (2025). Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/40326569/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40326569/ |
| — | Chiavaroli, L., et al. (2019). DASH Dietary Pattern and Cardiometabolic Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses. Nutrients . https://pubmed.ncbi.nlm.nih.gov/30764511/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30764511/ |
| — | Unutzer, J., et al. (2002). Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/12472325/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12472325/ |
| — | Hunkeler, E. M., et al. (2006). Long term outcomes from the IMPACT randomised trial for depressed elderly patients in primary care. BMJ . https://pubmed.ncbi.nlm.nih.gov/16428253/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16428253/ |
| — | Kim, J.-M., et al. (2018). Effect of escitalopram vs placebo treatment for depression on long-term cardiac outcomes in patients with acute coronary syndrome: a randomized clinical trial. JAMA . https://jamanetwork.com/journals/jama/fullarticle/2688569 | — | — | https://jamanetwork.com/journals/jama/fullarticle/2688569 |
| — | Brain, J., et al. (2025). Temporal dynamics in the association between depression and dementia: an umbrella review and meta-analysis. EClinicalMedicine . https://pubmed.ncbi.nlm.nih.gov/40687743/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40687743/ |
| — | Cuijpers, P., et al. (2026). Psychological treatment of depression in older adults: a network meta-analysis. International Psychogeriatrics . https://pubmed.ncbi.nlm.nih.gov/41991348/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41991348/ |
| — | Gallo, J. J., et al. (2013). Long term effect of depression care management on mortality in older adults: follow-up of cluster randomized clinical trial in primary care. BMJ . https://pubmed.ncbi.nlm.nih.gov/23738992/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23738992/ |
| — | Mallery, L., et al. (2019). Systematic review and meta-analysis of second-generation antidepressants for the treatment of older adults with depression: questionable benefit and considerations for frailty. BMC Geriatrics . https://pubmed.ncbi.nlm.nih.gov/31718566/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31718566/ |
| — | Wassink-Vossen, S., et al. (2022). Effectiveness of late-life depression interventions on functional limitations: a systematic review. International Journal of Mental Health Nursing . https://pubmed.ncbi.nlm.nih.gov/35142015/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35142015/ |
| — | Berkman, L. F., et al. (2003). Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the ENRICHD randomized trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/12813116/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12813116/ |
| — | Ainsworth, N. J., et al. (2024). Cognitive outcomes after antidepressant pharmacotherapy for late-life depression: a systematic review and meta-analysis. American Journal of Psychiatry . https://pubmed.ncbi.nlm.nih.gov/38321915/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38321915/ |
| — | Uusitupa, M., et al. (2009). Ten-year mortality and cardiovascular morbidity in the Finnish Diabetes Prevention Study: secondary analysis of the randomized trial. PLoS ONE . https://pubmed.ncbi.nlm.nih.gov/19479072/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19479072/ |
| — | Diabetes Prevention Program Research Group. (2002). Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/11832527/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11832527/ |
| — | Goldberg, R. B., et al. (2022). Effects of long-term metformin and lifestyle interventions on cardiovascular events in the Diabetes Prevention Program and its Outcome Study. Circulation . https://pubmed.ncbi.nlm.nih.gov/35603600/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35603600/ |
| — | Knowler, W. C., et al. (2025). Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial. The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/40311647/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40311647/ |
| — | Lee, C. G., et al. (2021). Effect of metformin and lifestyle interventions on mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study. Diabetes Care . https://pubmed.ncbi.nlm.nih.gov/34697033/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34697033/ |
| — | Gong, Q., et al. (2019). Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study. The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/31036503/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31036503/ |
| — | Haw, J. S., et al. (2017). Long-term sustainability of diabetes prevention approaches: a systematic review and meta-analysis of randomized clinical trials. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/29114778/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29114778/ |
| — | Tuomilehto, J., et al. (2001). Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/11333990/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11333990/ |
| — | Diabetes Prevention Program Research Group. (2015). Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study. The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/26377054/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26377054/ |
| — | Vinelli, V., et al. (2022). Effects of dietary fibers on short-chain fatty acids and gut microbiota composition in healthy adults: a systematic review. Nutrients . https://pubmed.ncbi.nlm.nih.gov/35807739/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35807739/ |
| — | Fu, L., et al. (2022). Associations between dietary fiber intake and cardiovascular risk factors: An umbrella review of meta-analyses of randomized controlled trials. Frontiers in Nutrition . https://pubmed.ncbi.nlm.nih.gov/36172520/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36172520/ |
| — | Reynolds, A., et al. (2019). Carbohydrate quality and human health: a series of systematic reviews and meta-analyses. The Lancet . https://pubmed.ncbi.nlm.nih.gov/30638909/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30638909/ |
| — | So, D., et al. (2018). Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis. The American Journal of Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/29757343/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29757343/ |
| — | Park, Y., et al. (2011). Dietary fiber intake and mortality in the NIH-AARP Diet and Health Study. Archives of Internal Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC3513325/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3513325/ |
| — | Ramezani, F., et al. (2024). Dietary fiber intake and all-cause and cause-specific mortality: An updated systematic review and meta-analysis of prospective cohort studies. Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/38011755/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38011755/ |
| — | Jones, J. M. (2013). Dietary fiber future directions: integrating new definitions and findings to inform nutrition research and communication. Advances in Nutrition . https://pubmed.ncbi.nlm.nih.gov/23319118/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23319118/ |
| — | Valenzuela, P. L. et al. "Effects of physical exercise on physical function in older adults in residential care: a systematic review and network meta-analysis of randomised controlled trials." The Lancet Healthy Longevity (2023). https://pubmed.ncbi.nlm.nih.gov/37182530/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37182530/ |
| — | Zhao, W. et al. "Effect of physical activity on the risk of frailty: A systematic review and meta-analysis." PLOS ONE (2022). https://pubmed.ncbi.nlm.nih.gov/36454790/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36454790/ |
| — | Etayo-Urtasun, P. et al. "Effectiveness of post-discharge exercise interventions in older adults following acute hospitalisation: a systematic review and meta-analysis." The Lancet Healthy Longevity (2025). https://pubmed.ncbi.nlm.nih.gov/40754363/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40754363/ |
| — | Eidam, A. et al. "Interventions to prevent the onset of frailty in adults aged 60 and older (PRAE-Frail): a systematic review and network meta-analysis." European Geriatric Medicine (2024). https://pubmed.ncbi.nlm.nih.gov/39060779/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39060779/ |
| — | Yang, X. et al. "Effects of multicomponent exercise on frailty status and physical function in frail older adults: A meta-analysis and systematic review." Experimental Gerontology (2024). https://pubmed.ncbi.nlm.nih.gov/39426607/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39426607/ |
| — | Clegg, A. et al. "Frailty in elderly people." The Lancet (2013). https://pubmed.ncbi.nlm.nih.gov/23395245/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23395245/ |
| — | Tarazona-Santabalbina, F. J. et al. "A Multicomponent Exercise Intervention that Reverses Frailty and Improves Cognition, Emotion, and Social Networking in the Community-Dwelling Frail Elderly: A Randomized Clinical Trial." Journal of the American Medical Directors Association (2016). https://pubmed.ncbi.nlm.nih.gov/26947059/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26947059/ |
| — | Valenzuela, P. L. et al. "Effects of exercise interventions on the functional status of acutely hospitalised older adults: A systematic review and meta-analysis." Ageing Research Reviews (2020). https://pubmed.ncbi.nlm.nih.gov/32330558/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32330558/ |
| — | Hartley, P. et al. "Exercise for acutely hospitalised older medical patients." Cochrane Database of Systematic Reviews (2022). https://pubmed.ncbi.nlm.nih.gov/36355032/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36355032/ |
| — | Bohannon, R. W. et al. "Grip strength: an indispensable biomarker for older adults." Clinical Interventions in Aging (2019). https://www.tandfonline.com/doi/full/10.2147/CIA.S194543 | — | — | https://www.tandfonline.com/doi/full/10.2147/CIA.S194543 |
| — | Rantanen, T. et al. "Midlife hand grip strength as a predictor of old age disability." JAMA (1999). https://jamanetwork.com/journals/jama/fullarticle/190348 | — | — | https://jamanetwork.com/journals/jama/fullarticle/190348 |
| — | Yeo, B. S. H., et al. (2023). Association of hearing aids and cochlear implants with cognitive decline and dementia: a systematic review and meta-analysis. JAMA Neurology . https://pubmed.ncbi.nlm.nih.gov/36469314/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36469314/ |
| — | Reed, N. S., et al. (2025). Hearing intervention, social isolation, and loneliness: a secondary analysis of the ACHIEVE randomized clinical trial. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/40354063/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40354063/ |
| — | Deal, J. A., et al. (2017). Hearing impairment and incident dementia and cognitive decline in older adults: the Health ABC Study. The Journals of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/27071780/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27071780/ |
| — | Sanders, M. E., et al. (2021). The effect of hearing aids on cognitive function: a systematic review. PLOS ONE . https://pubmed.ncbi.nlm.nih.gov/34972121/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34972121/ |
| — | Lin, F. R., et al. (2011). Hearing loss and incident dementia. Archives of Neurology . https://pubmed.ncbi.nlm.nih.gov/21320988/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21320988/ |
| — | Wayne, R. V., & Johnsrude, I. S. (2015). A review of causal mechanisms underlying the link between age-related hearing loss and cognitive decline. Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/25625860/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25625860/ |
| — | Maharani, A., et al. (2024). Does social isolation mediate the association between hearing loss and cognition in adults? A systematic review and meta-analysis of longitudinal studies. Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/38292910/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38292910/ |
| — | MacInnis, M. J., & Gibala, M. J. (2017). Physiological adaptations to interval
training and the role of exercise intensity. The Journal of Physiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC5407969/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5407969/ |
| — | Edwards, J. J., et al. (2023). High-Intensity Interval Training and Cardiometabolic
Health in the General Population: A Systematic Review and Meta-Analysis of Randomised Controlled
Trials. Sports Medicine . https://pubmed.ncbi.nlm.nih.gov/37204620/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37204620/ |
| — | Kodama, S., et al. (2009). Cardiorespiratory fitness as a quantitative predictor of
all-cause mortality and cardiovascular events in healthy men and women: A meta-analysis. JAMA . https://pubmed.ncbi.nlm.nih.gov/19454641/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19454641/ |
| — | Stamatakis, E., et al. (2022). Association of wearable device-measured vigorous
intermittent lifestyle physical activity with mortality. Nature Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC9800274/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9800274/ |
| — | Stensvold, D., et al. (2020). Effect of exercise training for five years on all cause
mortality in older adults—the Generation 100 study: randomised controlled trial. BMJ . https://www.bmj.com/content/371/bmj.m3485 | — | — | https://www.bmj.com/content/371/bmj.m3485 |
| — | Wewege, M. A., et al. (2018). High-Intensity Interval Training for Patients With
Cardiovascular Disease—Is It Safe? A Systematic Review. Journal of the American Heart
Association . https://pmc.ncbi.nlm.nih.gov/articles/PMC6404189/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6404189/ |
| — | Byrne, P., et al. (2022). Evaluating the association between low-density lipoprotein cholesterol reduction and relative and absolute effects of statin treatment: a systematic review and meta-analysis. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/35285850/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35285850/ |
| — | Cannon, C. P., et al. (2015). Ezetimibe added to statin therapy after acute coronary syndromes. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/26039521/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26039521/ |
| — | Sabatine, M. S., et al. (2017). Evolocumab and clinical outcomes in patients with cardiovascular disease. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/28304224/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28304224/ |
| — | Cholesterol Treatment Trialists' Collaboration. (2024). Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis. The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/38554713/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38554713/ |
| — | Cholesterol Treatment Trialists' Collaboration. (2010). Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. The Lancet . https://pubmed.ncbi.nlm.nih.gov/21067804/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21067804/ |
| — | Cholesterol Treatment Trialists' Collaboration. (2022). Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials. The Lancet . https://pubmed.ncbi.nlm.nih.gov/36049498/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36049498/ |
| — | Yourman, L. C., et al. (2021). Evaluation of time to benefit of statins for the primary prevention of cardiovascular events in adults aged 50 to 75 years: a meta-analysis. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/33196766/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33196766/ |
| — | Silverman, M. G., et al. (2016). Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis. JAMA . https://pubmed.ncbi.nlm.nih.gov/27673306/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27673306/ |
| — | Cholesterol Treatment Trialists' Collaboration. (2019). Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials. The Lancet . https://pubmed.ncbi.nlm.nih.gov/30712900/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30712900/ |
| — | Cholesterol Treatment Trialists' Collaborators. (2012). The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. The Lancet . https://pubmed.ncbi.nlm.nih.gov/22607822/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22607822/ |
| — | Zhou, D., Chen, Z. & Tian, F. "Deprescribing Interventions for Older Patients: A Systematic Review and Meta-Analysis." Journal of the American Medical Directors Association (2023). https://pubmed.ncbi.nlm.nih.gov/37582482/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37582482/ |
| — | Hoel, R. W., Giddings Connolly, R. M. & Takahashi, P. Y. "Polypharmacy Management in Older Patients." Mayo Clinic Proceedings (2021). https://pubmed.ncbi.nlm.nih.gov/33413822/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33413822/ |
| — | Quek, H. W. et al. "The effect of deprescribing interventions on mortality and health outcomes in older people: An updated systematic review and meta-analysis." British Journal of Clinical Pharmacology (2024). https://pubmed.ncbi.nlm.nih.gov/39164070/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39164070/ |
| — | O'Mahony, D. et al. "STOPP/START criteria for potentially inappropriate prescribing in older people: version 2." Age and Ageing (2015). https://pubmed.ncbi.nlm.nih.gov/25324330/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25324330/ |
| — | Kua, C. H., Mak, V. S. L. & Huey Lee, S. W. "Health Outcomes of Deprescribing Interventions Among Older Residents in Nursing Homes: A Systematic Review and Meta-analysis." Journal of the American Medical Directors Association (2019). https://pubmed.ncbi.nlm.nih.gov/30655193/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30655193/ |
| — | Martin, P. et al. "Effect of a Pharmacist-Led Educational Intervention on Inappropriate Medication Prescriptions in Older Adults: The D-PRESCRIBE Randomized Clinical Trial." JAMA (2018). https://pubmed.ncbi.nlm.nih.gov/30422193/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30422193/ |
| — | Scott, I. A. et al. "Reducing inappropriate polypharmacy: the process of deprescribing." JAMA Internal Medicine (2015). https://pubmed.ncbi.nlm.nih.gov/25798731/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25798731/ |
| — | Linsky, A. M. et al. "Deprescribing in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis." JAMA Network Open (2025). https://pubmed.ncbi.nlm.nih.gov/40338546/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40338546/ |
| — | Soltani, S., et al. (2019). Adherence to the Mediterranean Diet in Relation to All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. Advances in Nutrition . https://pmc.ncbi.nlm.nih.gov/articles/PMC6855973/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6855973/ |
| — | Trichopoulou, A., et al. (2005). Modified Mediterranean diet and survival: EPIC-Elderly prospective cohort study. BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC557144/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC557144/ |
| — | Willett, W. C., et al. (1995). Mediterranean diet pyramid: a cultural model for healthy eating. The American Journal of Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/7754995/ | — | — | https://pubmed.ncbi.nlm.nih.gov/7754995/ |
| — | Estruch, R., et al. (2018). Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/29897866/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29897866/ |
| — | Urpi-Sarda, M., et al. (2021). The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease. Biomedicines . https://pubmed.ncbi.nlm.nih.gov/34440065/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34440065/ |
| — | Delgado-Lista, J., et al. (2022). Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. The Lancet . https://pubmed.ncbi.nlm.nih.gov/35525255/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35525255/ |
| — | Valls-Pedret, C., et al. (2015). Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/25961184/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25961184/ |
| — | Knight, A., et al. (2016). The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study. Nutrients . https://pubmed.ncbi.nlm.nih.gov/27657119/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27657119/ |
| — | Shumaker, S. A., et al. (2003). Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/12771112/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12771112/ |
| — | Cauley, J. A., et al. (2003). Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/14519707/ | — | — | https://pubmed.ncbi.nlm.nih.gov/14519707/ |
| — | Manson, J. E., et al. (2017). Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women's Health Initiative randomized trials. JAMA . https://pubmed.ncbi.nlm.nih.gov/28898378/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28898378/ |
| — | Wassertheil-Smoller, S., et al. (2003). Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/12771114/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12771114/ |
| — | Hodis, H. N., et al. (2016). Vascular effects of early versus late postmenopausal treatment with estradiol. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/27028912/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27028912/ |
| — | Chlebowski, R. T., et al. (2020). Association of menopausal hormone therapy with breast cancer incidence and mortality during long-term follow-up of the Women's Health Initiative randomized clinical trials. JAMA . https://pubmed.ncbi.nlm.nih.gov/32721007/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32721007/ |
| — | Manson, J. E., et al. (2013). Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. JAMA . https://pubmed.ncbi.nlm.nih.gov/24084921/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24084921/ |
| — | Cushman, M., et al. (2004). Estrogen plus progestin and risk of venous thrombosis. JAMA . https://pubmed.ncbi.nlm.nih.gov/15467059/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15467059/ |
| — | Boardman, H. M. P., et al. (2015). Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/25754617/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25754617/ |
| — | Harman, S. M., et al. (2014). Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial. Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/25069991/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25069991/ |
| — | Zhou, Z. et al. "Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants." Diabetologia (2021). https://pubmed.ncbi.nlm.nih.gov/34109441/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34109441/ |
