Glossary
What This Glossary Is For
This glossary gives concise definitions of key terms used across ageing biology, biomarkers, healthspan, and geroscience. It is designed to clarify terminology quickly, not to replace the longer explainer pages elsewhere on the site.
Start With Common Terms
- Biological Age: how biological state can differ from years lived.
- Healthspan: the years lived in relatively good health.
- Lifespan: the total length of life.
- Cellular Senescence: a non-dividing but active cellular state relevant to ageing and disease.
- Senolytics: compounds studied for selectively removing some senescent cells.
- Autophagy: the cellular recycling process often discussed in longevity research.
All Glossary Entries
- Advanced Glycation End-Products / AGEs
- Allostatic Load
- Altered Nutrient Sensing
- AMPK
- Apoptosis
- Autophagy
- Biogerontology
- Biological Age
- Biological Variability
- Biomarker
- Cellular Reprogramming
- Cellular Senescence
- Chromatin
- Chronological Age
- Clinical Endpoint
- Clonal Hematopoiesis
- Composite Endpoint
- CpG Sites
- CRISPR
- Digital Biomarkers
- Disabled Macroautophagy
- DNA Damage Response
- DNA Methylation
- Dysbiosis
- ECM Crosslinking
- Epigenetic Age
- Epigenetic Alterations
- Epigenetic Clock
- Epigenetic Drift
- Epigenetics
- Exosomes
- Extracellular Matrix
- Frailty Index
- Frailty
- Functional Age
- Genomic Instability
- Gerontology
- Geroprotector
- Geroscience
- Gerotherapeutic
- Glycation
- GrimAge
- Hayflick Limit
- Hazard Ratio
- Healthspan
- Homeostasis
- Homeostatic Resilience
- Immunosenescence
- Inflammaging
- Inflammasome
- Intercellular Communication
- Intrinsic Capacity
- Lifespan
- Lysosome
- Macroautophagy
- Macrophage Polarization
- Macrophage
- Microbiome
- Mitochondrial Dysfunction
- Mitophagy
- Morbidity
- mTOR
- Multimorbidity
- Oxidative Stress
- p16INK4a
- p21
- Parabiosis
- PhenoAge
- Proteasome
- Proteostasis
- Quiescence
- Reactive Oxygen Species
- Replicative Senescence
- Sarcopenia
- SASP
- Senescence Surveillance
- Senescence
- Senolytics
- Senomorphics
- Sirtuins
- Stem Cell Exhaustion
- Surrogate Endpoint
- Telomerase
- Telomere Attrition
- Telomeres
- VO2 Max
- Yamanaka Factors
Note
This glossary defines terms as they are generally used in geroscience. Definitions and preferred frameworks can evolve as research develops.