Geroprotector
Definition
A geroprotector is an intervention or agent studied for its ability to slow, delay, or modify biological processes of ageing, usually with the aim of improving lifespan, healthspan, resilience, or age-related disease risk in experimental models or human research. [1] [2]
Why It Matters in Ageing Research
Geroprotectors are important in geroscience because they frame ageing itself as a target for research, rather than treating each age-related disease in isolation. Candidate geroprotectors are often evaluated through effects on lifespan, healthspan, frailty, biomarkers of ageing, and mechanisms such as nutrient sensing, inflammation, proteostasis, senescence, or mitochondrial function. [1] [3]
Common Confusion
- A geroprotector is a research term, not proof that an intervention is clinically effective in humans.
- Evidence from model organisms does not automatically translate to human healthspan or lifespan benefits.
- Geroprotector is broader than senolytic; senolytics specifically target senescent cells.
Related Reading
References
- Moskalev, A., Chernyagina, E., Kudryavtseva, A., & Shaposhnikov, M. (2017). Geroprotectors: A unified concept and screening approaches. Aging and Disease. https://pmc.ncbi.nlm.nih.gov/articles/PMC5440114/
- Moskalev, A., Chernyagina, E., de Magalhães, J. P., & Zhavoronkov, A. (2015). Geroprotectors.org: A new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging. https://pmc.ncbi.nlm.nih.gov/articles/PMC4600621/
- Trendelenburg, A. U., Scheuren, A. C., Potter, P., Müller, R., & Bellantuono, I. (2019). Geroprotectors: A role in the treatment of frailty. Mechanisms of Ageing and Development. https://www.sciencedirect.com/science/article/pii/S0047637419300363
This glossary entry is provided for educational purposes only and does not constitute medical advice.