| — | Alberti, K. G. M. M. et al. "Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity." Circulation (2009). https://pubmed.ncbi.nlm.nih.gov/19805654/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19805654/ |
| — | Konopka, A. R., et al. (2019). Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell . https://pubmed.ncbi.nlm.nih.gov/30548390/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30548390/ |
| — | Nabrdalik, K., et al. (2022). Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials. Frontiers in Endocrinology . https://pubmed.ncbi.nlm.nih.gov/36187122/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36187122/ |
| — | Adler, A. I., et al. (2024). Post-trial monitoring of a randomised controlled trial of intensive glycaemic control in type 2 diabetes extended from 10 years to 24 years (UKPDS 91). The Lancet . https://pubmed.ncbi.nlm.nih.gov/38772405/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38772405/ |
| — | Witham, M. D., et al. (2025). Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): A double-blind, randomised, placebo-controlled trial. The Lancet Healthy Longevity . https://pubmed.ncbi.nlm.nih.gov/40147475/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40147475/ |
| — | Kulkarni, A. S., et al. (2018). Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. Aging Cell . https://pubmed.ncbi.nlm.nih.gov/29383869/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29383869/ |
| — | UK Prospective Diabetes Study Group. (1998). Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). The Lancet . https://pubmed.ncbi.nlm.nih.gov/9742977/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9742977/ |
| — | LaMoia, T. E., and Shulman, G. I. (2021). Cellular and molecular mechanisms of metformin action. Endocrine Reviews . https://pubmed.ncbi.nlm.nih.gov/32897388/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32897388/ |
| — | Diabetes Prevention Program Research Group. (2025). Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial. The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/40311647/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40311647/ |
| — | Barzilai, N., et al. (2016). Metformin as a tool to target aging. Cell Metabolism . https://pubmed.ncbi.nlm.nih.gov/27304507/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27304507/ |
| — | Campbell, J. M., et al. (2017). Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis. Ageing Research Reviews . https://pubmed.ncbi.nlm.nih.gov/28802803/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28802803/ |
| — | Walton, R. G., et al. (2019). Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: The MASTERS trial. Aging Cell . https://pubmed.ncbi.nlm.nih.gov/31557380/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31557380/ |
| — | Gnesin, F., et al. (2020). Metformin monotherapy for adults with type 2 diabetes mellitus. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/32501595/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32501595/ |
| — | Ngandu, T. et al. "A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial." The Lancet (2015). https://pubmed.ncbi.nlm.nih.gov/25771249/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25771249/ |
| — | Moll van Charante, E. P. et al. "Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial." The Lancet (2016). https://pubmed.ncbi.nlm.nih.gov/27474376/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27474376/ |
| — | Liao, X., Shen, J., and Li, M. "Effects of multi-domain intervention on intrinsic capacity in older adults: A systematic review of randomized controlled trials (RCTs)." Experimental Gerontology (2023). https://pubmed.ncbi.nlm.nih.gov/36736466/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36736466/ |
| — | Brodaty, H. et al. "An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: a randomized controlled trial." Nature Medicine (2025). https://pubmed.ncbi.nlm.nih.gov/39875685/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39875685/ |
| — | Hafdi, M., Hoevenaar-Blom, M. P., and Richard, E. "Multi-domain interventions for the prevention of dementia and cognitive decline." Cochrane Database of Systematic Reviews (2021). https://pubmed.ncbi.nlm.nih.gov/34748207/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34748207/ |
| — | Zülke, A. et al. "A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial." Alzheimer's & Dementia (2024). https://pubmed.ncbi.nlm.nih.gov/37768074/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37768074/ |
| — | Dedeyne, L. et al. "Effects of multi-domain interventions in (pre)frail elderly on frailty, functional, and cognitive status: a systematic review." Clinical Interventions in Aging (2017). https://pubmed.ncbi.nlm.nih.gov/28579766/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28579766/ |
| — | Manson, J. E., et al. (2019). Marine n-3 fatty acids and prevention of cardiovascular disease and cancer. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/30415637/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30415637/ |
| — | Gencer, B., et al. (2021). Effect of long-term marine omega-3 fatty acids supplementation on the risk of atrial fibrillation in randomized controlled trials of cardiovascular outcomes. Circulation . https://pubmed.ncbi.nlm.nih.gov/34612056/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34612056/ |
| — | Harris, W. S., et al. (2021). Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Nature Communications . https://pubmed.ncbi.nlm.nih.gov/33888689/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33888689/ |
| — | Bhatt, D. L., et al. (2019). Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/30415628/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30415628/ |
| — | Abdelhamid, A. S., et al. (2020). Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/32114706/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32114706/ |
| — | Nicholls, S. J., et al. (2020). Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/33190147/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33190147/ |
| — | ASCEND Study Collaborative Group. (2018). Effects of n-3 fatty acid supplements in diabetes mellitus. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/30146932/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30146932/ |
| — | Calder, P. C. (2020). Eicosapentaenoic and docosahexaenoic acid derived specialised pro-resolving mediators: concentrations in humans and the effects of age, sex, disease and increased omega-3 fatty acid intake. Biochimie . https://pubmed.ncbi.nlm.nih.gov/31866423/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31866423/ |
| — | Cao, Y., et al. (2022). Oral care measures for preventing nursing home-acquired pneumonia. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/36383760/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36383760/ |
| — | Salazar, J., et al. (2024). Effect of oral health interventions for dependent older people: a systematic review. Gerodontology . https://pubmed.ncbi.nlm.nih.gov/37847812/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37847812/ |
| — | Peng, J., et al. (2019). The relationship between tooth loss and mortality from all causes, cardiovascular diseases, and coronary heart disease in the general population: systematic review and dose-response meta-analysis of prospective cohort studies. Bioscience Reports . https://pubmed.ncbi.nlm.nih.gov/30530864/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30530864/ |
| — | Huang, J., et al. (2025). Association between oral health status and frailty in older adults: a systematic review and meta-analysis. Frontiers in Public Health . https://pubmed.ncbi.nlm.nih.gov/40231179/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40231179/ |
| — | Chan, A. K. Y., et al. (2022). Clinical evidence for professionally applied fluoride therapy to prevent and arrest dental caries in older adults: a systematic review. Journal of Dentistry . https://pubmed.ncbi.nlm.nih.gov/36058347/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36058347/ |
| — | Hägglund, P., et al. (2020). Effects of domiciliary professional oral care for care-dependent elderly in nursing homes: oral hygiene, gingival bleeding, root caries and nursing staff's oral health knowledge and attitudes. Clinical Interventions in Aging . https://pubmed.ncbi.nlm.nih.gov/32982191/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32982191/ |
| — | Sen, S., et al. (2023). Periodontal disease treatment after stroke or transient ischemic attack: the PREMIERS study, a randomized clinical trial. Stroke . https://pubmed.ncbi.nlm.nih.gov/37548008/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37548008/ |
| — | D'Aiuto, F., et al. (2018). Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial. The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/30472992/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30472992/ |
| — | Black, D. M., et al. (2006). Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX). JAMA . https://pubmed.ncbi.nlm.nih.gov/17190893/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17190893/ |
| — | Saag, K. G., et al. (2017). Romosozumab or alendronate for fracture prevention in women with osteoporosis. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/28892457/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28892457/ |
| — | Cummings, S. R., et al. (1998). Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/9875874/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9875874/ |
| — | Cummings, S. R., et al. (2009). Denosumab for prevention of fractures in postmenopausal women with osteoporosis. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/19671655/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19671655/ |
| — | Johansson, H., et al. (2017). Imminent risk of fracture after fracture. Osteoporosis International . https://pubmed.ncbi.nlm.nih.gov/28028554/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28028554/ |
| — | Kendler, D. L., et al. (2018). Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. The Lancet . https://pubmed.ncbi.nlm.nih.gov/29129436/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29129436/ |
| — | Lyles, K. W., et al. (2007). Zoledronic acid and clinical fractures and mortality after hip fracture. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/17878149/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17878149/ |
| — | Wang, Q., et al. (2020). Effectiveness of exercise intervention on fall-related fractures in older adults: a systematic review and meta-analysis of randomized controlled trials. BMC Geriatrics . https://pubmed.ncbi.nlm.nih.gov/32887571/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32887571/ |
| — | Black, D. M., et al. (2022). Bisphosphonates and the risk of atypical femur fractures. Bone . https://pubmed.ncbi.nlm.nih.gov/34920168/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34920168/ |
| — | Black, D. M., et al. (2007). Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/17476007/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17476007/ |
| — | LeBoff, M. S., et al. (2022). The clinician's guide to prevention and treatment of osteoporosis. Osteoporosis International . https://pubmed.ncbi.nlm.nih.gov/35478046/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35478046/ |
| — | Wu, C. H., et al. (2018). Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: a systematic literature review and meta-analysis. Bone . https://pubmed.ncbi.nlm.nih.gov/29555309/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29555309/ |
| — | Cosman, F., et al. (2022). Multiple vertebral fractures after denosumab discontinuation: FREEDOM and FREEDOM Extension trials additional post hoc analyses. Journal of Bone and Mineral Research . https://pubmed.ncbi.nlm.nih.gov/36088628/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36088628/ |
| — | Tong, T. Y. N., et al. (2019). Risks of ischaemic heart disease and stroke in meat eaters, fish eaters, and vegetarians over 18 years of follow-up: results from the prospective EPIC-Oxford study. BMJ . https://pubmed.ncbi.nlm.nih.gov/31484644/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31484644/ |
| — | Wang, T., et al. (2023). Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Network Open . https://pubmed.ncbi.nlm.nih.gov/37490288/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37490288/ |
| — | Neufingerl, N., & Eilander, A. (2022). Nutrient Intake and Status in Adults Consuming Plant-Based Diets Compared to Meat-Eaters: A Systematic Review. Nutrients . https://pubmed.ncbi.nlm.nih.gov/35010904/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35010904/ |
| — | Kim, J., et al. (2024). Plant-based dietary patterns and mortality from all causes, cardiovascular disease, and cancer: The Multiethnic Cohort Study. Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/38703511/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38703511/ |
| — | Abris, G. P., et al. (2024). Cause-specific and all-cause mortalities in vegetarian compared with those in nonvegetarian participants from the Adventist Health Study-2 cohort. The American Journal of Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/39098708/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39098708/ |
| — | Termannsen, A.-D., et al. (2022). Effects of vegan diets on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials. Obesity Reviews . https://pubmed.ncbi.nlm.nih.gov/35672940/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35672940/ |
| — | Orlich, M. J., et al. (2013). Vegetarian dietary patterns and mortality in Adventist Health Study 2. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/23836264/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23836264/ |
| — | Kim, H., Caulfield, L. E., & Rebholz, C. M. (2018). Healthy Plant-Based Diets Are Associated with Lower Risk of All-Cause Mortality in US Adults. The Journal of Nutrition . https://pubmed.ncbi.nlm.nih.gov/29659968/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29659968/ |
| — | Clemson, L. et al. "Environmental interventions for preventing falls in older people living in the community." Cochrane Database of Systematic Reviews (2023). https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013258.pub2/full | — | — | https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013258.pub2/full |
| — | Pighills, A. C. et al. "Environmental assessment and modification to prevent falls in older people." Journal of the American Geriatrics Society (2011). https://pubmed.ncbi.nlm.nih.gov/21226674/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21226674/ |
| — | Keall, M. D. et al. "Home modifications to reduce injuries from falls in the Home Injury Prevention Intervention (HIPI) study: a cluster-randomised controlled trial." The Lancet (2015). https://pubmed.ncbi.nlm.nih.gov/25255696/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25255696/ |
| — | Cumming, R. G. et al. "Home visits by an occupational therapist for assessment and modification of environmental hazards: a randomized trial of falls prevention." Journal of the American Geriatrics Society (1999). https://pubmed.ncbi.nlm.nih.gov/10591231/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10591231/ |
| — | Bauer, J., et al. (2013). Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. Journal of the American Medical Directors Association . https://pubmed.ncbi.nlm.nih.gov/23867520/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23867520/ |
| — | Tu, D.-Y., et al. (2021). Sarcopenia among the elderly population: a systematic review and meta-analysis of randomized controlled trials. Healthcare . https://pubmed.ncbi.nlm.nih.gov/34072617/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34072617/ |
| — | Song, M., et al. (2016). Association of animal and plant protein intake with all-cause and cause-specific mortality. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/27479196/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27479196/ |
| — | Kidney Disease: Improving Global Outcomes CKD Work Group. (2024). KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International . https://kdigo.org/wp-content/uploads/2024/03/KDIGO-2024-CKD-Guideline.pdf | — | — | https://kdigo.org/wp-content/uploads/2024/03/KDIGO-2024-CKD-Guideline.pdf |
| — | Kurata, H., et al. (2023). Dietary protein intake and all-cause mortality: results from The Kawasaki Aging and Wellbeing Project. BMC Geriatrics . https://pubmed.ncbi.nlm.nih.gov/37558986/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37558986/ |
| — | Finger, D., et al. (2015). Effects of protein supplementation in older adults undergoing resistance training: a systematic review and meta-analysis. Sports Medicine . https://pubmed.ncbi.nlm.nih.gov/25355074/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25355074/ |
| — | Naghshi, S., et al. (2020). Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ . https://pubmed.ncbi.nlm.nih.gov/32699048/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32699048/ |
| — | Ardisson Korat, A. V., et al. (2024). Dietary protein intake in midlife in relation to healthy aging—results from the prospective Nurses’ Health Study cohort. The American Journal of Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/38309825/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38309825/ |
| — | Solon-Biet, S. M., et al. (2014). The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metabolism . https://pubmed.ncbi.nlm.nih.gov/24606899/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24606899/ |
| — | Levine, M. E., et al. (2014). Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism . https://pubmed.ncbi.nlm.nih.gov/24606898/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24606898/ |
| — | Dowman, L., et al. (2021). Pulmonary rehabilitation for interstitial lung disease. Cochrane Database of Systematic Reviews . https://pmc.ncbi.nlm.nih.gov/articles/PMC8094410/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8094410/ |
| — | McCarthy, B., et al. (2015). Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews . https://pmc.ncbi.nlm.nih.gov/articles/PMC10008021/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10008021/ |
| — | Rochester, C. L., et al. (2023). Pulmonary rehabilitation for adults with chronic respiratory disease: An official American Thoracic Society clinical practice guideline. American Journal of Respiratory and Critical Care Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC10449064/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10449064/ |
| — | Maddocks, M., et al. (2016). Physical frailty and pulmonary rehabilitation in COPD: a prospective cohort study. Thorax . https://pmc.ncbi.nlm.nih.gov/articles/PMC5099190/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5099190/ |
| — | Puhan, M. A., et al. (2016). Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews . https://pmc.ncbi.nlm.nih.gov/articles/PMC6463852/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6463852/ |
| — | Beauchamp, M. K., et al. (2013). Systematic review of supervised exercise programs after pulmonary rehabilitation in individuals with COPD. Chest . https://pubmed.ncbi.nlm.nih.gov/23429931/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23429931/ |
| — | Spruit, M. A., et al. (2013). An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. American Journal of Respiratory and Critical Care Medicine . https://pubmed.ncbi.nlm.nih.gov/24127811/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24127811/ |
| — | Saxton, R. A., and Sabatini, D. M. (2017). mTOR signaling in growth, metabolism, and disease. Cell . https://pubmed.ncbi.nlm.nih.gov/28283069/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28283069/ |
| — | Stanfield, B., et al. (2026). Exercise and weekly sirolimus (rapamycin) in older adults: RAPA-EX-01 randomised, double-blind, placebo-controlled trial. Journal of Cachexia, Sarcopenia and Muscle . https://pubmed.ncbi.nlm.nih.gov/41985884/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41985884/ |
| — | Tedesco-Silva, H., et al. (2019). Safety of everolimus with reduced calcineurin inhibitor exposure in de novo kidney transplants: An analysis from the randomized TRANSFORM study. Transplantation . https://pubmed.ncbi.nlm.nih.gov/30801548/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30801548/ |
| — | Kraig, E., et al. (2018). A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. Experimental Gerontology . https://pubmed.ncbi.nlm.nih.gov/29408453/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29408453/ |
| — | Mannick, J. B., et al. (2021). Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: Phase 2b and phase 3 randomised trials. The Lancet Healthy Longevity . https://pubmed.ncbi.nlm.nih.gov/33977284/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33977284/ |
| — | Moel, M., et al. (2025). Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results. Aging . https://pubmed.ncbi.nlm.nih.gov/40188830/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40188830/ |
| — | Harrison, D. E., et al. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature . https://pubmed.ncbi.nlm.nih.gov/19587680/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19587680/ |
| — | Jakobsen, M. U., et al. (2009). Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. The American Journal of Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/19211817/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19211817/ |
| — | Wang, D. D., et al. (2016). Association of specific dietary fats with total and cause-specific mortality. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/27379574/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27379574/ |
| — | Mozaffarian, D., et al. (2010). Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Medicine . https://pubmed.ncbi.nlm.nih.gov/20351774/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20351774/ |
| — | Guasch-Ferré, M., et al. (2019). Associations of monounsaturated fatty acids from plant and animal sources with total and cause-specific mortality in two US prospective cohort studies. Circulation Research . https://pubmed.ncbi.nlm.nih.gov/30689516/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30689516/ |
| — | Sacks, F. M., et al. (2017). Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation . https://pubmed.ncbi.nlm.nih.gov/28620111/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28620111/ |
| — | Mensink, R. P., et al. (2003). Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. The American Journal of Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/12716665/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12716665/ |
