Epigenetics
Definition
Epigenetics refers to changes in gene regulation that do not alter the underlying DNA sequence. These changes help determine which genes are more or less active in different cells and conditions. [1] [2]
Why It Matters in Ageing Research
Epigenetics matters in ageing research because gene regulation changes over time and can be influenced by environment, stress, and cellular state. Age-related epigenetic changes are often discussed as part of altered gene control and are also used in DNA methylation-based ageing biomarkers. [3] [6] [7]
Common Confusion
- Epigenetics is not the same as genetics; it changes gene activity without changing DNA sequence.
- Epigenetics is broader than DNA methylation alone.
- Epigenetics does not automatically mean changes are permanent or inherited across generations.
Related Reading
References
- Bird, A. (2007). Perceptions of epigenetics. https://doi.org/10.1038/nature05913
- Berger, S. L., et al. (2009). An operational definition of epigenetics. https://doi.org/10.1101/gad.1787609
- Allis, C. D., & Jenuwein, T. (2016). The molecular hallmarks of epigenetic control. https://doi.org/10.1038/nrg.2016.59
- Kouzarides, T. (2007). Chromatin modifications and their function. https://doi.org/10.1016/j.cell.2007.02.005
- Portela, A., & Esteller, M. (2010). Epigenetic modifications and human disease. https://doi.org/10.1038/nbt.1684
- Lopez-Otin, C., et al. (2013). The hallmarks of aging. https://doi.org/10.1016/j.cell.2013.05.039
- Benayoun, B. A., et al. (2016). Epigenetic regulation of ageing: linking environmental inputs to genomic stability. https://doi.org/10.1038/nrm.2015.16
Note
This glossary entry is provided for educational purposes only and does not constitute medical advice.