Homeostasis
Definition
Homeostasis is the self-regulating process by which biological systems maintain internal stability while adjusting to changing internal or external conditions. [1] [2]
Why It Matters in Ageing Research
Ageing can reduce the ability of cells, tissues, and organs to maintain or restore stable function after stress. In ageing research, declining homeostatic regulation is closely related to resilience, physiological reserve, frailty, and vulnerability to disease or functional decline. [3]
Common Confusion
- Homeostasis does not mean that the body is static; it refers to regulated stability within changing conditions.
- Homeostasis is not the same as allostasis, which refers to achieving stability through adaptive change.
- Loss of homeostatic control can appear as reduced resilience, slower recovery, or greater vulnerability to stressors.
Related Reading
References
- Billman, G. E. (2020). Homeostasis: The underappreciated and far too often ignored central organizing principle of physiology. Frontiers in Physiology. https://pmc.ncbi.nlm.nih.gov/articles/PMC7076167/
- OpenStax. Homeostasis. https://openstax.org/books/anatomy-and-physiology-2e/pages/1-5-homeostasis
- Promislow, D. (2022). Resilience integrates concepts in aging research. GeroScience. https://pmc.ncbi.nlm.nih.gov/articles/PMC9044173/
Note
This glossary entry is provided for educational purposes only and does not constitute medical advice.