| — | Ramsden, C. E., et al. (2016). Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ . https://pubmed.ncbi.nlm.nih.gov/27071971/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27071971/ |
| — | Steen, J. P., et al. (2026). Effect of interventions aimed at reducing or modifying saturated fat intake on cholesterol, mortality, and major cardiovascular events: a risk-stratified systematic review of randomized trials. Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/41397264/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41397264/ |
| — | de Souza, R. J., et al. (2015). Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ . https://pubmed.ncbi.nlm.nih.gov/26268692/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26268692/ |
| — | Li, Y., et al. (2015). Saturated fats compared with unsaturated fats and sources of carbohydrates in relation to risk of coronary heart disease: a prospective cohort study. Journal of the American College of Cardiology . https://pubmed.ncbi.nlm.nih.gov/26429077/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26429077/ |
| — | Hooper, L., et al. (2020). Reduction in saturated fat intake for cardiovascular disease. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/32428300/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32428300/ |
| — | Laukkanen, T., et al. (2018). Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study. BMC Medicine . https://pubmed.ncbi.nlm.nih.gov/30486813/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30486813/ |
| — | Atencio, J. K., et al. (2025). Comparison of thermoregulatory, cardiovascular, and immune responses to different passive heat therapy modalities. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology . https://pubmed.ncbi.nlm.nih.gov/40332494/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40332494/ |
| — | Lee, E., et al. (2022). Effects of regular sauna bathing in conjunction with exercise on cardiovascular function: a multi-arm, randomized controlled trial. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology . https://pubmed.ncbi.nlm.nih.gov/35785965/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35785965/ |
| — | Debray, A., et al. (2023). Finnish sauna bathing and vascular health of adults with coronary artery disease: a randomized controlled trial. Journal of Applied Physiology . https://pubmed.ncbi.nlm.nih.gov/37650138/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37650138/ |
| — | Laukkanen, T., et al. (2018). Sauna exposure leads to improved arterial compliance: findings from a non-randomised experimental study. European Journal of Preventive Cardiology . https://pubmed.ncbi.nlm.nih.gov/29048215/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29048215/ |
| — | Laukkanen, T., et al. (2015). Association between sauna bathing and fatal cardiovascular and all-cause mortality events. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/25705824/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25705824/ |
| — | Ekelund, U. et al. "Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women." The Lancet (2016). https://pubmed.ncbi.nlm.nih.gov/27475271/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27475271/ |
| — | Raffaele, M., and Vinciguerra, M. (2022). The costs and benefits of senotherapeutics for human health. The Lancet Healthy Longevity . https://pubmed.ncbi.nlm.nih.gov/36098323/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36098323/ |
| — | Yousefzadeh, M. J., et al. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine . https://pubmed.ncbi.nlm.nih.gov/30279143/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30279143/ |
| — | Unity Biotechnology, Inc. (2021). A study to assess the safety and efficacy of a single dose of UBX0101 in patients with osteoarthritis of the knee (NCT04129944). ClinicalTrials.gov . https://clinicaltrials.gov/study/NCT04129944 | — | — | https://clinicaltrials.gov/study/NCT04129944 |
| — | Gonzales, M. M., et al. (2023). Senolytic therapy in mild Alzheimer’s disease: A phase 1 feasibility trial. Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/37679434/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37679434/ |
| — | Justice, J. N., et al. (2019). Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine . https://pubmed.ncbi.nlm.nih.gov/30616998/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30616998/ |
| — | Farr, J. N., et al. (2024). Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: A phase 2 randomized controlled trial. Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/38956196/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38956196/ |
| — | Nambiar, A. M., et al. (2023). Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: Results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability. EBioMedicine . https://pubmed.ncbi.nlm.nih.gov/36857968/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36857968/ |
| — | Lane, N., et al. (2021). A phase 2, randomized, double-blind, placebo-controlled study of senolytic molecule UBX0101 in the treatment of painful knee osteoarthritis. Osteoarthritis and Cartilage . https://www.oarsijournal.com/article/S1063-4584(21)00114-X/fulltext | — | — | https://www.oarsijournal.com/article/S1063-4584(21)00114-X/fulltext |
| — | Hickson, L. J., et al. (2019). Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine . https://pubmed.ncbi.nlm.nih.gov/31542391/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31542391/ |
| — | Gorgoulis, V., et al. (2019). Cellular senescence: Defining a path forward. Cell . https://pubmed.ncbi.nlm.nih.gov/31675495/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31675495/ |
| — | Zhu, Y., et al. (2015). The Achilles’ heel of senescent cells: From transcriptome to senolytic drugs. Aging Cell . https://pubmed.ncbi.nlm.nih.gov/25754370/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25754370/ |
| — | Sánchez-de-la-Torre, M., et al. (2023). Adherence to CPAP treatment and the risk of recurrent cardiovascular events: a meta-analysis. JAMA . https://pubmed.ncbi.nlm.nih.gov/37787793/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37787793/ |
| — | McEvoy, R. D., et al. (2016). CPAP for prevention of cardiovascular events in obstructive sleep apnea. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/27571048/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27571048/ |
| — | Bratton, D. J., et al. (2015). CPAP vs mandibular advancement devices and blood pressure in patients with obstructive sleep apnea: a systematic review and meta-analysis. JAMA . https://pubmed.ncbi.nlm.nih.gov/26624827/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26624827/ |
| — | McMillan, A., et al. (2014). Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial. The Lancet Respiratory Medicine . https://pubmed.ncbi.nlm.nih.gov/25172769/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25172769/ |
| — | Richards, K. C., et al. (2020). One year of continuous positive airway pressure adherence improves cognition in older adults with mild apnea and mild cognitive impairment. Journal of the American Geriatrics Society . https://pubmed.ncbi.nlm.nih.gov/32108738/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32108738/ |
| — | Fava, C., et al. (2014). Effect of CPAP on blood pressure in patients with OSA/hypopnoea: a systematic review and meta-analysis. Chest . https://pubmed.ncbi.nlm.nih.gov/24077181/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24077181/ |
| — | Yaffe, K., et al. (2011). Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA . https://pubmed.ncbi.nlm.nih.gov/21828324/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21828324/ |
| — | Jordan, A. S., et al. (2014). Adult obstructive sleep apnoea. The Lancet . https://pubmed.ncbi.nlm.nih.gov/23910433/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23910433/ |
| — | Martínez-García, M. Á., et al. (2019). The role of CPAP treatment in elderly patients with moderate obstructive sleep apnoea: a multicentre randomised controlled trial. European Respiratory Journal . https://pubmed.ncbi.nlm.nih.gov/31164429/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31164429/ |
| — | Anthonisen, N. R., et al. (2005). The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/15710956/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15710956/ |
| — | Cho, E. R., et al. (2024). Smoking cessation and short- and longer-term mortality. NEJM Evidence . https://pubmed.ncbi.nlm.nih.gov/38329816/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38329816/ |
| — | Duncan, M. S., et al. (2019). Association of smoking cessation with subsequent risk of cardiovascular disease. JAMA . https://pubmed.ncbi.nlm.nih.gov/31429895/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31429895/ |
| — | Doll, R., Peto, R., Boreham, J., & Sutherland, I. (2004). Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ . https://pubmed.ncbi.nlm.nih.gov/15213107/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15213107/ |
| — | Pirie, K., Peto, R., Reeves, G. K., Green, J., & Beral, V. (2013). The 21st century hazards of smoking and benefits of stopping: a prospective study of one million women in the UK. The Lancet . https://pubmed.ncbi.nlm.nih.gov/23107252/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23107252/ |
| — | Jha, P., et al. (2013). 21st-century hazards of smoking and benefits of cessation in the United States. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/23343063/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23343063/ |
| — | Hu, Y., et al. (2018). Smoking cessation, weight change, type 2 diabetes, and mortality. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/30110591/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30110591/ |
| — | Dugué, P.-A., et al. (2020). Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility. Epigenetics . https://pubmed.ncbi.nlm.nih.gov/31552803/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31552803/ |
| — | Scanlon, P. D., et al. (2000). Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease: the Lung Health Study. American Journal of Respiratory and Critical Care Medicine . https://pubmed.ncbi.nlm.nih.gov/10673175/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10673175/ |
| — | Wang, F., et al. (2023). A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality. Nature Human Behaviour . https://pubmed.ncbi.nlm.nih.gov/37337095/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37337095/ |
| — | Berkman, L. F., et al. (2003). Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) randomized trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/12813116/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12813116/ |
| — | Smith, T. B., et al. (2021). Effects of psychosocial support interventions on survival in inpatient and outpatient healthcare settings: a meta-analysis of 106 randomized controlled trials. PLoS Medicine . https://pubmed.ncbi.nlm.nih.gov/34003832/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34003832/ |
| — | Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). Social relationships and mortality risk: a meta-analytic review. PLoS Medicine . https://pubmed.ncbi.nlm.nih.gov/20668659/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20668659/ |
| — | Shekelle, P. G., et al. (2024). Interventions to reduce loneliness in community-living older adults: a systematic review and meta-analysis. Journal of General Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/38200279/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38200279/ |
| — | Foster, H. M. E., et al. (2023). Social connection and mortality in UK Biobank: a prospective cohort analysis. BMC Medicine . https://pubmed.ncbi.nlm.nih.gov/37946218/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37946218/ |
| — | Hakulinen, C., et al. (2018). Social isolation and loneliness as risk factors for myocardial infarction, stroke and mortality: UK Biobank cohort study of 479,054 men and women. Heart . https://pubmed.ncbi.nlm.nih.gov/29588329/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29588329/ |
| — | Neal, B., et al. (2021). Effect of salt substitution on cardiovascular events and death. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/34459569/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34459569/ |
| — | Cook, N. R., et al. (2007). Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the Trials of Hypertension Prevention. BMJ . https://pubmed.ncbi.nlm.nih.gov/17449506/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17449506/ |
| — | Ezekowitz, J. A., et al. (2022). Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial. The Lancet . https://pubmed.ncbi.nlm.nih.gov/35381194/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35381194/ |
| — | Adler, A. J., et al. (2014). Reduced dietary salt for the prevention of cardiovascular disease. Cochrane Database of Systematic Reviews . https://pubmed.ncbi.nlm.nih.gov/25519688/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25519688/ |
| — | O'Donnell, M., et al. (2014). Urinary sodium and potassium excretion, mortality, and cardiovascular events. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/25119607/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25119607/ |
| — | Huang, L., et al. (2020). Effect of dose and duration of reduction in dietary sodium on blood pressure levels: systematic review and meta-analysis of randomised trials. BMJ . https://pubmed.ncbi.nlm.nih.gov/32094151/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32094151/ |
| — | McLean, R. M., et al. (2019). Comparison of 24-hour urine and 24-hour diet recall for estimating dietary sodium intake in populations: a systematic review and meta-analysis. The Journal of Clinical Hypertension . https://pubmed.ncbi.nlm.nih.gov/31769168/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31769168/ |
| — | Cobb, L. K., et al. (2014). Methodological issues in cohort studies that relate sodium intake to cardiovascular disease outcomes: a science advisory from the American Heart Association. Circulation . https://pubmed.ncbi.nlm.nih.gov/24515991/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24515991/ |
| — | Acosta-Rodríguez, V., et al. (2022). Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice. Science . https://pubmed.ncbi.nlm.nih.gov/35511946/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35511946/ |
| — | Liu, D., et al. (2022). Calorie restriction with or without time-restricted eating in weight loss. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/35443107/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35443107/ |
| — | Iiams, S. E., et al. (2026). Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6J mice. Nature Aging . https://pubmed.ncbi.nlm.nih.gov/42230994/ | — | — | https://pubmed.ncbi.nlm.nih.gov/42230994/ |
| — | de Cabo, R., & Mattson, M. P. (2019). Effects of intermittent fasting on health, aging, and disease. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/31881139/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31881139/ |
| — | Lowe, D. A., et al. (2020). Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity: the TREAT randomized clinical trial. JAMA Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/32986097/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32986097/ |
| — | Chaix, A., et al. (2021). Sex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high-sucrose diet in C57BL/6J mice. Cell Reports . https://pubmed.ncbi.nlm.nih.gov/34407415/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34407415/ |
| — | Manoogian, E. N. C., et al. (2024). Time-restricted eating in adults with metabolic syndrome: a randomized controlled trial. Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/39348690/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39348690/ |
| — | Chen, Y.-E., Tsai, H.-L., Tu, Y.-K., & Chen, L.-W. (2026). Effects of timing and eating duration of time restricted eating on metabolic outcomes: systematic review and network meta-analysis. BMJ Medicine . https://pubmed.ncbi.nlm.nih.gov/41586347/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41586347/ |
| — | Sutton, E. F., et al. (2018). Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metabolism . https://pubmed.ncbi.nlm.nih.gov/29754952/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29754952/ |
| — | Mitchell, S. J., et al. (2019). Daily fasting improves health and survival in male mice independent of diet composition and calories. Cell Metabolism . https://pubmed.ncbi.nlm.nih.gov/30197301/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30197301/ |
| — | Andrew, M. K. et al. "Persistent Functional Decline Following Hospitalization with Influenza or Acute Respiratory Illness." Journal of the American Geriatrics Society (2021). https://pubmed.ncbi.nlm.nih.gov/33294986/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33294986/ |
| — | Gustafson, C. E. et al. "Understanding and improving vaccine efficacy in older adults." Nature Aging (2025). https://pubmed.ncbi.nlm.nih.gov/40813812/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40813812/ |
| — | Lal, H. et al. "Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults." New England Journal of Medicine (2015). https://pubmed.ncbi.nlm.nih.gov/25916341/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25916341/ |
| — | Bonten, M. J. M. et al. "Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults." New England Journal of Medicine (2015). https://pubmed.ncbi.nlm.nih.gov/25785969/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25785969/ |
| — | Addario, A. et al. "Impact of influenza, herpes zoster, and pneumococcal vaccinations on the incidence of cardiovascular events in subjects aged over 65 years: a systematic review." GeroScience (2023). https://pubmed.ncbi.nlm.nih.gov/37269492/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37269492/ |
| — | Cunningham, A. L. et al. "Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older." New England Journal of Medicine (2016). https://pubmed.ncbi.nlm.nih.gov/27626517/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27626517/ |
| — | Keng, B. M. H. et al. "Trivalent and quadrivalent seasonal influenza vaccine in adults aged 60 and older: a systematic review and network meta-analysis." Age and Ageing (2024). https://pubmed.ncbi.nlm.nih.gov/38604619/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38604619/ |
| — | Papi, A. et al. "Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults." New England Journal of Medicine (2023). https://pubmed.ncbi.nlm.nih.gov/36791160/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36791160/ |
| — | LeBoff, M. S., et al. (2022). Supplemental vitamin D and incident fractures in midlife and older adults. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/35939577/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35939577/ |
| — | Beauchet, O., et al. (2021). Vitamin D supplementation and cognition in adults: A systematic review of randomized controlled trials. CNS Drugs . https://pubmed.ncbi.nlm.nih.gov/34806158/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34806158/ |
| — | Bischoff-Ferrari, H. A., et al. (2020). Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: The DO-HEALTH randomized clinical trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/33170239/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33170239/ |
| — | Zhang, Y., et al. (2019). Association between vitamin D supplementation and mortality: Systematic review and meta-analysis. BMJ . https://pubmed.ncbi.nlm.nih.gov/31405892/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31405892/ |
| — | Manson, J. E., et al. (2019). Vitamin D supplements and prevention of cancer and cardiovascular disease. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/30415629/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30415629/ |
| — | Bouillon, R., et al. (2019). Skeletal and extraskeletal actions of vitamin D: Current evidence and outstanding questions. Endocrine Reviews . https://pubmed.ncbi.nlm.nih.gov/30321335/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30321335/ |
| — | Sanders, K. M., et al. (2010). Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA . https://pubmed.ncbi.nlm.nih.gov/20460620/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20460620/ |
| — | Autier, P., et al. (2014). Vitamin D status and ill health: A systematic review. The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/24622671/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24622671/ |
| — | Bischoff-Ferrari, H. A., et al. (2022). Effects of vitamin D, omega-3 fatty acids, and a simple home strength exercise program on fall prevention: The DO-HEALTH randomized clinical trial. American Journal of Clinical Nutrition . https://pubmed.ncbi.nlm.nih.gov/35136915/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35136915/ |
| — | Gaddey, H. L., & Holder, K. K. (2014). Unintentional weight loss in older adults. American Family Physician . https://pubmed.ncbi.nlm.nih.gov/24784334/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24784334/ |
| — | Carlsson, L. M. S., et al. (2020). Life expectancy after bariatric surgery in the Swedish Obese Subjects study. The New England Journal of Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC7580786/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7580786/ |
| — | Look AHEAD Research Group. (2013). Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/23796131/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23796131/ |
| — | Villareal, D. T., et al. (2017). Aerobic or resistance exercise, or both, in dieting obese older adults. The New England Journal of Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC5552187/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5552187/ |
| — | Kritchevsky, S. B., et al. (2015). Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. PLOS ONE . https://pmc.ncbi.nlm.nih.gov/articles/PMC4368053/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4368053/ |
| — | Global BMI Mortality Collaboration. (2016). Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. The Lancet . https://pubmed.ncbi.nlm.nih.gov/27423262/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27423262/ |
| — | Look AHEAD Research Group. (2022). Effects of intensive lifestyle intervention on all-cause mortality in older adults with type 2 diabetes and overweight/obesity: results from the Look AHEAD study. Diabetes Care . https://pmc.ncbi.nlm.nih.gov/articles/PMC9174966/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9174966/ |
| — | Locher, J. L., et al. (2007). Body mass index, weight loss, and mortality in community-dwelling older adults. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC2750037/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2750037/ |
| — | Ding, B.-S., Nolan, D. J., Butler, J. M., et al. (2010). Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature . https://pmc.ncbi.nlm.nih.gov/articles/PMC3058628/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3058628/ |
| — | Johnson, K. E., & Wilgus, T. A. (2014). Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair. Advances in Wound Care . https://pmc.ncbi.nlm.nih.gov/articles/PMC4183920/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4183920/ |
| — | Potente, M., Gerhardt, H., & Carmeliet, P. (2011). Basic and therapeutic aspects of angiogenesis. Cell . https://pubmed.ncbi.nlm.nih.gov/21925313/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21925313/ |
| — | Rafii, S., Butler, J. M., & Ding, B.-S. (2016). Angiocrine functions of organ-specific endothelial cells. Nature . https://pmc.ncbi.nlm.nih.gov/articles/PMC4878406/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4878406/ |
| — | Marín-Juez, R., Marass, M., Gauvrit, S., et al. (2016). Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC5056108/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5056108/ |
| — | Matsuo, R., Kishibe, M., Horiuchi, K., et al. (2022). Ninjurin1 deletion in NG2-positive pericytes prevents microvessel maturation and delays wound healing. JID Innovations . https://pmc.ncbi.nlm.nih.gov/articles/PMC9573932/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9573932/ |
| — | Howdieshell, T. R., Callaway, D., Webb, W. L., et al. (2001). Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation. Journal of Surgical Research . https://pubmed.ncbi.nlm.nih.gov/11266270/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11266270/ |
| — | Gurevich, D. B., Severn, C. E., Twomey, C., et al. (2018). Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. The EMBO Journal . https://pmc.ncbi.nlm.nih.gov/articles/PMC6028026/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6028026/ |
| — | Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., & Levin, M. (2017). Long-term, stochastic editing of regenerative anatomy via targeting endogenous bioelectric gradients. Biophysical Journal . https://pubmed.ncbi.nlm.nih.gov/28538159/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28538159/ |
| — | Ferreira, F., Luxardi, G., Reid, B., & Zhao, M. (2016). Early bioelectric activities mediate redox-modulated regeneration. Development . https://pmc.ncbi.nlm.nih.gov/articles/PMC5201032/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5201032/ |
| — | Yi, C., Spitters, T. W. G. M., Al-Far, E. A.-D. A., et al. (2021). A calcineurin-mediated scaling mechanism that controls a K + -leak channel to regulate morphogen and growth factor transcription. eLife . https://pmc.ncbi.nlm.nih.gov/articles/PMC8110307/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8110307/ |
| — | Oviedo, N. J., Morokuma, J., Walentek, P., et al. (2010). Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. Developmental Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC2823934/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2823934/ |
| — | Zhao, M., Song, B., Pu, J., et al. (2006). Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature . https://pubmed.ncbi.nlm.nih.gov/16871217/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16871217/ |
| — | Beane, W. S., Morokuma, J., Adams, D. S., & Levin, M. (2011). A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chemistry & Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3278711/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3278711/ |
| — | Adams, D. S., Masi, A., & Levin, M. (2007). H + pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration. Development . https://pubmed.ncbi.nlm.nih.gov/17329365/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17329365/ |
| — | Beane, W. S., Morokuma, J., Lemire, J. M., & Levin, M. (2013). Bioelectric signaling regulates head and organ size during planarian regeneration. Development . https://pmc.ncbi.nlm.nih.gov/articles/PMC3597208/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3597208/ |
| — | Godwin, J. W., Pinto, A. R., Rosenthal, N. A. "Macrophages are required for adult
salamander limb regeneration." Proceedings of the National Academy of Sciences (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC3677454/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3677454/ |
| — | Sandoval-Guzmán, T. et al. "Fundamental differences in dedifferentiation and stem
cell recruitment during skeletal muscle regeneration in two salamander species." Cell Stem Cell (2014). https://pubmed.ncbi.nlm.nih.gov/24268695/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24268695/ |
| — | McCusker, C. D., Gardiner, D. M. "Positional information is reprogrammed in
blastema cells of the regenerating limb of the axolotl (Ambystoma mexicanum)." PLoS ONE (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC3785456/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3785456/ |
| — | Josephson, A. M., et al. (2019). Age-related inflammation triggers skeletal stem/progenitor cell dysfunction. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC6452701/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6452701/ |
| — | Lu, C., et al. (2008). Effect of age on vascularization during fracture repair. Journal of Orthopaedic Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC2846969/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2846969/ |
| — | Ambrosi, T. H., et al. (2021). Aged skeletal stem cells generate an inflammatory degenerative niche. Nature . https://www.nature.com/articles/s41586-021-03795-7 | — | — | https://www.nature.com/articles/s41586-021-03795-7 |
| — | Zou, N.-Y., et al. (2024). Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing. Bone Research . https://www.nature.com/articles/s41413-023-00309-1 | — | — | https://www.nature.com/articles/s41413-023-00309-1 |
| — | Clark, D., et al. (2020). Age-related changes to macrophages are detrimental to fracture healing in mice. Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC7059136/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7059136/ |
| — | Duchamp de Lageneste, O., et al. (2018). Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nature Communications . https://www.nature.com/articles/s41467-018-03124-z | — | — | https://www.nature.com/articles/s41467-018-03124-z |
| — | Ambrosi, T. H., et al. (2020). Geriatric fragility fractures are associated with a human skeletal stem cell defect. Aging Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC7370785/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7370785/ |
| — | Eschenhagen, T., Bolli, R., Braun, T., et al. (2017). Cardiomyocyte regeneration: a consensus statement. Circulation . https://pubmed.ncbi.nlm.nih.gov/28684531/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28684531/ |
| — | van Berlo, J. H., Kanisicak, O., Maillet, M., et al. (2014). c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature . https://pubmed.ncbi.nlm.nih.gov/24805242/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24805242/ |
| — | Frangogiannis, N. G. (2017). The extracellular matrix in myocardial injury, repair, and remodeling. Journal of Clinical Investigation . https://pubmed.ncbi.nlm.nih.gov/28459429/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28459429/ |
| — | Bergmann, O., Bhardwaj, R. D., Bernard, S., et al. (2009). Evidence for cardiomyocyte renewal in humans. Science . https://pubmed.ncbi.nlm.nih.gov/19342590/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19342590/ |
| — | Puente, B. N., Kimura, W., Muralidhar, S. A., et al. (2014). The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell . https://pubmed.ncbi.nlm.nih.gov/24766806/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24766806/ |
| — | Chong, J. J. H., Yang, X., Don, C. W., et al. (2014). Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature . https://pubmed.ncbi.nlm.nih.gov/24776797/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24776797/ |
| — | Bergmann, O., Zdunek, S., Felker, A., et al. (2015). Dynamics of cell generation and turnover in the human heart. Cell . https://pubmed.ncbi.nlm.nih.gov/26073943/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26073943/ |
| — | Porrello, E. R., Mahmoud, A. I., Simpson, E., et al. (2011). Transient regenerative potential of the neonatal mouse heart. Science . https://pubmed.ncbi.nlm.nih.gov/21350179/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21350179/ |
| — | Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., et al. (2013). Mammalian heart renewal by pre-existing cardiomyocytes. Nature . https://pubmed.ncbi.nlm.nih.gov/23222518/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23222518/ |
| — | Jebran, A.-F., Seidler, T., Tiburcy, M., et al. (2025). Engineered heart muscle allografts for heart repair in primates and humans. Nature . https://pubmed.ncbi.nlm.nih.gov/39880949/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39880949/ |
| — | Prabhu, S. D., & Frangogiannis, N. G. (2016). The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circulation Research . https://pubmed.ncbi.nlm.nih.gov/27340270/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27340270/ |
| — | Derks, W., Rode, J., Collin, S., et al. (2025). A latent cardiomyocyte regeneration potential in human heart disease. Circulation . https://pubmed.ncbi.nlm.nih.gov/39569515/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39569515/ |
| — | Vagnozzi, R. J., Maillet, M., Sargent, M. A., et al. (2020). An acute immune response underlies the benefit of cardiac stem cell therapy. Nature . https://pubmed.ncbi.nlm.nih.gov/31775156/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31775156/ |
| — | Loeser, R. F. (2009). Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Mechanisms of Ageing and Development . https://pubmed.ncbi.nlm.nih.gov/19303469/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19303469/ |
| — | Jeon, O. H., Kim, C., Laberge, R. M., et al. (2017). Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/28436958/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28436958/ |
| — | Rikkers, M., Korpershoek, J. V., Levato, R., et al. (2022). The clinical potential of articular cartilage-derived progenitor cells: a systematic review. npj Regenerative Medicine . https://pubmed.ncbi.nlm.nih.gov/35013329/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35013329/ |
| — | Singla, M., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science . https://pubmed.ncbi.nlm.nih.gov/41308124/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41308124/ |
| — | Caramés, B., Olmer, M., Kiosses, W. B., et al. (2015). The relationship of autophagy defects to cartilage damage during joint aging in a mouse model. Arthritis & Rheumatology . https://pubmed.ncbi.nlm.nih.gov/25708836/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25708836/ |
| — | Lotz, M., Loeser, R. F. (2012). Effects of aging on articular cartilage homeostasis. Bone . https://pubmed.ncbi.nlm.nih.gov/22487298/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22487298/ |
| — | Eltawil, N. M., De Bari, C., Achan, P., et al. (2009). A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury. Osteoarthritis and Cartilage . https://pubmed.ncbi.nlm.nih.gov/19070514/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19070514/ |
| — | Ng, J. Q., Jafarov, T. H., Little, C. B., et al. (2023). Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis. Nature Communications . https://pubmed.ncbi.nlm.nih.gov/37907525/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37907525/ |
| — | Willet, S. G. et al. "Regenerative proliferation of differentiated cells by
mTORC1-dependent paligenosis." The EMBO Journal (2018). https://pmc.ncbi.nlm.nih.gov/articles/PMC5881627/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5881627/ |
| — | Tanaka, E. M., Reddien, P. W. "The cellular basis for animal regeneration." Developmental Cell (2011). https://pmc.ncbi.nlm.nih.gov/articles/PMC3139400/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3139400/ |
| — | Jopling, C., Boue, S., Izpisua Belmonte, J. C. "Dedifferentiation,
transdifferentiation and reprogramming: three routes to regeneration." Nature Reviews Molecular Cell Biology (2011). https://www.nature.com/articles/nrm3043 | — | — | https://www.nature.com/articles/nrm3043 |
| — | van Es, J. H. et al. "Dll1-positive secretory progenitor cells revert to stem cells
upon crypt damage." Nature Cell Biology (2012). https://www.nature.com/articles/ncb2581 | — | — | https://www.nature.com/articles/ncb2581 |
| — | Rhinn, M., Ritschka, B., Keyes, W. M. "Cellular senescence in development, regeneration
and disease." Development (2019). https://pubmed.ncbi.nlm.nih.gov/31575608/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31575608/ |
| — | Walters, H. E. et al. "Senescent cells enhance newt limb regeneration by promoting muscle
dedifferentiation." Aging Cell (2023). https://pubmed.ncbi.nlm.nih.gov/37025070/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37025070/ |
| — | Gorgoulis, V. et al. "Cellular Senescence: Defining a Path Forward." Cell (2019). https://pubmed.ncbi.nlm.nih.gov/31675495/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31675495/ |
| — | Reddien, P. W. "The cellular and molecular basis for planarian regeneration." Cell (2018). https://www.cell.com/cell/fulltext/S0092-8674(18)30075-8 | — | — | https://www.cell.com/cell/fulltext/S0092-8674(18)30075-8 |
| — | Tanaka, E. M. "The molecular and cellular choreography of appendage regeneration." Cell (2016). https://www.cell.com/cell/fulltext/S0092-8674(16)30207-8 | — | — | https://www.cell.com/cell/fulltext/S0092-8674(16)30207-8 |
| — | Jadhav, U. et al. "Dynamic Reorganization of Chromatin Accessibility Signatures during
Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells." Cell Stem Cell (2017). https://pubmed.ncbi.nlm.nih.gov/28648363/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28648363/ |
| — | Hernando-Herraez, I. et al. "Ageing affects DNA methylation drift and transcriptional
cell-to-cell variability in mouse muscle stem cells." Nature Communications (2019). https://pubmed.ncbi.nlm.nih.gov/31554804/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31554804/ |
| — | Liu, L. et al. "Chromatin modifications as determinants of muscle stem cell quiescence
and chronological aging." Cell Reports (2013). https://pubmed.ncbi.nlm.nih.gov/23810552/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23810552/ |
| — | Avgustinova, A., Aznar Benitah, S. "Epigenetic control of adult stem cell function." Nature Reviews Molecular Cell Biology (2016). https://pubmed.ncbi.nlm.nih.gov/27405257/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27405257/ |
| — | Stewart, S. et al. "A histone demethylase is necessary for regeneration in zebrafish." Proceedings of the National Academy of Sciences (2009). https://pubmed.ncbi.nlm.nih.gov/19897725/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19897725/ |
| — | Yang, B. A. et al. "Three-dimensional chromatin re-organization during muscle stem cell
aging." Aging Cell (2023). https://pubmed.ncbi.nlm.nih.gov/36727578/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36727578/ |
| — | Wynn, T. A., & Vannella, K. M. (2016). Macrophages in tissue repair, regeneration, and fibrosis. Immunity . https://pmc.ncbi.nlm.nih.gov/articles/PMC4794754/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4794754/ |
| — | Atala, A., Irvine, D. J., Moses, M., & Shaunak, S. (2010). Wound healing versus regeneration: role of the tissue environment in regenerative medicine. MRS Bulletin . https://pmc.ncbi.nlm.nih.gov/articles/PMC3826556/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3826556/ |
| — | Calve, S., Odelberg, S. J., & Simon, H.-G. (2010). A transitional extracellular matrix instructs cell behavior during muscle regeneration. Developmental Biology . https://pubmed.ncbi.nlm.nih.gov/20478295/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20478295/ |
| — | Bonnans, C., Chou, J., & Werb, Z. (2014). Remodelling the extracellular matrix in development and disease. Nature Reviews Molecular Cell Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4316204/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4316204/ |
| — | Wang, J., Karra, R., Dickson, A. L., & Poss, K. D. (2013). Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. Developmental Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3852765/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3852765/ |
| — | Frangogiannis, N. G. (2017). The extracellular matrix in myocardial injury, repair, and remodeling. Journal of Clinical Investigation . https://pmc.ncbi.nlm.nih.gov/articles/PMC5409799/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5409799/ |
| — | Matsubayashi, Y. (2022). Dynamic movement and turnover of extracellular matrices during tissue development and maintenance. Fly . https://pmc.ncbi.nlm.nih.gov/articles/PMC9302511/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9302511/ |
| — | Wynn, T. A., Vannella, K. M. "Macrophages in Tissue Repair, Regeneration, and Fibrosis." Immunity (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC4794754/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4794754/ |
| — | Porrello, E. R. et al. "Transient regenerative potential of the neonatal mouse heart." Science (2011). https://pubmed.ncbi.nlm.nih.gov/21350179/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21350179/ |
| — | Keyes, B. E. et al. "Nfatc1 orchestrates aging in hair follicle stem cells." Proceedings of the National Academy of Sciences (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC3870727/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3870727/ |
| — | Ge, Y. et al. "The aging skin microenvironment dictates stem cell behavior." Proceedings of the National Academy of Sciences (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7071859/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7071859/ |
| — | Gay, D. et al. "Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding." Nature Medicine (2013). https://www.nature.com/articles/nm.3181 | — | — | https://www.nature.com/articles/nm.3181 |
| — | Morgan, B. A. "The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle." Cold Spring Harbor Perspectives in Medicine (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4066645/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4066645/ |
| — | Nakada, Y., Canseco, D. C., Thet, S., et al. (2017). Hypoxia induces heart regeneration in adult mice. Nature . https://www.nature.com/articles/nature20173 | — | — | https://www.nature.com/articles/nature20173 |
| — | Ivan, M., Kondo, K., Yang, H., et al. (2001). HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science . https://pubmed.ncbi.nlm.nih.gov/11292862/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11292862/ |
| — | Tsissios, G., Leleu, M., Hu, K., et al. (2026). Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration. Science . https://pubmed.ncbi.nlm.nih.gov/41955383/ | — | — | https://pubmed.ncbi.nlm.nih.gov/41955383/ |
| — | Semenza, G. L. (2012). Hypoxia-inducible factors in physiology and medicine. Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC3437543/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3437543/ |
| — | Wan, C., Gilbert, S. R., Wang, Y., et al. (2008). Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/18184809/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18184809/ |
| — | Jopling, C., Suñé, G., Faucherre, A., Fabregat, C., & Izpisua Belmonte, J. C. (2012). Hypoxia induces myocardial regeneration in zebrafish. Circulation . https://pubmed.ncbi.nlm.nih.gov/23151342/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23151342/ |
| — | Kaelin, W. G., Jr., & Ratcliffe, P. J. (2008). Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Molecular Cell . https://pubmed.ncbi.nlm.nih.gov/18498744/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18498744/ |
| — | Albina, J. E., Mastrofrancesco, B., Vessella, J. A., et al. (2001). HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha. American Journal of Physiology-Cell Physiology . https://pubmed.ncbi.nlm.nih.gov/11698256/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11698256/ |
| — | Eming, S. A., Wynn, T. A., Martin, P. "Inflammation and metabolism in tissue repair and
regeneration." Science (2017). https://pubmed.ncbi.nlm.nih.gov/28596335/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28596335/ |
| — | Tidball, J. G., Villalta, S. A. "Regulatory interactions between muscle and the immune
system during muscle regeneration." American Journal of Physiology-Regulatory, Integrative and
Comparative Physiology (2010). https://pubmed.ncbi.nlm.nih.gov/20219869/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20219869/ |
| — | Wang, J. "Neutrophils in tissue injury and repair." Cell and Tissue Research (2018). https://pubmed.ncbi.nlm.nih.gov/29383445/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29383445/ |
| — | Godwin, J. W., Pinto, A. R., Rosenthal, N. A. "Macrophages are required for adult
salamander limb regeneration." Proceedings of the National Academy of Sciences (2013). https://pubmed.ncbi.nlm.nih.gov/23690624/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23690624/ |
| — | Gieseck, R. L. III, Wilson, M. S., Wynn, T. A. "Type 2 immunity in tissue repair and
fibrosis." Nature Reviews Immunology (2018). https://pubmed.ncbi.nlm.nih.gov/28853443/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28853443/ |
| — | Wynn, T. A., Vannella, K. M. "Macrophages in Tissue Repair, Regeneration, and Fibrosis." Immunity (2016). https://pubmed.ncbi.nlm.nih.gov/26982353/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26982353/ |
| — | McArthur, S. et al. "Annexin A1 drives macrophage skewing to accelerate muscle
regeneration through AMPK activation." Journal of Clinical Investigation (2020). https://pubmed.ncbi.nlm.nih.gov/32015229/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32015229/ |
| — | Bannenberg, G., Serhan, C. N. "Specialized pro-resolving lipid mediators in the
inflammatory response: an update." Biochimica et Biophysica Acta (2010). https://pubmed.ncbi.nlm.nih.gov/20708099/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20708099/ |
| — | Serhan, C. N., Levy, B. D. "Resolvins in inflammation: emergence of the pro-resolving
superfamily of mediators." Journal of Clinical Investigation (2018). https://pubmed.ncbi.nlm.nih.gov/29757195/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29757195/ |
| — | Quiros, M. et al. "Resolvin E1 is a pro-repair molecule that promotes intestinal
epithelial wound healing." Proceedings of the National Academy of Sciences (2020). https://pubmed.ncbi.nlm.nih.gov/32300016/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32300016/ |
| — | Omrani, O. et al. "IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration." Nature Communications (2023). https://www.nature.com/articles/s41467-023-41683-y | — | — | https://www.nature.com/articles/s41467-023-41683-y |
| — | Kirita, Y., Wu, H., Uchimura, K., et al. (2020). Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC7355049/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7355049/ |
| — | Yang, L., Besschetnova, T. Y., Brooks, C. R., et al. (2010). Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/20436483/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20436483/ |
| — | Aggarwal, S., Grange, J., Mugisho, O. O., et al. (2024). SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys. Science . https://pubmed.ncbi.nlm.nih.gov/38386758/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38386758/ |
| — | Coca, S. G., Singanamala, S., & Parikh, C. R. (2012). Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney International . https://pmc.ncbi.nlm.nih.gov/articles/PMC3788581/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3788581/ |
| — | Humphreys, B. D., Czerniak, S., DiRocco, D. P., et al. (2011). Repair of injured proximal tubule does not involve specialized progenitors. Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/21576461/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21576461/ |
| — | Kramann, R., Wongboonsin, J., Chang-Panesso, M., et al. (2017). Gli1-positive pericyte loss induces capillary rarefaction and proximal tubular injury. Journal of the American Society of Nephrology . https://pubmed.ncbi.nlm.nih.gov/27624490/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27624490/ |
| — | Kusaba, T., Lalli, M., Kramann, R., et al. (2014). Differentiated kidney epithelial cells repair injured proximal tubule. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC3910580/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3910580/ |
| — | Klocke, J., Kim, S. J., Skopnik, C. M., et al. (2022). Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury. Kidney International . https://pubmed.ncbi.nlm.nih.gov/36049643/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36049643/ |
| — | Borowiak, M., Garratt, A. N., Wüstefeld, T., et al. (2004). Met provides essential signals for liver regeneration. Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/15249655/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15249655/ |
| — | Tsai, J. M., Koh, P. W., Stefanska, A., et al. (2017). Localized hepatic lobular regeneration by central-vein-associated lineage-restricted progenitors. Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/28330992/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28330992/ |
| — | Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., et al. (1996). Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science . https://pubmed.ncbi.nlm.nih.gov/8910279/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8910279/ |
| — | Yanger, K., Knigin, D., Zong, Y., et al. (2014). Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/25130492/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25130492/ |
| — | Miyaoka, Y., Ebato, K., Kato, H., et al. (2012). Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration. Current Biology . https://pubmed.ncbi.nlm.nih.gov/22658593/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22658593/ |
| — | Raven, A., Lu, W.-Y., Man, T. Y., et al. (2017). Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration. Nature . https://pmc.ncbi.nlm.nih.gov/articles/PMC5522613/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5522613/ |
| — | Aierken, Y., Kong, L.-X., Li, B., et al. (2020). Liver fibrosis is a major risk factor for liver regeneration: a comparison between healthy and fibrotic liver. Medicine . https://pubmed.ncbi.nlm.nih.gov/32481371/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32481371/ |
| — | Yamanaka, N., Okamoto, E., Kawamura, E., et al. (1993). Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function. Hepatology . https://pubmed.ncbi.nlm.nih.gov/8392029/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8392029/ |
| — | Butler, J. P., Loring, S. H., Patz, S., Tsuda, A., Yablonskiy, D. A., & Mentzer, S. J. (2012). Evidence for adult lung growth in humans. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/22808959/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22808959/ |
| — | Barkauskas, C. E., Cronce, M. J., Rackley, C. R., et al. (2013). Type 2 alveolar cells are stem cells in adult lung. Journal of Clinical Investigation . https://pubmed.ncbi.nlm.nih.gov/23921127/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23921127/ |
| — | Choi, J., Park, J.-E., Tsagkogeorga, G., et al. (2020). Inflammatory signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration. Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/32750316/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32750316/ |
| — | Wang, F., Ting, C., Riemondy, K. A., et al. (2023). Regulation of epithelial transitional states in murine and human pulmonary fibrosis. Journal of Clinical Investigation . https://pubmed.ncbi.nlm.nih.gov/37768734/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37768734/ |
| — | Strunz, M., Simon, L. M., Ansari, M., et al. (2020). Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. Nature Communications . https://pubmed.ncbi.nlm.nih.gov/32678092/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32678092/ |
| — | Godoy, R. S., Cober, N. D., Cook, D. P., et al. (2023). Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation. eLife . https://pubmed.ncbi.nlm.nih.gov/37078698/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37078698/ |
| — | Adams, T. S., Schupp, J. C., Poli, S., et al. (2020). Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances . https://pubmed.ncbi.nlm.nih.gov/32832599/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32832599/ |
| — | Zacharias, W. J., Frank, D. B., Zepp, J. A., et al. (2018). Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature . https://pubmed.ncbi.nlm.nih.gov/29489752/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29489752/ |
| — | Nabhan, A. N., Brownfield, D. G., Harbury, P. B., Krasnow, M. A., & Desai, T. J. (2018). Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells. Science . https://pubmed.ncbi.nlm.nih.gov/29420258/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29420258/ |
| — | Kobayashi, Y., Tata, A., Konkimalla, A., et al. (2020). Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis. Nature Cell Biology . https://pubmed.ncbi.nlm.nih.gov/32661339/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32661339/ |
| — | Louie, S. M., Moye, A. L., Wong, I. G., et al. (2022). Progenitor potential of lung epithelial organoid cells in a transplantation model. Cell Reports . https://pubmed.ncbi.nlm.nih.gov/35417699/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35417699/ |
| — | Rowbotham, S. P., Pessina, P., Garcia-de-Alba, C., et al. (2023). Age-associated H3K9me2 loss alters the regenerative equilibrium between murine lung alveolar and bronchiolar progenitors. Developmental Cell . https://pubmed.ncbi.nlm.nih.gov/37977149/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37977149/ |
| — | Lavine, K. J. et al. "Distinct macrophage lineages contribute to disparate patterns of
cardiac recovery and remodeling in the neonatal and adult heart." Proceedings of the National
Academy of Sciences (2014). https://pubmed.ncbi.nlm.nih.gov/25349429/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25349429/ |
| — | Izumi, T. et al. "Vagus-macrophage-hepatocyte link promotes post-injury liver
regeneration and whole-body survival through hepatic FoxM1 activation." Nature Communications (2018). https://pubmed.ncbi.nlm.nih.gov/30546054/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30546054/ |
| — | Goldman, J. A., Poss, K. D. (2020). “Gene regulatory programmes of tissue regeneration.” Nature Reviews Genetics . https://www.nature.com/articles/s41576-020-0239-7 | — | — | https://www.nature.com/articles/s41576-020-0239-7 |
| — | Percie du Sert, N., et al. (2020). “The ARRIVE guidelines 2.0: Updated guidelines for
reporting animal research.” PLOS Biology . https://doi.org/10.1371/journal.pbio.3000410 | — | — | https://doi.org/10.1371/journal.pbio.3000410 |
| — | Wells, J. M., Watt, F. M. (2018). “Diverse mechanisms for endogenous regeneration and
repair in mammalian organs.” Nature . https://www.nature.com/articles/s41586-018-0073-7 | — | — | https://www.nature.com/articles/s41586-018-0073-7 |
| — | Hirano, K., Tsuchiya, M., Shiomi, A., et al. (2022). The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration. Life Science Alliance . https://pubmed.ncbi.nlm.nih.gov/36446523/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36446523/ |
| — | Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y., & Wrana, J. L. (2015). Yap-dependent reprogramming of Lgr5-positive stem cells drives intestinal regeneration and cancer. Nature . https://www.nature.com/articles/nature15382 | — | — | https://www.nature.com/articles/nature15382 |
| — | Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014). Mechanotransduction and extracellular matrix homeostasis. Nature Reviews Molecular Cell Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4346132/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4346132/ |
| — | Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., et al. (2017). Force triggers YAP nuclear entry by regulating transport across nuclear pores. Cell . https://pubmed.ncbi.nlm.nih.gov/29107331/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29107331/ |
| — | Dupont, S., Morsut, L., Aragona, M., et al. (2011). Role of YAP/TAZ in mechanotransduction. Nature . https://pubmed.ncbi.nlm.nih.gov/21654799/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21654799/ |
| — | Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006). Matrix elasticity directs stem cell lineage specification. Cell . https://pubmed.ncbi.nlm.nih.gov/16923388/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16923388/ |
| — | Jaalouk, D. E., & Lammerding, J. (2009). Mechanotransduction gone awry. Nature Reviews Molecular Cell Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC2668954/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2668954/ |
| — | Coste, B., Mathur, J., Schmidt, M., et al. (2010). Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science . https://pubmed.ncbi.nlm.nih.gov/20813920/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20813920/ |
| — | Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., et al. (2010). Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science . https://pmc.ncbi.nlm.nih.gov/articles/PMC2929271/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2929271/ |
| — | Silver, J. S., Günay, K. A., Cutler, A. A., et al. (2021). Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction. Science Advances . https://pmc.ncbi.nlm.nih.gov/articles/PMC7954458/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7954458/ |
| — | Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017). Mechanobiology of YAP and TAZ in physiology and disease. Nature Reviews Molecular Cell Biology . https://www.nature.com/articles/nrm.2017.87 | — | — | https://www.nature.com/articles/nrm.2017.87 |
| — | Eming, S. A., Wynn, T. A., & Martin, P. (2017). Inflammation and metabolism in tissue repair and regeneration. Science . https://pubmed.ncbi.nlm.nih.gov/28596335/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28596335/ |
| — | Meacham, C. E., DeVilbiss, A. W., & Morrison, S. J. (2022). Metabolic regulation of somatic stem cells in vivo. Nature Reviews Molecular Cell Biology . https://www.nature.com/articles/s41580-022-00462-1 | — | — | https://www.nature.com/articles/s41580-022-00462-1 |
| — | Chaves-Perez, A., Millman, S. E., Janaki-Raman, S., et al. (2025). Metabolic adaptations direct cell fate during tissue regeneration. Nature . https://pmc.ncbi.nlm.nih.gov/articles/PMC12240837/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12240837/ |
| — | Rodgers, J. T., King, K. Y., Brett, J. O., et al. (2014). mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G Alert . Nature . https://pmc.ncbi.nlm.nih.gov/articles/PMC4065227/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4065227/ |
| — | Ciuffoli, V., Feng, X., Jiang, K., et al. (2024). Psat1-generated alpha-ketoglutarate and glutamine promote muscle stem cell activation and regeneration. Genes & Development . https://pubmed.ncbi.nlm.nih.gov/38453480/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38453480/ |
| — | Mihaylova, M. M., Cheng, C. W., Cao, A. Q., et al. (2018). Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and aging. Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/29727683/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29727683/ |
| — | Wang, X., Menezes, C. J., Jia, Y., et al. (2024). Metabolic inflexibility promotes mitochondrial health during liver regeneration. Science . https://pubmed.ncbi.nlm.nih.gov/38870309/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38870309/ |
| — | Schell, J. C., Wisidagama, D. R., Bensard, C., et al. (2017). Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nature Cell Biology . https://pubmed.ncbi.nlm.nih.gov/28812582/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28812582/ |
| — | Ryall, J. G., Dell'Orso, S., Derfoul, A., et al. (2015). The NAD + -dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells. Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/25600643/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25600643/ |
| — | Farkas, J. E., & Monaghan, J. R. (2017). A brief history of the study of nerve dependent regeneration. Neurogenesis . https://pubmed.ncbi.nlm.nih.gov/28459075/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28459075/ |
| — | Farkas, J. E., Freitas, P. D., Bryant, D. M., Whited, J. L., & Monaghan, J. R. (2016). Neuregulin-1 signaling is essential for nerve-dependent axolotl limb regeneration. Development . https://pubmed.ncbi.nlm.nih.gov/27317805/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27317805/ |
| — | Lu, Y.-Z., Nayer, B., Singh, S. K., et al. (2024). CGRP sensory neurons promote tissue healing via neutrophils and macrophages. Nature . https://www.nature.com/articles/s41586-024-07237-y | — | — | https://www.nature.com/articles/s41586-024-07237-y |
| — | Kumar, A., Godwin, J. W., Gates, P. B., Garza-Garcia, A. A., & Brockes, J. P. (2007). Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate. Science . https://pubmed.ncbi.nlm.nih.gov/17975060/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17975060/ |
| — | Johnston, A. P. W., Yuzwa, S. A., Carr, M. J., et al. (2016). Dedifferentiated Schwann cell precursors secreting paracrine factors are required for regeneration of the mammalian digit tip. Cell Stem Cell . https://doi.org/10.1016/j.stem.2016.06.002 | — | — | https://doi.org/10.1016/j.stem.2016.06.002 |
| — | Dolan, C. P., Imholt, F., Yan, M., et al. (2022). Digit specific denervation does not inhibit mouse digit tip regeneration. Developmental Biology . https://pubmed.ncbi.nlm.nih.gov/35353991/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35353991/ |
| — | Satoh, A., Gardiner, D. M., Bryant, S. V., & Endo, T. (2007). Nerve-induced ectopic limb blastemas in the axolotl are equivalent to amputation-induced blastemas. Developmental Biology . https://pubmed.ncbi.nlm.nih.gov/17959163/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17959163/ |
| — | Maita, K. C., Garcia, J. P., Avila, F. R., et al. (2023). Evaluation of the aging effect on peripheral nerve regeneration: A systematic review. Journal of Surgical Research . https://pubmed.ncbi.nlm.nih.gov/37060859/ | — | — | https://pubmed.ncbi.nlm.nih.gov/37060859/ |
| — | Wells, K. M., Kelley, K., Baumel, M., Vieira, W. A., & McCusker, C. D. (2021). Neural control of growth and size in the axolotl limb regenerate. eLife . https://pubmed.ncbi.nlm.nih.gov/34779399/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34779399/ |
| — | Subramanian, A., Sidhom, E.-H., Emani, M., et al. (2019). Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nature Communications . https://pubmed.ncbi.nlm.nih.gov/31784515/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31784515/ |
| — | Sugimoto, S., Ohta, Y., Fujii, M., et al. (2018). Reconstruction of the human colon epithelium in vivo. Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/29290616/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29290616/ |
| — | Takebe, T., Sekine, K., Enomura, M., et al. (2013). Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature . https://pubmed.ncbi.nlm.nih.gov/23823721/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23823721/ |
| — | Sachs, N., Papaspyropoulos, A., Zomer-van Ommen, D. D., et al. (2019). Long-term expanding human airway organoids for disease modeling. The EMBO Journal . https://pubmed.ncbi.nlm.nih.gov/30643021/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30643021/ |
| — | Homan, K. A., Gupta, N., Kroll, K. T., et al. (2019). Flow-enhanced vascularization and maturation of kidney organoids in vitro. Nature Methods . https://pubmed.ncbi.nlm.nih.gov/30742039/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30742039/ |
| — | Yui, S., Azzolin, L., Maimets, M., et al. (2018). YAP/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration. Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/29249464/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29249464/ |
| — | Huch, M., Gehart, H., van Boxtel, R., et al. (2015). Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell . https://pubmed.ncbi.nlm.nih.gov/25533785/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25533785/ |
| — | Wu, H., Uchimura, K., Donnelly, E. L., Kirita, Y., Morris, S. A., & Humphreys, B. D. (2018). Comparative analysis and refinement of human PSC-derived kidney organoid differentiation with single-cell transcriptomics. Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/30449713/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30449713/ |
| — | Spence, J. R., Mayhew, C. N., Rankin, S. A., et al. (2011). Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature . https://pubmed.ncbi.nlm.nih.gov/21151107/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21151107/ |
| — | Phipson, B., Er, P. X., Combes, A. N., et al. (2019). Evaluation of variability in human kidney organoids. Nature Methods . https://pubmed.ncbi.nlm.nih.gov/30573816/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30573816/ |
| — | Sato, T., Vries, R. G., Snippert, H. J., et al. (2009). Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature . https://pubmed.ncbi.nlm.nih.gov/19329995/ | — | — | https://pubmed.ncbi.nlm.nih.gov/19329995/ |
| — | Gjorevski, N., Sachs, N., Manfrin, A., et al. (2016). Designer matrices for intestinal stem cell and organoid culture. Nature . https://pubmed.ncbi.nlm.nih.gov/27851739/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27851739/ |
| — | Otsuki, L., Tanaka, E. M. "Positional Memory in Vertebrate Regeneration: A
Century's Insights from the Salamander Limb." Cold Spring Harbor Perspectives in Biology (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC9248832/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9248832/ |
| — | Autumn, M. et al. "Growth patterns of caudal fin rays are informed by both
external signals from the regenerating organ and remembered identity autonomous to the local
tissue." Developmental Biology (2024). https://pubmed.ncbi.nlm.nih.gov/39029570/ | — | — | https://pubmed.ncbi.nlm.nih.gov/39029570/ |
| — | Witchley, J. N. et al. "Muscle Cells Provide Instructions for Planarian
Regeneration." Cell Reports (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC4101538/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4101538/ |
| — | Yoshioka, K. et al. "Hoxa10 mediates positional memory to govern stem cell
function in adult skeletal muscle." Science Advances (2021). https://pmc.ncbi.nlm.nih.gov/articles/PMC8189581/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8189581/ |
| — | Subramanian, A. et al. "Tig1 regulates proximo-distal identity during salamander
limb regeneration." Nature Communications (2022). https://www.nature.com/articles/s41467-022-28755-1 | — | — | https://www.nature.com/articles/s41467-022-28755-1 |
| — | Nachtrab, G. et al. "Transcriptional components of anteroposterior positional
information during zebrafish fin regeneration." Development (2013). https://pmc.ncbi.nlm.nih.gov/articles/PMC3754474/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3754474/ |
| — | Nacu, E. et al. "Connective tissue cells, but not muscle cells, are involved in
establishing the proximo-distal outcome of limb regeneration in the axolotl." Development (2013). https://pubmed.ncbi.nlm.nih.gov/23293283/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23293283/ |
| — | Ge, Y., Fuchs, E. "Stretching the limits: from homeostasis to stem cell plasticity
in wound healing and cancer." Nature Reviews Genetics (2018). https://www.nature.com/articles/nrg.2018.9 | — | — | https://www.nature.com/articles/nrg.2018.9 |
| — | Wells, J. M., Watt, F. M. "Diverse mechanisms for endogenous regeneration and
repair in mammalian organs." Nature (2018). https://www.nature.com/articles/s41586-018-0073-7 | — | — | https://www.nature.com/articles/s41586-018-0073-7 |
| — | Merrell, A. J., Stanger, B. Z. "Adult cell plasticity in vivo: de-differentiation
and transdifferentiation are back in style." Nature Reviews Molecular Cell Biology (2016). https://www.nature.com/articles/nrm.2016.24 | — | — | https://www.nature.com/articles/nrm.2016.24 |
| — | Brunet, A., Goodell, M. A., Rando, T. A. "Ageing and rejuvenation of tissue stem
cells and their niches." Nature Reviews Molecular Cell Biology (2023). https://www.nature.com/articles/s41580-022-00510-w | — | — | https://www.nature.com/articles/s41580-022-00510-w |
| — | Yu, F.-X., Zhao, B., & Guan, K.-L. (2015). Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC4638384/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4638384/ |
| — | Andersson, E. R., Sandberg, R., & Lendahl, U. (2011). Notch signaling: Simplicity in design, versatility in function. Development . https://pubmed.ncbi.nlm.nih.gov/21828089/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21828089/ |
| — | Zhao, L., Ben-Yair, R., Burns, C. E., & Burns, C. G. (2019). Endocardial Notch signaling promotes cardiomyocyte proliferation in the regenerating zebrafish heart through Wnt pathway antagonism. Cell Reports . https://pmc.ncbi.nlm.nih.gov/articles/PMC6366857/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6366857/ |
| — | Wehner, D., Cizelsky, W., Vasudevaro, M. D., et al. (2014). Wnt/β-catenin signaling defines organizing centers that orchestrate growth and differentiation of the regenerating zebrafish caudal fin. Cell Reports . https://pubmed.ncbi.nlm.nih.gov/24485658/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24485658/ |
| — | Stewart, S., Gomez, A. W., Armstrong, B. E., Henner, A., & Stankunas, K. (2014). Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration. Cell Reports . https://pmc.ncbi.nlm.nih.gov/articles/PMC4009375/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4009375/ |
| — | Xin, M., Kim, Y., Sutherland, L. B., et al. (2013). Hippo pathway effector Yap promotes cardiac regeneration. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC3752208/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3752208/ |
| — | Nusse, R., & Clevers, H. (2017). Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell . https://pubmed.ncbi.nlm.nih.gov/28575679/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28575679/ |
| — | Zhao, L., Borikova, A. L., Ben-Yair, R., et al. (2014). Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proceedings of the National Academy of Sciences . https://pmc.ncbi.nlm.nih.gov/articles/PMC3910613/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3910613/ |
| — | Conboy, I. M., & Rando, T. A. (2002). The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Developmental Cell . https://pubmed.ncbi.nlm.nih.gov/12361602/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12361602/ |
| — | Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y., & Wrana, J. L. (2015). Yap-dependent reprogramming of Lgr5-positive stem cells drives intestinal regeneration and cancer. Nature . https://pubmed.ncbi.nlm.nih.gov/26503053/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26503053/ |
| — | Yimlamai, D., Christodoulou, C., Galli, G. G., et al. (2014). Hippo pathway activity influences liver cell fate. Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC4136468/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4136468/ |
| — | de Lima, S., Koriyama, Y., Kurimoto, T., et al. (2012). Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/22615390/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22615390/ |
| — | da Cruz, L., Fynes, K., Georgiadis, O., et al. (2018). Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nature Biotechnology . https://pubmed.ncbi.nlm.nih.gov/29553577/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29553577/ |
| — | Mehat, M. S., Sundaram, V., Ripamonti, C., et al. (2018). Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in macular degeneration. Ophthalmology . https://pubmed.ncbi.nlm.nih.gov/29884405/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29884405/ |
| — | Ozaki, A., Kawai, A., Akiba, R., et al. (2026). Long-term functional synaptic integration of genome-edited retinal organoids in a primate model of macular degeneration. Molecular Therapy . https://pubmed.ncbi.nlm.nih.gov/42365435/ | — | — | https://pubmed.ncbi.nlm.nih.gov/42365435/ |
| — | Santos-Ferreira, T., Llonch, S., Borsch, O., et al. (2016). Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange. Nature Communications . https://pubmed.ncbi.nlm.nih.gov/27701381/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27701381/ |
| — | Russell, S., Bennett, J., Wellman, J. A., et al. (2017). Efficacy and safety of voretigene neparvovec in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. The Lancet . https://pubmed.ncbi.nlm.nih.gov/28712537/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28712537/ |
| — | Hirami, Y., Mandai, M., Sugita, S., et al. (2023). Safety and stable survival of stem-cell-derived retinal organoid for 2 years in patients with retinitis pigmentosa. Cell Stem Cell . https://pubmed.ncbi.nlm.nih.gov/38065067/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38065067/ |
| — | Sahel, J.-A., Boulanger-Scemama, E., Pagot, C., et al. (2021). Partial recovery of visual function in a blind patient after optogenetic therapy. Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/34031601/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34031601/ |
| — | Jorstad, N. L., Wilken, M. S., Grimes, W. N., et al. (2017). Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature . https://pubmed.ncbi.nlm.nih.gov/28746305/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28746305/ |
| — | Pearson, R. A., Barber, A. C., Rizzi, M., et al. (2012). Restoration of vision after transplantation of photoreceptors. Nature . https://pubmed.ncbi.nlm.nih.gov/22522934/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22522934/ |
| — | Martins, R. R., Zamzam, M., Tracey-White, D., et al. (2022). Müller glia maintain their regenerative potential despite degeneration in the aged zebrafish retina. Aging Cell . https://pubmed.ncbi.nlm.nih.gov/35315590/ | — | — | https://pubmed.ncbi.nlm.nih.gov/35315590/ |
| — | Bjornson, C. R. R., Cheung, T. H., Liu, L., et al. (2012). Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells . https://pubmed.ncbi.nlm.nih.gov/22045613/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22045613/ |
| — | Yamamoto, M., Legendre, N. P., Biswas, A. A., et al. (2018). Loss of MyoD and Myf5 in skeletal muscle stem cells results in altered myogenic programming and failed regeneration. Stem Cell Reports . https://pubmed.ncbi.nlm.nih.gov/29478898/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29478898/ |
| — | Kuang, S., Kuroda, K., Le Grand, F., Rudnicki, M. A. (2007). Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell . https://pubmed.ncbi.nlm.nih.gov/17540178/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17540178/ |
| — | Gurevich, D. B., Nguyen, P. D., Siegel, A. L., et al. (2016). Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo. Science . https://pubmed.ncbi.nlm.nih.gov/27198673/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27198673/ |
| — | von Maltzahn, J., Jones, A. E., Parks, R. J., Rudnicki, M. A. (2013). Pax7 is critical for the normal function of satellite cells in adult skeletal muscle. Proceedings of the National Academy of Sciences . https://pubmed.ncbi.nlm.nih.gov/24065826/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24065826/ |
| — | Xu, X., Wilschut, K. J., Kouklis, G., et al. (2015). Human satellite cell transplantation and regeneration from diverse skeletal muscles. Stem Cell Reports . https://pubmed.ncbi.nlm.nih.gov/26352798/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26352798/ |
| — | Sambasivan, R., Yao, R., Kissenpfennig, A., et al. (2011). Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. Development . https://pubmed.ncbi.nlm.nih.gov/21828093/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21828093/ |
| — | Poss, K. D. (2010). Nature Reviews Genetics . https://www.nature.com/articles/nrg2879 | — | — | https://www.nature.com/articles/nrg2879 |
| — | Gurtner, G. C., Werner, S., Barrandon, Y., Longaker, M. T. (2008). Nature . https://www.nature.com/articles/nature07039 | — | — | https://www.nature.com/articles/nature07039 |
| — | Seifert, A. W., Kiama, S. G., Seifert, M. G., Goheen, J. R., Palmer, T. M., Maden, M. (2012). Nature . https://www.nature.com/articles/nature11499 | — | — | https://www.nature.com/articles/nature11499 |
| — | Wynn, T. A., Vannella, K. M. (2016). Immunity . https://pmc.ncbi.nlm.nih.gov/articles/PMC4794754/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4794754/ |
| — | Larson, B. J., Longaker, M. T., Lorenz, H. P. (2010). Plastic and Reconstructive Surgery . https://pmc.ncbi.nlm.nih.gov/articles/PMC4229131/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4229131/ |
| — | Eming, S. A., Martin, P., Tomic-Canic, M. (2014). Science Translational Medicine . https://www.science.org/doi/10.1126/scitranslmed.3009337 | — | — | https://www.science.org/doi/10.1126/scitranslmed.3009337 |
| — | Porrello, E. R., Mahmoud, A. I., Simpson, E., et al. (2011). Science . https://pubmed.ncbi.nlm.nih.gov/21350179/ | — | — | https://pubmed.ncbi.nlm.nih.gov/21350179/ |
| — | Nachtrab, G., Czerwinski, M., Poss, K. D. "Sexually dimorphic fin regeneration in
zebrafish controlled by androgen/GSK3 signaling." Current Biology (2011). https://pubmed.ncbi.nlm.nih.gov/22079110/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22079110/ |
| — | Ashcroft, G. S. et al. "Topical estrogen accelerates cutaneous wound healing in aged
humans associated with an altered inflammatory response." American Journal of Pathology (1999). https://pubmed.ncbi.nlm.nih.gov/10514397/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10514397/ |
| — | Andrew, T. W. et al. "Sexually dimorphic estrogen sensing in skeletal stem cells
controls skeletal regeneration." Nature Communications (2022). https://pubmed.ncbi.nlm.nih.gov/36310174/ | — | — | https://pubmed.ncbi.nlm.nih.gov/36310174/ |
| — | Neal, A., Boldrin, L., Morgan, J. E. "The satellite cell in male and female,
developing and adult mouse muscle: distinct stem cells for growth and regeneration." PLoS ONE (2012). https://pubmed.ncbi.nlm.nih.gov/22662253/ | — | — | https://pubmed.ncbi.nlm.nih.gov/22662253/ |
| — | Ashcroft, G. S., Mills, S. J. "Androgen receptor-mediated inhibition of cutaneous wound
healing." Journal of Clinical Investigation (2002). https://pubmed.ncbi.nlm.nih.gov/12208862/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12208862/ |
| — | Brorson, J., Lin, L., Wang, J., et al. (2025). Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle. Nature Communications . https://pubmed.ncbi.nlm.nih.gov/40473693/ | — | — | https://pubmed.ncbi.nlm.nih.gov/40473693/ |
| — | Almada, A. E., Wagers, A. J. (2016). Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. Nature Reviews Molecular Cell Biology . https://pubmed.ncbi.nlm.nih.gov/26956195/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26956195/ |
| — | Fry, C. S., Lee, J. D., Mula, J., et al. (2015). Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/25501907/ | — | — | https://pubmed.ncbi.nlm.nih.gov/25501907/ |
| — | Stearns-Reider, K. M., D'Amore, A., Beezhold, K., et al. (2017). Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. Aging Cell . https://pubmed.ncbi.nlm.nih.gov/28371268/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28371268/ |
| — | Bernet, J. D., Doles, J. D., Hall, J. K., et al. (2014). p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/24531379/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24531379/ |
| — | Karlsen, A., Soendenbroe, C., Malmgaard-Clausen, N. M., et al. (2020). Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men. FASEB Journal . https://pubmed.ncbi.nlm.nih.gov/32167202/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32167202/ |
| — | Renault, V., Thornell, L. E., Eriksson, P. O., et al. (2002). Regenerative potential of human skeletal muscle during aging. Aging Cell . https://pubmed.ncbi.nlm.nih.gov/12882343/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12882343/ |
| — | Conboy, I. M., Conboy, M. J., Wagers, A. J., et al. (2005). Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature . https://pubmed.ncbi.nlm.nih.gov/15716955/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15716955/ |
| — | Wang, Y., Wehling-Henricks, M., Welc, S. S., et al. (2019). Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia. FASEB Journal . https://pubmed.ncbi.nlm.nih.gov/30130434/ | — | — | https://pubmed.ncbi.nlm.nih.gov/30130434/ |
| — | Brunet, A., Goodell, M. A., Rando, T. A. "Ageing and rejuvenation of tissue stem cells and their niches." Nature Reviews Molecular Cell Biology (2023). https://www.nature.com/articles/s41580-022-00510-w | — | — | https://www.nature.com/articles/s41580-022-00510-w |
| — | Blair, M. J. et al. "Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging." Advances in Wound Care (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC6985772/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6985772/ |
| — | Rittié, L., Fisher, G. J. "Natural and Sun-Induced Aging of Human Skin." Cold Spring Harbor Perspectives in Medicine (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4292080/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4292080/ |
| — | Eming, S. A., Martin, P., Tomic-Canic, M. "Wound repair and regeneration: mechanisms, signaling, and translation." Science Translational Medicine (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4973620/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4973620/ |
| — | Sharpe, P. T. "Dental stem cells." Development (2016). https://journals.biologists.com/dev/article/143/13/2273/47703/Dental-stem-cells | — | — | https://journals.biologists.com/dev/article/143/13/2273/47703/Dental-stem-cells |
| — | Scadden, D. T. "The stem cell niche." Nature (2006). https://pubmed.ncbi.nlm.nih.gov/16799783/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16799783/ |
| — | Tanaka, E. M., Reddien, P. W. "The cellular basis for animal regeneration." Developmental Cell (2011). https://www.cell.com/developmental-cell/fulltext/S1534-5807(11)00250-4 | — | — | https://www.cell.com/developmental-cell/fulltext/S1534-5807(11)00250-4 |
| — | Thesleff, I. "Developmental biology and building a tooth." Current Opinion in Genetics & Development (2003). https://openurl.ebsco.com/EPDB%3Agcd%3A16%3A10128048/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A37298522&crl=c&link_origin=starlightlongevity.com | — | — | https://openurl.ebsco.com/EPDB%3Agcd%3A16%3A10128048/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A37298522&crl=c&link_origin=starlightlongevity.com |
| — | Morrison, S. J., Spradling, A. C. "Stem cell niches: mechanisms that promote stem cell maintenance throughout life." Cell (2008). https://www.cell.com/fulltext/S0092-8674(08)00139-6 | — | — | https://www.cell.com/fulltext/S0092-8674(08)00139-6 |
| — | Willenborg, S., Injarabian, L., Eming, S. A. "Role of Macrophages in Wound Healing." Cold Spring Harbor Perspectives in Biology (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC9732901/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9732901/ |
| — | Eming, S. A., Martin, P., Tomic-Canic, M. "Wound repair and regeneration: mechanisms,
signaling, and translation." Science Translational Medicine (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4973620/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4973620/ |
| — | Gosain, A., DiPietro, L. A. "Aging and wound healing." World Journal of Surgery (2004). https://pubmed.ncbi.nlm.nih.gov/14961191/ | — | — | https://pubmed.ncbi.nlm.nih.gov/14961191/ |
| — | Rittié, L., Fisher, G. J. "Natural and sun-induced aging of human skin." Cold Spring Harbor Perspectives in Medicine (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4292080/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4292080/ |
| — | Wilkinson, H. N., Hardman, M. J. "Cellular Senescence in Acute and Chronic Wound
Repair." Cold Spring Harbor Perspectives in Biology (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC9620855/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9620855/ |
| — | Bang, H., Ni, L., and Davis, C. E. (2004). Assessment of blinding in clinical trials. Controlled Clinical Trials . https://pubmed.ncbi.nlm.nih.gov/15020033/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15020033/ |
| — | Benedetti, F., Pollo, A., Lopiano, L., Lanotte, M., Vighetti, S., and Rainero, I. (2003). Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. Journal of Neuroscience . https://pubmed.ncbi.nlm.nih.gov/12764120/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12764120/ |
| — | Hróbjartsson, A., Thomsen, A. S. S., Emanuelsson, F., et al. (2012). Observer bias in randomised clinical trials with binary outcomes: systematic review of trials with both blinded and non-blinded outcome assessors. BMJ . https://www.bmj.com/content/344/bmj.e1119 | — | — | https://www.bmj.com/content/344/bmj.e1119 |
| — | Wood, L., Egger, M., Gluud, L. L., et al. (2008). Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ . https://www.bmj.com/content/336/7644/601 | — | — | https://www.bmj.com/content/336/7644/601 |
| — | Golomb, B. A., Erickson, L. C., Koperski, S., Sack, D., Enkin, M., and Howick, J. (2010). What’s in placebos: who knows? Analysis of randomized, controlled trials. Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/20956710/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20956710/ |
| — | Cummings, S. R., and Kritchevsky, S. B. (2022). Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age. GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC9768060/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9768060/ |
| — | Hopewell, S., Chan, A.-W., Collins, G. S., et al. (2025). CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials. BMJ . https://www.bmj.com/content/389/bmj-2024-081124 | — | — | https://www.bmj.com/content/389/bmj-2024-081124 |
| — | Ravussin, E., Redman, L. M., Rochon, J., et al. (2015). A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC4841173/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4841173/ |
| — | Boutron, I., Guittet, L., Estellat, C., et al. (2007). Reporting methods of blinding in randomized trials assessing nonpharmacological treatments. PLoS Medicine . https://doi.org/10.1371/journal.pmed.0040061 | — | — | https://doi.org/10.1371/journal.pmed.0040061 |
| — | Moustgaard, H., Clayton, G. L., Jones, H. E., et al. (2020). Impact of blinding on estimated treatment effects in randomised clinical trials: meta-epidemiological study. BMJ . https://www.bmj.com/content/368/bmj.l6802 | — | — | https://www.bmj.com/content/368/bmj.l6802 |
| — | Andersen, P. K., et al. (2012). Competing risks in epidemiology: possibilities and pitfalls . International Journal of Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3396320/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3396320/ |
| — | Lee, S. J., et al. (2018). The Competing Risk of Death in Longitudinal Geriatric Outcomes . Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC6367003/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6367003/ |
| — | Austin, P. C., et al. (2016). Introduction to the Analysis of Survival Data in the Presence of Competing Risks . Circulation . https://pubmed.ncbi.nlm.nih.gov/26858290/ | — | — | https://pubmed.ncbi.nlm.nih.gov/26858290/ |
| — | Berry, S. D., et al. (2010). Competing Risk of Death: An Important Consideration in Studies of Older Adults . Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC2873048/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2873048/ |
| — | Putter, H., et al. (2007). Tutorial in biostatistics: competing risks and multi-state models . Statistics in Medicine . https://pubmed.ncbi.nlm.nih.gov/17031868/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17031868/ |
| — | Fine, J. P., & Gray, R. J. (1999). A Proportional Hazards Model for the Subdistribution of a Competing Risk . Journal of the American Statistical Association . https://doi.org/10.1080/01621459.1999.10474144 | — | — | https://doi.org/10.1080/01621459.1999.10474144 |
| — | Gooley, T. A., et al. (1999). Estimation of failure probabilities in the presence of competing risks: new representations of old estimators . Statistics in Medicine . https://pubmed.ncbi.nlm.nih.gov/10204198/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10204198/ |
| — | Koller, M. T., et al. (2012). Competing risks and the clinical community: irrelevance or ignorance? Statistics in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC3575691/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3575691/ |
| — | Justice, J. N., et al. (2016). Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes . Journal of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC5055651/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5055651/ |
| — | Ferreira-Gonzalez, I., et al. (2007). Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns . Journal of Clinical Epidemiology . https://pubmed.ncbi.nlm.nih.gov/17573977/ | — | — | https://pubmed.ncbi.nlm.nih.gov/17573977/ |
| — | Espeland, M. A., et al. (2017). Clinical Trials Targeting Aging and Age-Related Multimorbidity . Journal of Gerontology: Series A . https://pubmed.ncbi.nlm.nih.gov/28364543/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28364543/ |
| — | Neumann, J. T., et al. (2022). Prediction of disability-free survival in healthy older people . Geroscience . https://pmc.ncbi.nlm.nih.gov/articles/PMC9213595/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9213595/ |
| — | Barzilai, N., et al. (2018). Journals of Gerontology Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC6230116/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6230116/ |
| — | Mansournia, M. A., et al. (2017). BMJ . https://www.bmj.com/content/359/bmj.j4587 | — | — | https://www.bmj.com/content/359/bmj.j4587 |
| — | Hernan, M. A., & Robins, J. M. (2016). American Journal of Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4832051/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4832051/ |
| — | Benson, K., & Hartz, A. J. (2000). New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/10861324/ | — | — | https://pubmed.ncbi.nlm.nih.gov/10861324/ |
| — | Cummings, S. R., & Kritchevsky, S. B. (2022). GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC9768060/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9768060/ |
| — | Sterne, J. A. C., et al. (2016). BMJ . https://www.bmj.com/content/355/bmj.i4919 | — | — | https://www.bmj.com/content/355/bmj.i4919 |
| — | Schulz, K. F., Altman, D. G., & Moher, D. (2010). BMJ . https://www.bmj.com/content/340/bmj.c332 | — | — | https://www.bmj.com/content/340/bmj.c332 |
| — | van Deudekom, F. J., Postmus, I., van der Ham, D. J., et al. (2017). External validity of randomized controlled trials in older adults, a systematic review. PLOS ONE , 12(3), e0174053. https://pmc.ncbi.nlm.nih.gov/articles/PMC5367677/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5367677/ |
| — | Oakes, J. M., et al. (2023). Investigating and remediating selection bias in geriatrics research: the Selection Bias Toolkit. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC9930538/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9930538/ |
| — | Zulman, D. M., et al. (2011). Examining the Evidence: A Systematic Review of the Inclusion and Analysis of Older Adults in Randomized Controlled Trials. Journal of General Internal Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC3138606/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3138606/ |
| — | Loudon, K., et al. (2015). The PRECIS-2 tool: designing trials that are fit for purpose. BMJ . https://www.bmj.com/content/350/bmj.h2147 | — | — | https://www.bmj.com/content/350/bmj.h2147 |
| — | Lyall, D. M., et al. (2022). Quantifying bias in psychological and physical health in the UK Biobank imaging sub-sample. Brain Communications . https://pmc.ncbi.nlm.nih.gov/articles/PMC9150072/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9150072/ |
| — | Nichols, E., and Hayes-Larson, E. (2024). Common methodological issues in observational epidemiological studies of older adults. BMJ Medicine . https://bmjmedicine.bmj.com/content/4/1/e001332 | — | — | https://bmjmedicine.bmj.com/content/4/1/e001332 |
| — | van Alten, S., et al. (2024). Reweighting UK Biobank corrects for pervasive selection bias due to volunteering. International Journal of Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC11076923/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11076923/ |
| — | Canevelli, M., et al. (2017). External Validity of Randomized Controlled Trials on Alzheimer's Disease: The Biases of Frailty and Biological Aging. Frontiers in Neurology . https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2017.00628/full | — | — | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2017.00628/full |
| — | Ford, I., and Norrie, J. (2016). Pragmatic Trials. The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/27557339/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27557339/ |
| — | Rothwell, P. M. (2005). External validity of randomised controlled trials: "To whom do the results of this trial apply?" The Lancet . https://pubmed.ncbi.nlm.nih.gov/15950722/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15950722/ |
| — | Justice JN, et al. Frameworks for proof-of-concept clinical trials of interventions that target fundamental aging processes. Journals of Gerontology A (2018). | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6523054/ |
| — | National Institute on Aging (NIA): Geroscience and the intersection of aging biology and chronic disease. | — | — | https://www.nia.nih.gov/research/dab/geroscience-intersection-basic-aging-biology-chronic-disease-and-health |
| — | López-Otín C, et al. The Hallmarks of Aging. Cell (2013). | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ |
| — | Ioannidis JPA. Why Most Published Research Findings Are False. PLoS Medicine (2005). | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1182327/ |
| — | Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMJ (2010). | — | — | https://www.bmj.com/content/340/bmj.c332 |
| — | von Elm E, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. PLoS Medicine (2007). | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2020496/ |
| — | Guyatt GH, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ (2008). | — | — | https://www.bmj.com/content/336/7650/924 |
| — | Page MJ, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (2021). | — | — | https://www.bmj.com/content/372/bmj.n71 |
| — | Sterne JA, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ (2016). | — | — | https://www.bmj.com/content/355/bmj.i4919 |
| — | Bland JM, Altman DG. Statistics Notes: The odds ratio. BMJ (1998). | — | — | https://www.bmj.com/content/316/7136/989 |
| — | Hopewell S, et al. CONSORT for reporting randomised trials in journal and conference abstracts. Lancet (2008). | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6398298/ |
| — | Justice, J. N., Kritchevsky, S. B., and Ferrucci, L. (2018). Frameworks for proof-of-concept clinical trials of interventions that target fundamental aging processes. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC6523054/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6523054/ |
| — | von Elm, E., Altman, D. G., Egger, M., et al. (2007). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC2020496/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2020496/ |
| — | FDA-NIH Biomarker Working Group. (2016). BEST (Biomarkers, EndpointS, and other Tools) Resource. FDA-NIH Biomarker Working Group . https://www.ncbi.nlm.nih.gov/books/NBK326791/ | — | — | https://www.ncbi.nlm.nih.gov/books/NBK326791/ |
| — | Page, M. J., McKenzie, J. E., Bossuyt, P. M., et al. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ . https://www.bmj.com/content/372/bmj.n71 | — | — | https://www.bmj.com/content/372/bmj.n71 |
| — | Higgins, J. P. T., Thomas, J., Chandler, J., et al., editors. Cochrane Handbook for Systematic Reviews of Interventions. Cochrane . https://www.ncbi.nlm.nih.gov/books/NBK557996/ | — | — | https://www.ncbi.nlm.nih.gov/books/NBK557996/ |
| — | Sterne, J. A. C., Hernan, M. A., Reeves, B. C., et al. (2016). ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ . https://www.bmj.com/content/355/bmj.i4919 | — | — | https://www.bmj.com/content/355/bmj.i4919 |
| — | Percie du Sert, N., Hurst, V., Ahluwalia, A., et al. (2020). The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLOS Biology . https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000410 | — | — | https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000410 |
| — | Ioannidis, J. P. A. (2005). Why most published research findings are false. PLoS Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC1182327/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1182327/ |
| — | Sterne, J. A. C., Savovic, J., Page, M. J., et al. (2019). RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ . https://www.bmj.com/content/366/bmj.l4898 | — | — | https://www.bmj.com/content/366/bmj.l4898 |
| — | Schulz, K. F., Altman, D. G., and Moher, D. (2010). CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMJ . https://www.bmj.com/content/340/bmj.c332 | — | — | https://www.bmj.com/content/340/bmj.c332 |
| — | Sumner, P., et al. (2014). BMJ . https://www.bmj.com/content/349/bmj.g7015 | — | — | https://www.bmj.com/content/349/bmj.g7015 |
| — | Chiu, K., Grundy, Q., and Bero, L. (2017). PLOS Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC5593172/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5593172/ |
| — | Oxman, M., et al. (2021). F1000Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC8756300/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8756300/ |
| — | Justice, J. N., et al. (2018). Journals of Gerontology Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC6523054/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6523054/ |
| — | van der Worp, H. B., et al. (2010). PLOS Medicine . https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000245 | — | — | https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000245 |
| — | Sumner, P., et al. (2016). PLOS ONE . https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168217 | — | — | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168217 |
| — | Khan, M. S., et al. (2019). JAMA Network Open . https://pmc.ncbi.nlm.nih.gov/articles/PMC6503494/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6503494/ |
| — | Vail, E. A., et al. (2021). Attention to Immortal Time Bias in Critical Care Research . American Journal of Respiratory and Critical Care Medicine . https://pubmed.ncbi.nlm.nih.gov/33761299/ | — | — | https://pubmed.ncbi.nlm.nih.gov/33761299/ |
| — | Suissa, S. (2008). Immortal time bias in pharmaco-epidemiology . American Journal of Epidemiology . https://pubmed.ncbi.nlm.nih.gov/18056625/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18056625/ |
| — | van Walraven, C., et al. (2004). Time-dependent bias was common in survival analyses published in leading clinical journals . Journal of Clinical Epidemiology . https://pubmed.ncbi.nlm.nih.gov/15358395/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15358395/ |
| — | Hernán, M. A., et al. (2016). Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses . Journal of Clinical Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC5124536/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5124536/ |
| — | Hernán, M. A., et al. (2025). A structural description of biases that generate immortal time . Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC11598638/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11598638/ |
| — | Little, R. J., Cohen, M. L., Dickersin, K., et al. (2012). The design and conduct of clinical trials to limit missing data. Statistics in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC5944851/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5944851/ |
| — | Piaggio, G., Elbourne, D. R., Pocock, S. J., Evans, S. J. W., and Altman, D. G. (2012). Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA . https://pubmed.ncbi.nlm.nih.gov/23268518/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23268518/ |
| — | Moher, D., Hopewell, S., Schulz, K. F., et al. (2010). CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials. BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC2844943/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2844943/ |
| — | Rudolph, J. E., Naimi, A. I., Westreich, D., and Kennedy, E. H. (2020). Defining and identifying per-protocol effects in randomized trials. Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC7400733/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7400733/ |
| — | Hernan, M. A., and Robins, J. M. (2017). Per-protocol analyses of pragmatic trials. New England Journal of Medicine . https://www.nejm.org/doi/10.1056/NEJMsm1605385 | — | — | https://www.nejm.org/doi/10.1056/NEJMsm1605385 |
| — | Kang, M., Kendall, M. A., Ribaudo, H., et al. (2022). Incorporating estimands into clinical trial statistical analysis plans. Clinical Trials . https://pmc.ncbi.nlm.nih.gov/articles/PMC9232859/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9232859/ |
| — | White, I. R., Horton, N. J., Carpenter, J., and Pocock, S. J. (2011). Strategy for intention to treat analysis in randomised trials with missing outcome data. BMJ . https://www.bmj.com/content/342/bmj.d40 | — | — | https://www.bmj.com/content/342/bmj.d40 |
| — | Loudon, K., Treweek, S., Sullivan, F., Donnan, P., Thorpe, K. E., and Zwarenstein, M. (2015). The PRECIS-2 tool: designing trials that are fit for purpose. BMJ . https://www.bmj.com/content/350/bmj.h2147 | — | — | https://www.bmj.com/content/350/bmj.h2147 |
| — | Cummings, S. R., and Kritchevsky, S. B. (2022). Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biological age. GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC9768060/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9768060/ |
| — | Hoffmann, T. C., Glasziou, P. P., Boutron, I., et al. (2014). Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ . https://www.bmj.com/content/348/bmj.g1687 | — | — | https://www.bmj.com/content/348/bmj.g1687 |
| — | Kraus, W. E., Bhapkar, M., Huffman, K. M., et al. (2019). 2 years of calorie restriction and cardiometabolic risk: exploratory outcomes of a multicentre, phase 2, randomised controlled trial. The Lancet Diabetes & Endocrinology . https://pubmed.ncbi.nlm.nih.gov/31402175/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31402175/ |
| — | Hernan, M. A., and Robins, J. M. (2017). Per-protocol analyses of pragmatic trials. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/28564548/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28564548/ |
| — | Ravussin, E., Redman, L. M., Rochon, J., et al. (2015). A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC5315691/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5315691/ |
| — | Chewning, B. (2006). The healthy adherer and the placebo effect. BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC1488753/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1488753/ |
| — | Wolfson, C., et al. (2001). A reevaluation of the duration of survival after the onset of dementia . The New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/11297701/ | — | — | https://pubmed.ncbi.nlm.nih.gov/11297701/ |
| — | Baker, S. G., et al. (2002). Statistical issues in randomized trials of cancer screening . BMC Medical Research Methodology . https://pmc.ncbi.nlm.nih.gov/articles/PMC130026/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC130026/ |
| — | Black, W. C., & Welch, H. G. (1993). Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy . The New England Journal of Medicine . https://www.nejm.org/doi/full/10.1056/NEJM199304293281706 | — | — | https://www.nejm.org/doi/full/10.1056/NEJM199304293281706 |
| — | Duffy, S. W., et al. (2008). Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival . American Journal of Epidemiology . https://pubmed.ncbi.nlm.nih.gov/18504245/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18504245/ |
| — | Belsky, D. W., et al. (2015). Quantification of biological aging in young adults. PNAS . https://pmc.ncbi.nlm.nih.gov/articles/PMC4522793/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4522793/ |
| — | Jylhava, J., Pedersen, N. L., & Hagg, S. (2017). Biological age predictors. EBioMedicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC5514388/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5514388/ |
| — | Levine, M. E., et al. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/ |
| — | von Elm, E., et al. (2007). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. PLoS Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC2020495/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2020495/ |
| — | Belsky, D. W., et al. (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife . https://pmc.ncbi.nlm.nih.gov/articles/PMC8853656/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8853656/ |
| — | Belsky, D. W., et al. (2020). Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. eLife . https://pubmed.ncbi.nlm.nih.gov/32367804/ | — | — | https://pubmed.ncbi.nlm.nih.gov/32367804/ |
| — | Collins, G. S., et al. (2015). Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD). BMJ . https://www.bmj.com/content/350/bmj.g7594 | — | — | https://www.bmj.com/content/350/bmj.g7594 |
| — | Justice, J. N., et al. (2018). Frameworks for proof-of-concept clinical trials of interventions that target fundamental aging processes. The Journals of Gerontology: Series A . https://pmc.ncbi.nlm.nih.gov/articles/PMC6523054/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6523054/ |
| — | Ye, B., et al. (2023). Age and Ageing . https://www.ukbiobank.ac.uk/publications/the-role-of-lifestyle-in-the-association-between-frailty-and-all-cause-mortality-amongst-older-adults-a-mediation-analysis-in-the-uk-biobank/ | — | — | https://www.ukbiobank.ac.uk/publications/the-role-of-lifestyle-in-the-association-between-frailty-and-all-cause-mortality-amongst-older-adults-a-mediation-analysis-in-the-uk-biobank/ |
| — | Harries, L. W., et al. (2015). Age . https://pmc.ncbi.nlm.nih.gov/articles/PMC4600657/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4600657/ |
| — | Baron, R. M., & Kenny, D. A. (1986). Journal of Personality and Social Psychology . https://doi.org/10.1037/0022-3514.51.6.1173 | — | — | https://doi.org/10.1037/0022-3514.51.6.1173 |
| — | VanderWeele, T. J., & Vansteelandt, S. (2014). Epidemiologic Methods . https://pmc.ncbi.nlm.nih.gov/articles/PMC4287269/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4287269/ |
| — | VanderWeele, T. J., Vansteelandt, S., & Robins, J. M. (2014). Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4214081/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4214081/ |
| — | Jiang, R., et al. (2022). Clinical Epigenetics . https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-022-01380-x | — | — | https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-022-01380-x |
| — | Lin, S. H., Young, J., Logan, R., & VanderWeele, T. J. (2017). Statistics in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC6242332/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6242332/ |
| — | Zhang, X., et al. (2026). npj Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC12894700/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12894700/ |
| — | Kivimaki, M., et al. (2025). Nature Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC12092251/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12092251/ |
| — | VanderWeele, T. J., & Tchetgen Tchetgen, E. J. (2017). Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC5560424/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5560424/ |
| — | von Hippel, P. T. (2015). BMC Medical Research Methodology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4410499/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4410499/ |
| — | Cornell, J. E., et al. (2014). Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/24727843/ | — | — | https://pubmed.ncbi.nlm.nih.gov/24727843/ |
| — | IntHout, J., Ioannidis, J. P. A., Rovers, M. M., & Goeman, J. J. (2016). BMJ Open . https://bmjopen.bmj.com/content/6/7/e010247 | — | — | https://bmjopen.bmj.com/content/6/7/e010247 |
| — | Deeks, J. J., Higgins, J. P. T., Altman, D. G., McKenzie, J. E., & Veroniki, A. A. (2024). Cochrane Handbook for Systematic Reviews of Interventions , Chapter 10. https://training.cochrane.org/handbook/current/chapter-10 | — | — | https://training.cochrane.org/handbook/current/chapter-10 |
| — | O'Caoimh, R., et al. (2021). Age and Ageing . https://academic.oup.com/ageing/article/50/1/96/5928224 | — | — | https://academic.oup.com/ageing/article/50/1/96/5928224 |
| — | Thompson, S. G., & Higgins, J. P. T. (2002). Statistics in Medicine . https://pubmed.ncbi.nlm.nih.gov/12111920/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12111920/ |
| — | Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). BMJ . https://www.bmj.com/content/327/7414/557 | — | — | https://www.bmj.com/content/327/7414/557 |
| — | Higgins, J. P. T., & Thompson, S. G. (2002). Statistics in Medicine . https://pubmed.ncbi.nlm.nih.gov/12111919/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12111919/ |
| — | Partlett, C., & Riley, R. D. (2017). Statistics in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC5157768/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5157768/ |
| — | Chatfield, M. D., Brayne, C. E., and Matthews, F. E. (2005). A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies. Journal of Clinical Epidemiology . https://pubmed.ncbi.nlm.nih.gov/15649666/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15649666/ |
| — | Hernandez, R., Jin, H., Lee, P.-J., et al. (2024). Attrition from longitudinal ageing studies and performance across domains of cognitive functioning: an individual participant data meta-analysis. BMJ Open . https://bmjopen.bmj.com/content/14/3/e079241 | — | — | https://bmjopen.bmj.com/content/14/3/e079241 |
| — | Sterne, J. A. C., White, I. R., Carlin, J. B., et al. (2009). Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ . https://www.bmj.com/content/338/bmj.b2393 | — | — | https://www.bmj.com/content/338/bmj.b2393 |
| — | Okpara, C., Edokwe, C., Ioannidis, G., et al. (2022). The reporting and handling of missing data in longitudinal studies of older adults is suboptimal: a methodological survey of geriatric journals. BMC Medical Research Methodology . https://pmc.ncbi.nlm.nih.gov/articles/PMC9040343/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9040343/ |
| — | Duchesneau, E. D., Shmuel, S., Faurot, K. R., et al. (2023). Missing data approaches in longitudinal studies of aging: a case example using the National Health and Aging Trends Study. PLOS ONE . https://pmc.ncbi.nlm.nih.gov/articles/PMC10249888/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10249888/ |
| — | White, I. R., Royston, P., and Wood, A. M. (2011). Multiple imputation using chained equations: issues and guidance for practice. Statistics in Medicine . https://onlinelibrary.wiley.com/doi/10.1002/sim.4067 | — | — | https://onlinelibrary.wiley.com/doi/10.1002/sim.4067 |
| — | Little, R. J., D'Agostino, R., Cohen, M. L., et al. (2012). The prevention and treatment of missing data in clinical trials. New England Journal of Medicine . https://www.nejm.org/doi/10.1056/NEJMsr1203730 | — | — | https://www.nejm.org/doi/10.1056/NEJMsr1203730 |
| — | Weuve, J., Tchetgen Tchetgen, E. J., Glymour, M. M., et al. (2012). Accounting for bias due to selective attrition: the example of smoking and cognitive decline. Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3237815/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3237815/ |
| — | Dmitrienko, A., & D’Agostino, R. B. (2013). Traditional multiplicity adjustment methods in clinical trials. Statistics in Medicine . https://pubmed.ncbi.nlm.nih.gov/23529248/ | — | — | https://pubmed.ncbi.nlm.nih.gov/23529248/ |
| — | Moqri, M., et al. (2024). Validation of biomarkers of aging. Nature Medicine . https://www.nature.com/articles/s41591-023-02784-9 | — | — | https://www.nature.com/articles/s41591-023-02784-9 |
| — | Rothman, K. J. (1990). No adjustments are needed for multiple comparisons. Epidemiology . https://pubmed.ncbi.nlm.nih.gov/2081237/ | — | — | https://pubmed.ncbi.nlm.nih.gov/2081237/ |
| — | Greenland, S., et al. (2016). Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations. European Journal of Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4877414/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4877414/ |
| — | Head, M. L., et al. (2015). The extent and consequences of p-hacking in science. PLOS Biology . https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002106 | — | — | https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002106 |
| — | Nosek, B. A., et al. (2018). The preregistration revolution. Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1708274114 | — | — | https://doi.org/10.1073/pnas.1708274114 |
| — | Li, G., et al. (2017). An introduction to multiplicity issues in clinical trials: the what, why, when and how. International Journal of Epidemiology . https://academic.oup.com/ije/article/46/2/746/2622846 | — | — | https://academic.oup.com/ije/article/46/2/746/2622846 |
| — | Menýhárt, O., Weltz, B., & Győrffy, B. (2021). MultipleTesting.com: a tool for life science researchers for multiple hypothesis testing correction. PLOS ONE . https://pmc.ncbi.nlm.nih.gov/articles/PMC8189492/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC8189492/ |
| — | Ho, J., Tumkaya, T., Aryal, S., Choi, H., & Claridge-Chang, A. (2019). Moving beyond P values: data analysis with estimation graphics. Nature Methods . https://www.nature.com/articles/s41592-019-0470-3 | — | — | https://www.nature.com/articles/s41592-019-0470-3 |
| — | Wasserstein, R. L., Schirm, A. L., & Lazar, N. A. (2019). Moving to a world beyond “p < 0.05”. The American Statistician . https://doi.org/10.1080/00031305.2019.1583913 | — | — | https://doi.org/10.1080/00031305.2019.1583913 |
| — | Gelman, A., & Stern, H. (2006). The difference between “significant” and “not significant” is not itself statistically significant. The American Statistician . https://doi.org/10.1198/000313006X152649 | — | — | https://doi.org/10.1198/000313006X152649 |
| — | Kritchevsky, S. B., et al. (2024). Biomarkers of aging and the translational geroscience challenge. Nature Aging . https://www.nature.com/articles/s43587-024-00615-8 | — | — | https://www.nature.com/articles/s43587-024-00615-8 |
| — | Sterne, J. A. C., & Smith, G. D. (2001). Sifting the evidence: what’s wrong with significance tests? BMJ . https://www.bmj.com/content/322/7280/226 | — | — | https://www.bmj.com/content/322/7280/226 |
| — | Goodman, S. N. (2008). A dirty dozen: twelve p-value misconceptions. Seminars in Hematology . https://pubmed.ncbi.nlm.nih.gov/18582619/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18582619/ |
| — | Amrhein, V., Greenland, S., & McShane, B. (2019). Scientists rise up against statistical significance. Nature . https://www.nature.com/articles/d41586-019-00857-9 | — | — | https://www.nature.com/articles/d41586-019-00857-9 |
| — | Altman, D. G., & Bland, J. M. (1995). Absence of evidence is not evidence of absence. BMJ . https://www.bmj.com/content/311/7003/485 | — | — | https://www.bmj.com/content/311/7003/485 |
| — | About bioRxiv. | — | — | https://www.biorxiv.org/about-biorxiv |
| — | About medRxiv. | — | — | https://www.medrxiv.org/content/about-medrxiv |
| — | Fraser N, et al. Preprinting a pandemic: the role of preprints in the COVID-19 pandemic. bioRxiv/PLoS Biology context paper (2020). | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7081173/ |
| — | ASAPbio: Preprint FAQ. | — | — | https://asapbio.org/preprint-info/preprint-faq |
| — | Hardwicke, T. E., & Wagenmakers, E.-J. (2023). Nature Human Behaviour . https://www.nature.com/articles/s41562-022-01497-2 | — | — | https://www.nature.com/articles/s41562-022-01497-2 |
| — | Nosek, B. A., et al. (2018). Proceedings of the National Academy of Sciences . https://www.pnas.org/doi/10.1073/pnas.1708274114 | — | — | https://www.pnas.org/doi/10.1073/pnas.1708274114 |
| — | DeVito, N. J., et al. (2020). The Lancet . https://pubmed.ncbi.nlm.nih.gov/31958402/ | — | — | https://pubmed.ncbi.nlm.nih.gov/31958402/ |
| — | Chambers, C. D., & Tzavella, L. (2022). Nature Human Behaviour . https://www.nature.com/articles/s41562-021-01193-7 | — | — | https://www.nature.com/articles/s41562-021-01193-7 |
| — | TARG Meta-Research Group & Collaborators. (2023). BMJ Open . https://bmjopen.bmj.com/content/13/10/e076264 | — | — | https://bmjopen.bmj.com/content/13/10/e076264 |
| — | Soderberg, C. K., et al. (2021). Nature Human Behaviour . https://www.nature.com/articles/s41562-021-01142-4 | — | — | https://www.nature.com/articles/s41562-021-01142-4 |
| — | Weston, S. J., et al. (2019). Advances in Methods and Practices in Psychological Science . https://journals.sagepub.com/doi/10.1177/2515245919848684 | — | — | https://journals.sagepub.com/doi/10.1177/2515245919848684 |
| — | Higgins-Chen, A. T., et al. (2022). Nature Aging . https://www.nature.com/articles/s43587-022-00248-2 | — | — | https://www.nature.com/articles/s43587-022-00248-2 |
| — | Parish, A., et al. (2025). npj Aging . https://www.nature.com/articles/s41514-025-00287-0 | — | — | https://www.nature.com/articles/s41514-025-00287-0 |
| — | Dwan, K., Gamble, C., Williamson, P. R., and Kirkham, J. J. (2013). Systematic review of the empirical evidence of study publication bias and outcome reporting bias: an updated review. PLoS ONE . https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066844 | — | — | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066844 |
| — | Chan, A. W., Hrobjartsson, A., Haahr, M. T., Gotzsche, P. C., and Altman, D. G. (2004). Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA . https://jamanetwork.com/journals/jama/fullarticle/198809 | — | — | https://jamanetwork.com/journals/jama/fullarticle/198809 |
| — | Goldacre, B., et al. (2019). COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time. Trials . https://link.springer.com/article/10.1186/s13063-019-3173-2 | — | — | https://link.springer.com/article/10.1186/s13063-019-3173-2 |
| — | Hopewell, S., et al. (2025). CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials. BMJ . https://www.bmj.com/content/389/bmj-2024-081124 | — | — | https://www.bmj.com/content/389/bmj-2024-081124 |
| — | Kirkham, J. J., et al. (2018). Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews. BMJ . https://www.bmj.com/content/362/bmj.k3802 | — | — | https://www.bmj.com/content/362/bmj.k3802 |
| — | Chan, A. W., et al. (2025). SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials. BMJ . https://www.bmj.com/content/389/bmj-2024-081660 | — | — | https://www.bmj.com/content/389/bmj-2024-081660 |
| — | Kirkham, J. J., et al. (2010). The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews. BMJ . https://pubmed.ncbi.nlm.nih.gov/20156912/ | — | — | https://pubmed.ncbi.nlm.nih.gov/20156912/ |
| — | Justice, J. N., et al. (2018). A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC6294728/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6294728/ |
| — | Lopez-Otin, C. et al. (2013). The hallmarks of aging. Cell . https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ |
| — | Dwan, K., Gamble, C., Williamson, P. R., and Kirkham, J. J. (2013). Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLOS ONE . https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066844 | — | — | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066844 |
| — | Sterne, J. A. C., Sutton, A. J., Ioannidis, J. P. A., et al. (2011). Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ . https://www.bmj.com/content/343/bmj.d4002 | — | — | https://www.bmj.com/content/343/bmj.d4002 |
| — | Sumner, P., Vivian-Griffiths, S., Boivin, J., et al. (2014). The association between exaggeration in health related science news and academic press releases: retrospective observational study. BMJ . https://www.bmj.com/content/349/bmj.g7015 | — | — | https://www.bmj.com/content/349/bmj.g7015 |
| — | Loudon, K., et al. (2015). BMJ . https://www.bmj.com/content/350/bmj.h2147 | — | — | https://www.bmj.com/content/350/bmj.h2147 |
| — | von Elm, E., et al. (2007). BMJ . https://www.bmj.com/content/335/7624/806 | — | — | https://www.bmj.com/content/335/7624/806 |
| — | Guyatt, G. H., et al. (2008). BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC2335261/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2335261/ |
| — | Barnett, A. G., van der Pols, J. C., & Dobson, A. J. (2005). Regression to the mean: what it is and how to deal with it. International Journal of Epidemiology . https://academic.oup.com/ije/article/34/1/215/638499 | — | — | https://academic.oup.com/ije/article/34/1/215/638499 |
| — | Vickers, A. J., & Altman, D. G. (2001). Analysing controlled trials with baseline and follow up measurements. BMJ . https://www.bmj.com/content/323/7321/1123 | — | — | https://www.bmj.com/content/323/7321/1123 |
| — | Frison, L., & Pocock, S. J. (1992). Repeated measures in clinical trials: analysis using mean summary statistics and its implications for design. Statistics in Medicine . https://pubmed.ncbi.nlm.nih.gov/1485053/ | — | — | https://pubmed.ncbi.nlm.nih.gov/1485053/ |
| — | Bland, J. M., & Altman, D. G. (1994). Some examples of regression towards the mean. BMJ . https://www.bmj.com/content/309/6957/780 | — | — | https://www.bmj.com/content/309/6957/780 |
| — | Bland, J. M., & Altman, D. G. (2011). Comparisons within randomised groups can be very misleading. BMJ . https://www.bmj.com/content/342/bmj.d561 | — | — | https://www.bmj.com/content/342/bmj.d561 |
| — | Davis, C. E. (1976). The effect of regression to the mean in epidemiologic and clinical studies. American Journal of Epidemiology . https://pubmed.ncbi.nlm.nih.gov/984023/ | — | — | https://pubmed.ncbi.nlm.nih.gov/984023/ |
| — | Tennant, P. W. G., et al. (2022). Analyses of ‘change scores’ do not estimate causal effects in observational data. International Journal of Epidemiology . https://academic.oup.com/ije/article/51/5/1604/6294759 | — | — | https://academic.oup.com/ije/article/51/5/1604/6294759 |
| — | Percie du Sert, N., et al. (2020). PLoS Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC7610906/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7610906/ |
| — | Ioannidis, J. P. A. (2005). PLoS Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC1182327/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC1182327/ |
| — | Chambers, C. D., & Tzavella, L. (2022). Nature Human Behaviour . https://pubmed.ncbi.nlm.nih.gov/34782730/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34782730/ |
| — | Bell, C. G., et al. (2019). Genome Biology . https://pmc.ncbi.nlm.nih.gov/articles/PMC6876109/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6876109/ |
| — | Ioannidis, J. P. A. (2008). Epidemiology . https://pubmed.ncbi.nlm.nih.gov/18633328/ | — | — | https://pubmed.ncbi.nlm.nih.gov/18633328/ |
| — | Higgins-Chen, A. T., et al. (2022). Nature Aging . https://pmc.ncbi.nlm.nih.gov/articles/PMC9586209/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9586209/ |
| — | Warner, H. R. (2015). GeroScience . https://pmc.ncbi.nlm.nih.gov/articles/PMC4344944/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4344944/ |
| — | Penninkilampi, R., & Eslick, G. D. (2018). CNS Drugs . https://pubmed.ncbi.nlm.nih.gov/29926372/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29926372/ |
| — | Mok, A., et al. (2019). International Journal of Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC7124507/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC7124507/ |
| — | Pai, H., & Gulliford, M. C. (2022). BMJ Open . https://pmc.ncbi.nlm.nih.gov/articles/PMC9341213/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9341213/ |
| — | Charlton, J., et al. (2018). Journals of Gerontology Series A . https://pubmed.ncbi.nlm.nih.gov/29028914/ | — | — | https://pubmed.ncbi.nlm.nih.gov/29028914/ |
| — | Kivimaki, M., et al. (2019). BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC6468884/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6468884/ |
| — | Ioannidis, J. P. A. (2005). Why most published research findings are false. PLOS Medicine . https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124 | — | — | https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124 |
| — | Egger, M., et al. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC2127453/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2127453/ |
| — | Freiman, J. A., et al. (1978). The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials. New England Journal of Medicine . https://pubmed.ncbi.nlm.nih.gov/355881/ | — | — | https://pubmed.ncbi.nlm.nih.gov/355881/ |
| — | Nichols, E., and Hayes-Larson, E. (2024). Common methodological issues in observational epidemiological studies of older adults. BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC12406907/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC12406907/ |
| — | Enzenbach, C., Wicklein, B., Wirkner, K., Loeffler, M., and Engel, C. (2019). Evaluating selection bias in a population-based cohort study with low baseline participation: the LIFE-Adult-Study. BMC Medical Research Methodology . https://pmc.ncbi.nlm.nih.gov/articles/PMC6604357/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC6604357/ |
| — | van Alten, S., Domingue, B. W., Faul, J., Galama, T., and Marees, A. (2024). Reweighting UK Biobank corrects for pervasive selection bias due to volunteering. International Journal of Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC11076923/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11076923/ |
| — | Lyall, D. M., Quinn, T., Lyall, L. M., et al. (2022). Quantifying bias in psychological and physical health in the UK Biobank imaging sub-sample. Brain Communications . https://pmc.ncbi.nlm.nih.gov/articles/PMC9150072/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9150072/ |
| — | Hernan, M. A., Hernandez-Diaz, S., and Robins, J. M. (2004). A structural approach to selection bias. Epidemiology . https://journals.lww.com/epidem/abstract/2004/09000/a_structural_approach_to_selection_bias.8.aspx | — | — | https://journals.lww.com/epidem/abstract/2004/09000/a_structural_approach_to_selection_bias.8.aspx |
| — | Oakes, J. M., Heeringa, S. G., Colangelo, L. A., et al. (2023). Investigating and remediating selection bias in geriatrics research: the Selection Bias Toolkit. Journal of the American Geriatrics Society . https://pmc.ncbi.nlm.nih.gov/articles/PMC9930538/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9930538/ |
| — | Sterne, J. A. C., et al. (2009). BMJ . https://pmc.ncbi.nlm.nih.gov/articles/PMC2714692/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2714692/ |
| — | Patel, C. J., Burford, B., & Ioannidis, J. P. A. (2015). Journal of Clinical Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4555355/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4555355/ |
| — | Simonsohn, U., Simmons, J. P., & Nelson, L. D. (2020). Nature Human Behaviour . https://www.nature.com/articles/s41562-020-0912-z | — | — | https://www.nature.com/articles/s41562-020-0912-z |
| — | VanderWeele, T. J., & Ding, P. (2017). Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/28693043/ | — | — | https://pubmed.ncbi.nlm.nih.gov/28693043/ |
| — | Lash, T. L., Abrams, B., & Bodnar, L. M. (2014). Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4306386/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4306386/ |
| — | Steegen, S., Tuerlinckx, F., Gelman, A., & Vanpaemel, W. (2016). Perspectives on Psychological Science . https://pubmed.ncbi.nlm.nih.gov/27694465/ | — | — | https://pubmed.ncbi.nlm.nih.gov/27694465/ |
| — | Cooper, H., et al. (2021). International Journal of Epidemiology . https://pubmed.ncbi.nlm.nih.gov/34109395/ | — | — | https://pubmed.ncbi.nlm.nih.gov/34109395/ |
| — | Goudy, W. J. (1985). Journal of Gerontology . https://pubmed.ncbi.nlm.nih.gov/3989251/ | — | — | https://pubmed.ncbi.nlm.nih.gov/3989251/ |
| — | Austin, P. C., & Fine, J. P. (2017). Statistics in Medicine . https://pmc.ncbi.nlm.nih.gov/articles/PMC5698744/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5698744/ |
| — | Greenland, S. (1996). International Journal of Epidemiology . https://pubmed.ncbi.nlm.nih.gov/9027513/ | — | — | https://pubmed.ncbi.nlm.nih.gov/9027513/ |
| — | Weuve, J., et al. (2012). Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3237815/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3237815/ |
| — | Thabane, L., et al. (2013). BMC Medical Research Methodology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3720188/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3720188/ |
| — | Sun, X., et al. (2012). BMJ . https://www.bmj.com/content/344/bmj.e1553 | — | — | https://www.bmj.com/content/344/bmj.e1553 |
| — | VanderWeele, T. J., & Knol, M. J. (2014). Epidemiologic Methods . https://www.degruyter.com/document/doi/10.1515/em-2013-0005/html | — | — | https://www.degruyter.com/document/doi/10.1515/em-2013-0005/html |
| — | Sun, X., Briel, M., Walter, S. D., & Guyatt, G. H. (2010). BMJ . https://www.bmj.com/content/340/bmj.c117.long | — | — | https://www.bmj.com/content/340/bmj.c117.long |
| — | Kent, D. M., Rothwell, P. M., Ioannidis, J. P. A., Altman, D. G., & Hayward, R. A. (2010). Trials . https://pmc.ncbi.nlm.nih.gov/articles/PMC2928211/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2928211/ |
| — | Hopewell, S., et al. (2025). BMJ . https://www.bmj.com/content/389/bmj-2024-081124 | — | — | https://www.bmj.com/content/389/bmj-2024-081124 |
| — | Pocock, S. J., Assmann, S. E., Enos, L. E., & Kasten, L. E. (2002). Statistics in Medicine . https://onlinelibrary.wiley.com/doi/10.1002/sim.1296 | — | — | https://onlinelibrary.wiley.com/doi/10.1002/sim.1296 |
| — | Knol, M. J., & VanderWeele, T. J. (2012). International Journal of Epidemiology . https://academic.oup.com/ije/article/41/2/514/692957 | — | — | https://academic.oup.com/ije/article/41/2/514/692957 |
| — | VanderWeele, T. J. (2012). Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC4249691/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4249691/ |
| — | Royston, P., Altman, D. G., & Sauerbrei, W. (2006). Statistics in Medicine . https://pubmed.ncbi.nlm.nih.gov/16217841/ | — | — | https://pubmed.ncbi.nlm.nih.gov/16217841/ |
| — | Brookes, S. T., Whitely, E., Egger, M., Davey Smith, G., Mulheran, P. A., & Peters, T. J. (2004). Journal of Clinical Epidemiology . https://pubmed.ncbi.nlm.nih.gov/15066682/ | — | — | https://pubmed.ncbi.nlm.nih.gov/15066682/ |
| — | Schandelmaier, S., et al. (2014). BMJ . https://www.bmj.com/content/349/bmj.g4539 | — | — | https://www.bmj.com/content/349/bmj.g4539 |
| — | Wang, R., Lagakos, S. W., Ware, J. H., Hunter, D. J., & Drazen, J. M. (2007). New England Journal of Medicine . https://www.nejm.org/doi/full/10.1056/NEJMsr077003 | — | — | https://www.nejm.org/doi/full/10.1056/NEJMsr077003 |
| — | Buyse, M., et al. (2000). The validation of surrogate endpoints in meta-analyses of randomized experiments . Biostatistics . https://pubmed.ncbi.nlm.nih.gov/12933525/ | — | — | https://pubmed.ncbi.nlm.nih.gov/12933525/ |
| — | Fleming, T. R., & DeMets, D. L. (1996). Surrogate end points in clinical trials: are we being misled? Annals of Internal Medicine . https://pubmed.ncbi.nlm.nih.gov/8815760/ | — | — | https://pubmed.ncbi.nlm.nih.gov/8815760/ |
| — | Moqri, M., et al. (2024). Validation of biomarkers of aging . Nature Medicine . https://pubmed.ncbi.nlm.nih.gov/38355974/ | — | — | https://pubmed.ncbi.nlm.nih.gov/38355974/ |
| — | Cummings, S. R., & Kritchevsky, S. B. (2022). Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age . GeroScience . https://doi.org/10.1007/s11357-022-00671-8 | — | — | https://doi.org/10.1007/s11357-022-00671-8 |
| — | Prentice, R. L. (1989). Surrogate endpoints in clinical trials: definition and operational criteria . Statistics in Medicine . https://pubmed.ncbi.nlm.nih.gov/2727467/ | — | — | https://pubmed.ncbi.nlm.nih.gov/2727467/ |
| — | Jiang, N., et al. (2025). Deciphering the Timing and Impact of Life-Extending Interventions: Temporal Efficacy Profiler Distinguishes Early, Midlife, and Senescence Phase Efficacies . Nature Communications . https://doi.org/10.1038/s41467-025-65158-4 | — | — | https://doi.org/10.1038/s41467-025-65158-4 |
| — | Hernán, M. A. (2010). The Hazards of Hazard Ratios . Epidemiology . https://pmc.ncbi.nlm.nih.gov/articles/PMC3653612/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC3653612/ |
| — | Royston, P., & Parmar, M. K. B. (2013). Restricted Mean Survival Time: An Alternative to the Hazard Ratio for the Design and Analysis of Randomized Trials with a Time-to-Event Outcome . BMC Medical Research Methodology . https://doi.org/10.1186/1471-2288-13-152 | — | — | https://doi.org/10.1186/1471-2288-13-152 |
| — | Kaplan, E. L., & Meier, P. (1958). Nonparametric Estimation from Incomplete Observations . Journal of the American Statistical Association . https://doi.org/10.1080/01621459.1958.10501452 | — | — | https://doi.org/10.1080/01621459.1958.10501452 |
| — | Shea, B. J., et al. (2017). BMJ . https://www.bmj.com/content/358/bmj.j4008 | — | — | https://www.bmj.com/content/358/bmj.j4008 |
| — | Ferrari, R. (2015). Medical Writing . https://www.tandfonline.com/doi/full/10.1179/2047480615Z.000000000329 | — | — | https://www.tandfonline.com/doi/full/10.1179/2047480615Z.000000000329 |
| — | Page, M. J., et al. (2021). BMJ . https://www.bmj.com/content/372/bmj.n71 | — | — | https://www.bmj.com/content/372/bmj.n71 |
| — | Jylhävä J, Pedersen NL, Hägg S. Biological Age Predictors. Frontiers in Medicine (2018). | — | — | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00061/full |
| — | von Elm E, et al. STROBE statement. PLoS Medicine (2007). | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC2020496/ |
| — | Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement. BMJ (2010). | — | — | https://www.bmj.com/content/340/bmj.c332 |
| — | Collins GS, et al. Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD). BMJ (2015). | — | — | https://www.bmj.com/content/350/bmj.g7594 |
| — | Wolff RF, et al. PROBAST: A Tool to Assess Risk of Bias and Applicability of Prediction Model Studies. BMJ (2019). | — | — | https://www.bmj.com/content/366/bmj.l4898 |
| — | Lee JW, et al. Fit-for-purpose method development and validation for successful biomarker measurement. Pharmaceutical Research (2006). | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4975285/ |
| — | ClinicalTrials.gov. | — | — | https://clinicaltrials.gov/ |
| — | PubMed (NLM/NCBI). | — | — | https://pubmed.ncbi.nlm.nih.gov/ |
| — | Zarin DA, Tse T, et al. The ClinicalTrials.gov results database. New England Journal of Medicine (2011). | — | — | https://www.ovid.com/journals/nejm/abstract/00006024-201106020-00038~the-clinicaltrialsgov-results-database |
| — | Fries, J. F. (1980). Aging, natural death, and the compression of morbidity . New England Journal of Medicine. https://www.nejm.org/doi/abs/10.1056/NEJM198007173030304 | — | — | https://www.nejm.org/doi/abs/10.1056/NEJM198007173030304 |
| — | Moqri, M., Herzog, C., Poganik, J. R., et al. (2023). Biomarkers of aging for the identification and evaluation of longevity interventions . Cell. https://doi.org/10.1016/j.cell.2023.08.003 | — | — | https://doi.org/10.1016/j.cell.2023.08.003 |
| — | Kennedy, B. K., Berger, S. L., Brunet, A., et al. (2014). Geroscience: Linking aging to chronic disease . Cell. https://doi.org/10.1016/j.cell.2014.10.039 | — | — | https://doi.org/10.1016/j.cell.2014.10.039 |
| — | Seals, D. R., Justice, J. N., & LaRocca, T. J. (2016). Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity . The Journal of Physiology. https://pmc.ncbi.nlm.nih.gov/articles/PMC4933122/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4933122/ |
| — | Crimmins, E. M. (2015). Lifespan and Healthspan: Past, Present, and Promise . The Gerontologist. https://pmc.ncbi.nlm.nih.gov/articles/PMC4861644/ | — | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4861644/ |